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Volumn 1, Issue 2, 2001, Pages 159-175

Prodrug based optimal drug delivery via membrane transporter/receptor

Author keywords

Active transport; Blood brain barrier; Carrier mediated transport; Drug targeting; Prodntg

Indexed keywords

AMINO ACID TRANSPORTER; BILE ACID BINDING PROTEINS; CARRIER PROTEIN; MONOCARBOXYLATE TRANSPORTER; MONOSACCHARIDE; PRODRUG;

EID: 0035289188     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.1.2.159     Document Type: Article
Times cited : (62)

References (98)
  • 1
    • 0009528657 scopus 로고
    • Transepithelial transport of proteins by intestinal epithelial cells
    • Audus KL, Raub TJ (Eds), Plenum Press, NY, USA
    • NEUTRA M, KRAEHENBUHL JP: Transepithelial transport of proteins by intestinal epithelial cells. In: Biological Barriers to Protein Delivery. Audus KL, Raub TJ (Eds), Plenum Press, NY, USA (1993).
    • (1993) Biological Barriers to Protein Delivery
    • Neutra, M.1    Kraehenbuhl, J.P.2
  • 2
    • 26844567547 scopus 로고
    • Rectal and vaginal absorption of peptides and proteins
    • Audus KL and Raub TJ (Eds), Plenum Press, NY, USA
    • MURANISHI S, YAMAMOTO A, OKADA H: Rectal and vaginal absorption of peptides and proteins. In: Biological Barriers to Protein Delivery. Audus KL and Raub TJ (Eds), Plenum Press, NY, USA (1993):199-227.
    • (1993) Biological Barriers to Protein Delivery , pp. 199-227
    • Muranishi, S.1    Yamamoto, A.2    Okada, H.3
  • 3
    • 0026564618 scopus 로고
    • Drug delivery via the mucous membrane of the oral cavity
    • HARRIS D, ROBINSON JR: Drug delivery via the mucous membrane of the oral cavity. J. Pbarm. Set. (1992) 81:1-10.
    • (1992) J. Pbarm. Set. , vol.81 , pp. 1-10
    • Harris, D.1    Robinson, J.R.2
  • 5
    • 0000719150 scopus 로고
    • Macromolecular transport across nasal and respiratory epithelia
    • Audus KL, Raub TJ (Eds.), Plenum Press, NY, USA
    • JOHNSON LG, BOUCHER RC: Macromolecular transport across nasal and respiratory epithelia. In: Biological Barriers to Protein Delivery. Audus KL, Raub TJ (Eds.), Plenum Press, NY, USA (1993):161-178.
    • (1993) Biological Barriers to Protein Delivery , pp. 161-178
    • Johnson, L.G.1    Boucher, R.C.2
  • 6
    • 0022852854 scopus 로고
    • Topical ocular drug deHvery: Recent developments and future challenges
    • LEE VHL, ROBINSON JR: Topical ocular drug deHvery: recent developments and future challenges. J. Ocul. Pbarmacol. (1980) 2:67-108.
    • (1980) J. Ocul. Pbarmacol. , vol.2 , pp. 67-108
    • Lee, V.H.L.1    Robinson, J.R.2
  • 8
    • 44949274560 scopus 로고
    • Mechanism of peptide and protein absorption. 2. Transcellular mechanism of peptide and protein absorption: Passive aspects
    • BURTON PS, CONRADI RA, HILGERS RA: Mechanism of peptide and protein absorption. 2. Transcellular mechanism of peptide and protein absorption: Passive aspects. Adv. Drug Deliv. Res. (1991) 7:365-386.
    • (1991) Adv. Drug Deliv. Res. , vol.7 , pp. 365-386
    • Burton, P.S.1    Conradi, R.A.2    Hilgers, R.A.3
  • 9
    • 0000006139 scopus 로고
    • Exploitation of the intestinal oligopeptide transporter to enhance drug absorption
    • SMITH PL, EDDY EP, LEE CP, AND WILSON G: Exploitation of the intestinal oligopeptide transporter to enhance drug absorption. Drug Deliv. (1993) 1:103-111.
    • (1993) Drug Deliv. , vol.1 , pp. 103-111
    • Smith, P.L.1    Eddy, E.P.2    Lee, C.P.3    Wilson, G.4
  • 10
    • 0027181852 scopus 로고
    • Functional expression of a P-grycoproteln in apical membranes of human intestinal Caco-2 cells: Kinetics of vinblastine secretion and interaction with modulators
    • HUNTER J, JEPSON MA, TSURUO T, SIMMONS ML, HIRST BH: Functional expression of a P-grycoproteln in apical membranes of human intestinal Caco-2 cells: Kinetics of vinblastine secretion and interaction with modulators.J. Btol. Chem. (1993) 268:14991-14997.
    • (1993) J. Btol. Chem. , vol.268 , pp. 14991-14997
    • Hunter, J.1    Jepson, M.A.2    Tsuruo, T.3    Simmons, M.L.4    Hirst, B.H.5
  • 12
    • 4243497468 scopus 로고
    • Transcytosis of macromolecules through the blood-brain fluid barrier in vivo
    • Audus KL, Raub TJ (Eds), Plenum Press, NY, USA
    • BROADWELL R D: Transcytosis of macromolecules through the blood-brain fluid barrier In vivo. In: Biological Barriers to Protein Delivery. Audus KL, Raub TJ (Eds), Plenum Press, NY, USA (1993):269-296.
