Computational approaches to the prediction of the blood-brain distribution

Advanced Drug Delivery Reviews

Volumn 54, Issue 3, 2002, Pages 291-313

  Norinder, Ulf ^a   Haeberlein, Markus ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

2 D structures; 3 D structures; Blood brain barrier; E state indices; Free energy of solvation; Modelling; MolSurf; PSA; Statistics; Topological indices

Indexed keywords

BLOOD; COMPUTATION THEORY; MOLECULAR ORIENTATION;

BLOOD-BRAIN BARRIER;

DRUG THERAPY;

2 BUTANONE; 4 (2 DIPROPYLAMINOETHYL) 7 HYDROXY 2(3H) INDOLONE; ACETONE; ALCOHOL; CHLORAMBUCIL; CIMETIDINE; CLONIDINE; FLUROXENE; HEPTANE; HEXANE; HISTAMINE; ICOTIDINE; IMIPRAMINE; LUPITIDINE; MEPYRAMINE; N (ALPHA ETHYLBENZYL) 3 METHYL 2 PHENYL 4 QUINOLINECARBOXAMIDE; NITROGEN; OCTANOL; OXYGEN; PARACETAMOL; PENTANE; PROPANOL; RANITIDINE; ROPINIROLE; TEMELASTINE; TIOTIDINE; TOLUENE; UNINDEXED DRUG; VALPROIC ACID; ZOLANTIDINE;

BLOOD BRAIN BARRIER; BRAIN CAPILLARY; BRAIN PERFUSION; CALCULATION; CHEMICAL STRUCTURE; DRUG DISTRIBUTION; DRUG TRANSPORT; HUMAN; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PREDICTION; PRIORITY JOURNAL; PROTON TRANSPORT; QUANTITATIVE ANALYSIS; REVIEW; SOLVATION;

EID: 0037204545     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(02)00005-4     Document Type: Article

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