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Volumn 16, Issue 35, 2010, Pages 3932-3957

Do not say ever never more: The ins and outs of antiangiogenic therapies

Author keywords

Angiogenesis; Angiogenesis inhibitors; Arthritis; Cancer; Macular degeneration; Proliferative retinopathies; Psoriasis; VEGF

Indexed keywords

ANGIOZYME; BATIMASTAT; BEVACIZUMAB; CARBOPLATIN; CYTOKINE; FIBROBLAST GROWTH FACTOR; FIBRONECTIN; FLUOROURACIL; FOLINIC ACID; INCYCLINIDE; MARIMASTAT; MATRIX METALLOPROTEINASE; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PLATELET DERIVED GROWTH FACTOR; PROTEINASE; RAMUCIRUMAB; REBIMASTAT; SOLIMASTAT; SOMATOMEDIN C; SORAFENIB; SUNITINIB; TANOMASTAT; UNINDEXED DRUG; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 3;

EID: 79551619243     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161210794454950     Document Type: Article
Times cited : (42)

References (353)
  • 1
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000; 6: 389-95.
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 2
    • 0035745524 scopus 로고    scopus 로고
    • Arteriogenesis, a new concept of vascular adaptation in occlusive disease
    • Scholz D, Cai WJ, Schaper W. Arteriogenesis, a new concept of vascular adaptation in occlusive disease. Angiogenesis 2001; 4: 247-57.
    • (2001) Angiogenesis , vol.4 , pp. 247-257
    • Scholz, D.1    Cai, W.J.2    Schaper, W.3
  • 3
    • 0036527585 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphangiogenesis in health and disease
    • Alitalo K, Carmeliet P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 2002; 1: 219-27.
    • (2002) Cancer Cell , vol.1 , pp. 219-227
    • Alitalo, K.1    Carmeliet, P.2
  • 4
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 5
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995; 1: 27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 6
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet, P. Angiogenesis in life, disease and medicine. Nature 2005; 438: 932-6.
    • (2005) Nature , vol.438 , pp. 932-936
    • Carmeliet, P.1
  • 7
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007; 6(4): 273-86.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.4 , pp. 273-286
    • Folkman, J.1
  • 8
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 9
    • 47949107371 scopus 로고    scopus 로고
    • The scientific contributions of M. Judah Folkman to cancer research
    • Zetter BR. The scientific contributions of M. Judah Folkman to cancer research. Nat Rev Cancer 2008; 8(8): 647-54.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 647-654
    • Zetter, B.R.1
  • 10
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel RS. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 1991; 13(1): 31-6.
    • (1991) Bioessays , vol.13 , Issue.1 , pp. 31-36
    • Kerbel, R.S.1
  • 13
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present and the near future
    • Kerbel RS. Tumor angiogenesis: past, present and the near future. Carcinogenesis 2000; 21(3): 505-15.
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 505-515
    • Kerbel, R.S.1
  • 14
    • 0036716282 scopus 로고    scopus 로고
    • Strategies for MMP inhibition in cancer: Innovations for the post-trial era
    • Overall CM, Lopez-Otin C. Strategies for MMP inhibition in cancer: innovations for the post-trial era. Nat Rev Cancer 2002; 2(9): 657-72.
    • (2002) Nat Rev Cancer , vol.2 , Issue.9 , pp. 657-672
    • Overall, C.M.1    Lopez-Otin, C.2
  • 15
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002; 295: 2387-92.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 16
    • 0036170808 scopus 로고    scopus 로고
    • MMP inhibitors: Glimmers of hope amidst clinical failures
    • Dove A. MMP inhibitors: Glimmers of hope amidst clinical failures. Nat Med 2002; 8(2): 95.
    • (2002) Nat Med , vol.8 , Issue.2 , pp. 95
    • Dove, A.1
  • 17
    • 33745305095 scopus 로고    scopus 로고
    • Anti-angiogenic drugs: From bench to clinical trials
    • Quesada AR, Muñoz-Chápuli R, Medina MA. Anti-angiogenic drugs: from bench to clinical trials. Med Res Rev 2006; 26: 483-530.