    • (1993) In: Biological Barriers to Protein Delivery , pp. 269-296
    • Broadwell, R.D.1
  • 13
    • 0343825564 scopus 로고
    • Vascular endothelial barrier and its regulation
    • Audus KL, Raub TJ (Eds) Plenum Press, NY, USA
    • MAUK AB, BIRMBOIM AS: Vascular endothelial barrier and its regulation. In Biological Barriers to Protein Delivery. Audus KL, Raub TJ (Eds) Plenum Press, NY, USA (1993):231-267.
    • (1993) Biological Barriers to Protein Delivery , pp. 231-267
    • Mauk, A.B.1    Birmboim, A.S.2
  • 15
    • 0003693675 scopus 로고
    • Anderson JM, Kim SW (Eds.), Eisevier Amsterdam
    • Advances in Drtig Delivery Systems. Anderson JM, Kim SW (Eds.), Eisevier Amsterdam (1986).
    • (1986) Advances in Drtig Delivery Systems
  • 17
    • 0021800252 scopus 로고
    • Prodrugs: Do they have advantages in clinical practice?
    • STELLA VJ, CHARMAN WNA, NARINGREKAR VH: Prodrugs: do they have advantages in clinical practice? Drugs (1995) 29:455-473.
    • (1995) Drugs , vol.29 , pp. 455-473
    • Stella, V.J.1    Wna, C.2    Naringrekar, V.H.3
  • 18
    • 0032853619 scopus 로고    scopus 로고
    • Intestinal peptide transport systems and oral drug availability
    • YANG CY, DANTZIG All, PIDGEON: Intestinal peptide transport systems and oral drug availability. Pbarm. Res. (1999) 16:1331-1343.
    • (1999) Pbarm. Res. , vol.16 , pp. 1331-1343
    • Yang, C.Y.1    All, D.2
  • 19
    • 0029782485 scopus 로고
    • Carrier-mediated intestinal transport of drugs
    • TSUJI A, TAMAI I: Carrier-mediated intestinal transport of drugs. Pharm. Res. (1995) 13:963-977.
    • (1995) Pharm. Res. , vol.13 , pp. 963-977
    • Tsuji, A.1    Tamai, I.2
  • 20
    • 0028920129 scopus 로고
    • Human intestinal HVpeptlde cotransporter; cloning, functional expression and chromosomal localization
    • LIANG R, FEI YJ, PRASAD PD, RAMAMOORTHY S, HAN H, YANG-FENG L: Human intestinal HVpeptlde cotransporter; cloning, functional expression and chromosomal localization.J. Blol. Cbem. (1995) 270:6456-6463.
    • (1995) J. Blol. Cbem. , vol.270 , pp. 6456-6463
    • Liang, R.1    Fei, Y.J.2    Prasad, P.D.3    Ramamoorthy, S.4    Han, H.5    Yang-Feng, L.6
  • 21
    • 0000273754 scopus 로고
    • Intestinal transport of amino acids and peptides
    • LR. Johnson (Ed.), Raven Press, NY, USA
    • GANAPATHY V, DRANDSCH M, LEIBACH FH: Intestinal transport of amino acids and peptides. In: Physiology of the Gastrointestinal Tract. LR. Johnson (Ed.), Raven Press, NY, USA (1994):1773-1794.
    • (1994) Physiology of the Gastrointestinal Tract , pp. 1773-1794
    • Ganapathy, V.1    Drandsch, M.2    Leibach, F.H.3
  • 22
    • 0024505073 scopus 로고
    • Use of the peptide carrier system to improve the Intestinal absorption of L-alpha-methyldopa: Carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa
    • HU M, SUBRAMANIAN P, MOSBERG HI, AMIDON GL Use of the peptide carrier system to improve the Intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa. Pharm. Res. (1989) 6:66-70.
    • (1989) Pharm. Res. , vol.6 , pp. 66-70
    • Subramanian, P.1    Mosberg, H.I.2    Amidon, G.L.3
  • 23
    • 0025668535 scopus 로고
    • Mechanism of L-a-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2)
    • HUM, BORCHARDT RT: Mechanism of L-a-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). Pbarm. Res. (1990) 7:1313-1319.
    • (1990) Pbarm. Res. , vol.7 , pp. 1313-1319
    • Borchardt, R.T.1
  • 24
    • 0025359084 scopus 로고
    • Mechanism of absorption of the dipeptide cc-methyldopa-phe in the intestinal brush-border membrane vesicles
    • TSUJI A, TAMAI I, NAKANISHI M, AND AMIDON GL: Mechanism of absorption of the dipeptide cc-methyldopa-phe in the intestinal brush-border membrane vesicles. Pbarm. Res. (1990) 7:308-309.
    • (1990) Pbarm. Res. , vol.7 , pp. 308-309
    • Tsuji, A.1    Tamai, I.2    Nakanishi, M.3    Amidon, G.L.4
  • 25
    • 0026579888 scopus 로고
    • Utilization of peptide carrier system to improve intestinal absorption: Targeting prolidase as a prodrug-convertlng enzyme
    • BAI JP, HU M, SUBRAMANIAN P, MOSBERG HI, AND AMIDON GL: Utilization of peptide carrier system to improve intestinal absorption: targeting prolidase as a prodrug-convertlng enzyme. J. Pbarm. Sci. (1992) 81:113-116.
    • (1992) J. Pbarm. Sci. , vol.81 , pp. 113-116
    • Bai, J.P.1    Subramanian, P.2    Mosberg, H.I.3    Amidon, G.L.4
  • 27
    • 0028881527 scopus 로고
    • Carrier-mediated transport mechanism of foscarnet (trisodium phosphonoformate hexahydrate) in rat intestinal tissue
    • SWAAN PW, TUKKER JJ: Carrier-mediated transport mechanism of foscarnet (trisodium phosphonoformate hexahydrate) in rat intestinal tissue.J. Phannacol. Exp. Tber. (1995) 272:242-247.
