Synthesis, pharmacokinetics and anticonvulsant activity of 7-chlorokynurenic acid prodrugs

International Journal of Pharmaceutics

Volumn 202, Issue 1-2, 2000, Pages 79-88

  Bonina, Francesco P ^a   Arenare, Loredana ^b   Ippolito, Rosa ^b   Boatto, Gianpiero ^c   Battaglia, Giuseppe ^d   Bruno, Valeria ^d   De Caprariis, Paolo ^c  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF SASSARI   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

7 Chlorokynurenic acid; Anticonvulsant; Blood brain barrier; NMDA receptor; Prodrug

Indexed keywords

7 CHLOROKYNURENIC ACID; KYNURENIC ACID DERIVATIVE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEIZURE;

ANIMALS; BLOOD-BRAIN BARRIER; CELLS, CULTURED; ESTERS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; KYNURENIC ACID; MICE; N-METHYLASPARTATE; NEURONS; PRODRUGS; SEIZURES;

EID: 0034691811     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00421-X     Document Type: Article

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