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Volumn 1, Issue 4, 2010, Pages 535-562

Drug penetration across the blood-brain barrier: An overview

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; CENTRAL NERVOUS SYSTEM AGENTS; DYSTROGLYCAN; ESTERASE; GLYCOPROTEIN P; HEXOSE; INSULIN; INTEGRIN; NERVE GROWTH FACTOR; OXIDOREDUCTASE; POLY(ISOBUTYL 2 CYANOACRYLATE); PRODRUG; VIRUS VECTOR;

EID: 79954519753     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.10.37     Document Type: Review
Times cited : (26)

References (267)
  • 2
    • 0033962411 scopus 로고    scopus 로고
    • Inflammatory mediators and modulation of blood-brain barrier permeability
    • DOI 10.1023/A:1007074420772
    • Abbott NJ. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell Mol. Neurobiol. 20, 131-147 (2000). (Pubitemid 30091452)
    • (2000) Cellular and Molecular Neurobiology , vol.20 , Issue.2 , pp. 131-147
    • Abbott, N.J.1
  • 3
    • 0037288494 scopus 로고    scopus 로고
    • Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro
    • DOI 10.1016/S0026-2862(02)00009-2, PII S0026286202000092
    • Gaillard PJ, de Boer AB, Breimer DD. Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro. Microvasc. Res. 65, 24-31 (2003). (Pubitemid 36263287)
    • (2003) Microvascular Research , vol.65 , Issue.1 , pp. 24-31
    • Gaillard, P.J.1    De Boer, A.G.2    Breimer, D.D.3
  • 4
    • 0035696136 scopus 로고    scopus 로고
    • Drug delivery to damaged brain
    • DOI 10.1016/S0165-0173(01)00083-2, PII S0165017301000832
    • Lo EH, Singhal AB, Torchilin VP, Abbott NJ. Drug delivery to damaged brain. Brain Res. Brain Res. Rev. 38, 140-148 (2001). (Pubitemid 34066499)
    • (2001) Brain Research Reviews , vol.38 , Issue.1-2 , pp. 140-148
    • Lo, E.H.1    Singhal, A.B.2    Torchilin, V.P.3    Abbott N.Joan4
  • 5
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: Bottleneck in brain drug development
    • DOI 10.1602/neurorx.2.1.3
    • Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2, 3-14 (2005). (Pubitemid 40128022)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 3-14
    • Pardridge, W.M.1
  • 6
    • 70350054854 scopus 로고    scopus 로고
    • Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids
    • Friden M, Winiwarter S, Jerndal G et al. Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. J. Med. Chem. 52, 6233-6243 (2009).
    • (2009) J. Med. Chem. , vol.52 , pp. 6233-6243
    • Friden, M.1    Winiwarter, S.2    Jerndal, G.3
  • 10
    • 33644758151 scopus 로고    scopus 로고
    • Methods to assess drug permeability across the blood-brain barrier
    • DOI 10.1211/jpp.58.3.0001
    • Nicolazzo JA, Charman SA, Charman WN. Methods to assess drug permeability across the blood-brain barrier. J. Pharm. Pharmacol. 58, 281-293 (2006). (Pubitemid 43344570)
    • (2006) Journal of Pharmacy and Pharmacology , vol.58 , Issue.3 , pp. 281-293
    • Nicolazzo, J.A.1    Charman, S.A.2    Charman, W.N.3
  • 11
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the blood-cerebrospinal fluid barriers: Function and dysfunction
    • Engelhardt B, Sorokin L. The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin. Immunopathol. 31, 497-511 (2009).
    • (2009) Semin. Immunopathol. , vol.31 , pp. 497-511
    • Engelhardt, B.1    Sorokin, L.2
  • 12
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • DOI 10.1124/pr.57.2.4
    • Hawkins BT, Davis TP. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57, 173-185 (2005). (Pubitemid 41043883)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 13
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: Development, composition and regulation
    • DOI 10.1016/S1537-1891(02)00200-8, PII S1537189102002008
    • Wolburg H, Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul. Pharmacol. 38, 323-337 (2002). (Pubitemid 36398254)
    • (2002) Vascular Pharmacology , vol.38 , Issue.6 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 14
    • 0033976389 scopus 로고    scopus 로고
    • Neural induction of the blood-brain barrier: Still an enigma
    • DOI 10.1023/A:1006939825857
    • Bauer HC, Bauer H. Neural induction of the blood-brain barrier: still an enigma. Cell. Mol. Neurobiol. 20, 13-28 (2000). (Pubitemid 30090913)
    • (2000) Cellular and Molecular Neurobiology , vol.20 , Issue.1 , pp. 13-28
    • Bauer, H.-C.1    Bauer, H.2
  • 16
    • 2942671217 scopus 로고    scopus 로고
    • Role of platelet-derived growth factor in mesangium development and vasculopathies: Lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice
    • DOI 10.1097/00041552-200401000-00007
    • Betsholtz C, Lindblom P, Bjarnegard M, Enge M, Gerhardt H, Lindahl P. Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice. Curr. Opin. Nephrol. Hypertens. 13, 45-52 (2004). (Pubitemid 39069898)
    • (2004) Current Opinion in Nephrology and Hypertension , vol.13 , Issue.1 , pp. 45-52
    • Betsholtz, C.1    Lindblom, P.2    Bjarnegard, M.3    Enge, M.4    Gerhardt, H.5    Lindahl, P.6
  • 18
    • 0035947768 scopus 로고    scopus 로고
    • Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis
    • Sixt M, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin LM. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. J. Cell Biol. 153, 933-946 (2001).
    • (2001) J. Cell Biol. , vol.153 , pp. 933-946
    • Sixt, M.1    Engelhardt, B.2    Pausch, F.3    Hallmann, R.4    Wendler, O.5    Sorokin, L.M.6
  • 19
    • 33747417084 scopus 로고    scopus 로고
    • Integrin-matrix interactions in the cerebral microvasculature
    • DOI 10.1161/01.ATV.0000232525.65682.a2, PII 0004360520060900000007
    • del Zoppo GJ, Milner R. Integrin-matrix interactions in the cerebral microvasculature. Arterioscler. Thromb. Vasc. Biol. 26, 1966-1975 (2006). (Pubitemid 44253776)
    • (2006) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.26 , Issue.9 , pp. 1966-1975
    • Del Zoppo, G.J.1    Milner, R.2
  • 21
    • 85066313651 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal S, Anderson P, Durbeej M et al. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J. Exp. Med. 203, 1007-1019 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 1007-1019
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3
  • 22
    • 67349162632 scopus 로고    scopus 로고
    • Endothelial basement membrane laminin a5 selectively inhibits T lymphocyte extravasation into the brain
    • Wu C, Ivars F, Anderson P et al. Endothelial basement membrane laminin a5 selectively inhibits T lymphocyte extravasation into the brain. Nat. Med. 15, 519-527 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 519-527
    • Wu, C.1    Ivars, F.2    Anderson, P.3
  • 24
    • 66249093484 scopus 로고    scopus 로고
    • Microglial expression of avb3 and avb5 integrins is regulated by cytokines and the extracellular matrix: B5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin
    • Milner R. Microglial expression of avb3 and avb5 integrins is regulated by cytokines and the extracellular matrix: b5 integrin null microglia show no defects in adhesion or MMP-9 expression on vitronectin. Glia 57, 714-723 (2009).
    • (2009) Glia , vol.57 , pp. 714-723
    • Milner, R.1
  • 25
    • 27344444684 scopus 로고    scopus 로고
    • Vascular development of the brain requires β8 integrin expression in the neuroepithelium
    • DOI 10.1523/JNEUROSCI.3467-05.2005
    • Proctor JM, Zang K, Wang D, Wang R, Reichardt LF. Vascular development of the brain requires b8 integrin expression in the neuroepithelium. J. Neurosci. 25, 9940-9948 (2005). (Pubitemid 41528032)
    • (2005) Journal of Neuroscience , vol.25 , Issue.43 , pp. 9940-9948
    • Proctor, J.M.1    Zang, K.2    Wang, D.3    Wang, K.4    Reichardt, L.F.5
  • 26
    • 0035984003 scopus 로고    scopus 로고
    • β8 Integrins are required for vascular morphogenesis in mouse embryos
    • Zhu J, Motejlek K, Wang D, Zang K, Schmidt A, Reichardt LF. b8 integrins are required for vascular morphogenesis in mouse embryos. Development 129, 2891-2903 (2002). (Pubitemid 34874268)
    • (2002) Development , vol.129 , Issue.12 , pp. 2891-2903
    • Zhu, J.1    Motejlek, K.2    Wang, D.3    Zang, K.4    Schmidt, A.5    Reichardt, L.F.6
  • 27
    • 33845784758 scopus 로고    scopus 로고
    • Blood-brain barrier delivery
    • DOI 10.1016/j.drudis.2006.10.013, PII S1359644606004363
    • Pardridge WM. Blood-brain barrier delivery. Drug Discov. Today 12, 54-61 (2007). (Pubitemid 46014479)
    • (2007) Drug Discovery Today , vol.12 , Issue.1-2 , pp. 54-61
    • Pardridge, W.M.1
  • 30
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • DOI 10.1038/nrn1728
    • Loscher W, Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat. Rev. Neurosci. 6, 591-602 (2005). (Pubitemid 41059334)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.8 , pp. 591-602
    • Loscher, W.1    Potschka, H.2
  • 31
    • 73949111400 scopus 로고    scopus 로고
    • Multidrug resistance in oncology and beyond: From imaging of drug efflux pumps to cellular drug targets
    • Nagengast WB, Oude Munnink TH, Dijkers EC et al. Multidrug resistance in oncology and beyond: from imaging of drug efflux pumps to cellular drug targets. Methods Mol. Biol. 596, 15-31 (2010).
    • (2010) Methods Mol. Biol. , vol.596 , pp. 15-31
    • Nagengast, W.B.1    Oude Munnink, T.H.2    Dijkers, E.C.3
  • 32
    • 71849091734 scopus 로고    scopus 로고
    • Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia
    • Ziegler G, Prinz V, Albrecht MW et al. Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia. Biochim. Biophys. Acta 1792, 1198-1204 (2009).
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 1198-1204
    • Ziegler, G.1    Prinz, V.2    Albrecht, M.W.3
  • 33
    • 63349094264 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier and the impact of breast cancer resistance protein (ABCG2)
    • Nicolazzo JA, Katneni K. Drug transport across the blood-brain barrier and the impact of breast cancer resistance protein (ABCG2). Curr. Top. Med. Chem. 9, 130-147 (2009).
    • (2009) Curr. Top. Med. Chem. , vol.9 , pp. 130-147
    • Nicolazzo, J.A.1    Katneni, K.2
  • 34
    • 42449100856 scopus 로고    scopus 로고
    • Progress in brain penetration evaluation in drug discovery and development
    • DOI 10.1124/jpet.107.130294
    • Liu X, Chen C, Smith BJ. Progress in brain penetration evaluation in drug discovery and development. J. Pharmacol. Exp. Ther. 325, 349-356 (2008). (Pubitemid 351574780)
    • (2008) Journal of Pharmacology and Experimental Therapeutics , vol.325 , Issue.2 , pp. 349-356
    • Liu, X.1    Chen, C.2    Smith, B.J.3
  • 35
    • 85009583484 scopus 로고    scopus 로고
    • Intestinal absorption of drugs mediated by drug transporters: Mechanisms and regulation
    • Katsura T, Inui K. Intestinal absorption of drugs mediated by drug transporters: mechanisms and regulation. Drug Metab. Pharmacokinet. 18, 1-15 (2003).
    • (2003) Drug Metab. Pharmacokinet. , vol.18 , pp. 1-15
    • Katsura, T.1    Inui, K.2
  • 36
    • 65649123363 scopus 로고    scopus 로고
    • Expression profiling of the solute carrier gene family in the mouse brain
    • Dahlin A, Royall J, Hohmann JG, Wang J. Expression profiling of the solute carrier gene family in the mouse brain. J. Pharmacol. Exp. Ther. 329, 558-570 (2009).
