Physiology of the renal medullary microcirculation

American Journal of Physiology - Renal Physiology

Volumn 284, Issue 2 53-2, 2003, Pages

  Pallone, Thomas L ^a,b   Zhang, Zhong ^a   Rhinehart, Kristie ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

Calcium; Fura 2; Hypertension; Oxygenation; Patch clamp; Perfusion; Urinary concentration; Vasa recta

Indexed keywords

ANGIOTENSIN; AQUAPORIN 1; BRADYKININ; CALCIUM CHANNEL; CHLORIDE ION; ENDOTHELIN 1; FURA 2; SODIUM ION; UREA;

ARTERIOLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL MEMBRANE; CHLORIDE CONDUCTANCE; DEPOLARIZATION; DIFFUSION; FLUID BALANCE; GLOMERULUS; HYPERTENSION; INTERSTITIUM; KIDNEY CIRCULATION; KIDNEY MEDULLA; MEMBRANE DEPOLARIZATION; MICROCIRCULATION; PARACRINE SIGNALING; PATCH CLAMP; PERFUSION PRESSURE; PERICYTE; PRIORITY JOURNAL; REVIEW; SODIUM BALANCE; TISSUE OXYGENATION; VASOCONSTRICTION; VASODILATATION; WATER TRANSPORT;

EID: 0037302405     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00304.2002     Document Type: Review

References (185)

1. Adler S and Huang H. Impaired regulation of renal oxygen consumption in spontaneously hypertensive rats. J Am Soc Nephrol 13: 1788-1794, 2002.
2. 2-receptor agonists on intrarenal blood flow. Am J Physiol Renal Fluid Electrolyte Physiol 265: F802-F806, 1993.
3. Agre P, Preston GM, Smith BL, Jung JS, Raina S, Moon C, Guggino WB, and Nielsen S. Aquaporin CHIP: the archetypal molecular water channel. Am J Physiol Renal Fluid Electrolyte Physiol 265: F463-F476, 1993.
4. Aizawa T, Ishizaka N, Taguchi JI, Nagai R, Mori I, Tang SS, Inglefinger JR, and Ohno M. Heme oxygenase-1 is up-regulated in the kidney of angiotensin II-induced hypertensive rats: possible role in renoprotection. Hypertension 35: 800-806, 2000.
5. Bagnasco SM, Peng T, Nakayama Y, and Sands JM. Differential expression of individual UT-A urea transporter isoforms in rat kidney. J Am Soc Nephrol 11: 1980-1986, 2000.
6. Bankir L and de Rouffignac C. Urinary concentrating ability: insights from comparative anatomy. Am J Physiol Regul Integr Comp Physiol 249: R643-R666, 1985.
7. Bankir L, Kaissling B, de Rouffignac C, and Kriz W. The vascular organization of the kidney of Psammomys obesus. Anat Embryol (Berl) 155: 149-160, 1979.
8. Bankir LT and Trinh-Trang-Tan MM. Renal urea transporters. Direct and indirect regulation by vasopressin Exp Physiol 85: S243-S252, 2000.
9. Beach RE and Good DW. Effects of adenosine on ion transport in rat medullary thick ascending limb. Am J Physiol Renal Fluid Electrolyte Physiol 263: F482-F487, 1992.
10. Bell RD, Keyl MJ, Shrader FR, Jones EW, and Henry LP. Renal lymphatics: the internal distribution. Nephron 5: 454-463, 1968.
11. Brezis M, Heyman SN, Dinour D, Epstein FH, and Rosen S. Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys. J Clin Invest 88: 390-395, 1991.
12. Brezis M and Rosen S. Hypoxia of the renal medulla - its implications for disease. N Engl J Med 332: 647-655, 1995.
13. Carmines PK. Segment-specific effect of chloride channel blockade on rat renal arteriolar contractile responses to angiotensin II. Am J Hypertension 8: 90-94, 1995.
14. 2+] in renal arterioles. Am J Physiol Renal Fluid Electrolyte Physiol 265: F677-F685, 1993.
15. Carmines PK and Navar LG. Disparate effects of Ca channel blockade on afferent and efferent arteriolar responses to ANG II. Am J Physiol Renal Fluid Electrolyte Physiol 256: F1015-F1020, 1989.
16. Casellas D and Mimran A. Shunting in renal microvasculature of the rat: a scanning electron microscopic study of corrosion casts. Anat Rec 201: 237-248, 1981.
