Holy grails and in vitro blood-brain barrier models

Drug Discovery Today

Volumn 9, Issue 6, 2004, Pages 258-

  Pardridge, William M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Blood brain barrier; CNS; Drug Discovery; Endothelial cells; HTS; Neurobiology; Neuropharmaceutical; Pharmaceutical Science; Techniques Methods

Indexed keywords

LAT PROTEIN; LEVODOPA; TUMOR ANTIGEN;

ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; COCULTURE; DRUG DELIVERY SYSTEM; DRUG INDUSTRY; DRUG PENETRATION; GENE EXPRESSION; GENOMICS; NONHUMAN; ONCOGENE; SHORT SURVEY; TRANSGENIC ANIMAL; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

EID: 12144291079     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)03003-4     Document Type: Note

References (5)

1. Terasaki T., et al. New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov. Today. 8:2003;944-954.
2. Pardridge W.M., et al. Comparison of in vitro and in vivo models of drug transcytosis through the blood-brain barrier. J. Pharmacol. Exp. Ther. 253:1990;884-891.
3. Boado R.J., et al. Hypoxia induces de-stabilization of the LAT1 large neutral amino acid transporter mRNA in brain capillary endothelial cells. J. Neurochem. 85:2003;1037-1042.
4. Rauh J., et al. Development of an in vitro cell culture system to mimic the blood-brain barrier. Prog. Brain Res. 91:1992;117-121.
5. Yanai N., et al. Hepatocyte cell lines established from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene. Exp. Cell Res. 197:1991;50-56.