Toward the prediction of CNS drug-effect profiles in physiological and pathological conditions using microdialysis and mechanism-based pharmacokinetic-pharmacodynamic modeling

AAPS Journal

Volumn 7, Issue 3, 2005, Pages

  de Lange, Elizabeth C M ^a   Ravenstijn, Paulien G M ^a   Groenendaal, Dorien ^a   van Steeg, Tamara J ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Biophase; Blood brain barrier; Microdialysis; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ALFENTANIL; ANTICONVULSIVE AGENT; ANTIPARKINSON AGENT; BIOLOGICAL MARKER; BUTORPHANOL; CENTRAL NERVOUS SYSTEM AGENTS; ELACRIDAR; FENTANYL; GABAPENTIN; LOPERAMIDE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NALBUPHINE; OPIATE; SUFENTANIL;

ARTICLE; BLOOD BRAIN BARRIER; DISEASE COURSE; DRUG BLOOD LEVEL; DRUG INDICATION; DRUG INFORMATION; DRUG MECHANISM; DRUG RESEARCH; DRUG RESPONSE; DRUG TRANSPORT; DRUG USE; EXTRACELLULAR FLUID; HUMAN; INTRACTABLE EPILEPSY; MICRODIALYSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PHARMACODYNAMICS; PREDICTION; STATISTICAL MODEL; BIOLOGICAL MODEL; METHODOLOGY; PHARMACOKINETICS; PHYSIOLOGY; PREDICTION AND FORECASTING; PROTEIN BINDING; REVIEW; STATISTICS; TISSUE DISTRIBUTION;

CENTRAL NERVOUS SYSTEM AGENTS; HUMANS; MICRODIALYSIS; MODELS, BIOLOGICAL; PHARMACOKINETICS; PREDICTIVE VALUE OF TESTS; PROTEIN BINDING; TISSUE DISTRIBUTION;

EID: 33644812284     PISSN: 15221059     EISSN: 15221059     Source Type: Journal    
DOI: 10.1208/aapsj070354     Document Type: Article

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