Adenosine and renal tubular function

Current Opinion in Nephrology and Hypertension

Volumn 17, Issue 4, 2008, Pages 399-407

  Di Sole, Francesca ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Adenosine; Adenosine receptors; NaCl transport; Renal protection

Indexed keywords

ADENOSINE; ADENOSINE PHOSPHATE; ADENOSINE RECEPTOR; ADENOSINE TRIPHOSPHATE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; INOSINE;

DEPHOSPHORYLATION; DIURETIC ACTIVITY; FLUID TRANSPORT; HUMAN; ION TRANSPORT; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY EPITHELIUM; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE FUNCTION; METHYLATION; NEPHRON; OXYGEN CONSUMPTION; PARACRINE SIGNALING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; RENAL PROTECTION; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; URINARY EXCRETION; ANIMAL; BIOSYNTHESIS; KIDNEY DISEASE; KIDNEY TUBULE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; CYCLIC AMP; HUMANS; KIDNEY DISEASES; KIDNEY TUBULES; RECEPTORS, PURINERGIC P1;

EID: 55249120932     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/MNH.0b013e32830321e1     Document Type: Review

References (108)

1. Kiil F, Sejersted OM, Steen PA. Energetics and specificity of transcellular NaCl transport in the dog kidney. Int J Biochem 1980; 12:245-250.
2. Ostensen J, Stokke ES, Hartmann A, et al. Low oxygen cost of carbonic anhydrase-dependent sodium reabsorption in the dog kidney. Acta Physiol Scand 1989; 137:189-198.
3. Vallon V, Muhlbauer B, Osswald H. Adenosine and kidney function. Physiol Rev 2006; 86:901-940.
4. Jackson E, Dubey R. Role of the extracellular cAMP-adenosine pathway in renal physiology. Am J Physiol Renal Physiol 2001; 281:F597-F612.
5. Mangravite L, Xiao G, Giacomini K. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am J Physiol Renal Physiol 2003; 284:F902-F910.
6. Elwi A, Damaraju V, Baldwin S, et al. Renal nucleoside transporters: physiological and clinical implications. Biochem Cell Biol 2006; 84:844-858.
7. Pearson JD, Gordon JL. Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides. Nature 1979; 281:384-386.
8. Gordon EL, Pearson JD, Dickinson ES, et al. The hydrolysis of extracellular adenine nucleotides by arterial smooth muscle cells. Regulation of adenosine production at the cell surface. J Biol Chem 1989; 264:18986-18995.
9. LeRoy EC, Ager A, Gordon JL. Effects of neutrophil elastase and other proteases on porcine aortic endothelial prostaglandin I2 production, adenine nucleotide release, and responses to vasoactive agents. J Clin Invest 1984; 74:1003-1010.
10. Pearson JD, Carleton JS, Gordon JL. Metabolism of adenine nucleotides by ectoenzymes of vascular endothelial and smooth-muscle cells in culture. Biochem J 1980; 190:421-429.
11. Gordon JL. Extracellular ATP: effects, sources and fate. Biochem J 1986; 233:309-319.
12. Thorn J, Jarvis S. Adenosine transporters. Gen Pharmacol 1996; 27:613-620.
13. Rodriguez-Mulero S, Errasti-Murugarren E, Ballarin J, et al. Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes. Kidney Int 2005; 68:665-672.
14. Kroll K, Decking UK, Dreikorn K, et al. Rapid turnover of the AMP-adenosine metabolic cycle in the guinea pig heart. Circ Res 1993; 73:846-856.
15. Zimmermann H. 5′-Nucleotidase: molecular structure and functional aspects. Biochem J 1992; 285 (Pt 2):345-365.
16. Pearson JD, Coade SB, Cusack NJ. Characterization of ectonucleotidases on vascular smooth-muscle cells. Biochem J 1985; 230:503-507.
17. van Aubel R, Smeets P, Peters J, et al. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol 2002; 13:595-603.
18. Davoren PR, SutherlandEW. The effect of L-epinephrine and other agents on the synthesis and release of adenosine 3′,5′-phosphate by whole pigeon erythrocytes. J Biol Chem 1963; 238:3009-3015.
19. Barber R, Butcher R. The egress of cyclic AMP from metazoan cells. In: Greengard PRG, editor. Advances in cyclic nucleotide research. New York: Raven Press; 1983. pp. 119-138.
20. Siragy HM, Linden J. Sodium intake markedly alters renal interstitial fluid adenosine. Hypertension 1996; 27:404-407.
21. Zou A, Wu F, Li P, et al. Effect of chronic salt loading on adenosine metabolism and receptor expressioninrenal cortex and medullainrats. Hypertension 1999; 33:511-516.
22. Katholi R, Taylor G, McCann W, et al. Nephrotoxicity from contrast media: attenuation with theophylline. Radiology 1995; 195:17-22.
23. Baudouin-Legros M, Badou A, Paulais M, et al. Hypertonic NaCl enhances adenosine release and hormonal cAMP production in mouse thick ascending limb. Am J Physiol 1995; 269:F103-F109.
24. Miller W, Thomas R, Berne R, et al. Adenosine production in the ischemic kidney. Circ Res 1978; 43:390-397.
25. Sakai K, Akima M, Nabata H. A possible purinergic mechanism for reactive ischemia in isolated, cross-circulated rat kidney. Jpn J Pharmacol 1979; 29: 235-242.
26. Osswald H, Schmitz H, Kemper R. Tissue content of adenosine, inosine and hypoxanthine in the rat kidney after ischemia and postischemic recirculation. Pflugers Arch S 1977; 371:45-49.
27. Ramos-Salazar A, Baines A. Role of 5′-nucleotidase in adenosine-mediated renal vasoconstriction during hypoxia. JPharmacol Exp Ther 1986; 236:494-499.
28. Pfeifer C, Suzuki F, Jackson E. Selective A1 adenosine receptor antagonism augments beta-adrenergic-induced renin release in vivo. Am J Physiol 1995; 269:F469-F479.
29. Inscho E. Renal microvascular effects of P2 receptor stimulation. Clin Exp Pharmacol Physiol 2001; 28:332-339.
30. Schwiebert E, Kishore B. Extracellular nucleotide signaling along the renal epithelium. Am J Physiol Renal Physiol 2001; 280:F945-F963.
31. Lloyd HG, Deussen A, Wuppermann H, et al. The transmethylation pathway as a source for adenosine in the isolated guinea-pig heart. Biochem J 1988; 252:489-494.
32. Deussen A, Lloyd HG, Schrader J. Contribution of S-adenosylhomocysteine to cardiac adenosine formation. J Mol Cell Cardiol 1989; 21:773-782.
33. Jackson E, Mi Z, Zhu C, et al. Adenosine biosynthesis in the collecting duct. J Pharmacol Exp Ther 2003; 307:888-896.
34. Jackson E, Zacharia L, Zhang M, et al. cAMP-adenosine pathway in the proximal tubule. J Pharmacol Exp Ther 2006; 317:121 9-1229.
35. Spielman W, Parameswaran N, Sparks H. Adenosine: an intrarenal mediator of renal function. In: Seldin D, Giebisch G, editors. The kidney: physiology and pathophysiology, 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2000. pp. 905-913.
36. Thompson C, Sparks H, Spielman W. Renal handling and production of plasma and urinary adenosine. Am J Physiol 1985; 248:F545-F551.
37. Heyne N, Benohr P, Muhlbauer B, et al. Regulation of renal adenosine excretion in humans - role of sodium and fluid homeostasis. Nephrol Dial Transplant 2004; 19:2737-2741.
38. Olah M, Stiles G. The role of receptor structure in determining adenosine receptor activity. Pharmacol Ther S 2000; 85:55-75.
39. Poulsen S, Quinn R. Adenosine receptors: new opportunities for future drugs. Bioorg Med Chem 1998; 6:619-641.
40. Morton M, Sivaprasadarao A, Bowmer C, et al. Adenosine receptor mRNA levels during postnatal renal maturation in the rat. J Pharm Pharmacol 1998; 50:649-654.
41. Vitzthum H, Weiss B, Bachleitner W, et al. Gene expression of adenosine receptors along the nephron. Kidney Int 2004; 65:1180-1190.
42. Pawelczyk T, Grden M, Rzepko R, et al. Region-specific alterations of adenosine receptors expression level in kidney of diabetic rat. Am J Pathol 2005; 167:315-325.