17. Cowley AW. Role of the renal medulla in arterial blood pressure regulation. Am J Physiol Regul Integr Comp Physiol 273: R1-R15, 1997.
18. Cowley AW Jr, Mattson DL, Lu S, and Roman RJ. The renal medulla and hypertension. Hypertension 25: 663-673, 1995.
19. Cupples WA and Marsh DJ. Autoregulation of blood flow in renal medulla of the rat: no role for angiotensin II. Can J Physiol Pharmacol 66: 833-836, 1988.
20. Cuttino JT Jr, Clark RL, and Jennette JC. Microradiographic demonstration of human intrarenal microlymphatic pathways. Urol Radiol 11: 83-87, 1989.
21. 2 receptors in vivo and in vitro. Clin Exp Pharmacol Physiol 26: 48-55, 1999.
22. Dinour D and Brezis M. Effects of adenosine on intrarenal oxygenation. Am J Physiol Renal Fluid Electrolyte Physiol 261: F787-F791, 1991.
23. Edwards A, Delong MJ, and Pallone TL. Interstitial water and solute recovery by inner medullary vasa recta. Am J Physiol Renal Physiol 278: F257-F269, 2000.
24. Edwards A and Pallone TL. A multiunit model of solute and water removal by inner medullary vasa recta. Am J Physiol Heart Circ Physiol 274: H1202-H1210, 1998.
25. Edwards A, Silldforff EP, and Pallone TL. The renal medullary microcirculation. Front Biosci 5: E36-E52, 2000.
26. Fenoy FJ, Kauker ML, Milicic I, and Roman RJ. Normalization of pressure-natriuresis by nisoldipine in spontaneously hypertensive rats. Hypertension 19: 49-55, 1992.
27. Foresti R and Motterlini R. The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis. Free Radic Res 31: 459-475, 1999.
28. Franchini KG and Cowley AW Jr. Renal cortical and medullary blood flow responses during water restriction: role of vasopressin. Am J Physiol Regul Integr Comp Physiol 270: R1257-R1264, 1996.
29. Franchini KG and Cowley AW Jr. Sensitivity of the renal medullary circulation to plasma vasopressin. Am J Physiol Regul Integr Comp Physiol 271: R647-R653, 1996.
30. Franchini KG, Mattson DL, and Cowley AW Jr. Vasopressin modulation of medullary blood flow and pressure-natriuresis-diuresis in the decerebrated rat. Am J Physiol Regul Integr Comp Physiol 272: R1472-R1479, 1997.
31. Garcia NH, Plato CF, Stoos BA, and Garvin JL. Nitric oxide-induced inhibition of transport by thick ascending limbs from Dahl salt-sensitive rats. Hypertension 34: 508-513, 1999.
32. Garcia NH, Pomposiello SI, and Garvin JL. Nitric oxide inhibits ADH-stimulated osmotic water permeability in cortical collecting ducts. Am J Physiol Renal Fluid Electrolyte Physiol 270: F206-F210, 1996.
33. Garcia NH, Stoos BA, Carretero, OA, and Garvin JL. Mechanism of the nitric oxide-induced blockade of collecting duct water permeability. Hypertension 27: 679-683, 1996.
34. Goligorsky MS, Li H, Brodsky S, and Chen J. Relationships between caveolae and eNOS: everything in proximity and the proximity of everything. Am J Physiol Renal Physiol 283: F1-F10, 2002.
35. - currents in rabbit portal vein smooth muscle cells by external anions. J Physiol 516: 365-376, 1999.
36. Griendling KK, Mineiri D, Ollerenshaw D, and Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148, 1994.
37. Hansell P, Nygren A, and Ueda J. Influence of verapamil on regional renal blood flow: a study using multichannel laser-Doppler flowmetry. Acta Physiol Scand 139: 15-20, 1990.
38. Hansen PB, Jensen BL, Andreasen D, and Skott O. Differential expression of T- and L-type voltage-dependent calcium channels in renal resistance vessels. Circ Res 89: 630-638, 2001.
39. Hansen PB, Jensen BL, and Skott O. Chloride regulates afferent arteriolar contraction in response to depolarization. Hypertension 32: 1066-1070, 1998.
40. Haugen EN, Croatt AJ, and Nath KA. Angiotensin II induces renal oxidant stress in vivo and heme oxygenase-1 in vivo and in vitro. Kidney Int 58: 144-152, 2000.
41. Hebert SC and Andreoli TE. Control of NaCl transport in the thick ascending limb. Am J Physiol Renal Fluid Electrolyte Physiol 246: F745-F756, 1984.