    • (1995) J. Phannacol. Exp. Tber. , vol.272 , pp. 242-247
    • Swaan, P.W.1    Tukker, J.J.2
  • 28
    • 0024599205 scopus 로고
    • Acyclovh-. an updated review of its antiviral activity, Phamiacokinetic properties and therapeutic efficacy
    • O'BRIEN J, CAMPOLI-RICHARDS DM: Acyclovh-. An updated review of its antiviral activity, Phamiacokinetic properties and therapeutic efficacy. Drugs (1989) 37:233-309.
    • (1989) Drugs , vol.37 , pp. 233-309
    • O'Brien, J.1    Campoli-Richards, D.M.2
  • 30
    • 0032158915 scopus 로고    scopus 로고
    • Transport of L-valineacyclovir via the oligopeptide transporter in the human intestinal cell Une, Caco-2
    • DE VRUEH RL, SMITH PL, LEE CP: Transport of L-valineacyclovir via the oligopeptide transporter in the human intestinal cell Une, Caco-2. J. Pbannacol. Exp. mer. (1998) 286:1166-1170.
    • (1998) J. Pbannacol. Exp. Mer. , vol.286 , pp. 1166-1170
    • De Vrueh, R.L.1    Smith, P.L.2    Lee, C.P.3
  • 31
    • 0031662109 scopus 로고    scopus 로고
    • Amino acid ester of antiviral nucleosides, acyclovir and AZT are absorbed by the intestinal PEPT1 peptide transporter
    • HAN HK, DEVRUEH RLA, RHIE JK et al.: 5'-Amino acid ester of antiviral nucleosides, acyclovir and AZT are absorbed by the intestinal PEPT1 peptide transporter. Pbatm. Res. 1998 15:1154-1159.
    • (1998) Pbatm. Res. , vol.15 , pp. 1154-1159
    • Han, H.K.1    Rla, D.2    Rhie, J.K.3
  • 32
    • 0031981201 scopus 로고    scopus 로고
    • Carrier-mediated intestinal absorption of valacyclovir, the L-vatyl ester prodrug of acyclovir: 1. Interactions with peptides, organic onions and organic cations in rats
    • SINKO PJ, BAUMANE PV: Carrier-mediated intestinal absorption of valacyclovir, the L-vatyl ester prodrug of acyclovir: 1. Interactions with peptides, organic onions and organic cations in rats. Biopharm. Drug Dispos. (1998) 19:209-217.
    • (1998) Biopharm. Drug Dispos. , vol.19 , pp. 209-217
    • Sinko, P.J.1    Baumane, P.V.2
  • 33
    • 0032546467 scopus 로고    scopus 로고
    • Valacyclovir. a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2
    • GANAPATHY ME, HUANG W, WANG H, GANAPATHY V: Valacyclovir. a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Blochem. Biophys. Res. Commun. (1998) 246:470-475.
    • (1998) Blochem. Biophys. Res. Commun. , vol.246 , pp. 470-475
    • Ganapathy, M.E.1    Huang, W.2    Wang, H.3    Ganapathy, V.4
  • 34
    • 0033812228 scopus 로고    scopus 로고
    • Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT 1 and PETT2
    • SUGAWARA M, HUANG W, FEI YJ, LEIBACH FH, GANAPATHY V, AND GANAPATHY ME: Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT 1 and PETT2. J. Pbarm. Sci. (2000) 89:781-789.
    • (2000) J. Pbarm. Sci. , vol.89 , pp. 781-789
    • Sugawara, M.1    Huang, W.2    Fei, Y.J.3    Leibach, F.H.4    Ganapathy, V.5    Ganapathy, M.E.6
  • 35
    • 0027402753 scopus 로고
    • A saturable transport mechanism in the intestinal absorption of gabapentln is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma
    • STEWART BH, KUGLER AR, THOMPSON PR, BOCKBRADER N: A saturable transport mechanism in the intestinal absorption of gabapentln is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma. Phann. Res. (1993) 10:276-281.
    • (1993) Phann. Res. , vol.10 , pp. 276-281
    • Stewart, B.H.1    Kugler, A.R.2    Thompson, P.R.3    Bockbrader, N.4
  • 37
    • 0023567264 scopus 로고
    • Expression cloning and cDNA sequencing of the NaVgmcose cotransporter
    • HEDIGER MA, COADY MJ, IKEDA TS, WRIGHT EM: Expression cloning and cDNA sequencing of the NaVgmcose cotransporter. Nature (1987) 330:379-381.
    • (1987) Nature , vol.330 , pp. 379-381
    • Hediger, M.A.1    Coady, M.J.2    Ikeda, T.S.3    Wright, E.M.4
  • 38
    • 0027988020 scopus 로고
    • Characterization of the rabbit intestinal fructose transporter (GLUTS)
    • MIYAMOTO K, TATSUMI S, MORIMOTO A et al.: Characterization of the rabbit intestinal fructose transporter (GLUTS). Blocbem.J. (1994) 303:877-883
    • (1994) Blocbem.J. , vol.303 , pp. 877-883
    • Miyamoto, K.1    Tatsumi, S.2    Morimoto, A.3
  • 39
    • 0025329803 scopus 로고
    • Human facultative glucose transporters
    • KAYANO T, BURANT CF, FUKUMOTO H et al.: Human facultative glucose transporters. J. Blol. Chcm. (1990) 265:13276-13282.