43. Weaver D, Reppert S. Adenosine receptor gene expression in rat kidney. Am J Physiol 1992; 263:F991-F995.
44. Smith J, Sivaprasadarao A, Munsey T, et al. Immunolocalisation of adenosine A(1) receptors in the rat kidney. Biochem Pharmacol 2001; 61:237-244.
45. Nishiyama A, Inscho E, Navar L Interactions of adenosine A1 and A2a receptors on renal microvascular reactivity. Am J Physiol Renal Physiol 2001; 280:F406-F414.
46. Yamaguchi S, Umemura S, Tamura K, et al. Adenosine A1 receptor mRNA in microdissected rat nephron segments. Hypertension 1995; 26:1181-1185.
47. Zhao Z, Kapoian T, Shepard M, et al. Adenosine-induced apoptosis in glomerular mesangial cells. Kidney Int 2002; 61:1276-1285.
48. Duann P, Ho T, Desai B, et al. Mesangial cell apoptosis induced by stimulation of the adenosine A3 receptor: signaling and apoptotic events. J Investig Med 2005; 53:37-43.
49. Tang Y, Zhou L Characterization of adenosine A1 receptors in human proximal tubule epithelial (HK-2) cells. Receptors Channels 2003; 9:67-75.
50. Blanco J, Canela E, Mallol J, et al. Characterization of adenosine receptors in brush-border membranes from pig kidney. Br J Pharmacol 1992; 107:671-678.
51. Yaar R, Jones MR, Chen JF, et al. Animal models for the study of adenosine receptor function. J Cell Physiol 2005; 202:9-20.
52. Di Sole F, Cerull R, Petzke S, et al. Bimodal acute effects of A1 adenosine receptor activation on Na+/H+ exchanger 3 in opossum kidney cells. J Am Soc Nephrol 2003; 14:1720-1730.
53. Di Sole F, Cerull R, Casavola V, et al. Molecular aspects of acute inhibition of Na(+)-H(+) exchanger NHE3 byA(2)-adenosine receptor agonists. J Physiol S 2002; 541:529-543.
54. Di Sole F, Cerull R, BabichV, et al. Short-and long-term A3 adenosine receptor activation inhibits the Na+/H+ exchanger NHE3 activity and expression in opossum kidney cells. J Cell Physiol 2008; 216:221-233.
55. Hoenderop J, Hartog A, Willems P, et al. Adenosine-stimulated Ca2+ reabsorption is mediated by apical A1 receptors in rabbit cortical collecting system. Am J Physiol 1998; 274:F736-F743.
56. Macala L, Hayslett J. Basolateral and apical A1 adenosine receptors mediate sodium transport in cultured renal epithelial (A6) cells. Am J Physiol Renal Physiol 2002; 283:F1 216-F1225.
57. LeVier D, McCoy D, Spielman W. Functional localization of adenosine receptormediated pathways in the LLC-PK1 renal cell line. Am J Physiol Cell Physiol 1992; 263:C729-C735.
58. Casavola V, Guerra L, Reshkin S, et al. Polarization of adenosine effects on intracellular pH in A6 renal epithelial cells. Mol Pharmacol 1997; 51:516-523.
59. Di Sole F, Casavola V, Mastroberardino L, et al. Adenosine inhibits the transfected Na+-H+ exchanger NHE3 in Xenopus laevis renal epithelial cells (A6/C1). J Physiol 1999; 515:829-842.
60. Saunders C, Limbird L. Disruption of microtubules reveals two independent apical targeting mechanisms for G-protein-coupled receptors in polarized renal epithelial cells. J Biol Chem 1997; 272:19035-19045.
61. Nagai J, Yano I, Habu Y, et al. Inhibitory effect of KW-3902, an adenosine A(1) receptor antagonist, on p-aminohippurate transport in OK cells. Biochim Biophys Acta 1999; 1419:164-172.
62. Reshkin S, Guerra L, Bagorda A, et al. Activation of A(3) adenosine receptor induces calcium entry and chloride secretion in A(6) cells. J Membr Biol 2000; 178:103-113.
63. Knight R, Bowmer C, Yates M. The diuretic action of 8-cyclopentyl-1, 3-dipropylxanthine, a selective A1 adenosine receptor antagonist. Br J Pharmacol 1993; 109:271-277.
64. Wilcox C, Welch W, Schreiner G, et al. Natriuretic and diuretic actions of a highly selective adenosine A1 receptor antagonist. J Am Soc Nephrol 1999; 10:714-720.
