The Mechanism of Naked DNA Uptake and Expression

Advances in Genetics

Volumn 54, Issue , 2005, Pages 1-20

  Wolff, Jon A ^a   Budker, Vladimir ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; RECOMBINANT DNA;

ACTIVE TRANSPORT; ANIMAL; CYTOPLASM; GENE EXPRESSION; GENETICS; HUMAN; LIVER CELL; METABOLISM; MUSCLE CELL; PLASMID; REVIEW;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CYTOPLASM; DNA, RECOMBINANT; GENE EXPRESSION; HEPATOCYTES; HUMANS; MUSCLE CELLS; PLASMIDS; VACCINES, DNA;

EID: 33645937646     PISSN: 00652660     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2660(05)54001-X     Document Type: Review

References (49)

1. Acsadi G., Jiao S., et al. Direct gene transfer and expression into rat heart in vivo. New Biol. 3 1 (1991) 71-81
2. Andrianaivo F., Lecocq M., et al. Hydrodynamics-based transfection of the liver: Entrance into hepatocytes of DNA that causes expression takes place very early after injection. J. Gene Med. 6 (2004) 877-883
3. Browning J., Hogg N., et al. Capillary density in skeletal muscle of Wistar rats as a function of muscle weight and body weight. Microvas. Res. 52 3 (1996) 281-287
4. Budker V., Budker T., et al. Hypothesis: Naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process. Gene Ther. 2 (2000) 76-88
5. Budker V., Zhang G., et al. The efficient expression of intravascularly delivered DNA in rat muscle. Gene Ther. 5 2 (1998) 272-276
6. Buttrick P.M., Kass A., et al. Behavior of genes directly injected into the rat heart in vivo. Circ. Res. 70 1 (1992) 193-198
7. Condiotti R., Curran M., et al. Prolonged liver-specific transgene expression by a non-primate lentiviral vector. Biochem. Biophys. Res. Commun. 320 (2004) 998-1006
8. Danko I., J., Fritz D., et al. Pharmacological enhancement of in vivo foreign gene expression in muscle. Gene Ther. 1 (1994) 114-121
9. Danko I., Williams P., et al. High expression of naked plasmid DNA in muscles of young rodents. Hum. Mol. Genet. 6 9 (1997) 1435-1443
10. Davis H.L., Demeneix B.A., et al. Plasmid DNA is superior to viral vectors for direct gene transfer into adult mouse skeletal muscle. Hum. Gene Ther. 4 6 (1993) 733-740
11. Davis H.L., and Jasmin B.J. Direct gene transfer into mouse diaphragm. FEBS Lett. 333 1-2 (1993) 146-150
12. Eastman S.J., Baskin K.M., et al. Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA. Hum. Gene Ther. 13 17 (2002) 2065-2077
13. Escriou V., Carriere M., et al. Critical assessment of the nuclear import of plasmid during cationic lipid-mediated gene transfer. J. Gene Med. 3 (2001) 179-187
14. Fahrenkrog B., and Aebi U. The nuclear pore complex: Nucleocytoplasmic transport and beyond. Nature Rev. Mol. Cell Biol. 4 10 (2003) 757-766
15. Fishman D.M., and Patterson G.D. Light scattering studies of supercoiled and nicked DNA. Biopolymers 38 (1996) 535-552
16. Hagstrom J., Ludtke J., et al. Nuclear import of DNA in digitonin-permeabilized cells. J. Cell Sci. 110 Part 18 (1997) 2323-2331
17. Hagstrom J.E., et al. A facile non-viral method for delivering genes and siRNA to skeletal muscle of mammalian limbs. Mol. Ther. J. Am. Soc. Gene Ther. 10 (2004) 386-398
18. Herweijer H., Zhang G., et al. Time course of gene expression after plasmid DNA gene transfer to the liver. J. Gene Med. 3 3 (2001) 280-291
19. Hickman M.A., Malone R.W., et al. Hepatic gene expression after direct dna injection. Adv. Drug Deliv. Rev. 17 3 (1995) 265-271
20. Hofman C.R., Dileo J.P., et al. Efficient in vivo gene transfer by PCR amplified fragment with reduced inflammatory activity. Gene Ther. 8 (2001) 71-74
21. Jiang C., O'Conner S., et al. Efficiency of cationic lipid-mediated transfection of polarized and differentiated airway epithelial cells in vitro and in vivo. Hum. Gene Ther. 9 (1998) 1531-1542
22. Jiao S., Williams P., et al. Direct gene transfer into nonhuman primate myofibers in vivo. Hum. Gene Ther. 3 1 (1992) 21-33
23. Kobayahi N., Kuramoto T., et al. Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures. J. Pharm. Exp. Ther. 297 (2001) 853-860