    • (2006) Med Res Rev , vol.26 , pp. 483-530
    • Quesada, A.R.1    Muñoz-Chápuli, R.2    Medina, M.A.3
  • 18
    • 36849080314 scopus 로고    scopus 로고
    • Matrix metalloproteinases at cancer tumor-host interface
    • Noël A, Jost M, Maquoi E. Matrix metalloproteinases at cancer tumor-host interface. Semin Cell Dev Biol 2008; 19(1): 52-60.
    • (2008) Semin Cell Dev Biol , vol.19 , Issue.1 , pp. 52-60
    • Noël, A.1    Jost, M.2    Maquoi, E.3
  • 19
    • 77049108176 scopus 로고    scopus 로고
    • Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions
    • Deryugina EI, Quigley JP. Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: Contrasting, overlapping and compensatory functions. Biochim Biophys Acta 2010; 1803(1): 103-120.
    • (2010) Biochim Biophys Acta , vol.1803 , Issue.1 , pp. 103-120
    • Deryugina, E.I.1    Quigley, J.P.2
  • 20
    • 0043177668 scopus 로고    scopus 로고
    • Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as a first-line therapy in subjects with metastatic CRC
    • Abstract 3646
    • Hurwitz H, Fehrenbacher L, Cartwright T, et al. Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as a first-line therapy in subjects with metastatic CRC. Proc Am Soc Clin Oncol Meeting 2003; Abstract 3646.
    • (2003) Proc Am Soc Clin Oncol Meeting
    • Hurwitz, H.1    Fehrenbacher, L.2    Cartwright, T.3
  • 21
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for metastatic colorectal cancer. N Engl J Med 2004; 350: 2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 22
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007; 25(12): 1539-44.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 23
    • 40949111793 scopus 로고    scopus 로고
    • Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab--an Eastern Cooperative Oncology Group Study
    • Dowlati A, Gray R, Sandler AB, Schiller JH, Johnson DH. Cell adhesion molecules, vascular endothelial growth factor, and basic fibroblast growth factor in patients with non-small cell lung cancer treated with chemotherapy with or without bevacizumab--an Eastern Cooperative Oncology Group Study. Clin Cancer Res 2008; 14(5): 1407-12.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1407-1412
    • Dowlati, A.1    Gray, R.2    Sandler, A.B.3    Schiller, J.H.4    Johnson, D.H.5
  • 24
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al. Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370(9605): 2103-11.
    • (2007) Lancet , vol.370 , Issue.9605 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 25
    • 77951258203 scopus 로고    scopus 로고
    • Bevacizumab as a treatment option in advanced renal cell carcinoma: An analysis and interpretation of clinical trial data
    • McDermott DF, George DJ. Bevacizumab as a treatment option in advanced renal cell carcinoma: An analysis and interpretation of clinical trial data. Cancer Treat Rev 2010; 36(3): 216-23.
    • (2010) Cancer Treat Rev , vol.36 , Issue.3 , pp. 216-223
    • McDermott, D.F.1    George, D.J.2
  • 26
    • 75749112233 scopus 로고    scopus 로고
    • Bevacizumab: In previously treated glioblastoma
    • Moen MD. Bevacizumab: in previously treated glioblastoma. Drugs 2010; 70(2): 181-9.
    • (2010) Drugs , vol.70 , Issue.2 , pp. 181-189
    • Moen, M.D.1
  • 27
    • 33846260566 scopus 로고    scopus 로고
    • Sorafenib for the treatment of advanced renal cell carcinoma
    • Kane RC, Farrell AT, Saber H, et al. Sorafenib for the treatment of advanced renal cell carcinoma. Clin Cancer Res 2006; 12(24): 7271-8.
    • (2006) Clin Cancer Res , vol.12 , Issue.24 , pp. 7271-7278
    • Kane, R.C.1    Farrell, A.T.2    Saber, H.3
  • 28
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359(4): 378-90.