    • (2009) J. Pharmacol. Exp. Ther. , vol.329 , pp. 558-570
    • Dahlin, A.1    Royall, J.2    Hohmann, J.G.3    Wang, J.4
  • 37
    • 0036889901 scopus 로고    scopus 로고
    • Assessment of blood-brain barrier penetration: In silico, in vitro and in vivo
    • DOI 10.2174/1389200023337063
    • Feng MR. Assessment of blood-brain barrier penetration: in silico, in vitro and in vivo. Curr. Drug Metab. 3, 647-657 (2002). (Pubitemid 35339328)
    • (2002) Current Drug Metabolism , vol.3 , Issue.6 , pp. 647-657
    • Feng, M.R.1
  • 38
    • 25844469583 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
    • DOI 10.1602/neurorx.2.4.554
    • Alavijeh MS, Chishty M, Qaiser MZ, Palmer AM. Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery. NeuroRx 2, 554-571 (2005). (Pubitemid 41393265)
    • (2005) NeuroRx , vol.2 , Issue.4 , pp. 554-571
    • Alavijeh, M.S.1    Chishty, M.2    Qaiser, M.Z.3    Palmer, A.M.4
  • 39
    • 3042548988 scopus 로고    scopus 로고
    • TOPS-MODE approach for the prediction of blood-brain barrier permeation
    • DOI 10.1002/jps.20081
    • Cabrera MA, Bermejo M, Perez M, Ramos R. TOPS-MODE approach for the prediction of blood-brain barrier permeation. J. Pharm. Sci. 93, 1701-1717 (2004). (Pubitemid 38823699)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.7 , pp. 1701-1717
    • Cabrera, M.A.1    Bermejo, M.2    Perez, M.3    Ramos, R.4
  • 40
    • 42449091379 scopus 로고    scopus 로고
    • Brain unbound drug concentration calculated from in vitro brain unbound fraction is consistent with brain extracellular fluid drug concentration measured by brain microdialysis for four model compounds
    • Liu X, Yeo H, Yau A, Van Natta K, Vilenski O, Weller P. Brain unbound drug concentration calculated from in vitro brain unbound fraction is consistent with brain extracellular fluid drug concentration measured by brain microdialysis for four model compounds. AAPS J. 9, 2439 (2007).
    • (2007) AAPS J. , vol.9 , pp. 2439
    • Liu, X.1    Yeo, H.2    Yau, A.3    Van Natta, K.4    Vilenski, O.5    Weller, P.6
  • 42
    • 1842635478 scopus 로고    scopus 로고
    • Log(BB), PS products and in silico models of drug brain penetration
    • DOI 10.1016/S1359-6446(04)03065-X, PII S135964460403065X
    • Pardridge WM. Log(BB), PS products and in silico models of drug brain penetration. Drug Discov. Today 9, 392-393 (2004). (Pubitemid 38479683)
    • (2004) Drug Discovery Today , vol.9 , Issue.9 , pp. 392-393
    • Pardridge, W.M.1
  • 43
    • 34047114789 scopus 로고    scopus 로고
    • Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: Comparison of unbound concentration ratios to in vivo P-glycoprotein efflux ratios
    • DOI 10.1124/dmd.106.012294
    • Kalvass JC, Maurer TS, Pollack GM. Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios. Drug Metab. Dispos. 35, 660-666 (2007). (Pubitemid 46513270)
    • (2007) Drug Metabolism and Disposition , vol.35 , Issue.4 , pp. 660-666
    • Kalvass, J.C.1    Maurer, T.S.2    Pollack, G.M.3
  • 44
    • 31544451294 scopus 로고    scopus 로고
    • Kinetic modelling of passive transport and active efflux of a fluoroquinolone across Caco-2 cells using a compartmental approach in NONMEM
    • DOI 10.1080/00498250500354469, PII GN314J6732868628
    • Gonzalez-Alvarez I, Fernandez-Teruel C, Garrigues TM, Casabo VG, Ruiz-Garcia A, Bermejo M. Kinetic modelling of passive transport and active efflux of a fluoroquinolone across Caco-2 cells using a compartmental approach in NONMEM. Xenobiotica 35, 1067-1088 (2005). (Pubitemid 43163247)
    • (2005) Xenobiotica , vol.35 , Issue.12 , pp. 1067-1088
    • Gonzalez-Alvarez, I.1    Fernandez-Teruel, C.2    Garrigues, T.M.3    Casabo, V.G.4    Ruiz-Garcia, A.5    Bermejo, M.6
  • 46
    • 72449185642 scopus 로고    scopus 로고
    • Addressing central nervous system (CNS) penetration in drug discovery: Basics and implications of the evolving new concept
    • Reichel A. Addressing central nervous system (CNS) penetration in drug discovery: basics and implications of the evolving new concept. Chem. Biodivers. 6, 2030-2049 (2009).
    • (2009) Chem. Biodivers. , vol.6 , pp. 2030-2049
    • Reichel, A.1
  • 47
    • 70449526541 scopus 로고    scopus 로고
    • Assessment of the blood-brain barrier in CNS drug discovery
    • Jeffrey P, Summerfield S. Assessment of the blood-brain barrier in CNS drug discovery. Neurobiol. Dis. 37, 33-37 (2010).
    • (2010) Neurobiol. Dis. , vol.3 , pp. 33-37
    • Jeffrey, P.1    Summerfield, S.2
  • 48
    • 85157279752 scopus 로고    scopus 로고
    • Evaluation of a combined high-throughput in vitro permeability assay with in silico P-gp estimations for the prediction of in vivo log BB data
    • Mensch J, Melis A, Mackie C et al. Evaluation of a combined high-throughput in vitro permeability assay with in silico P-gp estimations for the prediction of in vivo log BB data. Int. J. Pharma. 395(1-2), 182-197 (2010).
    • (2010) Int. J. Pharma. , vol.395 , Issue.1-2 , pp. 182-197
    • Mensch, J.1    Melis, A.2    MacKie, C.3
  • 49
    • 33646441134 scopus 로고    scopus 로고
    • Computational prediction of blood-brain barrier permeation
    • DOI 10.1016/S0065-7743(05)40026-3, PII S0065774305400263
    • Clark D. Computational prediction of blood-brain barrier permeation. Annu. Rep. Med. Chem. 40, 403-415 (2005). (Pubitemid 43693171)
    • (2005) Annual Reports in Medicinal Chemistry , vol.40 , pp. 403-415
    • Clark, D.E.1
  • 50
    • 0037208306 scopus 로고    scopus 로고
    • Prediction of CNS activity of compound libraries using substructure analysis
    • Engkvist O, Wrede P, Rester U. Prediction of CNS activity of compound libraries using substructure analysis. J. Chem. Inf. Comput. Sci. 43, 155-160 (2003).
    • (2003) J. Chem. Inf. Comput. Sci. , vol.43 , pp. 155-160
    • Engkvist, O.1    Wrede, P.2    Rester, U.3
  • 52
    • 1642384018 scopus 로고    scopus 로고
    • The factors that influence permeation across the blood-brain barrier
    • DOI 10.1016/j.ejmech.2003.12.004, PII S0223523403002356
    • Abraham MH. The factors that influence permeation across the blood-brain barrier. Eur. J. Med. Chem. 39, 235-240 (2004). (Pubitemid 38393750)
    • (2004) European Journal of Medicinal Chemistry , vol.39 , Issue.3 , pp. 235-240
    • Abraham, M.H.1
  • 53
    • 0037204545 scopus 로고    scopus 로고
    • Computational approaches to the prediction of the blood-brain distribution
    • DOI 10.1016/S0169-409X(02)00005-4, PII S0169409X02000054
    • Norinder U, Haeberlein M. Computational approaches to the prediction of the blood-brain distribution. Adv. Drug. Deliv. Rev. 54, 291-313 (2002). (Pubitemid 34260955)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.3 , pp. 291-313
    • Norinder, U.1    Haeberlein, M.2
  • 54
    • 13244271912 scopus 로고    scopus 로고
    • Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models
    • DOI 10.1016/j.ddtec.2004.11.014, PII S1740674904000629
    • Abbott NJ. Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models. Drug Discov. Today. 1(4), 407-416 (2004). (Pubitemid 40186344)
    • (2004) Drug Discovery Today: Technologies , vol.1 , Issue.4 , pp. 407-416
    • Abbott, N.J.1
  • 55
    • 1842535990 scopus 로고    scopus 로고
    • Classification analysis of P-glycoprotein substrate specificity
    • DOI 10.1080/10611860310001648248
    • Didziapetris R, Japertas P, Avdeef A, Petrauskas A. Classification analysis of P-glycoprotein substrate specificity. J. Drug Target. 11, 391-406 (2003). (Pubitemid 38455825)
    • (2003) Journal of Drug Targeting , vol.11 , Issue.7 , pp. 391-406
    • Didziapetris, R.1    Japertas, P.2    Avdeef, A.3    Petrauskas, A.4
  • 56
    • 0037337916 scopus 로고    scopus 로고
    • Computation of log BB values for compounds transported through carrier-mediated mechanisms using in vitro permeability data from brain microvessel endothelial cell (BMEC) monolayers
    • DOI 10.1023/A:1022647903205
    • Usansky HH, Sinko PJ. Computation of log BB values for compounds transported through carrier-mediated mechanisms using in vitro permeability data from brain microvessel endothelial cell (BMEC) monolayers. Pharm. Res. 20, 390-396 (2003). (Pubitemid 36288367)
    • (2003) Pharmaceutical Research , vol.20 , Issue.3 , pp. 390-396
    • Usansky, H.H.1    Sinko, P.J.2
  • 57
    • 1642579680 scopus 로고    scopus 로고
    • Development of a computational approach to predict blood-brain barrier permeability
    • DOI 10.1124/dmd.32.1.132
    • Liu X, Tu M, Kelly RS, Chen C, Smith BJ. Development of a computational approach to predict blood-brain barrier permeability. Drug Metab. Dispos. 32, 132-139 (2004). (Pubitemid 38112545)
    • (2004) Drug Metabolism and Disposition , vol.32 , Issue.1 , pp. 132-139
    • Liu, X.1    Tu, M.2    Kelly, R.S.3    Chen, C.4    Smith, B.J.5
  • 59
    • 0028291586 scopus 로고
    • Predicting the brain-penetrating capability of histaminergic compounds
    • Calder JA, Ganellin CR. Predicting the brain-penetrating capability of histaminergic compounds. Drug Des. Discov. 11, 259-268 (1994). (Pubitemid 24216199)
    • (1994) Drug Design and Discovery , vol.11 , Issue.4 , pp. 259-268
    • Calder, J.A.D.1    Ganellin, C.R.2
  • 60
    • 71649107843 scopus 로고    scopus 로고
    • In vivo, in vitro and in silico methods for small molecule transfer across the BBB
    • Mensch J, Oyarzabal J, Mackie C, Augustijns P. In vivo, in vitro and in silico methods for small molecule transfer across the BBB. J. Pharm. Sci. 98, 4429-4468 (2009).
    • (2009) J. Pharm. Sci. , vol.98 , pp. 4429-4468
    • Mensch, J.1    Oyarzabal, J.2    MacKie, C.3    Augustijns, P.4
  • 61
    • 0032811868 scopus 로고    scopus 로고
    • Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration
    • DOI 10.1021/js980402t
    • Clark DE. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration. J. Pharm Sci. 88, 815-821 (1999). (Pubitemid 29398551)
    • (1999) Journal of Pharmaceutical Sciences , vol.88 , Issue.8 , pp. 815-821
    • Clark, D.E.1
  • 62
    • 70350397386 scopus 로고    scopus 로고
    • Brain drug targeting: A computational approach for overcoming blood-brain barrier
    • Mehdipour AR, Hamidi M. Brain drug targeting: a computational approach for overcoming blood-brain barrier. Drug Discov. Today. 14, 1030-1036 (2009).
    • (2009) Drug Discov. Today. , vol.14 , pp. 1030-1036
    • Mehdipour, A.R.1    Hamidi, M.2
  • 63
    • 0028108085 scopus 로고
    • Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain
    • Abraham MH, Chadha HS, Mitchell RC. Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain. J. Pharm. Sci. 83, 1257-1268 (1994). (Pubitemid 24282331)
    • (1994) Journal of Pharmaceutical Sciences , vol.83 , Issue.9 , pp. 1257-1268
    • Abraham, M.H.1    Chadha, H.S.2    Mitchell, R.C.3
  • 64
    • 0033921869 scopus 로고    scopus 로고
    • Refinement of Catalyst hypotheses using simplex optimisation
    • DOI 10.1023/A:1008191129541
    • Norinder U. Refinement of catalyst hypotheses using simplex optimisation. J. Comput. Aided Mol. Des. 14, 545-557 (2000). (Pubitemid 30445058)
    • (2000) Journal of Computer-Aided Molecular Design , vol.14 , Issue.6 , pp. 545-557
    • Norinder, U.1
  • 65
    • 48049103004 scopus 로고    scopus 로고
    • In silico prediction of brain and CSF permeation of small molecules using PLS regression models
    • Bendels S, Kansy M, Wagner B, Huwyler J. In silico prediction of brain and CSF permeation of small molecules using PLS regression models. Eur. J. Med. Chem. 43, 1581-1592 (2008).
