Potential prodrugs of non-steroidal anti-inflammatory agents for targeted drug delivery to the CNS

European Journal of Medicinal Chemistry

Volumn 39, Issue 8, 2004, Pages 715-727

  Perioli, Luana ^a   Ambrogi, Valeria ^a   Bernardini, Claudia ^a   Grandolini, Giuliano ^a   Ricci, Maurizio ^a   Giovagnoli, Stefano ^a   Rossi, Carlo ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Alzheimer's disease; Lipophilicity; NSAIDs; Predicting blood brain barrier permeation; Prodrugs

Indexed keywords

ANTIINFLAMMATORY AGENT; CARBOXYLIC ACID; DIHYDROPYRIDINE; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG;

ALZHEIMER DISEASE; ANALYTIC METHOD; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CALCULATION; CENTRAL NERVOUS SYSTEM; CHEMICAL STRUCTURE; CHROMATOGRAPHY; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DRUG ANALYSIS; DRUG DELIVERY SYSTEM; DRUG PENETRATION; HUMAN; LIPOPHILICITY; PARAMETER;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; PERMEABILITY; PRODRUGS;

EID: 3242754345     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.05.006     Document Type: Article

References (26)

1. Diaz Brinton R., Yamazaki R.S. Pharm. Res. 15:1998;386-398
2. Eikelenboom P., Rozemuller A.J.M., Hoozemans J.J.M., Veerhuis R., Van Gool W.A. Alz. Dis. Assoc. Dis. 14:2000;S54-S61
3. Blom M.A.A., van Twillert M.G.H., de Vries S.C., Engels F., Finch C.E., Veerhuis R., Eikelenboom P. Brain Res. 777:1997;210-218
4. Anderson K., Launer L.J., Ott A., Hoes A.W., Breteler M.M., Hofman A. Neurology. 45:1995;1441-1445
5. Stewart W.F., Kawas C., Corrada M., Metter E.J. Neurology. 48:1997;626-632
6. Flynn B.L., Theesen K.A. Ann. Pharmacother. 33:1999;840-849
7. Sugaya K., Uz T., Kumar V., Manev H. Jpn. J. Pharmacol. 82:2000;85-94
8. McGeer P.L., Schulzer M., McGeer E.G. Rogers J. Neuroinflammatory Mechanism in Alzheimer's Disease. 2001;53-64 Birkhaeuser Verlag, Switzerland, Basel
9. Breitner J.C.S. Annu. Rev. Med. 47:1996;401-411
10. Aisen P.S., Davis K.L. Am. J. Psychiatr. 151:1994;1105-1113
11. Aisen P.S. Drug Develop. Res. 56:2001;421-427
12. Hull M., Lieb K., Fiebich B.L. Expert Opin. Inv. Drug. 9:2000;671-683
13. Crivori P., Cruciani G., Carrupt P.A., Testa B. J. Med. Chem. 43:2000;2204-2216
14. Cruciani G., Crivori P., Carrupt P.A., Testa B., Mol J. Struc-Theochem. 503:2000;17-30
15. Pop E. Curr. Med. Chem. 4:1997;279-294
16. Bodor N. Roch E.B. Theory of Application of Bioreversible Carriers to Drug Design. 1985;95-120 Pergamon, New York
17. Pop E., Shek E., Murakami T., Bodor N.S. J. Pharm. Sci. 78:1989;609-616
18. Pop E., Whei-Mei W., Shek E., Bodor N. J. Med. Chem. 32:1989;1774-1781
19. Pop E., Whei-Mei W., Bodor N. J. Med. Chem. 32:1989;1789-1795
20. Pop E., Anderson W., Prókai-Tátrai K., Brewster M.E., Fregly M., Bodor N. J. Med. Chem. 33:1990;2216-2221
21. Phelan M.J., Bodor N. Pharm. Res. 6:1989;667-676
22. Ogowa T., Katayama K., Maeda H., Kita Y. Chem. Pharm. Bull. 42:1994;1579-1589
23. Boyce C.B.C., Milborrow B.V. Nature. 208:1995;537-539
24. Biagi G.L., Barbaro A.M., Gamba M.F., Guerra M.C. J. Chromatog. 41:1969;371-379
25. Meylan W.M., Howard P.H. J. Pharm. Sci. 84:1995;83-92
26. Wold H. Research Papers in Statistics: Ferstschrift for J. Neyman. 1966;Wiley, New York