A new multidrug resistance protein at the blood-brain barrier

Biochemical and Biophysical Research Communications

Volumn 293, Issue 4, 2002, Pages 1273-1278

  Eisenblätter, Tanja ^a   Galla, Hans Joachim ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

ABC transporter; Blood brain barrier; Brain multidrug resistance protein (BMDP); Breast cancer resistance protein (BCRP); Multidrug resistance (MDR)

Indexed keywords

ABC TRANSPORTER; BRAIN MULTIDRUG RESISTANCE PROTEIN; COMPLEMENTARY DNA; HYDROCORTISONE; MULTIDRUG RESISTANCE PROTEIN; RNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIUM; CELL MEMBRANE PERMEABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CULTURE MEDIUM; DNA LIBRARY; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SOLUTE; SWINE;

AMINO ACID SEQUENCE; ANIMALS; BLOOD-BRAIN BARRIER; BLOTTING, NORTHERN; BRAIN; CAPILLARIES; CLONING, MOLECULAR; CULTURE MEDIA, SERUM-FREE; DNA, COMPLEMENTARY; GENE LIBRARY; HUMANS; MICE; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; P-GLYCOPROTEINS; PHYLOGENY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; SWINE; TISSUE DISTRIBUTION;

SUIDAE;

EID: 0036086485     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00376-5     Document Type: Article

References (20)

1. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
2. Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells
3. P-Glycoprotein, a gatekeeper in the blood-brain barrier
4. Xenobiotic efflux pumps in isolated fish brain capillaries
5. A multidrug resistance transporter from human MCF-7 breast cancer cells
6. Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
7. A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
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9. BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells
10. Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line
11. Expression of breast cancer resistance protein in blast cells from patients with acute leukemia
12. Camptothecin resistance: Role of the ATP-binding cassette ABC, mitoxantrone-resistance half-transporter MXR, and potential for glucuronidation in MXR-expressing cells
13. Primary cultures of brain microvessel endothelial cells: A valid and flexible model to study drug transport through the blood-brain barrier in vitro
14. Hydrocortisone reinforces the blood-brain properties in a serum free cell culture system
15. Patterns of variant polyadenylation signal usage in human genes
16. Distantly related sequences in the α- and β-subunits of ATP synthase, myosin, kinases and other ATP requiring enzymes and a common nucleotide binding fold
17. The mouse Bcrp1/Mxr/Abcp gene: Amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin
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19. Circumvention of breast cancer resistance protein (BCRP)-mediated resistance to camptothecins in vitro using non-substrate drugs or the BCRP inhibitor GF120918
20. Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan