-
1
-
-
33748452503
-
Molecular Trojan horses for blood-brain barrier drug delivery
-
Pardridge W.M. Molecular Trojan horses for blood-brain barrier drug delivery. Curr. Opin. Pharmacol. 6 (2006) 494-500
-
(2006)
Curr. Opin. Pharmacol.
, vol.6
, pp. 494-500
-
-
Pardridge, W.M.1
-
2
-
-
33845784758
-
Blood-brain barrier delivery
-
Pardridge W.M. Blood-brain barrier delivery. Drug Discov. Today 12 (2007) 54-61
-
(2007)
Drug Discov. Today
, vol.12
, pp. 54-61
-
-
Pardridge, W.M.1
-
3
-
-
34547645047
-
Modelling of the blood-brain barrier in drug discovery and development
-
Cecchelli R., et al. Modelling of the blood-brain barrier in drug discovery and development. Nat. Rev. Drug Discov. 6 (2007) 650-661
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 650-661
-
-
Cecchelli, R.1
-
4
-
-
33644900716
-
The role of blood-brain barrier studies in the pharmaceutical industry
-
Reichel A. The role of blood-brain barrier studies in the pharmaceutical industry. Curr. Drug Metab. 7 (2006) 183-203
-
(2006)
Curr. Drug Metab.
, vol.7
, pp. 183-203
-
-
Reichel, A.1
-
5
-
-
0141958109
-
In silico prediction of blood-brain barrier permeation
-
Clark D.E. In silico prediction of blood-brain barrier permeation. Drug Discov. Today 8 (2003) 927-933
-
(2003)
Drug Discov. Today
, vol.8
, pp. 927-933
-
-
Clark, D.E.1
-
6
-
-
34347387938
-
Strategies to improve drug delivery across the blood-brain barrier
-
de Boer A.G., and Gaillard P.J. Strategies to improve drug delivery across the blood-brain barrier. Clin. Pharmacokinet. 46 (2007) 553-576
-
(2007)
Clin. Pharmacokinet.
, vol.46
, pp. 553-576
-
-
de Boer, A.G.1
Gaillard, P.J.2
-
7
-
-
6944255523
-
Delivery of therapeutic agents to the central nervous system: the problems and the possibilities
-
Begley D.J. Delivery of therapeutic agents to the central nervous system: the problems and the possibilities. Pharmacol. Ther. 104 (2004) 29-45
-
(2004)
Pharmacol. Ther.
, vol.104
, pp. 29-45
-
-
Begley, D.J.1
-
8
-
-
55749084890
-
The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles?
-
Juillerat-Jeanneret L. The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles?. Drug Discov. Today 13 (2008) 1099-1106
-
(2008)
Drug Discov. Today
, vol.13
, pp. 1099-1106
-
-
Juillerat-Jeanneret, L.1
-
9
-
-
0037204545
-
Computational approaches to the prediction of the blood-brain distribution
-
Norinder U., and Haeberlein M. Computational approaches to the prediction of the blood-brain distribution. Adv. Drug Deliv. Rev. 54 (2002) 291-313
-
(2002)
Adv. Drug Deliv. Rev.
, vol.54
, pp. 291-313
-
-
Norinder, U.1
Haeberlein, M.2
-
10
-
-
45949107902
-
On the rate and extent of drug delivery to the brain
-
Hammarlund-Udenaes M., et al. On the rate and extent of drug delivery to the brain. Pharm. Res. 25 (2008) 1737-1750
-
(2008)
Pharm. Res.
, vol.25
, pp. 1737-1750
-
-
Hammarlund-Udenaes, M.1
-
11
-
-
0035106611
-
Lipophilicity in PK design: methyl, ethyl, futile
-
van de Waterbeemd H., et al. Lipophilicity in PK design: methyl, ethyl, futile. J. Comput. Aid. Mol. Des. 15 (2001) 273-286
-
(2001)
J. Comput. Aid. Mol. Des.
, vol.15
, pp. 273-286
-
-
van de Waterbeemd, H.1
-
12
-
-
34648813134
-
High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery
-
Wan H., et al. High-throughput screening of drug-brain tissue binding and in silico prediction for assessment of central nervous system drug delivery. J. Med. Chem. 50 (2007) 4606-4615
-
(2007)
J. Med. Chem.
, vol.50
, pp. 4606-4615
-
-
Wan, H.1
-
13
-
-
1042266257
-
Prediction of blood-brain barrier penetration: are we missing the point?