42. Heyman SN, Goldfarb M, Darmon D, and Brezis M. Tissue oxygenation modifies nitric oxide bioavailability. Microcirculation 6: 199-203, 1999.
43. Hogg RC, Wang Q, and Large WA. Effects of Cl channel blockers on Ca-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein. Br J Pharmacol 111: 1333-1341, 1994.
44. Hu MC, Bankir L, and Trinh-Trang-Tan MM. mRNA expression of renal urea transporters in normal and Brattleboro rats: effect of dietary protein intake. Exp Nephrol 7: 44-51, 1999.
45. Ishizaka N and Griendling KK. Heme oxygenase 1 is regulated by angiotensin II in rat vascular smooth muscle cells. Hypertension 29: 790-795, 1997.
46. Janssen LJ and Sims SM. Spontaneous transient inward currents and rhythmicity in canine and guinea-pig tracheal smooth muscle cells. Pflügers Arch 427: 473-480, 1994.
47. Jensen BL, Ellekvist P, and Skott O. Chloride is essential for contraction of afferent arterioles after agonists and potassium. Am J Physiol Renal Physiol 272: F389-F396, 1997.
48. Kaissling B, de Rouffignac C, Barrett JM, and Kriz W. The structural organization of the kidney of the desert rodent Psammomys obesus. Anat Embryol (Berl) 148: 121-43, 1975.
49. Kaissling B and Kriz W. Structural analysis of the rabbit kidney. Adv Anat Embryol Cell Biol 56: 1-123, 1979.
50. Kakoki M, Zou AP, and Mattson DL. The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney. Am J Physiol Regul Integr Comp Physiol 281: R91-R97, 2001.
51. Kim YH, Kim DU, Han KH, Jung JY, Sands JM, Knepper MA, Madsen KM, and Kim J. Expression of urea transporters in the developing rat kidney. Am J Physiol Renal Physiol 282: F530-F540, 2002.
52. Kim J, Kim WY, Han KH, Knepper MA, Nielsen S, and Madsen KM. Developmental expression of aquaporin 1 in the rat renal vasculature. Am J Physiol Renal Physiol 276: F498-F509, 1999.
53. Kitiyakara C and Wilcox CS. Antioxidants for hypertension. Curr Opin Nephrol Hypertens 7: 531-538, 1998.
54. Kreisberg MS, Silldorff EP, and Pallone TL. Localization of adenosine receptor subtype mRNA in rat outer medullary descending vasa recta by RT-PCR. Am J Physiol Heart Circ Physiol 272: H1231-H1238, 1997.
55. Kriz W. Structural organization of the renal medulla: comparative and functional aspects. Am J Physiol Regul Integr Comp Physiol 241: R3-R16, 1981.
56. Kriz W and Koepsell H. The structural organization of the mouse kidney. Z Anat Entwicklungsgesch 144: 137-63, 1974.
57. Laursen JB, Rajagopalan S, Galis Z, and Tarpey Freeman BA, and Harrison DG. Role of superoxide in angiotensin II-induced but not catecholamine-induced hypertension. Circulation 95: 588-593, 1997.
58. Lear S, Silva P, Kelley VE, and Epstein FH. Prostaglandin E2 inhibits oxygen consumption in rabbit medullary thick ascending limb. Am J Physiol Renal Fluid Electrolyte Physiol 258: F1372-F1378, 1990.
59. , Lemley KV and Kriz W. Anatomy of the renal interstitium. Kidney Int 39: 370-381, 1991.
60. Lemley KV and Kriz W. Cycles and separations: the histotopography of the urinary concentrating process. Kidney Int 31: 538-548, 1987.
61. Li H, Brodsky S, Basco M, Romanov V, De Angelis DA, and Goligorsky MS. Nitric oxide attenuates signal transduction: possible role in dissociating caveolin-1 scaffold. Circ Res 88: 229-236, 2001.
62. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, and Epstein CJ. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 1: 376-381, 1995.
63. Loutzenhiser R, Chilton L, and Trottier G. Membrane potential measurements in renal afferent and efferent arterioles: actions of angiotensin II. Am J Physiol Renal Physiol 273: F307-F314, 1997.
64. 2+ entry. Circ Res 87: 551-557, 2000.
65. Lu S, Roman RJ, Mattson DL, and Cowley AW Jr. Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in rats. Am J Physiol Regul Integr Comp Physiol 263: R1064-R1070, 1992.
