Microdialysis in the study of drug transporters in the CNS

Advanced Drug Delivery Reviews

Volumn 45, Issue 2-3, 2000, Pages 295-307

  Sawchuk, Ronald J ^a   Elmquist, William F ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Active transport; Blood brain barrier; Brain microdialysis; Drug efflux; P Glycoprotein

Indexed keywords

BLOOD; BODY FLUIDS; BRAIN; CONTROLLED DRUG DELIVERY; DRUG INFUSION; DRUG PRODUCTS; NEUROPHYSIOLOGY; PHARMACOKINETICS;

CENTRAL NERVOUS SYSTEM; DRUG TRANSPORTERS; MICRODIALYSIS;

DIALYSIS;

2',3' DIDEOXY 3' HYDROXYMETHYLCYTIDINE; 2',3' DIDEOXYCYTIDINE DERIVATIVE; ALPHA AMINO 5 (PHOSPHONOMETHYL)[1,1' BIPHENYL] 3 PROPANOIC ACID; BACLOFEN; CARRIER PROTEIN; CODEINE; COLCHICINE; CYCLOSPORIN A; DRUG CARRIER; ELACRIDAR; ETOPOSIDE; GLYCOPROTEIN P; ICM 567; MERCAPTOPURINE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; MRZ 2 570; MRZ 2 571; MRZ 2 576; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NALORPHINE; PROBENECID; RHODAMINE 123; STAVUDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VALSPODAR; ZALCITABINE; ZIDOVUDINE;

ACTIVE TRANSPORT; AREA UNDER THE CURVE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CENTRAL NERVOUS SYSTEM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TRANSPORT; HUMAN; MEMBRANE PERMEABILITY; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0034672607     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00104-6     Document Type: Article

References (28)

1. Kinetics of the multidrug transporter (P-glycoprotein) and its reversal
2. Drug equilibration across the blood-brain barrier-pharmacokinetic considerations based on the microdialysis method
3. Analysis of zidovudine distribution to specific regions in rabbit brain using microdialysis
4. Microdialysis calibration using retrodialysis and zero-net flux: Application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus
5. Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: Investigation of the inhibitory effect of probenecid utilizing microdialysis
6. Zidovudine transport in the rabbit brain during intravenous and intracerebroventricular infusion
7. Pharmacokinetics and distribution over the blood-brain barrier of zalcitabine (2',3'-dideoxycytidine) and BEA005 (2',3'-dideoxy-3'-hydroxymethylcytidine) in rats, studied by microdialysis
8. Zidovudine transport within the rabbit brain during intracerebroventricular administration and the effect of probenecid
9. Microdialysis studies of the distribution of stavudine into the central nervous system in the freely-moving rat
10. Morphine and morphine metabolite kinetics in the rat brain as assessed by transcortical microdialysis
11. The role of P-glycoprotein in blood-brain barrier transport of morphine: Transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice
12. Blood-brain barrier equilibration of codeine in rats studied with microdialysis
13. Effects of a potent and specific P-glycoprotein inhibitor on the blood-brain barrier distribution and antinociceptive effect of morphine in the rat
14. Effect of the P-glycoprotein inhibitor, cyclosporin A, on the distribution of rhodamine-123 to the brain: An in vivo microdialysis study in freely moving rats
15. BBB transport and P-glycoprotein functionality using mdr1a (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123
16. Modulation effects of cyclosporine on etoposide pharmacokinetics and CNS distribution in the rat utilizing microdialysis
17. Effect of the P-glycoprotein inhibitor, SDZ PSC 833, on the blood and brain pharmacokinetics of colchicine
18. Simultaneous microdialysis in brain and blood of the mouse: Extracellular and intracellular brain colchicine disposition
19. Assessment of valproic acid serum-cerebrospinal fluid transport by microdialysis
20. Study on brain interstitial fluid distribution and blood-brain barrier transport of baclofen in rats by microdialysis
21. Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: Possible involvement of the monocarboxylic acid transport system
22. The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: Microdialysis and maximum electroshock seizures studies
23. Brain distribution of 6-mercaptopurine is regulated by the efflux transport system in the blood-brain barrier
24. Investigation of the distribution of EAB 515 to cortical ECF and CSF in freely moving rats utilizing microdialysis
25. Aluminum transport out of brain extracellular fluid is proton dependent and inhibited by mersalyl acid, suggesting mediation by the monocarboxylate transporter (MCT1)
26. Microdialysis sampling to determine the pharmacokinetics of unbound SDZ ICM 567 in blood and brain in awake, freely-moving rats
27. The simultaneous estimation of the influx and efflux blood-brain barrier permeabilities of gabapentin using a microdialysis-pharmacokinetic approach
28. Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system