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 29
    • 33749505836 scopus 로고    scopus 로고
    • Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
    • Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006; 368(9544): 1329-38.
    • (2006) Lancet , vol.368 , Issue.9544 , pp. 1329-1338
    • Demetri, G.D.1    van Oosterom, A.T.2    Garrett, C.R.3
  • 30
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG, et al. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006; 24 (1): 16-24.
    • (2006) J Clin Oncol , vol.24 , Issue.1 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 31
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM, et al. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006; 295(21): 2516-24.
    • (2006) JAMA , vol.295 , Issue.21 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 32
    • 67651201656 scopus 로고    scopus 로고
    • Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: An expanded-access trial
    • Gore ME, Szczylik C, Porta C, et al. Safety and efficacy of sunitinib for metastatic renal-cell carcinoma: an expanded-access trial. Lancet Oncol 2009; 10(8): 757-63.
    • (2009) Lancet Oncol , vol.10 , Issue.8 , pp. 757-763
    • Gore, M.E.1    Szczylik, C.2    Porta, C.3
  • 33
    • 77949890945 scopus 로고    scopus 로고
    • Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial
    • Sternberg CN, Davis ID, Mardiak J, et al. Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial. J Clin Oncol 2010; 28(6): 1061-8.
    • (2010) J Clin Oncol , vol.28 , Issue.6 , pp. 1061-1068
    • Sternberg, C.N.1    Davis, I.D.2    Mardiak, J.3
  • 35
    • 4644356480 scopus 로고    scopus 로고
    • Angiogenesis and signal transduction in endothelial cells
    • Muñoz-Chápuli R, Quesada AR, Medina MA. Angiogenesis and signal transduction in endothelial cells. Cell Mol Life Sci 2004; 61(17): 2224-43.
    • (2004) Cell Mol Life Sci , vol.61 , Issue.17 , pp. 2224-2243
    • Muñoz-Chápuli, R.1    Quesada, A.R.2    Medina, M.A.3
  • 36
    • 0242405617 scopus 로고    scopus 로고
    • Endothelial-pericyte interactions in angiogenesis
    • Gerhardt H, Betsholtz C. Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res 2003; 314(1): 15-23.
    • (2003) Cell Tissue Res , vol.314 , Issue.1 , pp. 15-23
    • Gerhardt, H.1    Betsholtz, C.2
  • 37
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420(6917): 860-7.
    • (2002) Nature , vol.420 , Issue.6917 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 38
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick NA, Neilson EG, Moses HL. Stromal fibroblasts in cancer initiation and progression. Nature 2004; 432(7015): 332-7.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 39
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006; 6(5): 392-401.
    • (2006) Nat Rev Cancer , vol.6 , Issue.5 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 42
    • 0036085728 scopus 로고    scopus 로고
    • Mast cells and angiogenesis
    • Norrby K. Mast cells and angiogenesis. APMIS 2002; 110(5): 355-71.
    • (2002) APMIS , vol.110 , Issue.5 , pp. 355-371
    • Norrby, K.1
  • 43
    • 33845466231 scopus 로고    scopus 로고
    • Monocyte/ macrophage infiltration in tumors: Modulators of angiogenesis
    • Dirkx AE, Oude Egbrink MG, Wagstaff J, Griffioen AW. Monocyte/ macrophage infiltration in tumors: modulators of angiogenesis. J Leukoc Biol 2006; 80(6): 1183-96.
    • (2006) J Leukoc Biol , vol.80 , Issue.6 , pp. 1183-1196
    • Dirkx, A.E.1    Oude Egbrink, M.G.2    Wagstaff, J.3    Griffioen, A.W.4
  • 44
    • 33747602354 scopus 로고    scopus 로고
    • Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
    • Nozawa H, Chiu C, Hanahan D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc Natl Acad Sci USA 2006; 103(33):12493-8.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.33 , pp. 12493-12498
    • Nozawa, H.1    Chiu, C.2    Hanahan, D.3
  • 46
    • 69049117556 scopus 로고    scopus 로고
    • Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation
    • Maltby S, Khazaie K, McNagny KM. Mast cells in tumor growth: angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta 2009; 1796(1): 19-26.
    • (2009) Biochim Biophys Acta , vol.1796 , Issue.1 , pp. 19-26
    • Maltby, S.1    Khazaie, K.2    McNagny, K.M.3
  • 47
    • 65549145501 scopus 로고    scopus 로고
    • Neutrophils: Key mediators of tumour angiogenesis
    • Tazzyman S, Lewis CE, Murdoch C. Neutrophils: key mediators of tumour angiogenesis. Int J Exp Pathol 2009; 90(3): 222-31.
    • (2009) Int J Exp Pathol , vol.90 , Issue.3 , pp. 222-231
    • Tazzyman, S.1    Lewis, C.E.2    Murdoch, C.3
  • 48
    • 33746802333 scopus 로고    scopus 로고
    • Extracellular angiogenic growth factor interactions: An angiogenesis interactome survey
    • Rusnati M, Presta M. Extracellular angiogenic growth factor interactions: an angiogenesis interactome survey. Endothelium 2006; 13(2): 93-111.
    • (2006) Endothelium , vol.13 , Issue.2 , pp. 93-111
    • Rusnati, M.1    Presta, M.2
  • 49
    • 20144379162 scopus 로고    scopus 로고
    • Endogenous inhibitors of angiogenesis
    • Nyberg P, Xie L, Kalluri R. Endogenous inhibitors of angiogenesis. Cancer Res 2005; 65(10): 3967-79.
    • (2005) Cancer Res , vol.65 , Issue.10 , pp. 3967-3979
    • Nyberg, P.1    Xie, L.2    Kalluri, R.3
  • 50
    • 0034690028 scopus 로고    scopus 로고
    • Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
    • Kanno S, Oda N, Abe M, et al. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells. Oncogene 2000; 19(17): 2138-46.
    • (2000) Oncogene , vol.19 , Issue.17 , pp. 2138-2146
    • Kanno, S.1    Oda, N.2    Abe, M.3
  • 51
    • 0034681392 scopus 로고    scopus 로고
    • Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
    • Wu LW, Mayo LD, Dunbar JD, et al. Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation. J Biol Chem 2000; 275(7): 5096-103.
    • (2000) J Biol Chem , vol.275 , Issue.7 , pp. 5096-5103
    • Wu, L.W.1    Mayo, L.D.2    Dunbar, J.D.3
  • 53
    • 0032512822 scopus 로고    scopus 로고
    • Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium
    • Parenti A, Morbidelli L, Cui XL, et al. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium. J Biol Chem 1998; 273(7): 4220-6.
    • (1998) J Biol Chem , vol.273 , Issue.7 , pp. 4220-4226
    • Parenti, A.1    Morbidelli, L.2    Cui, X.L.3
  • 54
    • 0033609922 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src
    • He H, Venema VJ, Gu X, Venema RC, Marrero MB, Caldwell RB. Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src. J Biol Chem 1999; 274(35): 25130-5.
    • (1999) J Biol Chem , vol.274 , Issue.35 , pp. 25130-25135
    • He, H.1    Venema, V.J.2    Gu, X.3    Venema, R.C.4    Marrero, M.B.5    Caldwell, R.B.6
  • 55
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
    • Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem 1994; 269(43): 26988-95.
    • (1994) J Biol Chem , vol.269 , Issue.43 , pp. 26988-26995
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.H.5
  • 56
    • 0028798083 scopus 로고
    • A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF
    • Seetharam L, Gotoh N, Maru Y, Neufeld G, Yamaguchi S, Shibuya M. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene 1995; 10(1): 135-47.
