Opening the floodgates: Clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle

Molecular Therapy

Volumn 10, Issue 2, 2004, Pages 207-208

  Wells, Dominic J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE KINASE; DYSTROPHIN; NAKED DNA; PLASMID DNA; SMALL INTERFERING RNA; VIRUS VECTOR;

BLOOD VOLUME; BODY SIZE; DUCHENNE MUSCULAR DYSTROPHY; ELECTROPORATION; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; GENETIC TRANSFECTION; HYDRODYNAMICS; MUSCLE CELL; MUSCLE INJURY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NOTE; SKELETAL MUSCLE;

ANIMALS; DNA; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; INJECTIONS, INTRAMUSCULAR; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; PLASMIDS;

VECTORS;

EID: 4344700281     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2004.07.010     Document Type: Note

References (8)

1. Wolff, J. A., et al. (1990). Direct gene transfer into mouse muscle in vivo. Science 247: 1465-1468.
2. Wolff, J. A., et al. (1992). Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1: 363-369.
3. Budker, V., et al. (1998). The efficient expression of intravascularly delivered DNA in rat muscle. Gene Ther. 5: 272-276.
4. Zhang, G., et al. (2001). Efficient expression of naked dna delivered intraarterially to limb muscles of nonhuman primates. Hum. Gene Ther. 12: 427-438.
5. Liu, F., Song, Y., and Liu, D. (1999). Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther. 6: 1258-1266
6. Zhang, G., Budker, V., and Wolff, J. A. (1999). High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther. 10: 1735-1737.
7. Liang, K. W., et al. (2004). Restoration of dystrophin expression in mdx mice by intravascular injection of naked DNA containing full-length dystrophin cDNA. Gene Ther. 11: 901-908.
8. Hagstrom, J. E. et al. (2004). A facile non-viral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs. Mol. Ther., this issue.