In vivo blood-brain barrier transport of oxycodone in the rat: Indications for active influx and implications for pharmacokinetics/pharmacodynamics

Drug Metabolism and Disposition

Volumn 34, Issue 9, 2006, Pages 1624-1631

  Boström, Emma ^a   Simonsson, Ulrika S H ^a   Hammarlund Udenaes, Margareta ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

OXYCODONE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; CORPUS STRIATUM; DRUG TRANSPORT; IN VIVO STUDY; JUGULAR VEIN; LIQUID CHROMATOGRAPHY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; STEADY STATE; TANDEM MASS SPECTROMETRY;

ANALGESICS, OPIOID; ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; INFUSIONS, INTRAVENOUS; INJECTIONS, INTRAVENOUS; MALE; MICRODIALYSIS; MODELS, BIOLOGICAL; OXYCODONE; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 33747816123     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.009746     Document Type: Article

References (39)

1. Benveniste H, Drejer J, Schousboe A, and Diemer NH (1987) Regional cerebral glucose phosphorylation and blood flow after insertion of a microdialysis fiber through the dorsal hippocampus in the rat. J Neurochem 49:729-734.
2. Bickel U, Schumacher OP, Kang YS, and Voigt K (1996) Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat. J Pharmacol Exp Ther 278:107-113.
3. Boström E, Jansson B, Hammarlund-Udenaes M, and Simonsson US (2004) The use of liquid chromatography/mass spectrometry for quantitative analysis of oxycodone, oxymorphone and noroxycodone in Ringer solution, rat plasma and rat brain tissue. Rapid Commun Mass Spectrom 18:2565-2576.
4. Boström E, Simonsson US, and Hammarlund-Udenaes M (2005) Oxycodone pharmacokinetics and pharmacodynamics in the rat in the presence of the P-glycoprotein inhibitor PSC833. J Pharm Sci 94:1060-1066.
5. Bourasset F, Cisternino S, Temsamani J, and Scherrmann JM (2003) Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier. J Neurochem 86:1564-1567.
6. Dagenais C, Graff CL, and Pollack GM (2004) Variable modulation of opioid brain uptake by P-glycoprotein in mice. Biochem Pharmacol 67:269-276.
7. Dubey RK, McAllister CB, Inoue M, and Wilkinson GR (1989) Plasma binding and transport of diazepam across the blood-brain barrier. No evidence for in vivo enhanced dissociation. J Clin Investig 84:1155-1159.
8. Dumez H, Guetens G, De Boeck G, Highley MS, de Bruijn EA, van Oosterom AT, and Maes RA (2005) In vitro partition of irinotecan (CPT-11) in human volunteer blood: the influence of concentration, gender and smoking. Anticancer Drugs 16:893-895.
9. Goodman FR, Weiss GB, and Alderdice MT (1973) On the measurement of extracellular space in slices prepared from different rat brain areas. Neuropharmacology 12:867-873.
10. Groothuis DR, Ward S, Schlageter KE, Itskovich AC, Schwerin SC, Allen CV, Dills C, and Levy RM (1998) Changes in blood-brain barrier permeability associated with insertion of brain cannulas and microdialysis probes. Brain Res 803:218-230.
11. Gupta A, Chatelain P, Massingham R, Jonsson EN, and Hammarlund-Udenaes M (2006) Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu). Drug Metab Dispos 34:318-323.
12. Hammarlund-Udenaes M (2000) The use of microdialysis in CNS drug delivery studies. Pharmacokinetic perspectives and results with analgesics and antiepileptics. Adv Drug Deliv Rev 45:283-294.
13. Hammarlund-Udenaes M, Paalzow LK, and de Lange EC (1997) Drug equilibration across the blood-brain barrier - pharmacokinetic considerations based on the microdialysis method. Pharm Res (NY) 14:128-134.
14. Henthorn TK, Liu Y, Mahapatro M, and Ng KY (1999) Active transport of fentanyl by the blood-brain barrier. J Pharmacol Exp Ther 289:1084-1089.
15. Hoizey G, Kaltenbach ML, Dukic S, Lamiable D, Lallemand A, D'Arbigny P, Millart H, and Vistelle R (2000) Distribution of gacyclidine enantiomers in spinal cord extracellular fluid. Pharm Res (NY) 17:148-153.
16. Joel SP, Osborne RJ, and Slevin ML (1988) An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites. J Chromatogr 430:394-399.