    • (1995) Oncogene , vol.10 , Issue.1 , pp. 135-147
    • Seetharam, L.1    Gotoh, N.2    Maru, Y.3    Neufeld, G.4    Yamaguchi, S.5    Shibuya, M.6
  • 57
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 58
    • 0034254273 scopus 로고    scopus 로고
    • A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration
    • Gille H, Kowalski J, Yu L, et al. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration. EMBO J 2000; 19(15): 4064-73.
    • (2000) EMBO J , vol.19 , Issue.15 , pp. 4064-4073
    • Gille, H.1    Kowalski, J.2    Yu, L.3
  • 59
    • 56749174211 scopus 로고    scopus 로고
    • FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-angiogenic therapy?
    • Fischer C, Mazzone M, Jonckx B, Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? Nat Rev Cancer 2008; 8(12): 942-56.
    • (2008) Nat Rev Cancer , vol.8 , Issue.12 , pp. 942-956
    • Fischer, C.1    Mazzone, M.2    Jonckx, B.3    Carmeliet, P.4
  • 60
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25(4): 581-611.
    • (2004) Endocr Rev , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 61
    • 2442625634 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours
    • Jubb AM, Pham TQ, Hanby AM, et al. Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours. J Clin Pathol 2004; 57(5): 504-12.
    • (2004) J Clin Pathol , vol.57 , Issue.5 , pp. 504-512
    • Jubb, A.M.1    Pham, T.Q.2    Hanby, A.M.3
  • 62
    • 27944473690 scopus 로고    scopus 로고
    • VEGF as a key mediator of angiogenesis in cancer
    • Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 2005; 69 (Suppl 3): 4-10.
    • (2005) Oncology , vol.69 , Issue.SUPPL 3 , pp. 4-10
    • Carmeliet, P.1
  • 63
    • 27944490875 scopus 로고    scopus 로고
    • VEGF as a therapeutic target in cancer
    • Ferrara N. VEGF as a therapeutic target in cancer. Oncology 2005;69 (Suppl 3): 11-6.
    • (2005) Oncology , vol.69 , Issue.SUPPL 3 , pp. 11-16
    • Ferrara, N.1
  • 64
    • 0034665166 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice
    • Brekken RA, Overholser JP, Stastny VA, Waltenberger J, Minna JD, Thorpe PE. Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res 2000; 60(18): 5117-24.
    • (2000) Cancer Res , vol.60 , Issue.18 , pp. 5117-5124
    • Brekken, R.A.1    Overholser, J.P.2    Stastny, V.A.3    Waltenberger, J.4    Minna, J.D.5    Thorpe, P.E.6
  • 65
    • 34547657584 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap in non small cell lung cancer
    • Riely GJ, Miller VA.Vascular endothelial growth factor trap in non small cell lung cancer. Clin Cancer Res 2007; 13: s4623-7.
    • (2007) Clin Cancer Res , vol.13
    • Riely, G.J.1    Miller, V.A.2
  • 66
    • 33947531672 scopus 로고    scopus 로고
    • VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma
    • Wachsberger PR, Burd R, Cardi C, et al. VEGF trap in combination with radiotherapy improves tumor control in u87 glioblastoma. Int J Radiat Oncol Biol Phys 2007; 67: 1526-37.
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 1526-1537
    • Wachsberger, P.R.1    Burd, R.2    Cardi, C.3
  • 67
    • 74949101370 scopus 로고    scopus 로고
    • Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors
    • Tew WP, Gordon M, Murren J, et al. Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors. Clin Cancer Res 2010; 16(1): 358-66.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 358-366
    • Tew, W.P.1    Gordon, M.2    Murren, J.3
  • 68
    • 74949119167 scopus 로고    scopus 로고
    • Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors
    • Lockhart AC, Rothenberg ML, Dupont J, et al. Phase I study of intravenous vascular endothelial growth factor trap, aflibercept, in patients with advanced solid tumors. J Clin Oncol 2010; 28(2): 207-14.