-
Martin I. Prediction of blood-brain barrier penetration: are we missing the point?. Drug Discov. Today 9 (2004) 161-162
-
(2004)
Drug Discov. Today
, vol.9
, pp. 161-162
-
-
Martin, I.1
-
14
-
-
1842635478
-
Log(BB), PS products and in silico models of drug brain penetration
-
Pardridge W.M. Log(BB), PS products and in silico models of drug brain penetration. Drug Discov. Today 9 (2004) 392-393
-
(2004)
Drug Discov. Today
, vol.9
, pp. 392-393
-
-
Pardridge, W.M.1
-
15
-
-
35748977617
-
Challenges for blood-brain barrier (BBB) screening
-
Jeffrey P., and Summerfield S.G. Challenges for blood-brain barrier (BBB) screening. Xenobiotica 37 (2007) 1135-1151
-
(2007)
Xenobiotica
, vol.37
, pp. 1135-1151
-
-
Jeffrey, P.1
Summerfield, S.G.2
-
16
-
-
0019124032
-
Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability
-
Levin V.A. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23 (1980) 682-684
-
(1980)
J. Med. Chem.
, vol.23
, pp. 682-684
-
-
Levin, V.A.1
-
17
-
-
0023902147
-
2 receptor histamine antagonists
-
2 receptor histamine antagonists. J. Med. Chem. 31 (1988) 656-671
-
(1988)
J. Med. Chem.
, vol.31
, pp. 656-671
-
-
Young, R.C.1
-
18
-
-
0028108085
-
Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain
-
Abraham M.H., et al. Hydrogen bonding. 33. Factors that influence the distribution of solutes between blood and brain. J. Pharm. Sci. 83 (1994) 1257-1268
-
(1994)
J. Pharm. Sci.
, vol.83
, pp. 1257-1268
-
-
Abraham, M.H.1
-
19
-
-
0037107985
-
Application of hydrogen bonding calculations in property based drug design
-
Abraham M.H., et al. Application of hydrogen bonding calculations in property based drug design. Drug Discov. Today 7 (2002) 1056-1063
-
(2002)
Drug Discov. Today
, vol.7
, pp. 1056-1063
-
-
Abraham, M.H.1
-
20
-
-
0033088690
-
Prediction of the brain-blood distribution of a large set of drugs from structurally derived descriptors using partial least-squares (PLS) modeling
-
Luco J.M. Prediction of the brain-blood distribution of a large set of drugs from structurally derived descriptors using partial least-squares (PLS) modeling. J. Chem. Inf. Comput. Sci. 39 (1999) 396-404
-
(1999)
J. Chem. Inf. Comput. Sci.
, vol.39
, pp. 396-404
-
-
Luco, J.M.1
-
21
-
-
49849094738
-
Physiochemical drug properties associated with in vivo toxicological outcomes
-
Hughes J.D., et al. Physiochemical drug properties associated with in vivo toxicological outcomes. Bioorg. Med. Chem. Lett. 18 (2008) 4872-4875
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4872-4875
-
-
Hughes, J.D.1
-
22
-
-
0032811868
-
Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration
-
Clark D.E. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood-brain barrier penetration. J. Pharm. Sci. 88 (1999) 815-821
-
(1999)
J. Pharm. Sci.
, vol.88
, pp. 815-821
-
-
Clark, D.E.1
-
23
-
-
0034320657
-
Prediction of polar surface area and drug transport processes using simple parameters and PLS statistics
-
Osterberg T., and Norinder U. Prediction of polar surface area and drug transport processes using simple parameters and PLS statistics. J. Chem. Inf. Comput. Sci. 40 (2000) 1408-1411
-
(2000)
J. Chem. Inf. Comput. Sci.
, vol.40
, pp. 1408-1411
-
-
Osterberg, T.1
Norinder, U.2
-
24
-
-
1642384018
-
The factors that influence permeation across the blood-brain barrier
-
Abraham M.H. The factors that influence permeation across the blood-brain barrier. Eur. J. Med. Chem. 39 (2004) 235-240
-
(2004)
Eur. J. Med. Chem.
