TOPS-MODE approach for the prediction of blood-brain barrier permeation

Journal of Pharmaceutical Sciences

Volumn 93, Issue 7, 2004, Pages 1701-1717

  Cabrera, Miguel Angel ^a   Bermejo, Marival ^b   Pérez, Maykel ^a,c   Ramos, Ronal ^a  

^a CENTRAL UNIVERSITY OF LAS VILLAS   (Cuba)

^b UNIVERSITY OF VALENCIA   (Spain)

^c Experimental Sugar Cane Station   (Cuba)

Author keywords

Blood brain barrier permeation; in silico; logBB prediction; TOPS MODE

Indexed keywords

BBCPD 10; BBCPD 11; BBCPD 12; BBCPD 13; BBCPD 14; BBCPD 15; BBCPD 16; BBCPD 17; BBCPD 18; BBCPD 19; BBCPD 20; BBCPD 21; BBCPD 22; BBCPD 23; BBCPD 24; BBCPD 26; BBCPD 57; BBCPD 58; BBCPD 60; CIMETIDINE; CLONIDINE; ICI 17148; ICOTIDINE; IMIPRAMINE; LUPITIDINE; MEPYRAMINE; RANITIDINE; TIOTIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZOLANTIDINE;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER PERMEATION; DRUG DESIGN; DRUG PENETRATION; DRUG STRUCTURE; HYDROPHOBICITY; IN VIVO STUDY; LEAVE ONE OUT CROSSVALIDATION; LINEAR REGRESSION ANALYSIS; METHODOLOGY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; PARTITION COEFFICIENT; TOPOLOGICAL SUBSTRUCTURAL MOLECULAR DESIGN APPROACH; VALIDATION PROCESS; VARIANCE;

EID: 3042548988     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20081     Document Type: Article

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