    • (2010) J Clin Oncol , vol.28 , Issue.2 , pp. 207-214
    • Lockhart, A.C.1    Rothenberg, M.L.2    Dupont, J.3
  • 69
    • 65649129343 scopus 로고    scopus 로고
    • Nucleic Acid aptamers based on the g-quadruplex structure: Therapeutic and diagnostic potential
    • Gatto B, Palumbo M, Sissi C. Nucleic Acid aptamers based on the g-quadruplex structure: therapeutic and diagnostic potential. Curr Med Chem 2009; 16: 1248-65.
    • (2009) Curr Med Chem , vol.16 , pp. 1248-1265
    • Gatto, B.1    Palumbo, M.2    Sissi, C.3
  • 70
    • 0037454239 scopus 로고    scopus 로고
    • Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis
    • Von Marschall Z, Scholz A, Cramer T, et al. Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis. J Natl Cancer Inst 2003; 95: 437-48.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 437-448
    • Von Marschall, Z.1    Scholz, A.2    Cramer, T.3
  • 71
    • 46049100376 scopus 로고    scopus 로고
    • Vascular endothelial growth factor targeted RNA interference as a modulator of angiogenesis
    • Celec P, Yonemitsu Y. Vascular endothelial growth factor targeted RNA interference as a modulator of angiogenesis. Biomed Pharmacother 2008; 62: 349-51.
    • (2008) Biomed Pharmacother , vol.62 , pp. 349-351
    • Celec, P.1    Yonemitsu, Y.2
  • 72
    • 0035229158 scopus 로고    scopus 로고
    • Targeting tumor vasculature using VEGF-toxin conjugates
    • Ramakrishnan S, Wild R, Nojima D. Targeting tumor vasculature using VEGF-toxin conjugates. Methods Mol Biol 2001; 166: 219-34.
    • (2001) Methods Mol Biol , vol.166 , pp. 219-234
    • Ramakrishnan, S.1    Wild, R.2    Nojima, D.3
  • 73
    • 0035290919 scopus 로고    scopus 로고
    • Angiozyme: A novel angiogenesis inhibitor
    • Weng DE, Usman N. Angiozyme: a novel angiogenesis inhibitor. Curr Oncol Rep 2001; 3(2): 141-6.
    • (2001) Curr Oncol Rep , vol.3 , Issue.2 , pp. 141-146
    • Weng, D.E.1    Usman, N.2
  • 74
    • 21344433919 scopus 로고    scopus 로고
    • A phase I clinical trial of a ribozyme-based angiogenesis inhibitor targeting vascular endothelial growth factor receptor-1 for patients with refractory solid tumors
    • Weng DE, Masci PA, Radka SF, et al. A phase I clinical trial of a ribozyme-based angiogenesis inhibitor targeting vascular endothelial growth factor receptor-1 for patients with refractory solid tumors. Mol Cancer Ther 2005; 4(6): 948-55.
    • (2005) Mol Cancer Ther , vol.4 , Issue.6 , pp. 948-955
    • Weng, D.E.1    Masci, P.A.2    Radka, S.F.3
  • 75
    • 23244448047 scopus 로고    scopus 로고
    • Safety and pharmacokinetic study of RPI.4610 (ANGIOZYME), an anti-VEGFR-1 ribozyme, in combination with carboplatin and paclitaxel in patients with advanced solid tumors
    • Kobayashi H, Eckhardt SG, Lockridge JA, et al. Safety and pharmacokinetic study of RPI.4610 (ANGIOZYME), an anti-VEGFR-1 ribozyme, in combination with carboplatin and paclitaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 2005; 56(4): 329-36.
    • (2005) Cancer Chemother Pharmacol , vol.56 , Issue.4 , pp. 329-336
    • Kobayashi, H.1    Eckhardt, S.G.2    Lockridge, J.A.3
  • 76
    • 67650674112 scopus 로고    scopus 로고
    • Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR-2 for the potential treatment of cancer
    • Krupitskaya Y, Wakelee HA. Ramucirumab, a fully human mAb to the transmembrane signaling tyrosine kinase VEGFR-2 for the potential treatment of cancer. Curr Opin Investig Drugs 2009; 10(6): 597-605.