, vol.39
, pp. 235-240
-
-
Abraham, M.H.1
-
25
-
-
1642579680
-
Development of a computational approach to predict blood-brain barrier permeability
-
Liu X., et al. Development of a computational approach to predict blood-brain barrier permeability. Drug Metab. Dispos. 32 (2004) 132-139
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 132-139
-
-
Liu, X.1
-
26
-
-
48049103004
-
In silico prediction of brain and CSF permeation of small molecules using PLS regression models
-
Bendels S., et al. In silico prediction of brain and CSF permeation of small molecules using PLS regression models. Eur. J. Med. Chem. 43 (2008) 1581-1592
-
(2008)
Eur. J. Med. Chem.
, vol.43
, pp. 1581-1592
-
-
Bendels, S.1
-
27
-
-
33644756715
-
Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain
-
Summerfield S.G., et al. Improving the in vitro prediction of in vivo central nervous system penetration: integrating permeability, P-glycoprotein efflux, and free fractions in blood and brain. J. Pharmacol. Exp. Ther. 316 (2006) 1282-1290
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 1282-1290
-
-
Summerfield, S.G.1
-
28
-
-
27144435943
-
In silico predictions of blood-brain barrier penetration: considerations to "keep in mind"
-
Goodwin J.T., and Clark D.E. In silico predictions of blood-brain barrier penetration: considerations to "keep in mind". J. Pharmacol. Exp. Ther. 315 (2005) 477-483
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 477-483
-
-
Goodwin, J.T.1
Clark, D.E.2
-
29
-
-
2942538155
-
Modelling blood-brain barrier partitioning using Bayesian neural nets
-
Winkler D.A., and Burden F.R. Modelling blood-brain barrier partitioning using Bayesian neural nets. J. Mol. Graph Model. 22 (2004) 499-505
-
(2004)
J. Mol. Graph Model.
, vol.22
, pp. 499-505
-
-
Winkler, D.A.1
Burden, F.R.2
-
30
-
-
12844286268
-
Correlation ranking procedure for factor selection in PC-ANN modeling and application to ADMETox evaluation
-
Hemmateenejad B. Correlation ranking procedure for factor selection in PC-ANN modeling and application to ADMETox evaluation. Chemom. Intel Lab. Syst. 75 (2004) 231-245
-
(2004)
Chemom. Intel Lab. Syst.
, vol.75
, pp. 231-245
-
-
Hemmateenejad, B.1
-
31
-
-
33745924994
-
Accurate prediction of the blood-brain partitioning of a large set of solutes using ab initio calculations and genetic neural network modeling
-
Hemmateenejad B., et al. Accurate prediction of the blood-brain partitioning of a large set of solutes using ab initio calculations and genetic neural network modeling. J. Comput. Chem. 27 11 (2006) 1125-1135
-
(2006)
J. Comput. Chem.
, vol.27
, Issue.11
, pp. 1125-1135
-
-
Hemmateenejad, B.1
-
32
-
-
14044250851
-
New 4-aryl-1,4-dihydropyridines and 4-arylpyridines as P-glycoprotein inhibitors
-
Zhou X.F., et al. New 4-aryl-1,4-dihydropyridines and 4-arylpyridines as P-glycoprotein inhibitors. Drug Metab. Dispos. 33 (2005) 321-328
-
(2005)
Drug Metab. Dispos.
, vol.33
, pp. 321-328
-
-
Zhou, X.F.1
-
33
-
-
2642543421
-
A new nonlinear equation for the tissue/blood partition coefficients of neutral compounds
-
Zhang H. A new nonlinear equation for the tissue/blood partition coefficients of neutral compounds. J. Pharm. Sci. 93 (2004) 1595-1604
-
(2004)
J. Pharm. Sci.
, vol.93
, pp. 1595-1604
-
-
Zhang, H.1
-
34
-
-
31444431893
-
A recursive-partitioning model for blood-brain barrier permeation
-
Mente S.R., and Lombardo F. A recursive-partitioning model for blood-brain barrier permeation. J. Comput. Aid. Mol. Des. 19 (2005) 465-481
-
(2005)
