Carbamazepine uptake into rat brain following intra-olfactory transport

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 1, 2006, Pages 63-72

  Barakat, N S ^a,b   Omar, S A ^a   Ahmed, A A E ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CARBOMER; HYDROXYPROPYLMETHYLCELLULOSE; PHENACETIN; POLYMER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN METABOLISM; CENTRAL NERVOUS SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TRANSPORT; DRUG UPTAKE; EMERGENCY TREATMENT; LIPOPHILICITY; MALE; NONHUMAN; NOSE MUCOSA; OLFACTORY SYSTEM; RAT; TARGET CELL; TRANSPORT KINETICS;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; ANTICONVULSANTS; BIOLOGICAL TRANSPORT; BRAIN; CARBAMAZEPINE; INJECTIONS, INTRAVENOUS; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 29944434476     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.1.0008     Document Type: Article

References (50)

1. Bagger, M. A., Bechgaard, E. (2004) The potential of nasal application for delivery to the central brain - a microdialysis study of fluorescein in rats. Eur. J. Pharm. Sci. 21: 235-242
2. Bertilsson, L., Tomson, T. (1986) Clinical pharmacokinetics and pharmacological effects of carbamazepine and carbamazepine-10,11-epoxide: an update. Clin. Pharmacokinet. 11: 177-198
3. Chen, X.-Q., Fawcett, J. R., Rahman, Y.-E., Ala, T. A., Frey, II W. H. (1998) Delivery of nerve growth factor to the brain via the olfactory pathway. J. Alzheimer's Dis. 1: 35-44
4. Chien, Y. W., Chang, S. F. (1987) Intranasal drug delivery for systemic medications. CRC Crit. Rev. Ther. Drug Carrier Sys. 4: 67-194
5. Chou, K.-J., Donovan, M. D. (1997) Distribution of antihistamines into the CSF following intranasal delivery. Biopharm. Drug Dispos. 18: 335-346
6. Chow, H. H., Anavy, N., Villalobos, A. (2001) Direct nose-brain transport of benzoylecgonine following intranasal administration in rats. J. Pharm. Sci. 90: 1729-1735
7. Dahlin, M., Björk, E. (2000) Nasal absorption of (S)-UH-301 and its transport into the cerebrospinal fluid of rats. Int. J. Pharm. 195: 197-205
8. Dahlin, M., Björk, E. (2001) Nasal administration of a physostigmine analogue (NXX-066) for Alzheimer's disease to rats. Int. J. Pharm. 212: 267-274
9. Dahlin, M., Bergman, U., Jansson, B., Björk, E., Brittebo, E. (2000) Transfer of dopamine in the olfactory pathway following nasal administration in mice. Pharm. Res. 17: 737-742
10. Edman, P., Bjork, E., Ryden, L. (1992) Microspheres as a nasal delivery system for peptides. J. Control. Release 21: 165-172
11. Eriksson, C., Bergman, U., Franzen, A., Sjoblom, M., Brittebo, E. B. (1999) Transfer of some carboxylic acids in the olfactory system following intranasal administration. J. Drug Target. 7: 131-142
12. nd edn, Marcel Dekker, New York, pp 407-417
13. Gizurarson, S., Thorvaldsson, T., Sigurdsson, P., Gunnarsson, E. (1997) Selective delivery of insulin into the brain: intraolfactory absorption. Int. J. Pharm. 146: 135-141
14. Gross, E. A., Swenberg, J. A., Fields, S., Popp, J. A. (1982) Comparative morphometry of the nasal cavity in rats and mice. J. Anat. 135: 83-88
15. Hussain, M. A., Rakestraw, D., Rowe, S., Aungst, B. J. (1990) Nasal administration of a cognition enhancer provides improved bio-availability but not enhanced brain delivery. J. Pharm. Sci. 79: 771-772
16. Hussain, A. A. (1998) Intranasal drug delivery. Adv. Drug. Del. Rev. 29: 39-49
17. Ikada, K., Murata, K., Kobayashi, M., Noda, K. (1992) Enhancement of bioavailability of dopamine via nasal route in beagle dogs. Chem. Pharm. Bull. 40: 2155-2158
18. Illum, L. (2000) Transport of drugs from the nasal cavity to the central nervous system. Eur. J. Pharm. Sci. 11: 1-18
19. Illum, L. (2002) Nasal drug delivery: new developments and strategies. Drug Discovery Today 7: 1184-1189
20. Illum, L. (2004) Is nose-to-brain transport of drugs in man a reality? J. Pharm. Pharmacol. 56: 3-17
21. Kobayashi, Y., Ito, S., Itai, S., Yamamoto, K. (2000) Physical properties and bioavailability of carbamazepine polymorphs and dehydrate. Int. J. Pharm. 193: 137-146
22. Korsmeyer, R. W., Gurny, R., Doelker, E. M., Buri, P., Peppas, N. A. (1983) Mechanism of solute release from porous hydrophilic polymers. Int. J. Pharm. 15: 25-35
23. Kumar, T. C. A., David, G. F. X., Umberkoman, B., Saini, K. D. (1974) Uptake of radioactivity by body fluids and tissues in Rhesus monkeys after intravenous injection or intranasal spray of tritium-labeled oestradiol and progesterone. Contraception 43: 435-439
24. Kumar, T. C. A., David, G. F. X., Puri, V. (1979) Nasal spray contraceptives. In: Talwar, G. P. (ed.) Recent advances in reproduction and regulation of fertility. Elsevier, Amsterdam, pp 49-56