65. Mizumoto H, Karasawa A. Renal tubular site of action of KW-3902, a novel adenosine A1-receptor antagonist,in anesthetized rats. Jpn JPharmacol 1993; 61:251-253.
66. Balakrishnan V,ColesG,Williams J.A potential role for endogenous adenosine in control of human glomerular and tubular function. Am J Physiol 1993; 265:F504-510.
67. van Buren M, Bijlsma J, Boer P, et al. Natriuretic and hypotensive effect of adenosine-1 blockade in essential hypertension. Hypertension 1993; 22:728-734.
68. Rieg T, Steigele H, Schnermann J, et al. Requirement of intact adenosine A1 receptors for the diuretic and natriuretic action of the methylxanthines theophylline and caffeine. J Pharmacol Exp Ther 2005; 313:403-409.
69. Coulson R, Johnson R, Olsson R, et al. Adenosine stimulates phosphate and glucose transport in opossum kidney epithelial cells. Am J Physiol S 1991; 260:F921-F928.
70. Takeda M, Yoshitomi K, Imai M. Regulation of Na(+)-3HCO3- cotransport in rabbit proximal convoluted tubule via adenosine A1 receptor. Am J Physiol 1993; 265:F511-F519.
71. Cai H, Batuman V, Puschett D, et al. Effect of KW-3902, a novel adenosine A1 receptor antagonist, on sodium-dependent phosphate and glucose transport by the rat renal proximal tubular cell. Life Sci 1994; 55:839-845.
72. CoulsonR,ProchP,OlssonR, et al.Upregulatedrenal adenosineA1receptors augment PKC and glucose transport but inhibit proliferation. Am J Physiol 1996; 270:F263-F274.
73. Yagil C, Katni G, Yagil Y. The effects of adenosine on transepithelial resistance and sodium uptake in the inner medullary collecting duct. Pflugers Arch 1994; 427:225-232.
74. Fransen R, Koomans H. Adenosine and renal sodium handling: direct natriuresis and renal nerve-mediated antinatriuresis. J Am Soc Nephrol 1995; 6: 1491-1497.
75. Preisig P, Ives H, Cragoe EJ, et al. Role of the Na+/H+ antiporter in rat proximal tubule bicarbonate absorption. J Clin Invest S 1987; 80:970-978.
76. Preisig P, Rector FJ. Role of Na+-H+ antiport in rat proximal tubule NaCl absorption. Am J Physiol S 1988; 255:F461-F465.
77. Di Sole F, Cerull R, Babich V, et al. Acute regulation of Na/H exchanger NHE3 by adenosine A(1) receptors is mediated by calcineurin homologous protein. J Biol Chem 2004; 279:2962-2974.
78. Harris PJ, Young JA. Dose-dependent stimulation and inhibition of proximal tubular sodium reabsorption by angiotensin II in the rat kidney. Pflugers Arch 1977; 367:295-297.
79. Poggioli J, Lazar G, Houillier P, et al. Effects of angiotensin II and nonpeptide receptor antagonists on transduction pathways in rat proximal tubule. Am J Physiol 1992; 263:C750-C758.
80. Vallon V, Richter K, Huang D, et al. Functional consequences at the singlenephron level of the lack of adenosine A1 receptors and tubuloglomerular feedback in mice. Pflugers Arch 2004; 448:214-221.
81. Wengert M, Berto CJ, Kaufman J, et al. Stimulation of the proximal tubule Na+-ATPase activity by adenosine A(2A) receptor. Int J Biochem Cell Biol 2005; 37:155-165.
82. Mozaffari M, Abebe W, Warren B. Renal adenosine A3 receptors in the rat: assessment of functional role. Can J Physiol Pharmacol 2000; 78:428-432.
83. Burnatowska-Hledin M, Spielman W. Effects of adenosine on cAMP production and cytosolic Ca2+ in cultured rabbit medullary thick limb cells. Am J Physiol 1991; 260:C143-C150.
84. Torikai S.Effectofphenylisopropyladenosineonvasopressin-dependent cyclic AMP generation in defined nephron segments from rat. Ren Physiol 1987; 10:33-39.
85. Beach R, Good D. Effects of adenosine on ion transport in rat medullary thick ascending limb. Am J Physiol 1992; 263:F482-F487.
86. Pallone TL, Silldorff EP, Turner MR. Intrarenal blood flow: microvascular anatomy and the regulation of medullary perfusion. Clin Exp Pharmacol Physiol 1998; 25:383-392.