66. Ma T, Yang B, Gillespie A, Carlson EJ, Epstein CJ, and Verkman AS. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem 273: 4296-4269, 1998.
67. MacPhee PJ. Estimating rat renal medullary interstitial oncotic pressures and the driving force for fluid uptake into ascending vasa recta. J Physiol 506: 529-538, 1998.
68. MacPhee PJ and Michel CC. Fluid uptake from the renal medulla into the ascending vasa recta in anaesthetized rats. J Physiol 487: 169-183, 1995.
69. MacPhee PJ and Michel CC. Subatmospheric closing pressures in individual microvessels of rats and frogs. J Physiol 484: 183-187, 1995.
70. Majid DSA, Godfrey M, and Omoro SA. Pressure natriuresis and autoregulation of inner medullary blood flow in canine kidney. Hypertension 29: 210-215, 1997.
71. Manning J, Beutler K, Knepper MA, and Vehaskari VM. Upregulation of renal BSC1 and TSC in prenatally programmed hypertension. Am J Physiol Renal Physiol 283: F202-F206, 2002.
72. 1A receptors. Am J Physiol Renal Fluid Electrolyte Physiol 271: F1020-F1028, 1996.
73. Mattson DL. Importance of the renal medullary circulation in the control of sodium excretion and blood pressure. Am J Physiol Regul Integr Comp Physiol. In press.
74. Mattson DL and Bellehumeur TG. Neural nitric oxide synthase in the renal medulla and blood pressure regulation. Hypertension 28: 297-303, 1996.
75. Mattson DL, Lu SH, and Cowley AW Jr. Role of nitric oxide in the control of the renal medullary circulation. Clin Exp Pharm Physiol 24: 587-590, 1997.
76. Mattson DL, Lu S, Roman RJ, and Cowley AW Jr. Relationship between renal perfusion pressure and blood flow in different regions of the kidney. Am J Physiol Regul Integr Comp Physiol 264: R578-R583, 1993.
77. Mattson DL, Maeda CY, Bachman TD, and Cowley AW Jr. Inducible nitric oxide synthase and blood pressure. Hypertension 31: 15-20, 1998.
78. Mattson DL, Roman RJ, and Cowley AW Jr. Role of nitric oxide in renal papillary blood flow and sodium excretion in the rat. Hypertension 19: 766-769, 1992.
79. Mattson DL and Wu F. Control of arterial blood pressure and renal sodium excretion by nitric oxide synthase in the renal medulla. Acta Physiol Scand 168: 149-154, 2000.
80. Mattson DL and Wu F. Nitric oxide synthase activity and isoforms in the rat renal vasculature. Hypertension 35: 337- 341, 2000.
81. Michel CC. Renal medullary microcirculation: architecture and exchange. Microcirculation 2: 125-139, 1995.
82. Michel CC and Curry FE. Microvascular permeability. Physiol Rev 79: 703-761, 1999.
83. Miyata N and Cowley AW Jr. Renal intramedullary infusion of L-arginine prevents reduction of medullary blood flow and hypertension in Dahl salt-sensitive rats. Hypertension 33: 446- 450, 1999.
84. Miyata N, Zou AP, Mattson DL, and Cowley AW Jr. Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats. Am J Physiol Regul Integr Comp Physiol 275: R1667-R1673, 1998.
85. Moffat DB and Creasey M. The fine structure of the intraarterial cushions at the origins of the juxtamedullary afferent arterioles in the rat kidney. J Anat 110: 409-419, 1971.
86. Moffat DB and Fourman J. A vascular pattern of the rat kidney. J Am Soc Nephrol 12: 624-632, 2001.
87. Moridani BA and Kline RL. Effect of endogenous L-arginine on the measurement of nitric oxide synthase activity in the rat kidney. Can J Physiol Pharmacol 74: 1210-1214, 1996.
88. Nakanishi K, Mattson DL, and Cowley AW Jr. Role of renal medullary blood flow in the development of L-NAME hypertension in rats. Am J Physiol Regul Integr Comp Physiol 268: R317-R323, 1995.
89. Navar LG, Harrison-Bernard LM, Nishiyama A, and Kobori H. Regulation of intrarenal angiotensin II in hypertension. Hypertension 39: 316-322, 2002.
90. Navar LG, Inscho EW, Majid DSA, Imig JD, Harrison BL, and Mitchell KD. Paracrine regulation of the renal microcirculation. Physiol Rev 76: 425-536, 1996.