    • (2008) Eur. J. Med. Chem. , vol.43 , pp. 1581-1592
    • Bendels, S.1    Kansy, M.2    Wagner, B.3    Huwyler, J.4
  • 66
    • 2942538155 scopus 로고    scopus 로고
    • Modelling blood-brain barrier partitioning using Bayesian neural nets
    • DOI 10.1016/j.jmgm.2004.03.010, PII S1093326304000257, Bioactive Discovery in the New Millennium
    • Winkler DA, Burden FR. Modelling blood- brain barrier partitioning using Bayesian neural nets. J. Mol. Graph. Model. 22, 499-505 (2004). (Pubitemid 38746575)
    • (2004) Journal of Molecular Graphics and Modelling , vol.22 , Issue.6 , pp. 499-505
    • Winkler, D.A.1    Burden, F.R.2
  • 67
    • 0036962246 scopus 로고    scopus 로고
    • Quantitative structure-activity relationship study of recently synthesized 1,4-dihydropyridine calcium channel antagonists. Application of the Hansch analysis method
    • DOI 10.1002/ardp.200290001
    • Hemmateenejad B, Miri R, Akhond M, Shamsipur M. Quantitative structure-activity relationship study of recently synthesized 1,4-dihydropyridine calcium channel antagonists. Application of the Hansch analysis method. Arch. Pharm. (Weinheim). 335, 472-480 (2002). (Pubitemid 36125515)
    • (2002) Archiv der Pharmazie , vol.335 , Issue.10 , pp. 472-480
    • Hemmateenejad, B.1    Miri, R.2    Akhond, M.3    Shamsipur, M.4
  • 68
    • 2642543421 scopus 로고    scopus 로고
    • A new nonlinear equation for the tissue/blood partition coefficients of neutral compounds
    • DOI 10.1002/jps.20084
    • Zhang H. A new nonlinear equation for the tissue/blood partition coefficients of neutral compounds. J. Pharm. Sci. 93, 1595-1604 (2004). (Pubitemid 38725030)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.6 , pp. 1595-1604
    • Zhang, H.1
  • 69
    • 0036627422 scopus 로고    scopus 로고
    • The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry - Background and current status in the drug discovery process
    • DOI 10.1016/S1537-1891(02)00203-3, PII S1537189102002033
    • Lundquist S, Renftel M. The use of in vitro cell culture models for mechanistic studies and as permeability screens for the blood-brain barrier in the pharmaceutical industry- background and current status in the drug discovery process. Vascul. Pharmacol. 38, 355-364 (2002). (Pubitemid 36398257)
    • (2002) Vascular Pharmacology , vol.38 , Issue.6 , pp. 355-364
    • Lundquist, S.1    Renftel, M.2
  • 70
    • 0642372727 scopus 로고    scopus 로고
    • An overview of in vitro techniques for blood-brain barrier studies
    • Reichel A, Begley DJ, Abbott NJ. An overview of in vitro techniques for blood-brain barrier studies. Methods Mol. Med. 89, 307-324 (2003).
    • (2003) Methods Mol. Med. , vol.89 , pp. 307-324
    • Reichel, A.1    Begley, D.J.2    Abbott, N.J.3
  • 71
    • 0029058745 scopus 로고
    • IAM chromatography: An in vitro screen for predicting drug membrane permeability
    • Pidgeon C, Ong S, Liu H et al. IAM chromatography: an in vitro screen for predicting drug membrane permeability. J. Med. Chem. 38, 590-594 (1995).
    • (1995) J. Med. Chem. , vol.38 , pp. 590-594
    • Pidgeon, C.1    Ong, S.2    Liu, H.3
  • 74
    • 36148984960 scopus 로고    scopus 로고
    • Evaluation of in vitro brain penetration: Optimized PAMPA and MDCKII-MDR1 assay comparison
    • DOI 10.1016/j.ijpharm.2007.05.057, PII S0378517307004838
    • Carrara S, Reali V, Misiano P, Dondio G, Bigogno C. Evaluation of in vitro brain penetration: optimized PAMPA and MDCKII-MDR1 assay comparison. Int. J. Pharm. 345, 125-133 (2007). (Pubitemid 350103647)
    • (2007) International Journal of Pharmaceutics , vol.345 , Issue.1-2 , pp. 125-133
    • Carrara, S.1    Reali, V.2    Misiano, P.3    Dondio, G.4    Bigogno, C.5
  • 76
    • 31544477481 scopus 로고    scopus 로고
    • Novel tacrine-melatonin hybrids as dual-acting drugs for alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties
    • DOI 10.1021/jm050746d
    • Rodriguez-Franco MI, Fernandez- Bachiller MI, Perez C, Hernandez-Ledesma B, Bartolome B. Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties. J. Med. Chem. 49, 459-462 (2006). (Pubitemid 43157478)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.2 , pp. 459-462
    • Rodriguez-Franco, M.I.1    Fernandez-Bachiller, M.I.2    Perez, C.3    Hernandez-Ledesma, B.4    Bartolome, B.5
  • 78
    • 77649180725 scopus 로고    scopus 로고
    • Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability
    • Mensch J, Melis A, Mackie C, Verreck G, Brewster ME, Augustijns P. Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability. Eur. J. Pharm. Biopharm. 74(3), 495-502 (2010).
    • (2010) Eur. J. Pharm. Biopharm. , vol.74 , Issue.3 , pp. 495-502
    • Mensch, J.1    Melis, A.2    MacKie, C.3    Verreck, G.4    Brewster, M.E.5    Augustijns, P.6
  • 79
    • 2642527944 scopus 로고    scopus 로고
    • Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery
    • DOI 10.1002/jps.20075
    • Kerns EH, Di L, Petusky S, Farris M, Ley R, Jupp P. Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery. J. Pharm. Sci. 93, 1440-1453 (2004). (Pubitemid 38725018)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.6 , pp. 1440-1453
    • Kerns, E.H.1    Di, L.2    Petusky, S.3    Farris, M.4    Ley, R.5    Jupp, P.6
  • 80
    • 13244282955 scopus 로고    scopus 로고
    • Lipophilicity - Beyond octanol/water: A short comparison of modern technologies
    • DOI 10.1016/j.ddtec.2004.10.006, PII S1740674904000411
    • Hartmann T, Schmitt J. Lipophilicity beyond octanol/water: a short comparison of modern technologies. Drug Discov. Today. 1, 431-439 (2004). (Pubitemid 40186347)
    • (2004) Drug Discovery Today: Technologies , vol.1 , Issue.4 , pp. 431-439
    • Hartmann, T.1    Schmitt, J.2
  • 83
    • 12144291079 scopus 로고    scopus 로고
    • Holy grails and in vitro blood-brain barrier models
    • DOI 10.1016/S1359-6446(03)03003-4, PII S1359644603030034
    • Pardridge WM. Holy grails and in vitro blood-brain barrier models. Drug Discov. Today. 9, 258 (2004). (Pubitemid 38328509)
    • (2004) Drug Discovery Today , vol.9 , Issue.6 , pp. 258
    • Pardridge, W.M.1
  • 84
    • 0032261713 scopus 로고    scopus 로고
    • Understanding the physiology of the blood-brain barrier: In vitro models
    • Grant GA, Abbott NJ, Janigro D. Understanding the physiology of the blood-brain barrier: in vitro models. News Physiol. Sci. 13, 287-293 (1998).
    • (1998) News Physiol. Sci. , vol.13 , pp. 287-293
    • Grant, G.A.1    Abbott, N.J.2    Janigro, D.3
  • 85
    • 0033638592 scopus 로고    scopus 로고
    • Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier
    • Gaillard PJ, van der Sandt IC, Voorwinden LH et al. Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier. Pharm. Res. 17, 1198-1205 (2000).
    • (2000) Pharm. Res. , vol.17 , pp. 1198-1205
    • Gaillard, P.J.1    Van Der Sandt, I.C.2    Voorwinden, L.H.3
  • 86
    • 0023108382 scopus 로고
    • Astrocytes induce blood-brain barrier properties in endothelial cells
    • DOI 10.1038/325253a0
    • Janzer RC, Raff MC. Astrocytes induce blood-brain barrier properties in endothelial cells. Nature 325, 253-257 (1987). (Pubitemid 17049884)
    • (1987) Nature , vol.325 , Issue.6101 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 89
    • 0025048342 scopus 로고
    • Electrical resistance across the blood-brain barrier in anaesthetized rats: A developmental study
    • Butt AM, Jones HC, Abbott NJ. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J. Physiol. 429, 47-62 (1990). (Pubitemid 20327537)
    • (1990) Journal of Physiology , vol.429 , pp. 47-62
    • Butt, A.M.1    Jones, H.C.2    Abbott, N.J.3
  • 90
    • 12344322943 scopus 로고    scopus 로고
    • How to measure drug transport across the blood-brain barrier
    • DOI 10.1602/neurorx.2.1.15
    • Bickel U. How to measure drug transport across the blood-brain barrier. NeuroRx 2, 15-26 (2005). (Pubitemid 40128023)
    • (2005) NeuroRx , vol.2 , Issue.1 , pp. 15-26
    • Bickel, U.1
  • 91
    • 0030748912 scopus 로고    scopus 로고
    • F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: Effects of cyclic AMP and astrocytic factors
    • DOI 10.1016/S0006-8993(97)00586-6, PII S0006899397005866
    • Rist RJ, Romero IA, Chan MW, Couraud PO, Roux F, Abbott NJ. F-actin cytoskeleton and sucrose permeability of immortalised rat brain microvascular endothelial cell monolayers: effects of cyclic AMP and astrocytic factors. Brain Res. 768, 10-18 (1997). (Pubitemid 27433471)
    • (1997) Brain Research , vol.768 , Issue.1-2 , pp. 10-18
    • Rist, R.J.1    Romero, I.A.2    Chan, M.W.K.3    Couraud, P.-O.4    Roux, F.5    Abbott, N.J.6
  • 92
    • 0842346110 scopus 로고    scopus 로고
    • Development of an in vitro blood-brain barrier model - Cytotoxicity of mercury and aluminum
    • DOI 10.1016/j.taap.2003.11.002
    • Toimela T, Maenpaa H, Mannerstrom M, Tahti H. Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicol. Appl. Pharmacol. 195, 73-82 (2004). (Pubitemid 38177501)
    • (2004) Toxicology and Applied Pharmacology , vol.195 , Issue.1 , pp. 73-82
    • Toimela, T.1    Maenpaa, H.2    Mannerstrom, M.3    Tahti, H.4
  • 93
    • 1042302113 scopus 로고    scopus 로고
    • Development of an in vitro blood-brain barrier model based on immortalized porcine brain microvascular endothelial cells
    • DOI 10.1016/j.farmac.2003.11.007
    • Lauer R, Bauer R, Linz B et al. Development of an in vitro blood-brain barrier model based on immortalized porcine brain microvascular endothelial cells. Farmaco. 59, 133-137 (2004). (Pubitemid 38198270)
    • (2004) Farmaco , vol.59 , Issue.2 , pp. 133-137
    • Lauer, R.1    Bauer, R.2    Linz, B.3    Pittner, F.4    Peschek, G.A.5    Ecker, G.6    Friedl, P.7    Noe, C.R.8
  • 94
    • 10444231111 scopus 로고    scopus 로고
    • - in immortalized rat brain endothelial cells
    • DOI 10.1016/j.toxlet.2004.10.004, PII S0378427404004953
    • Nagasawa K, Ito S, Kakuda T et al. Transport mechanism for aluminum citrate at the blood-brain barrier: kinetic evidence implies involvement of system Xc- in immortalized rat brain endothelial cells. Toxicol. Lett. 155, 289-296 (2005). (Pubitemid 39643214)
    • (2005) Toxicology Letters , vol.155 , Issue.2 , pp. 289-296
    • Nagasawa, K.1    Ito, S.2    Kakuda, T.3    Nagai, K.4    Tamai, I.5    Tsuji, A.6    Fujimoto, S.7
  • 95
    • 0344393085 scopus 로고    scopus 로고
    • The L-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier
    • DOI 10.1046/j.1471-4159.2003.02063.x
    • Tetsuka K, Takanaga H, Ohtsuki S, Hosoya K, Terasaki T. The l-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier. J. Neurochem. 87, 891-901 (2003). (Pubitemid 37444565)
    • (2003) Journal of Neurochemistry , vol.87 , Issue.4 , pp. 891-901
    • Tetsuka, K.1    Takanaga, H.2    Ohtsuki, S.3    Hosoya, K.-I.4    Terasaki, T.5
  • 97
    • 0033673170 scopus 로고    scopus 로고
    • Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes
    • Gaillard PJ, Voorwinden LH, Nielsen JL et al. Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. Eur. J. Pharm. Sci. 12, 215-222 (2001).
