Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: A preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease

Journal of Drug Targeting

Volumn 8, Issue 6, 2000, Pages 371-381

  Deguchi, Y ^a   Hayashi, H ^a   Fujii, S ^a   Naito, T ^a   Yokoyama, Y ^a   Yamada, S ^a   Kimura, R ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Alzheimer disease; Blood brain barrier; Brain delivery; Glyceride ester prodrug; NSAID

Indexed keywords

1,3 DIACETYL 2 KETOPROFEN GLYCERIDE; ACYLGLYCEROL; DIAZEPAM; INDOMETACIN; KETOPROFEN; KETOPROFEN DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PROBENECID; PRODRUG; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; BRAIN CAPILLARY; BRAIN HOMOGENATE; BRAIN METABOLISM; BRAIN PERFUSION; CATTLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG INFUSION; DRUG METABOLISM; DRUG PENETRATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; EVALUATION; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INJECTION; INTERNAL CAROTID ARTERY; ISOLATED ORGAN; MALE; MEASUREMENT; MICRODIALYSIS; MODEL; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; TARGET ORGAN; TECHNIQUE;

EID: 0034453632     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.3109/10611860008997913     Document Type: Article

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