91. Nelson MT and Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol Cell Physiol 268: C799-C822, 1995.
92. Nielsen S, Frøkiær J, Marples D, and Kwon TH, Agre P, and Knepper MA. Aquaporins in the kidney: from molecules to medicine. Physiol Rev 82: 205-244, 2002.
93. Nielsen S, Pallone T, Smith BL, Christensen EI, Agre P, and Maunsbach AB. Aquaporin-1 water channels in short and long loop descending thin limbs and in descending vasa recta in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 268: F1023-F1037, 1995.
94. - and NO in the thick ascending limb. Hypertension 39: 591-6, 2002.
95. Ortiz PA and Garvin JL. NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase. Hypertension 37: 467-471, 2001.
96. Oury TD, Day BJ, and Crapo JD. Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability. Lab Invest 75: 617-636, 1996.
97. Pallone TL. Characterization of the urea transporter in outer medullary descending vasa recta. Am J Physiol Regul Integr Comp Physiol 267: R260-R267, 1994.
98. Pallone TL. Effect of sodium chloride gradients on water flux in rat descending vasa recta. J Clin Invest 87: 12-19, 1991.
99. Pallone TL. The extraglomerular circulation of the kidney. In: The Kidney: Physiology and Pathophysiology (3rd ed.), edited by Seldin DW and Giebisch G. Philadelphia, PA: Lippincott Williams & Wilkins, 2000, p. 791-822.
100. Pallone TL. Extravascular protein in the renal medulla: analysis by two methods. Am J Physiol Regul Integr Comp Physiol 266: R1429-R1436, 1994.
101. Pallone TL. Molecular sieving of albumin by the ascending vasa recta wall. J Clin Invest 90: 30-34, 1992.
102. Pallone TL. Resistance of ascending vasa recta to transport of water. Am J Physiol Renal Fluid Electrolyte Physiol 260: F303-F310, 1991.
103. Pallone TL. Transport of sodium chloride and water in rat ascending vasa recta. Am J Physiol Renal Fluid Electrolyte Physiol 261: F519-F525, 1991.
104. 2. Am J Physiol Renal Fluid Electrolyte Physiol 266: F850-F857, 1994.
105. Pallone TL, Edwards A, and Kreisberg MS. The intrarenal distribution of blood flow. Adv Organ Biol 9: 75-92, 2000.
106. Pallone TL, Edwards A, Ma T, Silldorff EP, and Verkman AS. Requirement of aquaporin-1 for NaCl-driven water transport across descending vasa recta. J Clin Invest 105: 215-222, 2000.
107. Pallone TL and Huang JMC. Control of descending vasa recta pericyte membrane potential by angiotensin II. Am J Physiol Renal Physiol 282: F1064-F1074, 2002.
108. Pallone TL, Kishore BK, Nielsen S, Agre P, and Knepper MA. Evidence that aquaporin-1 mediates NaCl-induced water flux across descending vasa recta. Am J Physiol Renal Physiol 272: F587-F596, 1997.
109. Pallone TL, Nielsen S, Silldorff EP, and Yang S. Diffusive transport of solute in the rat medullary microcirculation. Am J Physiol Renal Fluid Electrolyte Physiol 269: F55-F63, 1995.
110. Pallone TL, Robertson CR, and Jamison RL. Renal medullary microcirculation. Physiol Rev 70: 885-920, 1990.
111. Pallone TL and Silldorff EP. Pericyte regulation of renal medullary blood flow. Exp Nephrol 9: 165-170, 2001.
112. Pallone TL, Silldorff EP, and Cheung JY. Response of isolated descending vasa recta to bradykinin. Am J Physiol Heart Circ Physiol 274: H752-H759, 1998.
113. Pallone TL, Silldorff EP, and Turner MR. Intrarenal blood flow: microvascular anatomy and the regulation of medullary perfusion. Clin Exp Pharmacol Physiol 25: 383-392, 1998.
114. Pallone TL, Silldorff EP, and Zhang Z. Inhibition of calcium signaling in outer medullary descending vasa recta by angiotensin II. Am J Physiol Heart Circ Physiol 278: H1248-H1255, 2000.
115. Pallone TL, Work J, and Jamison RL. Resistance of descending vasa recta to the transport of water. Am J Physiol Renal Fluid Electrolyte Physiol 259: F688-F697, 1990.
116. Pallone TL, Work J, Myers RL, and Jamison RL. Transport of sodium and urea in outer medullary descending vasa recta. J Clin Invest 93: 212-222, 1994.