25. Kumar, T. C. A., David, G. F. X., Sankaranarayanan, A., Puri, V., Sandram, K. R. (1982) Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion or nasal spraying. Proc. Natl. Acad. Sci. 79: 4185-4189
26. Lai, C-H., Kuo, K.-H., Leo, J. M. (2005) Critical role of actin in modulating BBB permeability. Brain Res. Rev. 50: 7-13
27. Macdonald, R. L. (1989) Carbamazepine, mechanism of action. In: Levy, R. H., Dreifuses, F. E., Mattson, R. H., Meldrus, B. S., Penry, J. K. (eds) Antiepileptic drugs. Raven Press, New York, pp 447-455
28. Maines, L. W., Antonetti, D. A., Wolpert, E. B., Smith, C. D. (2005) Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazepine by bovine retinal endothelial cells. Europharmacology 49: 610-617
29. Mathison, S., Nagilla, R., Kompella, U. B. (1998) Nasal route for direct delivery of solutes to the central nervous system: fact or fiction? J. Drug Target. 5: 415-441
30. Morrison, E. E., Costanzo, R. M. (1990) Morphology of the human olfactory epithelium. J. Comp. Neurol. 297: 1-13
31. Nakamura, F., Ohta, R., Machida, Y., Nagai, T. (1996) In vitro and in vivo nasal mucoadhesion of some water-soluble polymers. Int. J. Pharm. 134: 173-181
32. Oldendorf, W. H. (1974) Lipid solubility and drug penetration of the blood brain barrier. Proc. Soc. Exp. Biol. Med. 147: 813-816
33. Pardridge, W. M. (1985) Strategies for drug delivery through the blood-brain barrier. In: Borchardt, R. T., Repta, A. J., Stella, V. J. (eds) Directed drug delivery. Humana Press, Clifton, pp 83-96
34. Pardridge, W. M. (1986) Receptor-mediated peptide transport through the blood-brain barrier. Endocr. Rev. 7: 314-330
35. Pardridge, W. M. (1991) Transnasal and intraventricular delivery of drugs. In: Peptide drug delivery to the brain. Raven Press, New York, pp 99-122
36. Pongjanyakul, T., Priprem, A., Puttipipatkhachorn, S. (2005) Influence of magnesium aluminium silicate on rheological, release and permeation characteristics of diclofenac sodium aqueous gels in-vitro. J. Pharm. Pharmacol. 57: 429-434
37. Rall, T. W., Schleifer, L. S. (1985) Drug effective in the therapy of the epilepsies. In: Goodman, M., Gilman, B. (eds) The pharmacological basis of therapeutics. 7th edn, Macmillan, New York, pp 446-472
38. Ritger, P. L., Peppas, N. A. (1987) A simple equation for description of solute release II. Fickian and Anomalous release from swellable devices. J. Control. Release 5: 23-36
39. Sam, E., Jeanjean, A. P., Maloteaux, J. M., Verbeke, N. (1995) Apomorphine pharmacokinetics in parkinsonism after intranasal and subcutaneous application. Eur. J. Drug Metab. Pharm. 20: 27-33
40. Sakane, T., Akizuki, M., Yoshida, M., Yamashita, S., Nadai, T., Hashida, M., Sezaki, H. (1991) The transport of a drug to the cerebrospinal fluid directly from the nasal cavity: the relation to the lipophilicity of the drug. Chem. Pharm. Bull. 39: 2456-2458
41. Sakane, T., Akizuki, M., Taki, Y., Yamashita, S., Sezaki, H., Nadai, T., Hashida, M. (1994) Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the dissociation of the drug. J. Pharm. Pharmacol. 46: 378-379
42. Sakane, T., Akizuki, M., Yamashita, S., Nadai, T., Hashida, M., Sezaki, H. (1995) Direct drug transport from the rat nasal cavity to the cerebrospinal fluid: the relation to the molecular weight of drugs. J. Pharm. Pharmacol. 47: 379-381
43. Seki, T., Sato, N., Hasegawa, T., Kawaguchi, T., Juni, K. (1994) Nasal absorption of zidovudine and its transport to CSF in rats. Biol. Pharm. Bull. 17: 1135-1137
44. Shah, V. P., Midha, K. K., Dighe, S., McGilveray, I. J., Skelly, J. P., Yacobi, A., Layloff, T., Viswanathan, C. T., Cook, C. E., McDowall, R. D., Pittman, K. A., Spector, S. (1992) Analytical methods validation: bioavailability, and pharmacokinetic studies. Int. J. Pharm. 82: 1-7
45. Throne, R. G., Emory, C. R., Ala, T. A., Frey, W. I. (1995) Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res. 692: 278-282
46. Ugwoke, M. I., Exaud, S., Van den Mooter, G., Verbeke, N., Kinget, R. (1999) Bioavailability of apomorphine following intranasal administration of mucoadhesive drug delivery system in rabbits. Eur. J. Pharm. Sci. 9: 213-219
47. Ugwoke, M. I., Kaufmann, G., Verbeke, N., Kinget, R. (2000) Intranasal bioavailability of apomorphine from carboxymethylcellulose-based drug delivery system. Int. J. Pharm. 202: 125-131
48. Uraih, L. C., Maronpot, R. R. (1990) Normal history of the nasal cavity and application of special techniques. Environ. Health Perspect. 85: 187-208
49. Vidgren, P., Vidgren, M., Arppe, J., Hakuli, T., Laine, E., Paronen, P. (1992) In vitro evaluation of spray-dried mucoadhesive microspheres for nasal administration. Drug Dev. Ind. Pharm. 18: 581-597
50. Wang, L., Zuo, C., Zhao, D., Wu, X. (2000) Brain distribution and efficacy of carbamazepine in kainic acid induced seizure in rats. Brain Dev. 22: 54-157