    • (2001) Eur. J. Pharm. Sci. , vol.12 , pp. 215-222
    • Gaillard, P.J.1    Voorwinden, L.H.2    Nielsen, J.L.3
  • 98
    • 0035947226 scopus 로고    scopus 로고
    • A comparison of the induction of immortalized endothelial cell impermeability by astrocytes
    • Tan KH, Dobbie MS, Felix RA, Barrand MA, Hurst RD. A comparison of the induction of immortalized endothelial cell impermeability by astrocytes. Neuroreport 12, 1329-1334 (2001). (Pubitemid 32476123)
    • (2001) NeuroReport , vol.12 , Issue.7 , pp. 1329-1334
    • Tan, K.H.1    Dobbie, M.S.2    Felix, R.A.3    Barrand, M.A.4    Hurst, R.D.5
  • 99
    • 0033528231 scopus 로고    scopus 로고
    • An improved low-permeability in vitro-model of the blood-brain barrier: Transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol
    • DOI 10.1016/S0006-8993(98)01282-7, PII S0006899398012827
    • Franke H, Galla HJ, Beuckmann CT. An improved low-permeability in vitro-model of the blood-brain barrier: transport studies on retinoids, sucrose, haloperidol, caffeine and mannitol. Brain Res. 818, 65-71 (1999). (Pubitemid 29227284)
    • (1999) Brain Research , vol.818 , Issue.1 , pp. 65-71
    • Franke, H.1    Galla, H.-J.2    Beuckmann, C.T.3
  • 101
    • 33745991935 scopus 로고    scopus 로고
    • A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2
    • DOI 10.1016/j.jbiotec.2006.02.019, PII S0168165606001726
    • Neuhaus W, Lauer R, Oelzant S, Fringeli UP, Ecker GF, Noe CR. A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2. J. Biotechnol. 125, 127-141 (2006). (Pubitemid 44066610)
    • (2006) Journal of Biotechnology , vol.125 , Issue.1 , pp. 127-141
    • Neuhaus, W.1    Lauer, R.2    Oelzant, S.3    Fringeli, U.P.4    Ecker, G.F.5    Noe, C.R.6
  • 102
    • 0029759938 scopus 로고    scopus 로고
    • A dynamic model of the blood-brain barrier 'in vitro'
    • Stanness KA, Guatteo E, Janigro D. A dynamic model of the blood-brain barrier 'in vitro'. Neurotoxicology 17, 481-496 (1996). (Pubitemid 26321348)
    • (1996) NeuroToxicology , vol.17 , Issue.2 , pp. 481-496
    • Stanness, C.A.1    Guatteo, E.2    Janigro, D.3
  • 104
    • 0033059802 scopus 로고    scopus 로고
    • Dynamic in vitro modeling of the blood-brain barrier: A novel tool for studies of drug delivery to the brain
    • DOI 10.1016/S1461-5347(98)00110-2, PII S1461534798001102
    • Janigro D, Leaman SM, Stanness KA. Dynamic modeling of the blood-brain barrier: a novel tool for studies of drug delivery to the brain. Pharm. Sci. Technolo. Today 2, 7-12 (1999). (Pubitemid 29132899)
    • (1999) Pharmaceutical Science and Technology Today , vol.2 , Issue.1 , pp. 7-12
    • Janigro, D.1    Leaman, S.M.2    Stanness, K.A.3
  • 105
    • 0642342127 scopus 로고    scopus 로고
    • Drug transport studies using quantitative microdialysis
    • Dai H, Elmquist WF. Drug transport studies using quantitative microdialysis. Methods Mol. Med. 89, 249-264 (2003).
    • (2003) Methods Mol. Med. , vol.89 , pp. 249-264
    • Dai, H.1    Elmquist, W.F.2
  • 108
    • 0035156232 scopus 로고    scopus 로고
    • Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier
    • DOI 10.1002/jps.1119
    • Gumbleton M, Audus KL. Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood- brain barrier. J. Pharm. Sci. 90, 1681-1698 (2001). (Pubitemid 33062590)
    • (2001) Journal of Pharmaceutical Sciences , vol.90 , Issue.11 , pp. 1681-1698
    • Gumbleton, M.1    Audus, K.L.2
  • 109
    • 0036086485 scopus 로고    scopus 로고
    • A new multidrug resistance protein at the blood-brain barrier
    • DOI 10.1016/S0006-291X(02)00376-5, PII S0006291X02003765
    • Eisenblatter T, Galla HJ. A new multidrug resistance protein at the blood-brain barrier. Biochem. Biophys. Res. Commun. 293, 1273-1278 (2002). (Pubitemid 34681079)
    • (2002) Biochemical and Biophysical Research Communications , vol.293 , Issue.4 , pp. 1273-1278
    • Eisenblatter, T.1    Galla, H.-J.2
  • 110
    • 0032859340 scopus 로고    scopus 로고
    • Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
    • Gao B, Stieger B, Noe B, Fritschy JM, Meier PJ. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J. Histochem. Cytochem. 47, 1255-1264 (1999).
    • (1999) J. Histochem. Cytochem. , vol.47 , pp. 1255-1264
    • Gao, B.1    Stieger, B.2    Noe, B.3    Fritschy, J.M.4    Meier, P.J.5
  • 113
    • 0029983527 scopus 로고    scopus 로고
    • Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier
    • DOI 10.1002/(SICI)1097-4652(199604)167:1<81::AID-JCP9>3.0.CO;2-8
    • Hurst RD, Fritz IB. Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier. J. Cell Physiol. 167, 81-88 (1996). (Pubitemid 26108736)
    • (1996) Journal of Cellular Physiology , vol.167 , Issue.1 , pp. 81-88
    • Hurst, R.D.1    Fritz, I.B.2
  • 114
    • 0031795168 scopus 로고    scopus 로고
    • Preliminary characterization of glial-secreted factors responsible for the induction of high electrical resistances across endothelial monolayers in a blood-brain barrier model
    • Ramsohoye PV, Fritz IB. Preliminary characterization of glial-secreted factors responsible for the induction of high electrical resistances across endothelial monolayers in a blood-brain barrier model. Neurochem. Res. 23, 1545-1551 (1998). (Pubitemid 28516295)
    • (1998) Neurochemical Research , vol.23 , Issue.12 , pp. 1545-1551
    • Ramsohoye, P.V.1    Fritz, I.B.2
  • 115
    • 0033961329 scopus 로고    scopus 로고
    • Blood-brain barrier formation of grafted human umbilical vein endothelial cells in athymic mouse brain
    • DOI 10.1016/S0006-8993(99)02471-3, PII S0006899399024713
    • Akiyama H, Kondoh T, Kokunai T, Nagashima T, Saito N, Tamaki N. Blood-brain barrier formation of grafted human umbilical vein endothelial cells in athymic mouse brain. Brain Res. 858, 172-176 (2000). (Pubitemid 30105796)
    • (2000) Brain Research , vol.858 , Issue.1 , pp. 172-176
    • Akiyama, H.1    Kondoh, T.2    Kokunai, T.3    Nagashima, T.4    Saito, N.5    Tamaki, N.6
  • 117
    • 85157038510 scopus 로고    scopus 로고
    • Prevalidation of in vitro models for prediction of secretion processes at intestinal level
    • 8-12 June
    • Centelles-Sanguesa A, Gunday N, Zengerly I et al. Prevalidation of in vitro models for prediction of secretion processes at intestinal level. Presented at: PharmSci Fair Exhibition. Nice, France, 8-12 June 2009.
    • (2009) PharmSci Fair Exhibition. Nice, France
    • Centelles-Sanguesa, A.1    Gunday, N.2    Zengerly, I.3
  • 118
    • 11144290156 scopus 로고    scopus 로고
    • Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice
    • DOI 10.1124/dmd.104.001222
    • Maurer TS, Debartolo DB, Tess DA, Scott DO. Relationship between exposure and nonspecific binding of thirty-three central nervous system drugs in mice. Drug Metab. Dispos. 33, 175-181 (2005). (Pubitemid 40023529)
    • (2005) Drug Metabolism and Disposition , vol.33 , Issue.1 , pp. 175-181
    • Maurer, T.S.1    Debartolo, D.B.2    Tess, D.A.3    Scott, D.O.4
  • 120
    • 33645821904 scopus 로고    scopus 로고
    • Evaluation of the utility of brain slice methods to study brain penetration
    • Becker S, Liu X. Evaluation of the utility of brain slice methods to study brain penetration. Drug Metab. Dispos. 34, 855-861 (2006).
    • (2006) Drug Metab. Dispos. , vol.34 , pp. 855-861
    • Becker, S.1    Liu, X.2
  • 121
    • 33746897339 scopus 로고    scopus 로고
    • Chromatographic estimation of drug disposition properties by means of immobilized artificial membranes (IAM) and C18 columns
    • DOI 10.1021/jm0602108
    • Lazaro E, Rafols C, Abraham MH, Roses M. Chromatographic estimation of drug disposition properties by means of immobilized artificial membranes (IAM) and C18 columns. J. Med. Chem. 49, 4861-4870 (2006). (Pubitemid 44201044)
    • (2006) Journal of Medicinal Chemistry , vol.49 , Issue.16 , pp. 4861-4870
    • Lazaro, E.1    Rafols, C.2    Abraham, M.H.3    Roses, M.4
  • 122
    • 0031060245 scopus 로고    scopus 로고
    • Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs
    • DOI 10.1016/S0731-7085(96)01883-3, PII S0731708596018833
    • Salminen T, Pulli A, Taskinen J. Relationship between immobilised artificial membrane chromatographic retention and the brain penetration of structurally diverse drugs. J. Pharm. Biomed. Anal. 15, 469-477 (1997). (Pubitemid 26384301)
    • (1997) Journal of Pharmaceutical and Biomedical Analysis , vol.15 , Issue.4 , pp. 469-477
    • Salminen, T.1    Pulli, A.2    Taskinen, J.3
  • 126
    • 0025265046 scopus 로고
    • An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro
    • Dehouck MP, Meresse S, Delorme P, Fruchart JC, Cecchelli R. An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro. J. Neurochem. 54, 1798-1801 (1990).
    • (1990) J. Neurochem. , vol.54 , pp. 1798-1801
    • Dehouck, M.P.1    Meresse, S.2    Delorme, P.3    Fruchart, J.C.4    Cecchelli, R.5
  • 127
    • 0023022986 scopus 로고
    • Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism
    • DOI 10.1023/A:1016337202335
    • Audus KL, Borchardt RT. Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism. Pharm. Res. 3, 81-87 (1986). (Pubitemid 17191154)
    • (1986) Pharmaceutical Research , vol.3 , Issue.2 , pp. 81-87
    • Audus, K.L.1    Borchardt, R.T.2
  • 129
    • 0035997330 scopus 로고    scopus 로고
    • Prediction of drug transport through the blood-brain barrier in Vivo: A comparison between two in Vitro cell models
    • DOI 10.1023/A:1016462205267
    • Lundquist S, Renftel M, Brillault J, Fenart L, Cecchelli R, Dehouck MP. Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models. Pharm. Res. 19, 976-981 (2002). (Pubitemid 34804239)
    • (2002) Pharmaceutical Research , vol.19 , Issue.7 , pp. 976-981
    • Lundquist, S.1    Renftel, M.2    Brillault, J.3    Fenart, L.4    Cecchelli, R.5    Dehouck, M.-P.6
  • 130
    • 0026638367 scopus 로고
    • Permeability of bovine brain microvessel endothelial cells in vitro: Barrier tightening by a factor released from astroglioma cells
    • Raub TJ, Kuentzel SL, Sawada GA. Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells. Exp. Cell Res. 199, 330-340 (1992).