    • (1990) J. Blol. Chcm. , vol.265 , pp. 13276-13282
    • Kayano, T.1    Burant, C.F.2    Fukumoto, H.3
  • 40
    • 0025061890 scopus 로고
    • Hypoglycémie effect of intestinally administered monosaccharide-modifted insulin derivatives in rats
    • HAGA M, SAITO K, SHIMAYA T, MAEZAWA Y, KATO Y, KIM SW: Hypoglycémie effect of intestinally administered monosaccharide-modifted insulin derivatives in rats. Chcm. Pbarm. Bull. (1990) 38:1983-1986.
    • (1990) Chcm. Pbarm. Bull. , vol.38 , pp. 1983-1986
    • Haga, M.1    Saito, K.2    Shimaya, T.3    Maezawa, Y.4    Kato, Y.5    Kim, S.W.6
  • 41
    • 0026594409 scopus 로고
    • Intestinal active absorption of sugar-conjugated compounds by glucose transport system: Implication of improvement of poorly absorbable drugs
    • MIZUMA T, OHTA K, HAYASHI M, AWAZU S: Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs. Biocbem. Pbarmacol. (1992) 43:2037-2039
    • (1992) Biocbem. Pbarmacol. , vol.43 , pp. 2037-2039
    • Mizuma, T.1    Ohta, K.2    Hayashi, M.3    Awazu, S.4
  • 42
    • 0027456264 scopus 로고
    • Comparative study of active absorption by the intestine and disposition of anomers of sugar-conjugated compounds
    • MIZUMA T, OHTA K, HAYASHI M, AWAZU S: Comparative study of active absorption by the intestine and disposition of anomers of sugar-conjugated compounds. Biocbem. Pbarmacol. (1993) 45:1520-1523.
    • (1993) Biocbem. Pbarmacol. , vol.45 , pp. 1520-1523
    • Mizuma, T.1    Ohta, K.2    Hayashi, M.3    Awazu, S.4
  • 43
    • 0028177268 scopus 로고
    • The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide : Conjugates
    • MIZUMA T, OHTA K, AWAZU S: The β-anomeric and glucose preferences of glucose transport carrier for intestinal active absorption of monosaccharide : conjugates. Biocbim. Btophys. Acta (1994) 1200:117-122.
    • (1994) Biocbim. Btophys. Acta , vol.1200 , pp. 117-122
    • Mizuma, T.1    Ohta, K.2    Awazu, S.3
  • 44
    • 0028019035 scopus 로고
    • +-Dependent transport of amlnopeptidease-resistant sugar-coupled tripeptides in rat intestine
    • +-Dependent transport of amlnopeptidease-resistant sugar-coupled tripeptides in rat intestine. Blocbcm. Blophys. Res. Commun. (1994) 203:1412-1416.
    • (1994) Blocbcm. Blophys. Res. Commun. , vol.203 , pp. 1412-1416
    • Mizuma, T.1    Sakai, N.2    Awazu, S.3
  • 45
    • 0032518981 scopus 로고    scopus 로고
    • Cloning and sequencing of four new mammalian moiiocarboxy late transporter (MCT) homologues confirms the existence of a transporter family with an ancient past
    • PRICE NT, JACKSON VN, HALESTRAP AP: Cloning and sequencing of four new mammalian moiiocarboxy late transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem. J. (1998) 329:321-328.
    • (1998) Biochem. J. , vol.329 , pp. 321-328
    • Price, N.T.1    Jackson, V.N.2    Halestrap, A.P.3
  • 46
    • 0031949384 scopus 로고    scopus 로고
    • Possible role of anion exchanger AE2 as the intestinal monocarboxylic acld/antiorter
    • YABUUCH1 H, TAMAI I, SAI Y, TSUJI A: Possible role of anion exchanger AE2 as the intestinal monocarboxylic acld/antiorter. Pharm. Res. (1998) 15:411-416.
    • (1998) Pharm. Res. , vol.15 , pp. 411-416
    • Yabuuch, H.1    Tamai, I.2    Sai, Y.3    Tsuji, A.4
  • 47
    • 0027527749 scopus 로고
    • Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits
    • TSUJI A, TAMAI I, NAKANISH1M, TERASAKIT, HAMANO S: Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits. J. Pharm. Pbannacol. (1993) 45:996-998.
    • (1993) J. Pharm. Pbannacol. , vol.45 , pp. 996-998
    • Tsuji, A.1    Tamai, I.2    Hamano, S.3
  • 48
    • 0032531789 scopus 로고    scopus 로고
    • Transport of phenethicillin into rat intestinal brush border membrane vesicles: Role of the monocarboxylic acid transport system
    • ITOH T, TANNO M, U YH, YAMADA H: Transport of phenethicillin into rat intestinal brush border membrane vesicles: role of the monocarboxylic acid transport system. Int.J. Pbann. (1998) 172:103-112.
    • (1998) Int.J. Pbann. , vol.172 , pp. 103-112
    • Itoh, T.1    Tanno, M.2    Yh, U.3    Yamada, H.4
  • 49
    • 0032745658 scopus 로고    scopus 로고
    • Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active β-Iactam prodrug: Carindacillin as a model
    • LI YH, TANNO M, ITOH T, YAMADA H: Role of the monocarboxylic acid transport system in the intestinal absorption of an orally active β-Iactam prodrug: carindacillin as a model. Int.J. Pbann. (1999) 191:151-159.
    • (1999) Int.J. Pbann. , vol.191 , pp. 151-159
    • Yh, L.I.1    Tanno, M.2    Itoh, T.3    Yamada, H.4
  • 50
    • 0019603573 scopus 로고
    • Intestinal transport of bUe acids
    • WILSON FA: Intestinal transport of bUe acids. Am. J. Physiol. (1981) 24l:G83-G92.