J. Comput. Aid. Mol. Des.
, vol.19
, pp. 465-481
-
-
Mente, S.R.1
Lombardo, F.2
-
35
-
-
1542503699
-
Computational models to predict blood-brain barrier permeation and CNS activity
-
Subramanian G., and Kitchen D.B. Computational models to predict blood-brain barrier permeation and CNS activity. J. Comput. Aid. Mol. Des. 17 (2003) 643-664
-
(2003)
J. Comput. Aid. Mol. Des.
, vol.17
, pp. 643-664
-
-
Subramanian, G.1
Kitchen, D.B.2
-
36
-
-
46749128531
-
New predictive models for blood-brain barrier permeability of drug-like molecules
-
Kortagere S., et al. New predictive models for blood-brain barrier permeability of drug-like molecules. Pharm. Res. 25 (2008) 1836-1845
-
(2008)
Pharm. Res.
, vol.25
, pp. 1836-1845
-
-
Kortagere, S.1
-
37
-
-
0023632674
-
Redox drug delivery systems for targeting drugs to the brain
-
Bodor N. Redox drug delivery systems for targeting drugs to the brain. Ann. N. Y. Acad. Sci. 507 (1987) 289-306
-
(1987)
Ann. N. Y. Acad. Sci.
, vol.507
, pp. 289-306
-
-
Bodor, N.1
-
38
-
-
3242754345
-
Potential prodrugs of non-steroidal anti-inflammatory agents for targeted drug delivery to the CNS
-
Perioli L., et al. Potential prodrugs of non-steroidal anti-inflammatory agents for targeted drug delivery to the CNS. Eur. J. Med. Chem. 39 (2004) 715-727
-
(2004)
Eur. J. Med. Chem.
, vol.39
, pp. 715-727
-
-
Perioli, L.1
-
39
-
-
0034213636
-
Predicting blood-brain barrier permeation from three-dimensional molecular structure
-
Crivori P., et al. Predicting blood-brain barrier permeation from three-dimensional molecular structure. J. Med. Chem. 43 (2000) 2204-2216
-
(2000)
J. Med. Chem.
, vol.43
, pp. 2204-2216
-
-
Crivori, P.1
-
40
-
-
34249895912
-
Novel l-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety
-
Denora N., et al. Novel l-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety. Pharm. Res. 24 (2007) 1309-1324
-
(2007)
Pharm. Res.
, vol.24
, pp. 1309-1324
-
-
Denora, N.1
-
41
-
-
29444447808
-
Evolutionary combinatorial chemistry, a novel tool for SAR studies on peptide transport across the blood-brain barrier. Part 2. Design, synthesis and evaluation of a first generation of peptides
-
Teixido M., et al. Evolutionary combinatorial chemistry, a novel tool for SAR studies on peptide transport across the blood-brain barrier. Part 2. Design, synthesis and evaluation of a first generation of peptides. J. Pept. Sci. 11 (2005) 789-804
-
(2005)
J. Pept. Sci.
, vol.11
, pp. 789-804
-
-
Teixido, M.1
-
42
-
-
0030458462
-
How structural features influence the biomembrane permeability of peptides
-
Burton P.S., et al. How structural features influence the biomembrane permeability of peptides. J. Pharm. Sci. 85 (1996) 1336-1340
-
(1996)
J. Pharm. Sci.
, vol.85
, pp. 1336-1340
-
-
Burton, P.S.1
-
43
-
-
0027141263
-
A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa
-
Kim D.C., et al. A correlation between the permeability characteristics of a series of peptides using an in vitro cell culture model (Caco-2) and those using an in situ perfused rat ileum model of the intestinal mucosa. Pharm. Res. 10 (1993) 1710-1714
-
(1993)
Pharm. Res.
, vol.10
, pp. 1710-1714
-
-
Kim, D.C.1
-
44
-
-
0028270064
-
Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides
-
Chikhale E.G., et al. Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharm. Res. 11 (1994) 412-419
-
(1994)
Pharm. Res.
, vol.11
, pp. 412-419
-
-
Chikhale, E.G.1
-
45
-
-
0026513211
-
The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability
-
Conradi R.A., et al. The influence of peptide structure on transport across Caco-2 cells. II. Peptide bond modification which results in improved permeability. Pharm. Res. 9 (1992) 435-439
-
(1992)
Pharm. Res.