    • (1992) Exp. Cell Res. , vol.199 , pp. 330-340
    • Raub, T.J.1    Kuentzel, S.L.2    Sawada, G.A.3
  • 131
    • 0031946993 scopus 로고    scopus 로고
    • In vitro blood-brain barrier permeability of nevirapine compared to other HIV antiretroviral agents
    • DOI 10.1021/js970291i
    • Glynn SL, Yazdanian M. In vitro blood-brain barrier permeability of nevirapine compared with other HIV antiretroviral agents. J. Pharm. Sci. 87, 306-310 (1998). (Pubitemid 28204583)
    • (1998) Journal of Pharmaceutical Sciences , vol.87 , Issue.3 , pp. 306-310
    • Glynn, S.L.1    Yazdanian, M.2
  • 132
    • 0033549263 scopus 로고    scopus 로고
    • Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium
    • DOI 10.1016/S0006-8993(99)01461-4, PII S0006899399014614
    • Rochat B, Baumann P, Audus KL. Transport mechanisms for the antidepressant citalopram in brain microvessel endothelium. Brain Res. 831, 229-236 (1999). (Pubitemid 29336205)
    • (1999) Brain Research , vol.831 , Issue.1-2 , pp. 229-236
    • Rochat, B.1    Baumann, P.2    Audus, K.L.3
  • 133
    • 23844497838 scopus 로고    scopus 로고
    • Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier
    • DOI 10.1007/s11095-005-5271-y
    • Bachmeier CJ, Spitzenberger TJ, Elmquist WF, Miller DW. Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier. Pharm. Res. 22, 1259-1268 (2005). (Pubitemid 41176029)
    • (2005) Pharmaceutical Research , vol.22 , Issue.8 , pp. 1259-1268
    • Bachmeier, C.J.1    Spitzenberger, T.J.2    Elmquist, W.F.3    Miller, D.W.4
  • 134
    • 0023714970 scopus 로고
    • Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure
    • Dingemanse J, Sollie FA, Breimer DD, Danhof M. Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure. J. Pharmacokinet. Biopharm. 16, 203-228 (1988).
    • (1988) J. Pharmacokinet. Biopharm. , vol.16 , pp. 203-228
    • Dingemanse, J.1    Sollie, F.A.2    Breimer, D.D.3    Danhof, M.4
  • 135
    • 0026050940 scopus 로고
    • Quazepam and flurazepam: Differential pharmacokinetic and pharmacodynamic characteristics
    • Hilbert JM, Battista D. Quazepam and flurazepam: differential pharmacokinetic and pharmacodynamic characteristics. J. Clin. Psychiatry. 52 Suppl, 21-26 (1991).
    • (1991) J. Clin. Psychiatry. 52 Suppl , pp. 21-26
    • Hilbert, J.M.1    Battista, D.2
  • 136
    • 0025123704 scopus 로고
    • Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization
    • Pardridge WM, Boado RJ, Farrell CR. Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. J. Biol Chem. 265, 18035-18040 (1990).
    • (1990) J. Biol Chem. , vol.265 , pp. 18035-18040
    • Pardridge, W.M.1    Boado, R.J.2    Farrell, C.R.3
  • 137
    • 0032489295 scopus 로고    scopus 로고
    • Hydrocortisone reinforces the blood-brain properties in a serum free cell culture system
    • Hoheisel D, Nitz T, Franke H et al. Hydrocortisone reinforces the blood-brain properties in a serum free cell culture system. Biochem. Biophys. Res. Commun. 247, 312-315 (1998).
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 312-315
    • Hoheisel, D.1    Nitz, T.2    Franke, H.3
  • 138
    • 4344638916 scopus 로고    scopus 로고
    • Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes
    • Kido Y, Tamai I, Nakanishi T et al. Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes. Drug Metab. Pharmacokinet. 17, 34-41 (2002).
    • (2002) Drug Metab. Pharmacokinet. , vol.17 , pp. 34-41
    • Kido, Y.1    Tamai, I.2    Nakanishi, T.3
  • 139
    • 0033961684 scopus 로고    scopus 로고
    • Carrier-mediated delivery of metabotropic glutamate receptor ligands to the central nervous system: Structural tolerance and potential of the L- system amino acid transporter at the blood-brain barrier
    • Reichel A, Begley DJ, Abbott NJ. Carrier-mediated delivery of metabotrophic glutamate receptor ligands to the central nervous system: structural tolerance and potential of the l-system amino acid transporter at the blood-brain barrier. J. Cereb. Blood Flow Metab. 20, 168-174 (2000). (Pubitemid 30019842)
    • (2000) Journal of Cerebral Blood Flow and Metabolism , vol.20 , Issue.1 , pp. 168-174
    • Reichel, A.1    Begley, D.J.2    Abbott, N.J.3
  • 141
    • 0035984809 scopus 로고    scopus 로고
    • Predicting blood-brain barrier permeability of drugs: Evaluation of different in vitro assays
    • DOI 10.1080/10611860290031903
    • Lohmann C, Huwel S, Galla HJ. Predicting blood-brain barrier permeability of drugs: evaluation of different in vitro assays. J. Drug Target. 10, 263-276 (2002). (Pubitemid 34746308)
    • (2002) Journal of Drug Targeting , vol.10 , Issue.4 , pp. 263-276
    • Lohmann, C.1    Huwel, S.2    Galla, H.-J.3
  • 142
    • 0001754099 scopus 로고    scopus 로고
    • A comparison of Madin-Darby canine kidney cells and bovine brain endothelial cells as a blood-brain barrier screen in early drug discovery
    • Balls M, van Zeller AM, Halder ME (Eds). Elsevier Sciences B.V., Amsterdam, The Netherlands
    • Polli JW, Humphreys JE, Wring SA et al. A comparison of Madin-Darby canine kidney cells and bovine brain endothelial cells as a blood-brain barrier screen in early drug discovery. In:Progress in the Reduction, Refinement and Replacement of Animal Experimentation. Balls M, van Zeller AM, Halder ME (Eds). Elsevier Sciences B.V., Amsterdam, The Netherlands, 271-289 (2000).
    • (2000) Progress in the Reduction, Refinement and Replacement of Animal Experimentation. , pp. 271-289
    • Polli, J.W.1    Humphreys, J.E.2    Wring, S.A.3
  • 143
    • 0345516038 scopus 로고    scopus 로고
    • Decreased endothelial cell glutathione and increased sensitivity to oxidative stress in an in vitro blood-brain barrier model system
    • DOI 10.1016/S0006-8993(98)00634-9, PII S0006899398006349
    • Hurst RD, Heales SJ, Dobbie MS, Barker JE, Clark JB. Decreased endothelial cell glutathione and increased sensitivity to oxidative stress in an in vitro blood-brain barrier model system. Brain Res. 802, 232-240 (1998). (Pubitemid 28392175)
    • (1998) Brain Research , vol.802 , Issue.1-2 , pp. 232-240
    • Hurst, R.D.1    Heales, S.J.R.2    Dobbie, M.S.3    Barker, J.E.4    Clark, J.B.5
  • 144
    • 0033606049 scopus 로고    scopus 로고
    • Astrocytes induce several blood-brain barrier properties in non-neural endothelial cells
    • Kuchler-Bopp S, Delaunoy JP, Artault JC, Zaepfel M, Dietrich JB. Astrocytes induce several blood-brain barrier properties in non-neural endothelial cells. Neuroreport. 10, 1347-1353 (1999). (Pubitemid 29403721)
    • (1999) NeuroReport , vol.10 , Issue.6 , pp. 1347-1353
    • Kuchler-Bopp, S.1    Delaunoy, J.-P.2    Artault, J.-C.3    Zaepfel, M.4    Dietrich, J.-B.5
  • 146
    • 0033975029 scopus 로고    scopus 로고
    • Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice
    • Dagenais C, Rousselle C, Pollack GM, Scherrmann JM. Development of an in situ mouse brain perfusion model and its application to mdr1a P-glycoprotein-deficient mice. J. Cereb. Blood Flow Metab. 20, 381-386 (2000). (Pubitemid 30108457)
    • (2000) Journal of Cerebral Blood Flow and Metabolism , vol.20 , Issue.2 , pp. 381-386
    • Dagenais, C.1    Rousselle, C.2    Pollack, G.M.3    Scherrmann, J.-M.4
  • 147
    • 0029035114 scopus 로고
    • Transport of small molecules through the blood-brain barrier: Biology and methodology
    • Pardridge WM. Transport of small molecules through the blood-brain barrier: biology and methodology. Adv. Drug Deliv. 15, 5-36 (1995).
    • (1995) Adv. Drug Deliv. , vol.15 , pp. 5-36
    • Pardridge, W.M.1
  • 149
    • 0028813608 scopus 로고
    • Animal models for studying transport across the blood-brain barrier
    • Bonate PL. Animal models for studying transport across the blood-brain barrier. J. Neurosci. Methods. 56, 1-15 (1995).
    • (1995) J. Neurosci. Methods. , vol.56 , pp. 1-15
    • Bonate, P.L.1
  • 150
    • 2342644918 scopus 로고    scopus 로고
    • Expression, up-regulation and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier
    • DOI 10.1158/0008-5472.CAN-03-2033
    • Cisternino S, Mercier C, Bourasset F, Roux F, Scherrmann JM. Expression, up-regulation and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier. Cancer Res. 64, 3296-3301 (2004). (Pubitemid 38581436)
    • (2004) Cancer Research , vol.64 , Issue.9 , pp. 3296-3301
    • Cisternino, S.1    Mercier, C.2    Bourasset, F.3    Roux, F.4    Scherrmann, J.-M.5
  • 151
    • 0033526176 scopus 로고    scopus 로고
    • P-Glycoprotein, a gatekeeper in the blood-brain barrier
    • DOI 10.1016/S0169-409X(98)00085-4, PII S0169409X98000854
    • Schinkel AH. P-glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Deliv. Rev. 36, 179-194 (1999). (Pubitemid 29121971)
    • (1999) Advanced Drug Delivery Reviews , vol.36 , Issue.2-3 , pp. 179-194
    • Schinkel, A.H.1
  • 153
    • 1042266257 scopus 로고    scopus 로고
    • Prediction of blood-brain barrier penetration: Are we missing the point?
    • DOI 10.1016/S1359-6446(03)02961-1, PII S1359644603029611
    • Martin I. Prediction of blood-brain barrier penetration: are we missing the point? Drug Discov. Today. 9, 161-162 (2004). (Pubitemid 38199960)
    • (2004) Drug Discovery Today , vol.9 , Issue.4 , pp. 161-162
    • Martin, I.1
  • 154
    • 35748977617 scopus 로고    scopus 로고
    • Challenges for blood-brain barrier (BBB) screening
    • DOI 10.1080/00498250701570285, PII 783596000, Modelling and Simulation Approaches to in vitro-in vivo, Extrapolation of ADME Properties in Drug Development, Editor: Gordon Gibson, Guest Editor: Amin Rostami-Hodjegan
    • Jeffrey P, Summerfield SG. Challenges for blood-brain barrier (BBB) screening. Xenobiotica 37, 1135-1151 (2007). (Pubitemid 350041554)
    • (2007) Xenobiotica , vol.37 , Issue.10-11 , pp. 1135-1151
    • Jeffrey, P.1    Summerfield, S.G.2
  • 155
    • 33747816123 scopus 로고    scopus 로고
    • In vivo blood-brain barrier transport of oxycodone in the rat: Indications for active influx and implications for pharmacokinetics/ pharmacodynamics
    • DOI 10.1124/dmd.106.009746
    • Bostrom E, Simonsson US, Hammarlund- Udenaes M. In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics. Drug Metab. Dispos. 34, 1624-1631 (2006). (Pubitemid 44285405)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.9 , pp. 1624-1631
    • Bostrom, E.1    Simonsson, U.S.H.2    Hammarlund-Udenaes, M.3
  • 157
    • 0027184484 scopus 로고
    • 2 (Tyr-W-MIF-1) is transported from the brain to the blood by peptide transport system-1
    • Banks WA, Kastin AJ, Ehrensing CA. Endogenous peptide Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1) is transported from the brain to the blood by peptide transport system-1. J. Neurosci. Res. 35, 690-695 (1993). (Pubitemid 23226720)
    • (1993) Journal of Neuroscience Research , vol.35 , Issue.6 , pp. 690-695
    • Banks, W.A.1    Kastin, A.J.2    Ehrensing, C.A.3
  • 159
    • 0033532065 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain
    • Kusuhara H, Sekine T, Utsunomiya- Tate N et al. Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 274, 13675-13680 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 13675-13680
    • Kusuhara, H.1    Sekine, T.2    Utsunomiya- Tate, N.3
  • 161
    • 0030806636 scopus 로고    scopus 로고
    • Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier
    • DOI 10.1016/S0165-0173(97)00014-3, PII S0165017397000143
    • de Lange EC, Danhof M, de Boer AG, Breimer DD. Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood- brain barrier. Brain Res. Brain Res. Rev. 25, 27-49 (1997). (Pubitemid 27459719)
    • (1997) Brain Research Reviews , vol.25 , Issue.1 , pp. 27-49
    • De Lange, E.C.M.1    Danhof, M.2    De Boer, A.G.3    Breimer, D.D.4
  • 162
    • 0034672607 scopus 로고    scopus 로고
    • Microdialysis in the study of drug transporters in the CNS
    • Sawchuk RJ, Elmquist WF. Microdialysis in the study of drug transporters in the CNS. Adv. Drug Deliv. Rev. 45, 295-307 (2000).