    • (1981) Am. J. Physiol. , vol.241
    • Wilson, F.A.1
  • 51
    • 0013909548 scopus 로고
    • Intestinal bUe salt transport: Structure-activity relationships and other properties
    • LACK L, WEINER IM: Intestinal bUe salt transport: structure-activity relationships and other properties. Am.J. Pbystol. (1966) 210:1142-1152.
    • (1966) Am.J. Pbystol. , vol.210 , pp. 1142-1152
    • Lack, L.1    Weiner, I.M.2
  • 52
    • 0029822826 scopus 로고    scopus 로고
    • BUe acid transport systems as pharmaceutical targets
    • KRAMER W, WESS G: BUe acid transport systems as pharmaceutical targets. Etirvp. J. Clin. Invest. (1996) 26:715-732.
    • (1996) Etirvp. J. Clin. Invest. , vol.26 , pp. 715-732
    • Kramer, W.1    Wess, G.2
  • 53
    • 0015177983 scopus 로고
    • The absorption, distribution and excretion of 3H-chlorambuciI hi rats bearing the Yoshidaascites sarcoma
    • HILL BT, RICHES PG: The absorption, distribution and excretion of 3H-chlorambuciI hi rats bearing the Yoshidaascites sarcoma. Br.J.Cancer(1971) 25:831-837.
    • (1971) Br.J.Cancer , vol.25 , pp. 831-837
    • Hill, B.T.1    Riches, P.G.2
  • 54
    • 0026655568 scopus 로고
    • Liver-specific drug targeting by coupling to bile acids
    • KRAMER W, WESS G, SCHUBERT G et al.: Liver-specific drug targeting by coupling to bile acids. J. Biol. Chem. (1992) 267:18598-18604.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18598-18604
    • Kramer, W.1    Wess, G.2    Schubert, G.3
  • 55
    • 0028102574 scopus 로고
    • Bile acid derived HMG-CoA reductase inhibitors
    • KRAMER W, WESS G, ENHSEN A et al: Bile acid derived HMG-CoA reductase inhibitors. Btocbtm. Biophys. Acta (1994) 1227:137-154.
    • (1994) Btocbtm. Biophys. Acta , vol.1227 , pp. 137-154
    • Kramer, W.1    Wess, G.2    Enhsen, A.3
  • 56
    • 0026502608 scopus 로고
    • Modified bile acids: Preparation of 7α,12α-dyhydroxy-3β- And 7α,12α-dihydrooxy-3α-(2-hydroxyethoxy)-5β-cholani c acid and their biological activity
    • WESS G, KRAMER W, BARTMANN W et al.: Modified bile acids: preparation of 7α,12α-dyhydroxy-3β- and 7α,12α-dihydrooxy-3α-(2-hydroxyethoxy)-5β-cholani c acid and their biological activity. Tetrahedron Lett. (1992) 33:195-198.
    • (1992) Tetrahedron Lett. , vol.33 , pp. 195-198
    • Wess, G.1    Kramer, W.2    Bartmann, W.3
  • 57
    • 0027404339 scopus 로고
    • Preparation of 3α and 3α-(w-aminoalkoxy)-7α, 12α-dihydroxy-5β-cholanoic acid esters: Versatile shuttles for drug targeting
    • WESS G, KRAMER W, ENHSEN A, GLOMBIK H, BARINGHAUS KH, BOCK K, KLEINE H, SCILMITT W: Preparation of 3α and 3α-(w-aminoalkoxy)-7α, 12α-dihydroxy-5β-cholanoic acid esters: versatile shuttles for drug targeting. Tetrahedron Lett. (1993) 34:817-818.
    • (1993) Tetrahedron Lett. , vol.34 , pp. 817-818
    • Wess, G.1    Kramer, W.2    Enhsen, A.3    Glombik, H.4    Baringhaus, K.H.5    Bock, K.6    Kleine, H.7    Scilmitt, W.8
  • 58
    • 0000714394 scopus 로고
    • Synthesis of bile acid-drug conjugates: Potential drug-shuttles for liver specific targeting
    • WESS G, KRAMER W, SCHUBERT G etal.: Synthesis of bile acid-drug conjugates: potential drug-shuttles for liver specific targeting. Tetrahedron Lett. (1993) 34:819-822.
    • (1993) Tetrahedron Lett. , vol.34 , pp. 819-822
    • Wess, G.1    Kramer, W.2    Schubert, G.3
  • 59
    • 0000116395 scopus 로고    scopus 로고
    • Oral delivery of an insulintransferrin conjugate in Streptozotocin-treated cf/1 mice
    • WANG J, SHEN D, SHEN WC: Oral delivery of an insulintransferrin conjugate in Streptozotocin-treated cf/1 mice. Pbarm. Res. (1997) 14:5469.
    • (1997) Pbarm. Res. , vol.14 , pp. 5469
    • Wang, J.1    Shen, D.2    Shen, W.C.3
  • 60
    • 0033136943 scopus 로고    scopus 로고
    • Nucleoside transporters: Molecular biology and implications for therapeutic development
    • BALDWIN SA, MACKEY JR, CASS CE, YOUNG JD: Nucleoside transporters: molecular biology and implications for therapeutic development. Mol. Med. Today (1999) 5:216-224.
    • (1999) Mol. Med. Today , vol.5 , pp. 216-224
    • Baldwin, S.A.1    Mackey, J.R.2    Cass, C.E.3    Young, J.D.4
  • 62
    • 0034010850 scopus 로고    scopus 로고
    • Kinetic and selectivity differences between rodent, rabbit and human organic cation transporters (OCT1)
    • DRESSER MJ, GRAY AT, GIACOMINI KM: Kinetic and selectivity differences between rodent, rabbit and human organic cation transporters (OCT1). J. Pharmacol. Exp. Ther. (2000) 292:1146-1152.
