Intranasal recombinant human erythropoietin protects rats against focal cerebral ischemia

Neuroscience Letters

Volumn 387, Issue 1, 2005, Pages 5-10

  Yu, Yue Ping ^a   Xu, Qiu Qin ^a,b   Zhang, Qi ^a   Zhang, Wei Ping ^a   Zhang, Li Hui ^b   Wei, Er Qing ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b HANGZHOU NORMAL UNIVERSITY   (China)

Author keywords

Cerebral ischemia; Intranasal delivery; Neuroprotection; Recombinant human erythropoietin

Indexed keywords

RECOMBINANT ERYTHROPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; CEREBRAL ARTERY DISEASE; CONTROLLED STUDY; DRUG EFFECT; EVALUATION; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADMINISTRATION, INTRANASAL; ANIMALS; BRAIN EDEMA; BRAIN ISCHEMIA; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROPOIETIN, RECOMBINANT; HUMANS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; TREATMENT OUTCOME;

EID: 23744459392     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2005.07.008     Document Type: Article

References (27)

1. C. Alafaci, F. Salpietro, G. Grasso, A. Sfacteria, M. Passalacqua, A. Morabito, E. Tripodo, G. Calapai, M. Buemi, and F. Tomasello Effect of recombinant human erythropoietin on cerebral ischemia following experimental subarachnoid hemorrhage Eur. J. Pharmacol. 406 2000 219 225
2. M. Bernaudin, H.H. Marti, S. Roussel, D. Divoux, A. Nouvelot, E.T. MacKenzie, and E. Petit A potential role for erythropoietin in focal permanent cerebral ischemia in mice J. Cereb. Blood Flow Metab. 19 1999 643 651
3. J. Born, T. Lange, W. Kern, G.P. McGregor, U. Bickel, and H.L. Fehm Sniffing neuropeptides: a transnasal approach to the human brain Nat. Neurosci. 5 2002 514 516
4. M.L. Brines, P. Ghezzi, S. Keenan, D. Agnello, N.C. de Lanerolle, C. Cerami, L.M. Itri, and A. Cerami Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury Proc. Natl. Acad. Sci. U.S.A. 97 2000 10526 10531
5. H. Ehrenreich, W. Timner, and A.L. Siren A novel role for an established player: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia Transfus. Apheresis Sci. 31 2004 39 44
6. S. Erbayraktar, G. Grasso, A. Sfacteria, Q.W. Xie, T. Coleman, M. Kreilgaard, L. Torup, T. Sager, Z. Erbayraktar, N. Gokmen, O. Yilmaz, P. Ghezzi, P. Villa, M. Fratelli, S. Casagrande, M. Leist, L. Helboe, J. Gerwein, S. Christensen, M.A. Geist, L.O. Pedersen, C. Cerami-Hand, J.P. Wuerth, A. Cerami, and M. Brines Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo Proc. Natl. Acad. Sci. U.S.A. 100 2003 6741 6746
7. G. Grasso Neuroprotective effect of recombinant human erythropoietin in experimental subarachnoid hemorrhage J. Neurosurg. Sci. 45 2001 7 14
8. G. Grasso, A. Sfacteria, A. Cerami, and M. Brines Erythropoietin as a tissue-protective cytokine in brain injury: what do we know and where do we go? Neuroscientist 10 2004 93 98
9. A. Kumral, E. Ozer, O. Yilmaz, M. Akhisaroglu, N. Gokmen, N. Duman, C. Ulukus, S. Genc, and H. Ozkan Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats Biol. Neonate 83 2003 224 228
10. X.F. Liu, J.R. Fawcett, R.G. Thorne, T.A. DeFor, and W.H. Frey 2nd Intranasal administration of insulin-like growth factor-I bypasses the blood-brain barrier and protects against focal cerebral ischemic damage J. Neurol. Sci. 187 2001 91 97