87. Brezis M, Rosen S. Hypoxia of the renal medulla - its implications for disease. N Engl J Med 1995; 332:647-655.
88. Beach R, Watts Br, Good D, et al. Effects of graded oxygen tension on adenosine release by renal medullary and thick ascending limb suspensions. Kidney Int 1991; 39:836-842.
89. ZouA,NithipatikomK,LiP, et al. Roleofrenal medullary adenosineinthe control of blood flow and sodium excretion. Am J Physiol 1999; 276:R790-R798.
90. Li D, Wei Y, Wang W. Dietary K intake regulates the response of apical K channels to adenosine in the thick ascending limb. Am J Physiol Renal Physiol 2004; 287:F954-F959.
91. Kang H,Kerstan D, Dai L, et al. Adenosine modulates Mg(2+) uptake in distal convoluted tubule cells via A(1) and A(2) purinoceptors. Am J Physiol Renal Physiol 2001; 281:F1141-F1147.
92. Hoenderop J, De Pont J, Bindels R, et al. Hormone-stimulated Ca2+ reabsorption in rabbit kidney cortical collecting system is cAMP-independent and involves a phorbol ester-insensitive PKC isotype. Kidney Int 1999; 55:225-233.
93. Chubanov V, Gudermann T, Schlingmann KP. Essential role for TRPM6 in epithelial magnesium transport and body magnesium homeostasis. Pflugers Arch 2005; 451:228-234.
94. Hoenderop JG, van Leeuwen JP, van der Eerden BC, et al. Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5. J Clin Invest 2003; 112:1906-1914.
95. Wei Y, Sun P, Wang Z, et al. Adenosine inhibits ENaC via cytochrome P-450 epoxygenase-dependent metabolites of arachidonic acid. Am J Physiol Renal Physiol 2006; 290:F1163-F1168.
96. Casavola V, Guerra L, Reshkin S, et al. Effect of adenosine on Na+ and Cl- currents in A6 monolayers. Receptor localization and messenger involvement. J Membr Biol 1996; 151:237-245.
97. Light DB, Schwiebert EM, Fejes-Toth G, et al. Chloride channels in the apical membrane of cortical collecting duct cells. Am J Physiol 1990; 258:F273-F280.
98. Rubera I, Barriere H, Tauc M, et al. Extracellular adenosine modulates a volume-sensitive-like chloride conductance in immortalized rabbit DC1 cells. Am J Physiol Renal Physiol 2001; 280:F126-F145.
99. Moyer B, McCoy D, Lee B, et al. Adenosine inhibits arginine vasopressinstimulated chloride secretion in a mouse IMCD cell line (mIMCD-K2). Am J Physiol Renal Physiol 1995; 269:F884-F891.
100. Yagil Y. Interaction of adenosine with vasopressin in the inner medullary collecting duct. Am J Physiol 1990; 259:F679-F687.
101. Gottlieb S, Skettino S, Wolff A, et al. Effects of BG9719 (CVT-124), an A1adenosine receptor antagonist, and furosemide on glomerular filtration rate and natriuresis in patients with congestive heart failure. J Am Coll Cardiol 2000; 35:56-59.
102. Gottlieb SS, Brater DC, Thomas I, et al. BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 2002; 105:1348-1353.
103. Welch W. Adenosine A1 receptor antagonists in the kidney: effects in fluidretaining disorders. Curr Opin Pharmacol 2002; 2:165-170.
104. Lee H, Emala C. Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A(1) and A(3) receptors. Am J Physiol Renal Physiol 2000; 278:F380-F387.
105. Lee H, Xu H, Nasr S, et al. A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion. Am J Physiol Renal Physiol 2004; 286:F298-F306.
106. Lee H, Ota-Setlik A, Xu H, et al. A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure. Am J Physiol Renal Physiol 2003; 284:F267-F273.
107. Lee H, Gallos G, Nasr S, et al. A1 adenosine receptor activation inhibits inflammation, necrosis, and apoptosis after renal ischemia-reperfusion injury in mice. J Am Soc Nephrol 2004; 15:102-111.
108. LiL, Okusa M. Blocking the immune responseinischemic acute kidney injury: the role of adenosine 2A agonists. Nat Clin Pract Nephrol 2006; 2:432-444.