Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity

Archiv der Pharmazie

Volumn 343, Issue 3, 2010, Pages 133-142

  Sozio, Piera ^a   D'Aurizio, Eleonora ^a   Iannitelli, Antonio ^a   Cataldi, Amelia ^a   Zara, Susi ^a   Cantalamessa, Franco ^b   Nasuti, Cinzia ^b   Di Stefano, Antonio ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

(R) lipoic acid; Alzheimer's disease; Codrug; Neuroprotective agent

Indexed keywords

5 (1,2 DITHIOLAN 3 YL) N [2 ((2 (4 ISOBUTYLPHENYL)PROPANOYL)AMINO)ETHYL]PENTANAMIDE; 5 (1,2 DITHIOLAN 3 YL) N [4 ((2 (4 ISOBUTYLPHENYL)PROPANOYL)AMINO)BUTYL]PENTANAMIDE; 5 (1,2 DITHIOLAN 3 YL) N [6 ((2 (4 ISOBUTYLPHENYL)PROPANOYL)AMINO)HEXYL]PENTANAMIDE; ANTIOXIDANT; IBUPROFEN; NEUROPROTECTIVE AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; THIOCTIC ACID; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AQUEOUS SOLUTION; ARTICLE; BIOTRANSFORMATION; BRAIN CORTEX; BRAIN TISSUE; CLINICAL TRIAL; DRUG DELIVERY SYSTEM; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HYDROLYSIS; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; INFLAMMATION; NEUROPROTECTION; OXIDATIVE STRESS; PHYSICAL CHEMISTRY; PRIORITY JOURNAL;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BRAIN; CHEMISTRY, PHARMACEUTICAL; DIAMIDE; DISEASE MODELS, ANIMAL; DRUG COMBINATIONS; DRUG STABILITY; FREE RADICAL SCAVENGERS; IBUPROFEN; MALE; NEUROPROTECTIVE AGENTS; PRODRUGS; RATS; RATS, WISTAR; THIOCTIC ACID;

EID: 77949369401     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900152     Document Type: Article

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