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , pp. 1146-1152
    • Dresser, M.J.1    Gray, A.T.2    Giacomini, K.M.3
  • 63
    • 0031800792 scopus 로고    scopus 로고
    • Role of organic cation transporters in drug absorption and elimination
    • ZHANG L, BRETT CM, GIACOMINI KM: Role of organic cation transporters in drug absorption and elimination. Ann. Rev. Pharmacol. Toxicol. (1998) 38:431-460.
    • (1998) Ann. Rev. Pharmacol. Toxicol. , vol.38 , pp. 431-460
    • Zhang, L.1    Brett, C.M.2    Giacomini, K.M.3
  • 64
    • 0033583827 scopus 로고    scopus 로고
    • Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human hing and small intestine
    • FEILD JA, ZHANG L, BRUN KA, BROOKS DP, EDWARDS RM: Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human hing and small intestine. Biochem. Biophys. Res. Comm. (1999) 258:578-582.
    • (1999) Biochem. Biophys. Res. Comm. , vol.258 , pp. 578-582
    • Feild, J.A.1    Zhang, L.2    Brun, K.A.3    Brooks, D.P.4    Edwards, R.M.5
  • 65
    • 0024499995 scopus 로고
    • + and pH dependent transport of foscarnet via the phosphate carrier system across intestinal brush-border membrane
    • + and pH dependent transport of foscarnet via the phosphate carrier system across intestinal brush-border membrane. Biochem. Pharmacol. (1989) 38:1019-1022.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1019-1022
    • Tsuji, A.1    Tamai, I.2
  • 66
    • 0026497776 scopus 로고
    • Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans
    • ISHIZAWA T, SADAHIRO S, HOSOI K, TAMAI I, TERASAKI T, TSUJI A: Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans. J. Pharmacobio. Dyn. (1992) 15:481-489.
    • (1992) J. Pharmacobio. Dyn. , vol.15 , pp. 481-489
    • Ishizawa, T.1    Sadahiro, S.2    Hosoi, K.3    Tamai, I.4    Terasaki, T.5    Tsuji, A.6
  • 67
    • 0026545612 scopus 로고
    • Potocytosis: Sequestration and transport of small molecules by caveolae
    • ANDERSON RG, KAMEN BA, ROTHBERG KG, LACEY SW: Potocytosis: sequestration and transport of small molecules by caveolae. Science (1992) 255:410-411.
    • (1992) Science , vol.255 , pp. 410-411
    • Anderson, R.G.1    Kamen, B.A.2    Rothberg, K.G.3    Lacey, S.W.4
  • 68
    • 0028301752 scopus 로고
    • Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
    • ROSS JF, CHAUDHURI PK, RATNAM M: Differential regulation of folate receptor isoforms in normal and malignant tissues In vivo and in established cell lines. Physiologic and clinical implications. Cancer (1994) 73:2432-2443.
    • (1994) Cancer , vol.73 , pp. 2432-2443
    • Ross, J.F.1    Chaudhuri, P.K.2    Ratnam, M.3
  • 69
    • 0029556349 scopus 로고
    • Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells
    • FAN J, KURESHY N, VTTOLS KS, HUENNEKENS FM: Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells. Oncol. Res. (1995)7:511-516.
    • (1995) Oncol. Res. , vol.7 , pp. 511-516
    • Fan, J.1    Kureshy, N.2    Vttols, K.S.3    Huennekens, F.M.4
  • 70
    • 0027280460 scopus 로고
    • Membrane folate-binding proteins are responsible for folate-protein conjugate endocytosis into cultured cells
    • LEAMON CP, LOW PS: Membrane folate-binding proteins are responsible for folate-protein conjugate endocytosis into cultured cells. Biocbem. J. (1993) 291:855-860.
    • (1993) Biocbem. J. , vol.291 , pp. 855-860
    • Leamon, C.P.1    Low, P.S.2
  • 71
    • 0028924955 scopus 로고
    • Delivery of antisense oligodeoxyribounucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folatc via polyethylene gh/coL
    • WANG S, LEE RJ, CAUCHON G, GORENSTEIN DG, LOW PS: Delivery of antisense oligodeoxyribounucleotides against the human epidermal growth factor receptor Into cultured KB cells with liposomes conjugated to folatc via polyethylene gh/coL Proc. Natl. Acad. Sci. USA (1995) 92:3318-3322.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3318-3322
    • Wang, S.1    Lee, R.J.2    Cauchon, G.3    Gorenstein, D.G.4    Low, P.S.5
  • 72
    • 0011727713 scopus 로고
    • Oral delivery of therapeutic proteins and peptides by the vitamin B12 uptake system
    • Taylor MD, Amidon GL (Eds.) : Washington DC: American Chemical Society
    • RUSSELL-JONES GJ: Oral delivery of therapeutic proteins and peptides by the vitamin B12 uptake system. In: Peptlde-Bascd Drug Design: Controlling Transport and Metabolism. Taylor MD, Amidon GL (Eds.) :181-198. Washington DC: American Chemical Society (1995).
    • (1995) In: Peptlde-Bascd Drug Design: Controlling Transport and Metabolism , pp. 181198
    • Russell-Jones, G.J.1
  • 73
    • 0029334731 scopus 로고
    • Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin
    • RUSSELL-JONES GJ, WESTWOOD SW, HABBERFIELD AD: Vitamin B12 mediated oral delivery systems for granulocyte-colony stimulating factor and erythropoietin. Bloconjug. Chcm. (1995) 6:459-465.