    • (2000) Adv. Drug Deliv. Rev. , vol.45 , pp. 295-307
    • Sawchuk, R.J.1    Elmquist, W.F.2
  • 163
    • 22244489382 scopus 로고    scopus 로고
    • Measurement of unbound cocaine in blood, brain and bile of anesthetized rats using microdialysis coupled with liquid chromatography and verified by tandem mass spectrometry
    • Chen YF, Chang CH, Wang SC, Tsai TH. Measurement of unbound cocaine in blood, brain and bile of anesthetized rats using microdialysis coupled with liquid chromatography and verified by tandem mass spectrometry. Biomed. Chromatogr. 19, 402-408 (2005).
    • (2005) Biomed. Chromatogr. , vol.19 , pp. 402-408
    • Chen, Y.F.1    Chang, C.H.2    Wang, S.C.3    Tsai, T.H.4
  • 166
    • 33644812284 scopus 로고    scopus 로고
    • Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling
    • de Lange EC, Ravenstijn PG, Groenendaal D, van Steeg TJ. Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic- pharmacodynamic modeling. AAPS J. 7, E532-543 (2005).
    • (2005) AAPS J. , vol.7
    • De Lange, E.C.1    Ravenstijn, P.G.2    Groenendaal, D.3    Van Steeg, T.J.4
  • 167
    • 0031952384 scopus 로고    scopus 로고
    • Analysis of promoter and androgen regulatory sequences required for optimal transcription of the rat androgen-binding protein gene
    • Fenstermacher DA, Joseph DR. Analysis of promoter and androgen regulatory sequences required for optimal transcription of the rat androgen-binding protein gene. J. Androl. 19, 81-91 (1998). (Pubitemid 28090863)
    • (1998) Journal of Andrology , vol.19 , Issue.1 , pp. 81-91
    • Fenstermacher, D.A.1    Joseph, D.R.2
  • 169
    • 0344197565 scopus 로고    scopus 로고
    • Whole-body autoradiography and quantitative organ-level distribution study of deramciclane in rats
    • Hazai I, Patfalusi M, Klebovich I, Urmos I. Whole-body autoradiography and quantitative organ-level distribution study of deramciclane in rats. J. Pharm. Pharmacol. 51, 165-174 (1999). (Pubitemid 29131309)
    • (1999) Journal of Pharmacy and Pharmacology , vol.51 , Issue.2 , pp. 165-174
    • Hazai, I.1    Patfalusi, M.2    Klebovich, I.3    Urmos, I.4
  • 170
    • 0033996507 scopus 로고    scopus 로고
    • Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor
    • DOI 10.1023/A:1007592720793
    • Coloma MJ, Lee HJ, Kurihara A et al. Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor. Pharm. Res. 17, 266-274 (2000) (Pubitemid 30225129)
    • (2000) Pharmaceutical Research , vol.17 , Issue.3 , pp. 266-274
    • Coloma, M.J.1    Lee, H.J.2    Kurihara, A.3    Landaw, E.M.4    Boado, R.J.5    Morrison, S.L.6    Pardridge, W.M.7
  • 171
    • 0033931130 scopus 로고    scopus 로고
    • Tissue distribution, autoradiography, and metabolism of 4-(2'-methoxyphenyl)-1-[2' -[N-2'-pyridinyl)-p-[(18)F] fluorobenzamido]ethyl] piperazine (p-[(18) F]MPPF), a new serotonin 5-HT(1A) antagonist for positron emission tomography: An in vivo study in rats
    • Plenevaux A, Weissmann D, Aerts J et al. Tissue distribution, autoradiography, and metabolism of 4-(2'-methoxyphenyl)-1-[2' -[N-2'-pyridinyl)-p-[(18)F] fluorobenzamido]ethyl]piperazine (p-[(18) F]MPPF), a new serotonin 5-HT(1A) antagonist for positron emission tomography: an in vivo study in rats. J. Neurochem. 75, 803-811 (2000).
    • (2000) J. Neurochem. , vol.75 , pp. 803-811
    • Plenevaux, A.1    Weissmann, D.2    Aerts, J.3
  • 174
    • 0346097881 scopus 로고    scopus 로고
    • Changes in cerebral perfusion precede plaque formation in multiple sclerosis: A longitudinal perfusion MRI study
    • DOI 10.1093/brain/awh007
    • Wuerfel J, Bellmann-Strobl J, Brunecker P et al. Changes in cerebral perfusion precede plaque formation in multiple sclerosis: a longitudinal perfusion MRI study. Brain 127, 111-119 (2004). (Pubitemid 38055350)
    • (2004) Brain , vol.127 , Issue.1 , pp. 111-119
    • Wuerfel, J.1    Bellmann-Strobl, J.2    Brunecker, P.3    Aktas, O.4    McFarland, H.5    Villringer, A.6    Zipp, F.7
  • 176
    • 4544231143 scopus 로고    scopus 로고
    • Radionuclide imaging in drug development
    • DOI 10.2174/1381612043383476
    • Perkins AC, Frier M. Radionuclide imaging in drug development. Curr. Pharm. Des. 10, 2907-2921 (2004). (Pubitemid 39220312)
    • (2004) Current Pharmaceutical Design , vol.10 , Issue.24 , pp. 2907-2921
    • Perkins, A.C.1    Frier, M.2
  • 177
    • 67849083569 scopus 로고    scopus 로고
    • PET radiotracers: Crossing the blood-brain barrier and surviving metabolism
    • Pike VW. PET radiotracers: crossing the blood-brain barrier and surviving metabolism. Trends Pharmacol. Sci. 30, 431-440 (2009).
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 431-440
    • Pike, V.W.1
  • 178
    • 4544315183 scopus 로고    scopus 로고
    • Transport across the blood-brain barrier: Stereoselectivity and PET-tracers
    • DOI 10.1016/j.mibio.2004.06.008, PII S1536163204002689
    • Luurtsema G, de Lange EC, Lammertsma AA, Franssen EJ. Transport across the blood-brain barrier: stereoselectivity and PET-tracers. Mol. Imaging Biol. 6, 306-318 (2004). (Pubitemid 39243064)
    • (2004) Molecular Imaging and Biology , vol.6 , Issue.5 , pp. 306-318
    • Luurtsema, G.1    De Lange, E.C.M.2    Lammertsma, A.A.3    Franssen, E.J.F.4
  • 179
    • 13244258485 scopus 로고    scopus 로고
    • 11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: Kinetics and metabolism in the rat
    • DOI 10.1016/j.nucmedbio.2004.06.007, PII S0969805104001246
    • Luurtsema G, Molthoff CF, Schuit RC, Windhorst AD, Lammertsma AA, Franssen EJ. Evaluation of (R)-[11C] verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat. Nucl. Med. Biol. 32, 87-93 (2005). (Pubitemid 40187385)
    • (2005) Nuclear Medicine and Biology , vol.32 , Issue.1 , pp. 87-93
    • Luurtsema, G.1    Molthoff, C.F.M.2    Schuit, R.C.3    Windhorst, A.D.4    Lammertsma, A.A.5    Franssen, E.J.F.6
  • 182
    • 70449529637 scopus 로고    scopus 로고
    • Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases
    • Gabathuler R. Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases. Neurobiol. Dis. 37, 48-57 (2010).
    • (2010) Neurobiol. Dis. , vol.37 , pp. 48-57
    • Gabathuler, R.1
  • 183
    • 77953912416 scopus 로고    scopus 로고
    • Strategy for effective brain drug delivery
    • Alam MI, Beg S, Samad A et al. Strategy for effective brain drug delivery. Eur. J. Pharm. Sci. 40(5), 385-403 (2010).
    • (2010) Eur. J. Pharm. Sci. , vol.40 , Issue.5 , pp. 385-403
    • Alam, M.I.1    Beg, S.2    Samad, A.3
  • 184
    • 33646547197 scopus 로고    scopus 로고
    • In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain
    • Nagaraja TN, Patel P, Gorski M, Gorevic PD, Patlak CS, Fenstermacher JD. In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain. Cerebrospinal Fluid Res. 2, 5 (2005).
    • (2005) Cerebrospinal Fluid Res. , vol.2 , pp. 5
    • Nagaraja, T.N.1    Patel, P.2    Gorski, M.3    Gorevic, P.D.4    Patlak, C.S.5    Fenstermacher, J.D.6
  • 185
    • 13144282676 scopus 로고    scopus 로고
    • Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: A two-year outcome study
    • DOI 10.1002/ana.20374
    • Patel NK, Bunnage M, Plaha P, Svendsen CN, Heywood P, Gill SS. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD: a two-year outcome study. Ann. Neurol. 57, 298-302 (2005). (Pubitemid 40179870)
    • (2005) Annals of Neurology , vol.57 , Issue.2 , pp. 298-302
    • Patel, N.K.1    Bunnage, M.2    Plaha, P.3    Svendsen, C.N.4    Heywood, P.5    Gill, S.S.6
  • 186
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Improvement of bilateral motor functions in patients with Parkinson's disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J. Neurosurg. 102, 216-222 (2005). (Pubitemid 43194069)
    • (2005) Journal of Neurosurgery , vol.102 , Issue.2 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Kryscio, R.5    Young, B.6
  • 188
    • 0026700607 scopus 로고
    • Clearance of brain edema and macromolecules through the cortical extracellular space
    • Ohata K, Marmarou A. Clearance of brain edema and macromolecules through the cortical extracellular space. J. Neurosurg. 77, 387-396 (1992).
    • (1992) J. Neurosurg. , vol.77 , pp. 387-396
    • Ohata, K.1    Marmarou, A.2
  • 189
    • 4344700281 scopus 로고    scopus 로고
    • Opening the floodgates: Clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle
    • DOI 10.1016/j.ymthe.2004.07.010, PII S1525001604013218
    • Wells DJ. Opening the floodgates: clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle. Mol. Ther. 10, 207-208 (2004). (Pubitemid 39127367)
    • (2004) Molecular Therapy , vol.10 , Issue.2 , pp. 207-208
    • Wells, D.J.1
  • 190
    • 33645937646 scopus 로고    scopus 로고
    • The mechanism of naked DNA uptake and expression
    • Wolff JA, Budker V. The mechanism of naked DNA uptake and expression. Adv. Genet. 54, 3-20 (2005).
    • (2005) Adv. Genet. , vol.54 , pp. 3-20
    • Wolff, J.A.1    Budker, V.2
  • 191
    • 0029045339 scopus 로고
    • Distribution of nerve growth factor following direct delivery to brain interstitium
    • Krewson CE, Klarman ML, Saltzman WM. Distribution of nerve growth factor following direct delivery to brain interstitium. Brain Res. 680, 196-206 (1995).
    • (1995) Brain Res. , vol.680 , pp. 196-206
    • Krewson, C.E.1    Klarman, M.L.2    Saltzman, W.M.3
  • 192
    • 1542530051 scopus 로고    scopus 로고
    • Overview of adeno-associated viral vectors
    • Daly TM. Overview of adeno-associated viral vectors. Methods Mol. Biol. 246, 157-165 (2004).
    • (2004) Methods Mol. Biol. , vol.246 , pp. 157-165
    • Daly, T.M.1
  • 193
    • 22144477188 scopus 로고    scopus 로고
    • Recombinant adeno-associated viral vectors in the nervous system
    • DOI 10.1089/hum.2005.16.781
    • Burger C, Nash K, Mandel RJ. Recombinant adeno-associated viral vectors in the nervous system. Hum. Gene Ther. 16, 781-791 (2005). (Pubitemid 40982327)
    • (2005) Human Gene Therapy , vol.16 , Issue.7 , pp. 781-791
    • Burger, C.1    Nash, K.2    Mandel, R.J.3
  • 195
    • 1542369977 scopus 로고    scopus 로고
    • From virus evolution to vector revolution: Use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy
    • Grimm D, Kay MA. From virus evolution to vector revolution: use of naturally occurring serotypes of adeno-associated virus (AAV) as novel vectors for human gene therapy. Curr. Gene Ther. 3, 281-304 (2003).