11. X.F. Liu, J.R. Fawcett, R.G. Thorne, and W.H. Frey 2nd Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion Neurosci. Lett. 308 2001 91 94
12. E.Z. Longa, P.R. Weinstein, S. Carlson, and R. Cummins Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1989 84 91
13. K. Maiese, F. Li, and Z.Z. Chong Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol. Sci. 25 2004 577 583
14. T.M. Ross, P.M. Martinez, J.C. Renner, R.G. Thorne, L.R. Hanson, and W.H. Frey 2nd Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis J. Neuroimmunol. 151 2004 66 77
15. M. Sakanaka, T.C. Wen, S. Matsuda, S. Masuda, E. Morishita, M. Nagao, and R. Sasaki In vivo evidence that erythropoietin protects neurons from ischemic damage Proc. Natl. Acad. Sci. U.S.A. 95 1998 4635 4640
16. N. Shimoda, Y. Maitani, Y. Machida, and T. Nagai Effects of dose, pH and osmolarity on intranasal absorption of recombinant human erythropoietin in rats Biol. Pharm. Bull. 18 1995 734 739
17. A.L. Siren, M. Fratelli, M. Brines, C. Goemans, S. Casagrande, P. Lewczuk, S. Keenan, C. Gleiter, C. Pasquali, A. Capobianco, T. Mennini, R. Heumann, A. Cerami, H. Ehrenreich, and P. Ghezzi Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress Proc. Natl. Acad. Sci. U.S.A. 98 2001 4044 4049
18. A. Sola, M. Rogido, B.H. Lee, T. Genetta, and T.C. Wen Erythropoietin after focal cerebral ischemia activates the Janus kinase-signal transducer and activator of transcription signaling pathway and improves brain injury in postnatal day 7 rats Pediatr. Res. 57 2005 481 487
19. I. Solaroglu, A. Solaroglu, E. Kaptanoglu, S. Dede, A. Haberal, E. Beskonakli, and K. Kilinc Erythropoietin prevents ischemia-reperfusion from inducing oxidative damage in fetal rat brain Childs Nerv. Syst. 19 2003 19 22
20. R.G. Thorne, C.R. Emory, T.A. Ala, and W.H. Frey 2nd Quantitative analysis of the olfactory pathway for drug delivery to the brain Brain Res. 692 1995 278 282
21. R.G. Thorne, G.J. Pronk, V. Padmanabhan, and W.H. Frey 2nd Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration Neuroscience 127 2004 481 496
22. M.P. van den Berg, S.G. Romeijn, J.C. Verhoef, and F.W. Merkus Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity J. Neurosci. Methods 116 2002 99 107
23. P. Villa, P. Bigini, T. Mennini, D. Agnello, T. Laragione, A. Cagnotto, B. Viviani, M. Marinovich, A. Cerami, T.R. Coleman, M. Brines, and P. Ghezzi Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis J. Exp. Med. 198 2003 971 975
24. C. Wiessner, P.R. Allegrini, D. Ekatodramis, U.R. Jewell, T. Stallmach, and M. Gassmann Increased cerebral infarct volumes in polyglobulic mice overexpressing erythropoietin J. Cereb. Blood Flow Metab. 21 2001 857 864
25. A. Xenocostas, W.K. Cheung, F. Farrell, C. Zakszewski, M. Kelley, A. Lutynski, M. Crump, J.H. Lipton, T.L. Kiss, C.Y. Lau, and H.A. Messner The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin Eur. J. Clin. Pharmacol. 61 2005 189 195
26. E. Yildirim, I. Solaroglu, O. Okutan, K. Ozisik, E. Kaptanoglu, M.F. Sargon, and U. Sakinci Ultrastructural changes in tracheobronchial epithelia following experimental traumatic brain injury in rats: protective effect of erythropoietin J. Heart Lung Transplant. 23 2004 1423 1429
27. F. Yonemori, H. Yamada, and A. Tamura Evaluation of a motor deficit after chronic focal cerebral ischemia in rats J. Cereb. Blood Flow Metab. 18 1998 1099 1106