    • (1995) Bloconjug. Chcm. , vol.6 , pp. 459-465
    • Russell-Jones, G.J.1    Westwood, S.W.2    Habberfield, A.D.3
  • 76
    • 0029814971 scopus 로고    scopus 로고
    • The use of the vitamin Bi2 transport system as a carrier for the oral delivery of peptides, proteins and nanoparticles
    • RUSSELL-JONES GJ, WESTWOOD SW, HABBERFIELD AD: The use of the vitamin Bi2 transport system as a carrier for the oral delivery of peptides, proteins and nanoparticles. Proc. Int. Symp. Control Rel. Bloact. Mater. (1996) 23:49-50.
    • (1996) Proc. Int. Symp. Control Rel. Bloact. Mater. , vol.23 , pp. 49-50
    • Russell-Jones, G.J.1    Westwood, S.W.2    Habberfield, A.D.3
  • 77
    • 0030472471 scopus 로고    scopus 로고
    • Riboflavin-enhanced transport of serum albumin across the distal pulmonary epithelium
    • WANGENSTEEN OD, BARTLETT ALM, JAMES JK, YANG ZF, LOW PS: Riboflavin-enhanced transport of serum albumin across the distal pulmonary epithelium. Pbann. Res. (1996) 13:1861-1864.
    • (1996) Pbann. Res. , vol.13 , pp. 1861-1864
    • Wangensteen, O.D.1    Alm, B.2    James, J.K.3    Yang, Z.F.4    Low, P.S.5
  • 78
    • 0031777867 scopus 로고    scopus 로고
    • Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways
    • SWAAN PW: Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways. Pbann. Res. (1998) 15:826-834.
    • (1998) Pbann. Res. , vol.15 , pp. 826-834
    • Swaan, P.W.1
  • 79
    • 0030025971 scopus 로고    scopus 로고
    • Molecular regulation of transferrin receptor and ferritin expression in the rat gastrointestinal tract
    • JEFFREY GP, BASCLAIN KA, ALLEN TL: Molecular regulation of transferrin receptor and ferritin expression in the rat gastrointestinal tract. Gastroenterology (1996) 110:790-800.
    • (1996) Gastroenterology , vol.110 , pp. 790-800
    • Jeffrey, G.P.1    Basclain, K.A.2    Allen, T.L.3
  • 80
    • 0030457349 scopus 로고    scopus 로고
    • Transcellular delivery of an insulintransferrin conjugate hi enterocyte-like Caco-2 cells
    • SHAH D, SHEN WC: Transcellular delivery of an insulintransferrin conjugate hi enterocyte-like Caco-2 cells. J Pharm. Sci. (1996) 85:1306-1311.
    • (1996) J Pharm. Sci. , vol.85 , pp. 1306-1311
    • Shah, D.1    Shen, W.C.2
  • 81
    • 0000116395 scopus 로고    scopus 로고
    • Oral delivery of an insulintransferrin conjugate in Streptozotocin-treated cf/1 mice
    • WANG J, SHEN D, SHEN WC: Oral delivery of an insulintransferrin conjugate in Streptozotocin-treated cf/1 mice. Pbann. Res. (1997) 14:8469.
    • (1997) Pbann. Res. , vol.14 , pp. 8469
    • Wang, J.1    Shen, D.2    Shen, W.C.3
  • 82
    • 0030895630 scopus 로고    scopus 로고
    • Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid
    • HOKARI M, WU HQ, SCHWARCZ R, SMITH: Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid. Keumreport QR (1996) 8:15-18.
    • (1996) Keumreport QR , vol.8 , pp. 15-18
    • Hokari, M.1    Wu, H.Q.2    Schwarcz, R.3    Smith4
  • 83
    • 0032897670 scopus 로고    scopus 로고
    • Synthesis, stability and pharmacological evaluation of nipecotic acid prodrugs
    • BONINA FP, ARENARE L, PALAGIANO F et ah Synthesis, stability and pharmacological evaluation of nipecotic acid prodrugs. J Pbann. Sci. (1999) 88:561-567.
    • (1999) J Pbann. Sci. , vol.88 , pp. 561-567
    • Bonina, F.P.1    Arenare, L.2    Palagiano, F.3
  • 84
    • 0028299081 scopus 로고
    • Drug delivery via active transport at the blood-brain barrier: Affinity of a prodrug of phosphonoformate for the large amino acid transporter
    • WALKER I, NICHOLLS D, IRWIN WJ, FREEMAN S: Drug delivery via active transport at the blood-brain barrier: affinity of a prodrug of phosphonoformate for the large amino acid transporter. J. Pbann. Sci. (1994) 84:157-167.
    • (1994) J. Pbann. Sci. , vol.84 , pp. 157-167
    • Walker, I.1    Nicholls, D.2    Irwin, W.J.3    Freeman, S.4
  • 85
    • 0028233389 scopus 로고
    • Gtycopeptide enkephalln analogues produce analgesia in mice: Evidence for penetration of the blood-brain barrier
    • POLT R, PORRECA F, SZABO LZ et al.: Gtycopeptide enkephalln analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proc. Natl. Acad. Sci. USA (1994) 91:7114-7118.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7114-7118
    • Polt, R.1    Porreca, F.2    Szabo, L.Z.3
  • 86
    • 0034737759 scopus 로고    scopus 로고
    • Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents
    • BATTAGLIA G, RUSSA ML, BRUNO V et al; Systemically administered D-glucose conjugates of 7-chlorokynurenic acid are centrally available and exert anticonvulsant activity in rodents. Brain Res. (2000) 860:149-156.