117. Pallone TL, Yagil Y, and Jamison RL. Effect of small-solute gradients on transcapillary fluid movement in renal inner medulla. Am J Physiol Renal Fluid Electrolyte Physiol 257: F547-F553, 1989.
118. Parekh N and Zou AP. Role of prostaglandins in renal medullary circulation: response to different vasoconstrictors. Am J Physiol Renal Fluid Electrolyte Physiol 271: F653-F658, 1996.
119. Park F, Mattson DL, Roberts LA, and Cowley AW Jr. Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla. Am J Physiol Regul Integr Comp Physiol 273: R1742-R1748, 1997.
120. Park F, Zou AP, and Cowley AW Jr. Arginine vasopressin-mediated stimulation of nitric oxide within the rat renal medulla. Hypertension 32: 896-901, 1998.
121. Plato CF, Shesely EG, and Garvin JL. eNOS mediates L-arginine-induced inhibition of thick ascending limb chloride flux. Hypertension 35: 319-323, 2000.
122. Plato CF, Stoos BA, Wang D, and Garvin JL. Endogenous nitric oxide inhibits chloride transport in the thick ascending limb. Am J Physiol Renal Physiol 276: F159-F163, 1999.
123. Prasad PV, Priatna A, Spokes K, and Epstein FH. Changes in intrarenal oxygenation as evaluated by BOLD MRI in a rat kidney model for radiocontrast nephropathy. J Magn Reson Imaging 13: 744-747, 2001.
124. Promeneur D, Rousselet G, Bankir L, Bailly P, Cartron JP, Ripoche P, and Trinh-Trang-Tan MM. Evidence for distinct vascular and tubular urea transporters in the rat kidney. J Am Soc Nephrol 7: 852 -860, 1996.
125. Pueyo ME, Jean-Francois A, Ramland J, and Michel JB. Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells. Am J Physiol Cell Physiol 274: C214-C220, 1998.
126. Qi Z, Hao CM, Langenbach RI, Breyer RM, Redha R, Morrow JD, and Breyer MD. Opposite effects of cyclooxygenase-1 and -2 activity on the pressor response to angiotensin II. J Clin Invest 110: 61-69, 2002.
127. Ramsey CR, Berndt TJ, and Knox FG. Indomethacin blocks enhanced paracellular backflux in proximal tubules. J Am Soc Nephrol 13: 1449-1454, 2002.
128. Rhinehart K and Pallone TL. Nitric oxide generation by isolated descending vasa recta. Am J Physiol Heart Circ Physiol 281: H316-H324, 2001.
129. 2+ signaling and membrane potential in descending vasa recta pericytes and endothelia. Am J Physiol Renal Physiol 283: F852-F860, 2002.
130. Roman RJ, Cowley AW, Garcia-Estan J, and Lombard JH. Pressure-diuresis in volume expanded rats: cortical and medullary hemodynamics. Hypertension 12: 168-176, 1988.
131. Sabolic I, Valenti G, Verbavatz JM, Van Hoek AN, Verkman AS, Ausiello DA, and Brown D. Localization of the CHIP28 water channel in rat kidney. Am J Physiol Cell Physiol 263: C1225-C1233, 1992.
132. Sanders KM. Invited review: mechanisms of calcium handling in smooth muscles. J Appl Physiol 91: 1438-1449, 2001.
133. Sands JM. Regulation of renal urea transporters. J Am Soc Nephrol 10: 635-646, 1999.
134. Sands JM, Timmer RT, and Gunn RB. Urea transporters in kidney and erythrocytes. Am J Physiol Renal Physiol 273: F321-F339, 1997.
135. Sanjana V, Johnston PA, Deen WM, Robertson CR, Brenner BM, and Jamison RL. Hydraulic and oncotic pressure measurements in inner medulla of mammalian kidney. Am J Physiol 228: 1921-1926, 1975.
136. Sanjana VM, Johnston PA, Robertson CR, and Jamison RL. An examination of transcapillary water flux in renal inner medulla. Am J Physiol 231: 313-318, 1976.
137. Schwartz MM, Karnovsky MJ, and Venkatachalam MA. Ultrastructural differences between rat inner medullary descending and ascending vasa recta. Lab Invest 35: 161-170, 1976.
138. Schnackenberg CG, Welch WJ, and Wilcox CS. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: role of nitric oxide. Hypertension 32: 59-64, 1998.