    • (2003) Curr. Gene Ther. , vol.3 , pp. 281-304
    • Grimm, D.1    Kay, M.A.2
  • 196
    • 24944553351 scopus 로고    scopus 로고
    • Metabolic correction in microglia derived from Sandhoff disease model mice
    • DOI 10.1111/j.1471-4159.2005.03317.x
    • Tsuji D, Kuroki A, Ishibashi Y, Itakura T, Itoh K. Metabolic correction in microglia derived from Sandhoff disease model mice. J. Neurochem. 94, 1631-1638 (2005). (Pubitemid 41324644)
    • (2005) Journal of Neurochemistry , vol.94 , Issue.6 , pp. 1631-1638
    • Tsuji, D.1    Kuroki, A.2    Ishibashi, Y.3    Itakura, T.4    Itoh, K.5
  • 198
    • 23644452944 scopus 로고    scopus 로고
    • Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct
    • DOI 10.1016/j.expneurol.2005.03.006, PII S0014488605001093
    • Fjord-Larsen L, Johansen JL, Kusk P et al. Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct. Exp. Neurol. 195, 49-60 (2005). (Pubitemid 41116813)
    • (2005) Experimental Neurology , vol.195 , Issue.1 , pp. 49-60
    • Fjord-Larsen, L.1    Johansen, J.L.2    Kusk, P.3    Tornoe, J.4    Gronborg, M.5    Rosenblad, C.6    Wahlberg, L.U.7
  • 199
    • 5644254312 scopus 로고    scopus 로고
    • Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector
    • DOI 10.1089/hum.2004.15.934
    • Georgievska B, Jakobsson J, Persson E, Ericson C, Kirik D, Lundberg C. Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector. Hum. Gene Ther. 15, 934-944 (2004). (Pubitemid 39372570)
    • (2004) Human Gene Therapy , vol.15 , Issue.10 , pp. 934-944
    • Georgievska, B.1    Jakobsson, J.2    Persson, E.3    Ericson, C.4    Kirik, D.5    Lundberg, C.6
  • 200
    • 33744494277 scopus 로고    scopus 로고
    • Gene therapy in epilepsy
    • Vezzani A. Gene therapy in epilepsy. Epilepsy Curr. 4, 87-90 (2004).
    • (2004) Epilepsy Curr. , vol.4 , pp. 87-90
    • Vezzani, A.1
  • 202
    • 11244349670 scopus 로고    scopus 로고
    • Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes
    • DOI 10.1007/s11060-004-6046-8
    • Steffens S, Tebbets J, Kramm CM, Lindemann D, Flake A, Sena-Esteves M. Transduction of human glial and neuronal tumor cells with different lentivirus vector pseudotypes. J. Neurooncol. 70, 281-288 (2004). (Pubitemid 40057956)
    • (2004) Journal of Neuro-Oncology , vol.70 , Issue.3 , pp. 281-288
    • Steffens, S.1    Tebbets, J.2    Kramm, C.M.3    Lindemann, D.4    Flake, A.5    Sena-Esteves, M.6
  • 205
    • 0037119577 scopus 로고    scopus 로고
    • Drug targeting: Breaking down barriers
    • DOI 10.1126/science.297.5584.1116
    • Miller G. Drug targeting. Breaking down barriers. Science 297, 1116-1118 (2002). (Pubitemid 36193322)
    • (2002) Science , vol.297 , Issue.5584 , pp. 1116-1118
    • Miller, G.1
  • 206
    • 1642504354 scopus 로고    scopus 로고
    • Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries
    • DOI 10.1038/sj.bjp.0705554
    • Erdlenbruch B, Alipour M, Fricker G et al. Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries. Br. J. Pharmacol. 140, 1201-1210 (2003). (Pubitemid 38117424)
    • (2003) British Journal of Pharmacology , vol.140 , Issue.7 , pp. 1201-1210
    • Erdlenbruch, B.1    Alipour, M.2    Fricker, G.3    Miller, D.S.4    Kugler, W.5    Eibl, H.6    Lakomek, M.7
  • 208
    • 5644276383 scopus 로고    scopus 로고
    • Delivery of bioactive molecules into the cell: The Trojan horse approach
    • DOI 10.1016/j.mcn.2004.03.005, PII S1044743104000715
    • Dietz GP, Bahr M. Delivery of bioactive molecules into the cell: the Trojan horse approach. Mol. Cell Neurosci. 27, 85-131 (2004). (Pubitemid 39370094)
    • (2004) Molecular and Cellular Neuroscience , vol.27 , Issue.2 , pp. 85-131
    • Dietz, G.P.H.1    Bahr, M.2
  • 209
    • 0017238493 scopus 로고
    • Amino acid assignment to one of three blood-brain barrier amino acid carriers
    • Oldendorf WH, Szabo J. Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am. J. Physiol. 230, 94-98 (1976).
    • (1976) Am. J. Physiol. , vol.230 , pp. 94-98
    • Oldendorf, W.H.1    Szabo, J.2
  • 210
    • 0015186836 scopus 로고
    • Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
    • Oldendorf WH. Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol. 221, 1629-1639 (1971).
    • (1971) Am. J. Physiol. , vol.221 , pp. 1629-1639
    • Oldendorf, W.H.1
  • 211
    • 0034866384 scopus 로고    scopus 로고
    • 3-receptor agonist
    • Krause M, Stark H, Schunack W. Azomethine prodrugs of (R)-a-methylhistamine, a highly potent and selective histamine H3-receptor agonist. Curr. Med. Chem. 8, 1329-1340 (2001). (Pubitemid 32791799)
    • (2001) Current Medicinal Chemistry , vol.8 , Issue.11 , pp. 1329-1340
    • Krause, M.1    Stark, H.2    Schunack, W.3
  • 212
    • 0034453632 scopus 로고    scopus 로고
    • Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: A preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease
    • Deguchi Y, Hayashi H, Fujii S et al. Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease. J. Drug Target. 8, 371-381 (2000). (Pubitemid 32366705)
    • (2000) Journal of Drug Targeting , vol.8 , Issue.6 , pp. 371-381
    • Deguchi, Y.1    Hayashi, H.2    Fujii, S.3    Naito, T.4    Yokoyama, Y.5    Yamada, S.6    Kimura, R.7
  • 213
    • 0018386217 scopus 로고
    • Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice
    • DOI 10.1016/0028-3908(79)90108-4
    • Frey HH, Popp C, Loscher W. Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in mice. Neuropharmacology. 18, 581-590 (1979). (Pubitemid 9206168)
    • (1979) Neuropharmacology , vol.18 , Issue.7 , pp. 581-590
    • Frey, H.H.1    Popp, C.2    Loescher, W.3
  • 214
    • 0029803908 scopus 로고    scopus 로고
    • Synthesis and evaluation of the anti-inflammatory effects of niflumic acid lipophilic prodrugs in brain edema
    • el Kihel L, Bourass J, Richomme P, Petit JY, Letourneux Y. Synthesis and evaluation of the anti-inflammatory effects of niflumic acid lipophilic prodrugs in brain edema. Arzneimittelforschung. 46, 1040-1044 (1996).
    • (1996) Arzneimittelforschung. , vol.46 , pp. 1040-1044
    • El Kihel, L.1    Bourass, J.2    Richomme, P.3    Petit, J.Y.4    Letourneux, Y.5
  • 215
    • 0023181886 scopus 로고
    • Immunohistochemical localization of aminopeptidase M in rat brain and periphery: Relationship of enzyme localization and enkephalin metabolism
    • DOI 10.1016/0196-9781(87)90019-2
    • Hersh LB, Aboukhair N, Watson S. Immunohistochemical localization of aminopeptidase M in rat brain and periphery: relationship of enzyme localization and enkephalin metabolism. Peptides 8, 523-532 (1987). (Pubitemid 17119188)
    • (1987) Peptides , vol.8 , Issue.3 , pp. 523-532
    • Hersh, L.B.1    Aboukhair, N.2    Watson, S.3
  • 217
    • 0030929865 scopus 로고    scopus 로고
    • Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2'-β-fluoro-2',3'- dideoxyinosine and 2'-β-fluoro-2',3'-dideoxyadenosine in rats
    • DOI 10.1023/A:1012110724604
    • Singhal D, Morgan ME, Anderson BD. Role of brain tissue localized purine metabolizing enzymes in the central nervous system delivery of anti-HIV agents 2′-b-fluoro-2′,3′-dideoxyinosine and 2′-b-fluoro- 2′,3′-dideoxyadenosine in rats. Pharm. Res. 14, 786-792 (1997). (Pubitemid 27281675)
    • (1997) Pharmaceutical Research , vol.14 , Issue.6 , pp. 786-792
    • Singhal, D.1    Morgan, M.E.2    Andersen, B.D.3
  • 219
    • 34547637590 scopus 로고    scopus 로고
    • Drug targeting to the brain
    • DOI 10.1007/s11095-007-9324-2
    • Pardridge WM. Drug targeting to the brain. Pharm. Res. 24, 1733-1744 (2007). (Pubitemid 47206623)
    • (2007) Pharmaceutical Research , vol.24 , Issue.9 , pp. 1733-1744
    • Pardridge, W.M.1
  • 220
    • 0033756459 scopus 로고    scopus 로고
    • Transporter-mediated permeation of drugs across the blood-brain barrier
    • Tamai I, Tsuji A. Transporter-mediated permeation of drugs across the blood-brain barrier. J. Pharm. Sci. 89, 1371-1388 (2000).
    • (2000) J. Pharm. Sci. , vol.89 , pp. 1371-1388
    • Tamai, I.1    Tsuji, A.2
  • 221
    • 33751114416 scopus 로고    scopus 로고
    • Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system
    • DOI 10.1080/10717540600559510, PII X751QJ32H277U701
    • Killian DM, Hermeling S, Chikhale PJ. Targeting the cerebrovascular large neutral amino acid transporter (LAT1) isoform using a novel disulfide-based brain drug delivery system. Drug Deliv. 14, 25-31 (2007). (Pubitemid 44764456)
    • (2007) Drug Delivery , vol.14 , Issue.1 , pp. 25-31
    • Killian, D.M.1    Hermeling, S.2    Chikhale, P.J.3
  • 224
    • 0034737759 scopus 로고    scopus 로고
    • Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents
    • DOI 10.1016/S0006-8993(00)01962-4, PII S0006899300019624
    • Battaglia G, La Russa M, Bruno V et al. Systemically administered d-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents. Brain Res. 860, 149-156 (2000). (Pubitemid 30155848)
    • (2000) Brain Research , vol.860 , Issue.1-2 , pp. 149-156
    • Battaglia, G.1    La Russa, M.2    Bruno, V.3    Arenare, L.4    Ippolito, R.5    Copani, A.6    Bonina, F.7    Nicoletti, F.8
  • 227
    • 0035289188 scopus 로고    scopus 로고
    • Prodrug based optimal drug delivery via membrane transporter/receptor
    • Yang C, Tirucherai GS, Mitra AK. Prodrug based optimal drug delivery via membrane transporter/receptor. Expert Opin. Biol. Ther. 1, 159-175 (2001). (Pubitemid 33770074)
    • (2001) Expert Opinion on Biological Therapy , vol.1 , Issue.2 , pp. 159-175
    • Yang, C.1    Tirucherai, G.S.2    Mitra, A.K.3
  • 228
    • 77952329581 scopus 로고    scopus 로고
    • Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse
    • Boado RJ, Hui EK, Lu JZ, Pardridge WM. Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse. J. Pharmacol Exp. Ther. 333, 961-969
    • J. Pharmacol Exp. Ther. , vol.333 , pp. 961-969
    • Boado, R.J.1    Hui, E.K.2    Lu, J.Z.3    Pardridge, W.M.4
  • 229
    • 71049162181 scopus 로고    scopus 로고
    • Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey
    • Boado RJ, Pardridge WM. Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey. Drug Metab. Dispos. 37, 2299-2304 (2009).
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 2299-2304
    • Boado, R.J.1    Pardridge, W.M.2
  • 230
    • 77956291663 scopus 로고    scopus 로고
    • Preparation of Trojan horse liposomes (THLs) for gene transfer across the blood-brain barrier
    • DOI:10.1101/pdb.prot5407
    • Pardridge WM. Preparation of Trojan horse liposomes (THLs) for gene transfer across the blood-brain barrier. Cold Spring Harb. Protoc. DOI:10.1101/pdb.prot5407 (2010).
    • (2010) Cold Spring Harb. Protoc.
    • Pardridge, W.M.1
  • 231
    • 77949375780 scopus 로고    scopus 로고
    • Biopharmaceutical drug targeting to the brain
    • Pardridge WM. Biopharmaceutical drug targeting to the brain. J. Drug Target. 18, 157-167 (2010).
    • (2010) J. Drug Target. , vol.18 , pp. 157-167
    • Pardridge, W.M.1
  • 232
    • 60549115096 scopus 로고    scopus 로고
    • Codrugs linking l-dopa and sulfur-containing antioxidants: New pharmacological tools against Parkinson's disease
    • Pinnen F, Cacciatore I, Cornacchia C et al. Codrugs linking l-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease. J. Med. Chem. 52, 559-563 (2009).