, vol.9
, pp. 435-439
-
-
Conradi, R.A.1
-
46
-
-
0030911575
-
Structure-activity relationships of a series of [d-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability
-
Thomas S.A., et al. Structure-activity relationships of a series of [d-Ala2]deltorphin I and II analogues; in vitro blood-brain barrier permeability and stability. J. Pharmacol. Exp. Ther. 281 (1997) 817-825
-
(1997)
J. Pharmacol. Exp. Ther.
, vol.281
, pp. 817-825
-
-
Thomas, S.A.1
-
47
-
-
38949213664
-
Predicting cell-penetrating peptides
-
Hansen M., et al. Predicting cell-penetrating peptides. Adv. Drug Deliv. Rev. 60 (2008) 572-579
-
(2008)
Adv. Drug Deliv. Rev.
, vol.60
, pp. 572-579
-
-
Hansen, M.1
-
48
-
-
28844504689
-
Prediction of cell-penetrating peptides
-
Hällbrink M., et al. Prediction of cell-penetrating peptides. Int. J. Pep. Res. Ther. 11 (2005) 249-259
-
(2005)
Int. J. Pep. Res. Ther.
, vol.11
, pp. 249-259
-
-
Hällbrink, M.1
-
49
-
-
40049110714
-
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
-
Dobson P.D., and Kell D.B. Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?. Nat. Rev. Drug Discov. 7 (2008) 205-220
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 205-220
-
-
Dobson, P.D.1
Kell, D.B.2
-
50
-
-
18944373550
-
In silico strategies for modeling membrane transporter function
-
Chang C., et al. In silico strategies for modeling membrane transporter function. Drug Discov. Today 10 (2005) 663-671
-
(2005)
Drug Discov. Today
, vol.10
, pp. 663-671
-
-
Chang, C.1
-
51
-
-
33644843831
-
Computational approaches to modeling drug transporters
-
Chang C., and Swaan P.W. Computational approaches to modeling drug transporters. Eur. J. Pharm. Sci. 27 (2006) 411-424
-
(2006)
Eur. J. Pharm. Sci.
, vol.27
, pp. 411-424
-
-
Chang, C.1
Swaan, P.W.2
-
52
-
-
33644892767
-
Recent advances in molecular modeling and medicinal chemistry aspects of phospho-glycoprotein
-
Srinivas E., et al. Recent advances in molecular modeling and medicinal chemistry aspects of phospho-glycoprotein. Curr. Drug Metab. 7 (2006) 205-217
-
(2006)
Curr. Drug Metab.
, vol.7
, pp. 205-217
-
-
Srinivas, E.1
-
53
-
-
33751301012
-
Pharmacophore-based discovery of ligands for drug transporters
-
Chang C., et al. Pharmacophore-based discovery of ligands for drug transporters. Adv. Drug Deliv. Rev. 58 (2006) 1431-1450
-
(2006)
Adv. Drug Deliv. Rev.
, vol.58
, pp. 1431-1450
-
-
Chang, C.1
-
54
-
-
31344441398
-
Molecular modeling of blood-brain barrier nutrient transporters: in silico basis for evaluation of potential drug delivery to the central nervous system
-
Allen D.D., and Geldenhuys W.J. Molecular modeling of blood-brain barrier nutrient transporters: in silico basis for evaluation of potential drug delivery to the central nervous system. Life Sci. 78 (2006) 1029-1033
-
(2006)
Life Sci.
, vol.78
, pp. 1029-1033
-
-
Allen, D.D.1
Geldenhuys, W.J.2
-
55
-
-
2442570755
-
Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter
-
Geldenhuys W.J., et al. Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter. Bioorg. Med. Chem. Lett. 14 (2004) 3085-3092
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 3085-3092
-
-
Geldenhuys, W.J.1
-
56
-
-
20344387212
-
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter
-
Geldenhuys W.J., et al. 3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter. Bioorg. Med. Chem. 13 (2005) 4253-4261
-
(2005)
Bioorg. Med. Chem.
, vol.13
, pp. 4253-4261
-
-
Geldenhuys, W.J.1
|