139. - and NO. Am J Physiol Renal Physiol 279: F302-F308, 2000.
140. 2α. Hypertension 33: 124-128, 1999.
141. Seikaly MG, Arent BS, and Seney FD. Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 86: 1352-1357, 1990.
142. Silldorff EP, Hilbun LR, and Pallone TL. Angiotensin II constriction of rat vasa recta is partially thromboxane dependent. Hypertension 40: 541-546, 2002.
143. Silldorff EP, Kreisberg MA, and Pallone TL. Adenosine modulates vasomotor tone in outer medullary descending vasa recta of the rat. J Clin Invest 98: 18-23, 1996.
144. Silldorff EP and Pallone TL. Adenosine signaling in outer medullary descending vasa recta. Am J Physiol Regul Integr Comp Physiol 280: R854-R861, 2001.
145. 2 abrogates endothelin-induced vasoconstriction in renal outer medullary descending vasa recta of the rat. J Clin Invest 95: 2734-2740, 1995.
146. 2 on chloride transport across the rabbit thick ascending limb of Henle. Selective inhibitions of the medullary portion. J Clin Invest 64: 495-502, 1979.
147. Stoos BA, Carretero OA, and Garvin JL. Endothelial-derived nitric oxide inhibits sodium transport by affecting apical membrane channels in cultured collecting duct cells. J Am Soc Nephrol 4: 1855-1860, 1994.
148. Stoos BA, Garcia NH, and Garvin JL. Nitric oxide inhibits sodium reabsorption in the isolated perfused cortical collecting duct. J Am Soc Nephrol 6: 89-94, 1995.
149. Szentivanyi M Jr, Park F, Maeda CY, and Cowley AW Jr. Nitric oxide in the renal medulla protects from vasopressin-induced hypertension. Hypertension 35: 740-745, 2000.
150. Szentivanyi M Jr, Zou AP, Maeda CY, Mattson DL, and Cowley AW Jr. Increase in renal medullary nitric oxide synthase activity protects from norepinephrine-induced hypertension. Hypertension 35: 418-423, 2000.
151. Thomas SR. Cycles and separations in a model of the renal medulla. Am J Physiol Renal Physiol 275: F671-F690, 1998.
152. 1 receptor inhibition blunts angiotensin II-stimulated nitric oxide release in renal arteries. J Am Soc Nephrol Suppl 11: S220-S224, 1999.
153. Thorup C, Kornfeld M, Winaver JM, Goligorsky MS, and Moore LC. Angiotensin-II stimulates nitric oxide release in isolated perfused renal resistance arteries. Pflügers Arch 435: 432-434, 1998.
154. Timmer RT, Klein JD, Bagnasco SM, Doran JJ, Verlander JW, Gunn RB, and Sands JM. Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues. Am J Physiol Cell Physiol 281: C1318-C1325, 2001.
155. Tsukaguchi H, Shayakul C, Berger LTV, and Hediger MA. Urea transporters in kidney: molecular analysis and contribution to the urinary concentrating process. Am J Physiol Renal Physiol 275: F319-F324, 1998.
156. Tsukaguchi H, Shayakul C, Berger LTV, Tokui T, Brown D, and Hediger MA. Cloning and characterization of the urea transporter UT3: localization in rat kidney and testis. J Clin Invest 99: 1506-1515, 1997.
157. Turner MR and Pallone TL. Hydraulic and diffusional permeabilities of isolated outer medullary descending vasa recta from the rat. Am J Physiol Heart Circ Physiol 272: H392-H400, 1997.
158. phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. J Biol Chem 271: 23317-23321, 1996.
159. Wang W and Michel CC. Effects of anastomoses on solute transcapillary exchange in countercurrent systems. Microcirculation 4: 381-390, 1997.
160. Wang W and Michel CC. Modeling exchange of plasma proteins between microcirculation and interstitium of the renal medulla. Am J Physiol Renal Physiol 279: F334-F344, 2000.
161. Wang W, Parker KH, and Michel CC. Theoretical studies of steady-state transcapillary exchange in countercurrent systems. Microcirculation 3: 301-311, 1996.
162. , Wang X, Thomas SR, and Wexler AS. Outer medullary anatomy and the urine concentrating mechanism. Am J Physiol Renal Physiol 274: F413-F424, 1998.
163. Welch WJ, Tojo A, and Wilcox CS. Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR. Am J Physiol Renal Physiol 278: F769-F776, 2000.