    • (2009) J. Med. Chem. , vol.52 , pp. 559-563
    • Pinnen, F.1    Cacciatore, I.2    Cornacchia, C.3
  • 233
    • 77949369401 scopus 로고    scopus 로고
    • Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity
    • Sozio P, D'Aurizio E, Iannitelli A et al. Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity. Arch. Pharm. (Weinheim) 343, 133-142 (2010).
    • (2010) Arch. Pharm. (Weinheim) , vol.343 , pp. 133-142
    • Sozio, P.1    D'Aurizio, E.2    Iannitelli, A.3
  • 234
    • 77954242152 scopus 로고    scopus 로고
    • Activation of PKC isoform b(I) at the blood- brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain
    • Rigor RR, Hawkins BT, Miller DS. Activation of PKC isoform b(I) at the blood- brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain. J. Cereb. Blood Flow Metab. 30(7), 1373-83 (2010).
    • (2010) J. Cereb. Blood Flow Metab. , vol.30 , Issue.7 , pp. 1373-1383
    • Rigor, R.R.1    Hawkins, B.T.2    Miller, D.S.3
  • 235
    • 57649134261 scopus 로고    scopus 로고
    • Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
    • Hanson LR, Frey WH 2nd. Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease. BMC Neurosci. 9 (Suppl. 3), S5 (2008).
    • (2008) BMC Neurosci. , vol.9 , Issue.SUPPL. 3
    • Hanson, L.R.1    Frey II, W.H.2
  • 236
    • 16844374013 scopus 로고    scopus 로고
    • Intranasal drug delivery for brain targeting
    • DOI 10.2174/1567201053586047
    • Vyas TK, Shahiwala A, Marathe S, Misra A. Intranasal drug delivery for brain targeting. Curr. Drug Deliv. 2, 165-175 (2005). (Pubitemid 40488626)
    • (2005) Current Drug Delivery , vol.2 , Issue.2 , pp. 165-175
    • Vyas, T.K.1    Shahiwala, A.2    Marathe, S.3    Misra, A.4
  • 237
    • 0037802511 scopus 로고    scopus 로고
    • Bypassing the blood-brain barrier to delivery therapeutics agents to the brain and spinal cord
    • Frey WH 2nd. Bypassing the blood-brain barrier to delivery therapeutics agents to the brain and spinal cord. Drug Delivery Technology. 5, 46-49 (2002).
    • (2002) Drug Delivery Technology. , vol.5 , pp. 46-49
    • Frey II, W.H.1
  • 238
    • 1042269557 scopus 로고    scopus 로고
    • Is nose-to-brain transport of drugs in man a reality?
    • DOI 10.1211/0022357022539
    • Illum L. Is nose-to-brain transport of drugs in man a reality? J. Pharm. Pharmacol. 56, 3-17 (2004). (Pubitemid 38195323)
    • (2004) Journal of Pharmacy and Pharmacology , vol.56 , Issue.1 , pp. 3-17
    • Illum, L.1
  • 241
    • 0037125974 scopus 로고    scopus 로고
    • Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in antinerve growth factor mice
    • Capsoni S, Giannotta S, Cattaneo A. Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in antinerve growth factor mice. Proc. Natl Acad. Sci. USA 99, 12432-12437 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12432-12437
    • Capsoni, S.1    Giannotta, S.2    Cattaneo, A.3
  • 246
    • 1842584318 scopus 로고    scopus 로고
    • The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats
    • DOI 10.1016/j.jstrokecerebrovasdis.2004.01.005
    • Liu XF, Fawcett JR, Hanson LR, Frey WH 2nd. The window of opportunity for treatment of focal cerebral ischemic damage with noninvasive intranasal insulin-like growth factor-I in rats. J. Stroke Cerebrovasc. Dis. 13, 16-23 (2004). (Pubitemid 38419175)
    • (2004) Journal of Stroke and Cerebrovascular Diseases , vol.13 , Issue.1 , pp. 16-23
    • Liu, X.-F.1    Fawcett, J.R.2    Hanson, L.R.3    Frey, I.I.W.H.4
  • 248
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates b-amyloid in early AD
    • Reger MA, Watson GS, Green PS et al. Intranasal insulin improves cognition and modulates b-amyloid in early AD. Neurology 70, 440-448 (2008).
    • (2008) Neurology , vol.70 , pp. 440-448
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3
  • 250
    • 1942453805 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for parenteral drug delivery
    • DOI 10.1016/j.addr.2003.12.002, PII S0169409X04000456
    • Wissing SA, Kayser O, Muller RH. Solid lipid nanoparticles for parenteral drug delivery. Adv. Drug Deliv. Rev. 56, 1257-1272 (2004). (Pubitemid 38510473)
    • (2004) Advanced Drug Delivery Reviews , vol.56 , Issue.9 , pp. 1257-1272
    • Wissing, S.A.1    Kayser, O.2    Muller, R.H.3
  • 252
    • 2442528684 scopus 로고    scopus 로고
    • Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: A non-invasive treatment strategy for multiple sclerosis
    • DOI 10.1016/j.jneuroim.2004.02.011, PII S0165572804000773
    • Ross TM, Martinez PM, Renner JC, Thorne RG, Hanson LR, Frey WH 2nd. Intranasal administration of interferon-b bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a noninvasive treatment strategy for multiple sclerosis. J. Neuroimmunol. 151, 66-77 (2004). (Pubitemid 38624401)
    • (2004) Journal of Neuroimmunology , vol.151 , Issue.1-2 , pp. 66-77
    • Ross, T.M.1    Martinez, P.M.2    Renner, J.C.3    Thorne, R.G.4    Hanson, L.R.5    Frey, I.I.W.H.6
  • 253
    • 0028928571 scopus 로고
    • Analgesic activity of the hexapeptide dalargin absorbed on the surface of polysrbate 80-coated poly(butyl cyanoacrylate) nanoparticles
    • Alyautdin RN, Gothier D, Petrov V, Kharkevich D, Kreuter J. Analgesic activity of the hexapeptide dalargin absorbed on the surface of polysrbate 80-coated poly(butyl cyanoacrylate) nanoparticles. Eur. J.Pharm. Biopharm. 41, 44-48 (1995).
    • (1995) Eur. J.Pharm. Biopharm. , vol.41 , pp. 44-48
    • Alyautdin, R.N.1    Gothier, D.2    Petrov, V.3    Kharkevich, D.4    Kreuter, J.5
  • 254
    • 0028911362 scopus 로고
    • Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles)
    • Kreuter J, Alyautdin RN, Kharkevich DA, Ivanov AA. Passage of peptides through the blood-brain barrier with colloidal polymer particles (nanoparticles). Brain Res. 674, 171-174 (1995).
    • (1995) Brain Res. , vol.674 , pp. 171-174
    • Kreuter, J.1    Alyautdin, R.N.2    Kharkevich, D.A.3    Ivanov, A.A.4
  • 256
    • 3242740239 scopus 로고    scopus 로고
    • Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
    • DOI 10.1016/j.neuroscience.2004.05.029, PII S0306452204004002
    • Thorne RG, Pronk GJ, Padmanabhan V, Frey WH 2nd. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 127, 481-496 (2004). (Pubitemid 38950662)
    • (2004) Neuroscience , vol.127 , Issue.2 , pp. 481-496
    • Thorne, R.G.1    Pronk, G.J.2    Padmanabhan, V.3    Frey, I.I.W.H.4
  • 257
    • 23744459392 scopus 로고    scopus 로고
    • Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia
    • DOI 10.1016/j.neulet.2005.07.008, PII S0304394005007913
    • Yu YP, Xu QQ, Zhang Q, Zhang WP, Zhang LH, Wei EQ. Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia. Neurosci. Lett. 387, 5-10 (2005). (Pubitemid 41138199)
    • (2005) Neuroscience Letters , vol.387 , Issue.1 , pp. 5-10
    • Yu, Y.-P.1    Xu, Q.-Q.2    Zhang, Q.3    Zhang, W.-P.4    Zhang, L.-H.5    Wei, E.-Q.6
  • 258
    • 28244473037 scopus 로고    scopus 로고
    • Study on brain targeting of raltitrexed following intranasal administration in rats
    • DOI 10.1007/s00280-005-0018-3
    • Wang D, Gao Y, Yun L. Study on brain targeting of raltitrexed following intranasal administration in rats. Cancer Chemother. Pharmacol. 57, 97-104 (2006). (Pubitemid 41704922)
    • (2006) Cancer Chemotherapy and Pharmacology , vol.57 , Issue.1 , pp. 97-104
    • Wang, D.1    Gao, Y.2    Yun, L.3
  • 259
    • 29944434476 scopus 로고    scopus 로고
    • Carbamazepine uptake into rat brain following intra-olfactory transport
    • DOI 10.1211/jpp.58.1.0008
    • Barakat NS, Omar SA, Ahmed AA. Carbamazepine uptake into rat brain following intra-olfactory transport. J. Pharm. Pharmacol. 58, 63-72 (2006). (Pubitemid 43041997)
    • (2006) Journal of Pharmacy and Pharmacology , vol.58 , Issue.1 , pp. 63-72
    • Barakat, N.S.1    Omar, S.A.2    Ahmed, A.A.E.3
  • 260
    • 12344307628 scopus 로고    scopus 로고
    • Drug transport to brain with targeted nanoparticles
    • Olivier JC. Drug transport to brain with targeted nanoparticles. NeuroRx 2, 108-119 (2005).
    • (2005) NeuroRx , vol.2 , pp. 108-119
    • Olivier, J.C.1
  • 261
    • 0038382954 scopus 로고    scopus 로고
    • Antitumor properties of irinotecan-containing nanoparticles prepared using poly(DL-lactic acid) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)
    • DOI 10.1248/bpb.26.116
    • Onishi H, Machida Y, Machida Y. Antitumor properties of irinotecan-containing nanoparticles prepared using poly(d,l-lactic acid) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol). Biol. Pharm. Bull. 26, 116-119 (2003). (Pubitemid 39663658)
    • (2003) Biological and Pharmaceutical Bulletin , vol.26 , Issue.1 , pp. 116-119
    • Onishi, H.1    MacHida, Y.2    MacHida, Y.3
  • 262
    • 1542291181 scopus 로고    scopus 로고
    • Nanoparticles of biodegradable polymers for clinical administration of paclitaxel
    • DOI 10.2174/0929867043455909
    • Feng SS, Mu L, Win KY, Huang G. Nanoparticles of biodegradable polymers for clinical administration of paclitaxel. Curr. Med. Chem. 11, 413-424 (2004). (Pubitemid 38294346)
    • (2004) Current Medicinal Chemistry , vol.11 , Issue.4 , pp. 413-424
    • Feng, S.-S.1    Mu, L.2    Win, K.Y.3    Huang, G.4
  • 263
    • 0033997473 scopus 로고    scopus 로고
    • Nanoparticulate delivery system of a tyrphostin for the treatment of restenosis
    • DOI 10.1016/S0168-3659(99)00244-8, PII S0168365999002448
    • Fishbein I, Chorny M, Rabinovich L, Banai S, Gati I, Golomb G. Nanoparticulate delivery system of a tyrphostin for the treatment of restenosis. J. Control. Release. 65, 221-229 (2000). (Pubitemid 30122927)
    • (2000) Journal of Controlled Release , vol.65 , Issue.1-2 , pp. 221-229
    • Fishbein, I.1    Chorny, M.2    Rabinovich, L.3    Banai, S.4    Gati, I.5    Golomb, G.6
  • 264
    • 2942562255 scopus 로고    scopus 로고
    • Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells
    • DOI 10.1016/j.vaccine.2003.12.032, PII S0264410X0400249X, Modern Vaccine Adjuvants and Delivery Systems
    • Elamanchili P, Diwan M, Cao M, Samuel J. Characterization of poly(d,l-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells. Vaccine 22, 2406-2412 (2004). (Pubitemid 38757337)
    • (2004) Vaccine , vol.22 , Issue.19 , pp. 2406-2412
    • Elamanchili, P.1    Diwan, M.2    Cao, M.3    Samuel, J.4
  • 265
    • 34347403252 scopus 로고    scopus 로고
    • Drug development for CNS disorders: Strategies for balancing risk and reducing attrition
    • DOI 10.1038/nrd2094, PII NRD2094
    • Pangalos MN, Schechter LE, Hurko O. Drug development for CNS disorders: strategies for balancing risk and reducing attrition. Nat. Rev. Drug Discov. 6, 521-532 (2007). (Pubitemid 47019441)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.7 , pp. 521-532
    • Pangalos, M.N.1    Schechter, L.E.2    Hurko, O.3


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