24. Lechardeur D., and Lukacs G.L. Intracellular barriers to non-viral gene transfer. Curr.Gene Ther. 2 2 (2002) 183-194
25. Lecocq M., Andrianaivo F., et al. Uptake by mouse liver and intracellular fate of plasmid DNA after a rapid tail vein injection of a small or a large volume. J. Gene Med. 5 (2003) 142-156
26. Lee J., and Schmid-Schonbein G.W. Biomechanics of skeletal muscle capillaries: Hemodynamic resistance, endothelial distensibility, and pseudopod formation. Ann. Biomed. Eng. 23 3 (1995) 226-246
27. Lewis D.L., Hagstrom J.E., et al. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nature Genet. 32 1 (2002) 107-108
28. Liang K.W., Nishikawa M., et al. Restoration of dystrophin expression in mdx mice by intravascular injection of naked DNA containing full-length dystrophin cDNA. Gene Ther. 11 11 (2004) 901-908
29. Liu F., and Huang L. Noninvasive gene delivery to the liver by mechanical massage. Hepatology 35 6 (2002) 1314-1319
30. Liu F., Lei J., et al. Mechanism of liver gene transfer by mechanical massage. Mol. Ther. J. Am. Soc. Gene Ther. 9 3 (2004) 452-457
31. Liu F., Nishikawa M., et al. Transfer of full-length Dmd to the diaphragm muscle of Dmd(mdx/mdx) mice through systemic administration of plasmid DNA. Mol.Ther. J. Am. Soc. Gene Ther. 4 1 (2001) 45-51
32. Ludtke J.J., Sebestyen M.G., et al. The effect of cell division on the cellular dynamics of microinjected DNA and dextran.[erratum appears in Mol. Ther. 6(1),134 (2002)]. Mol. Ther. J. Am. Soc. Gene Ther. 5 5 Pt 1 (2002) 579-588
33. Manthorpe M., Cornefert-Jensen F., et al. Gene therapy by intramuscular injection of plasmid DNA: Studies on firefly luciferase gene expression in mice. Hum.Gene Ther. 4 4 (1993) 419-431
34. McCaffrey A.P., Meuse L., et al. RNA interference in adult mice. Nature 418 6893 (2002) 38-39
35. McCaffrey A.P., Meuse L., et al. A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice. Hepatology 38 2 (2003) 503-508
36. Meier O., Boucke K., et al. Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake. J. Cell Biol. 158 6 (2002) 1119-1131
37. Mumper R.J., Duguid J.G., et al. Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle. Pharm. Res. 13 5 (1996) 701-709
38. Rossmanith W., Chabicovsky M., et al. Cellular gene dose and kinetics of gene expression in mouse livers transfected by high-volume tail-vein injected of naked DNA. DNA Cell Biol. 21 (2002) 847-853
39. Rybenkov V.V., Vologodskii A.V., et al. The effect of ionic conditions on the conformations of supercoiled DNA.1. Sedimentation analysis. J. Mol. Biol. 267 (1997) 299-311
40. Salman H., Zbaida D., et al. Kinetics and mechanism of DNA uptake into the cell nucleus. Proc. Natl. Acad. Sci. USA 98 (2001) 7247-7252
41. Sebestyen M.G., Ludtke J.J., et al. DNA vector chemistry: The covalent attachment of signal peptides to plasmid DNA. Nature Biotechnol. 16 1 (1998) 80-85
42. Takeshita S., Tsurumi Y., et al. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Lab. Invest. 75 4 (1996) 487-501
43. Tsurumi Y., Takeshita S., et al. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion. Circulation 94 12 (1996) 3281-3290
44. Vitadello M., Schiaffino M.V., et al. Gene transfer in regenerating muscle. Hum. Gene Ther. 5 1 (1994) 11-18
45. Vlassov V., Deeva E., et al. Transport of oligonucleotides across natural and model membranes. Biochim. Biophys. Acta 1197 (1994) 95-108
46. Wells D.J., and Wells K.E. Gene transfer studies in animals: What do they really tell us about the prospects for gene therapy in DMD. Neuromusc. Disord. 12 (2002) S11-S22
47. Wolff J.A., Malone R.W., et al. Direct gene transfer into mouse muscle in vivo. Science 247 4949 Pt 1 (1990) 1465-1468
48. Wolff J.A., Williams P., et al. Conditions affecting direct gene transfer into rodent muscle in vivo. Biotechniques 11 4 (1991) 474-485
49. Zhang G., Budker V., et al. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum. Gene Ther. 10 10 (1999) 1735-1737