164. , Wilcox CS. Reactive oxygen species: roles in blood pressure and kidney function, Curr Hypertens Rep 4: 160-166, 2002.
165. Wu F, Cholewa B, and Mattson DL. Characterization of L-arginine transporters in isolated rat renal inner medullary collecting duct cells. Am J Physiol Regul Integr Comp Physiol 278: R1506-R1512, 2000.
166. Wu F, Park F, Cowley AW Jr, and Mattson DL. Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney. Am J Physiol Renal Physiol 276: F874-F881, 1999.
167. Xu Y, Olives B, Bailly P, Fischer E, Ripoche P, Ronco P, Cartron JP, and Rondeau E. Endothelial cells of the kidney vasa recta express the urea transporter HUT11. Kidney Int 51: 138-146.
168. Yagil Y, Miyamoto M, Frasier L, Oizumi K, and Koike H. Effects of CS-905, a novel dihydropyridine calcium channel blocker, on arterial pressure, renal excretory function, and inner medullary blood flow in the rat. Am J Hypertension 7: 637-646, 1994.
169. Yang B, Bankir L, Gillespie A, Epstein CJ, and Verkman AS. Urea-selective concentrating defect in transgenic mice lacking urea transporter UT-B. J Biol Chem 277: 10633-10637, 2002.
170. Yang B and Verkman AS. Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B: evidence for UT-B facilitated water transport in erythrocytes. J Biol Chem. 277: 36782-36786, 2002.
171. Yang B and Verkman AS. Urea transporter UT3 functions as an efficient water channel. Direct evidence for a common water/urea pathway. J Biol Chem 273: 9369-9372, 1998.
172. Zhang W and Edwards A. Oxygen transport across vasa recta in the renal medulla. Am J Physiol Heart Circ Physiol 283: H1042-H1055, 2002.
173. Zhang W and Edwards A. Transport of plasma proteins across vasa recta in the renal medulla. Am J Physiol Renal Physiol 281: F478-F492, 2001.
174. Zhang Z, Huang JMC, Rhinehart K, Turner MR, and Pallone TL. Role of chloride in constriction of descending vasa recta by angiotensin II. Am J Physiol Regul Integr Comp Physiol 280: R1878-R1886, 2001.
175. Zhang Z, Rhinehart K, and Pallone TL. Membrane potential controls calcium entry into descending vasa recta pericytes. Am J Physiol Regul Integr Comp Physiol 283: R949-R957, 2002.
176. Zhang H, Schmeisser A, Garlichs CD, Plotze K, Damme U, Mugge A, and Daniel WG. Angiotensin II-induced superoxide anion generation in human vascular endothelial cells: role of membrane-bound NADH-/NADPH-oxidases. Cardiovasc Res 44: 215-222, 1999.
177. Zhuo J, Dean R, Maric C, Aldred PG, Harris P, Alcorn D, and Mendelsohn FA. Localization and interactions of vasoacpeptide receptors in renomedullary interstitial cells of the kidney. Kidney Int 67: S22-S28, 1998.
178. Zhuo JL. Renomedullary interstitial cells: a target for endocrine and paracrine actions of vasoactive peptides in the renal medulla. Clin Exp Pharmacol Physiol 27: 465-473, 2000.
179. Zou AP, Billington H, Su N, and Cowley AW Jr. Expression and actions of heme oxygenase in the renal medulla of rats. Hypertension 35: 342-347, 2000.
180. 2-Adrenergic receptor-mediated increase in NO production buffers renal medullary vasoconstriction. Am J Physiol Regul Integr Comp Physiol 279: R769-R777, 2000.
181. Zou AP and Cowley AW Jr. Nitric oxide in renal cortex and medulla. An in vivo microdialysis study. Hypertension 29: 194-198, 1997.
182. Zou AP, Li N, and Cowley AW Jr. Production and actions of superoxide in the renal medulla. Hypertension 37: 547-553, 2001.
183. Zou AP, Nithipatikom K, Li PL, and Cowley AW Jr. Role of renal medullary adenosine in the control of blood flow and sodium excretion. Am J Physiol Regul Integr Comp Physiol 276: R790-R798, 1999.
184. Zou AP, Wu F, and Cowley AW Jr. Protective effect of angiotension II-induced increase in nitric oxide in the renal medullary circulation. Hypertension 31: 271-276, 1998.
185. Zusman RM and Keiser HR. Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Mechanism of stimulation by angiotensin II, bradykinin, and arginine vasopressin. J Biol Chem 252: 2069-2071, 1997.