17. Jonsson EN and Karlsson MO (1999) Xpose - an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Comput Methods Programs Biomed 58:51-64.
18. Kageyama T, Nakamura M, Matsuo A, Yamasaki Y, Takakura Y, Hashida M, Kanai Y, Naito M, Tsuruo T, Minato N, et al. (2000) The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res 879:115-121.
19. Kerb R (2006) Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 234:4-33.
20. Kerbusch T, Herben VM, Jeuken MJ, Ouwerkerk J, Keizer HJ, and Beijnen JH (2001) Distribution of ifosfamide and metabolites between plasma and erythrocytes. Biopharm Drug Dispos 22:99-108.
21. Leonard R and Ruben Z (1986) Hematology reference values for peripheral blood of laboratory rats. Lab Anim Sci 36:277-281.
22. Letrent SP, Pollack GM, Brouwer KR, and Brouwer KL (1998) Effect of GF120918, a potent P-glycoprotein inhibitor, on morphine pharmacokinetics and pharmacodynamics in the rat. Pharm Res (NY) 15:599-605.
23. Loscher W and Potschka H (2005) Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx 2:86-98.
24. Luer MS, Hamani C, Dujovny M, Gidal B, Cwik M, Deyo K, and Fischer JH (1999) Saturable transport of gabapentin at the blood-brain barrier. Neurol Res 21:559-562.
25. Monory K, Greiner E, Sartania N, Sallai L, Pouille Y, Schmidhammer H, Hanoune J, and Borsodi A (1999) Opioid binding profiles of new hydrazone, oxime, carbazone and semicarbazone derivatives of 14-alkoxymorphinans. Life Sci 64:2011-2020.
26. Peckham EM and Traynor JR (2006) Comparison of the antinociceptive response to morphine and morphine-like compounds in male and female Sprague-Dawley rats. J Pharmacol Exp Ther 316:1195-1201.
27. Sam E, Sarre S, Michotte Y, and Verbeke N (1997) Distribution of apomorphine enantiomers in plasma, brain tissue and striatal extracellular fluid. Eur J Pharmacol 329:9-15.
28. Shockley RP and LaManna JC (1988) Determination of rat cerebral cortical blood volume changes by capillary mean transit time analysis during hypoxia, hypercapnia and hyperventilation. Brain Res 454:170-178.
29. Silvasti M, Rosenberg P, Seppala T, Svartling N, and Pitkanen M (1998) Comparison of analgesic efficacy of oxycodone and morphine in postoperative intravenous patient-controlled analgesia. Acta Anaesthesiol Scand 42:576-580.
30. Suzuki T, Oshimi M, Tomono K, Hanano M, and Watanabe J (2002) Investigation of transport mechanism of pentazocine across the blood-brain barrier using the in situ rat brain perfusion technique. J Pharm Sci 91:2346-2353.
31. Szentistvanyi I, Patlak CS, Ellis RA, and Cserr HF (1984) Drainage of interstitial fluid from different regions of rat brain. Am J Physiol 246:F835-F844.
32. Thomas SA, Abbruscato TJ, Hruby VJ, and Davis TP (1997) The entry of [D-penicillamine2,5]enkephalin into the central nervous system: saturation kinetics and specificity. J Pharmacol Exp Ther 280:1235-1240.
33. Tozer TN (1981) Concepts basic to pharmacokinetics. Pharmacol Ther 12:109-131.
34. Tunblad K, Hammarlund-Udenaes M, and Jonsson EN (2004) An integrated model for the analysis of pharmacokinetic data from microdialysis experiments. Pharm Res (NY) 21:1698-1707.
35. Tunblad K, Hammarlund-Udenaes M, and Jonsson EN (2005) Influence of probenecid on the delivery of morphine-6-glucuronide to the brain. Eur J Pharm Sci 24:49-57.
36. Tunblad K, Jonsson EN, and Hammarlund-Udenaes M (2003) Morphine blood-brain barrier transport is influenced by probenecid co-administration. Pharm Res (NY) 20:618-623.
37. Wang JS, Ruan Y, Taylor RM, Donovan JL, Markowitz JS, and DeVane CL (2004) Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice. Psychopharmacology (Berl) 173:132-138.
38. Xie R, Bouw MR, and Hammarlund-Udenaes M (2000) Modelling of the blood-brain barrier transport of morphine-3- glucuronide studied using microdialysis in the rat: involvement of probenecid-sensitive transport. Br J Pharmacol 131:1784-1792.
39. Xie R and Hammarlund-Udenaes M (1998) Blood-brain barrier equilibration of codeine in rats studied with microdialysis. Pharm Res (NY) 15:570-575.