    • (2000) Brain Res. , vol.860 , pp. 149-156
    • Battaglia, G.1    Russa, M.L.2    Bruno, V.3
  • 87
    • 0021992609 scopus 로고    scopus 로고
    • Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor
    • JEFFERIES WA, BRANDON MR, WILLIAMS AF, HUNT SV: Analysis of lymphopoietic stem cells with a monoclonal antibody to the rat transferrin receptor. Immunology W85) 54:333-341.
    • Immunology W , vol.85 , pp. 333-341
    • Jefferies, W.A.1    Brandon, M.R.2    Williams, A.F.3    Hunt, S.V.4
  • 88
    • 0025281428 scopus 로고
    • Identification of epitopes on the human Insulin receptor reacting -with rabbit polyclonal antisera and mouse monoclonal antibodies
    • PRIGENT SA, STANLEY KK, SIDDLE K: Identification of epitopes on the human Insulin receptor reacting -with rabbit polyclonal antisera and mouse monoclonal antibodies. J Blol. Chem. (1990) 265:9970-9977.
    • (1990) J Blol. Chem. , vol.265 , pp. 9970-9977
    • Prigent, S.A.1    Stanley, K.K.2    Siddle, K.3
  • 89
    • 0000283112 scopus 로고
    • Blood-brain barrier peptide transport and peptide drug delivery to the brain
    • Taylor MD, Amidon GL (Eds). American Chemical Society. Washington DC
    • PARDRIDGE WM: Blood-brain barrier peptide transport and peptide drug delivery to the brain. In: Peptide-Based Drug Design: Controlling Transport and Metabolism. Taylor MD, Amidon GL (Eds). American Chemical Society. Washington DC (1995):265-296.
    • (1995) Peptide-Based Drug Design: Controlling Transport and Metabolism , pp. 265-296
    • Pardridge, W.M.1
  • 91
    • 0030426639 scopus 로고    scopus 로고
    • CNS pharmacologie effect in conscious rats after intravenous injection of a biotinylatcd vasoactive intestinal peptide analogue coupled to a blood-brain barrier drug delivery system
    • WU D, PARDRIGE WM: CNS pharmacologie effect in conscious rats after intravenous injection of a biotinylatcd vasoactive intestinal peptide analogue coupled to a blood-brain barrier drug delivery system. J. Pharmacol. Exp. Tber. (1996) 279:77-83.
    • (1996) J. Pharmacol. Exp. Tber. , vol.279 , pp. 77-83
    • Wu, D.1    Pardrige, W.M.2
  • 92
    • 0028971069 scopus 로고
    • 125I-labeled beta-amyloid peptide a beta 1-40 through the blood-brain barrier and binding to Alzheimer's disease amyloid of the a beta 1-40/vector complex
    • 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer's disease amyloid of the A beta 1-40/vector complex. Proc. Natl. Acad. Set. USA (1995) 92:10227-10231.
    • (1995) Proc. Natl. Acad. Set. USA , vol.92 , pp. 10227-10231
    • Satto, Y.1    Buciak, J.2    Yang, J.3    Pardrige, W.M.4
  • 93
    • 0030930364 scopus 로고    scopus 로고
    • Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor
    • WU D, YANG J, PARDRIGE W M: Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor. J. Clin. Int-cst. (1997) 100:1804-1812.
    • (1997) J. Clin. Int-cst. , vol.100 , pp. 1804-1812
    • Wu, D.1    Yang, J.2    Pardrige, W.M.3
  • 94
    • 0031901771 scopus 로고    scopus 로고
    • Combined use of carboxyl-directed protein peglyation and vectormediated blood brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration
    • PARDRIGE WM, WU D, SAKANE T: Combined use of carboxyl-directed protein peglyation and vectormediated blood brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration, Pharm. Res. (1998) 15:576-582.
    • (1998) Pharm. Res. , vol.15 , pp. 576-582
    • Pardrige, W.M.1    Wu, D.2    Sakane, T.3
  • 95
    • 0030759006 scopus 로고    scopus 로고
    • Carboxyl-directed pegylalion of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biological activity
    • SAKANE T, PARDRIGE WM: Carboxyl-directed pegylalion of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biological activity. Pharm. Res. (1997) 14:1085-1091.
    • (1997) Pharm. Res. , vol.14 , pp. 1085-1091
    • Sakane, T.1    Pardrige, W.M.2
  • 96
    • 33745989416 scopus 로고
    • Rational design of peptides with enhanced membrane permeability
    • Yamazaki M (Ed) Blackwell, Oxford, UK
    • BORCHARDT RT: Rational design of peptides with enhanced membrane permeability. In Medicinal Chemistry: Today, Tomorrow1. Yamazaki M (Ed) Blackwell, Oxford, UK (1995):191-196.
    • (1995) Medicinal , pp. 191-196
    • Borchardt, R.T.1    Chemistry2    Today, T.3
  • 97
    • 85037292397 scopus 로고    scopus 로고
    • Nasal absorption of tyrosine linked model compounds
    • (In Press)
    • YANG C, MITRA AK: Nasal absorption of tyrosine linked model compounds. J Pharm. Set. (In Press).
    • J Pharm. Set.
    • Yang, C.1    Mitra, A.K.2
  • 98
    • 85037306783 scopus 로고    scopus 로고
    • Chemical stability, enzymatic hydrolysis and nasal uptake of amino acid ester prodnigs of acyclovlr
    • (In Press)
    • YANG C, MITRA AK: Chemical stability, enzymatic hydrolysis and nasal uptake of amino acid ester prodnigs of acyclovlr. J. Pharm. Set. (In Press).
    • J. Pharm. Set.
    • Yang, C.1    Mitra, A.K.2


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