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.6 , pp. 597-605
    • Krupitskaya, Y.1    Wakelee, H.A.2
  • 77
    • 73349135923 scopus 로고    scopus 로고
    • TRIO-012: A multicenter, multinational, randomized, double-blind phase III study of IMC- 1121B plus docetaxel versus placebo plus docetaxel in previously untreated patients with HER2-negative, unresectable, locally recurrent or metastatic breast cancer
    • Mackey J, Gelmon K, Martin M, et al. TRIO-012: a multicenter, multinational, randomized, double-blind phase III study of IMC- 1121B plus docetaxel versus placebo plus docetaxel in previously untreated patients with HER2-negative, unresectable, locally recurrent or metastatic breast cancer. Clin Breast Cancer 2009; 9(4): 258-61.
    • (2009) Clin Breast Cancer , vol.9 , Issue.4 , pp. 258-261
    • Mackey, J.1    Gelmon, K.2    Martin, M.3
  • 78
    • 77649213706 scopus 로고    scopus 로고
    • Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2
    • Spratlin JL, Cohen RB, Eadens M, et al. Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2. J Clin Oncol 2010; 28(5): 780-7.
    • (2010) J Clin Oncol , vol.28 , Issue.5 , pp. 780-787
    • Spratlin, J.L.1    Cohen, R.B.2    Eadens, M.3
  • 79
    • 33646448005 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of solid tumours: A review of current clinical data
    • Motzer RJ, Hoosen S, Bello CL, Christensen JG. Sunitinib malate for the treatment of solid tumours: a review of current clinical data. Expert Opin Investig Drugs 2006; 15(5): 553-61.
    • (2006) Expert Opin Investig Drugs , vol.15 , Issue.5 , pp. 553-561
    • Motzer, R.J.1    Hoosen, S.2    Bello, C.L.3    Christensen, J.G.4
  • 81
    • 34548310428 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors
    • Adams VR, Leggas M. Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Clin Ther 2007; 29(7): 1338-53.
    • (2007) Clin Ther , vol.29 , Issue.7 , pp. 1338-1353
    • Adams, V.R.1    Leggas, M.2
  • 82
    • 49249133069 scopus 로고    scopus 로고
    • Quality of life in patients with metastatic renal cell carcinoma treated with sunitinib or interferon alfa: Results from a phase III randomized trial
    • Cella D, Li JZ, Cappelleri JC, et al. Quality of life in patients with metastatic renal cell carcinoma treated with sunitinib or interferon alfa: results from a phase III randomized trial. J Clin Oncol 2008; 26(22): 3763-9.
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3763-3769
    • Cella, D.1    Li, J.Z.2    Cappelleri, J.C.3
  • 83
    • 49149114782 scopus 로고    scopus 로고
    • Activity of sunitinib in patients with advanced neuroendocrine tumors
    • Kulke MH, Lenz HJ, Meropol NJ, et al. Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 2008; 26(20): 3403-10.
    • (2008) J Clin Oncol , vol.26 , Issue.20 , pp. 3403-3410
    • Kulke, M.H.1    Lenz, H.J.2    Meropol, N.J.3
  • 85
    • 78650004173 scopus 로고    scopus 로고
    • Phase I/II Trial of Sunitinib Plus Gefitinib in Patients With Metastatic Renal Cell Carcinoma
    • Feb 5. [Epub ahead of print]
    • Motzer RJ, Hudes GR, Ginsberg MS, et al. Phase I/II Trial of Sunitinib Plus Gefitinib in Patients With Metastatic Renal Cell Carcinoma. Am J Clin Oncol 2010 Feb 5. [Epub ahead of print]
    • (2010) Am J Clin Oncol
    • Motzer, R.J.1    Hudes, G.R.2    Ginsberg, M.S.3
  • 86
    • 60849120120 scopus 로고    scopus 로고
    • A population-based study evaluating the impact of sunitinib on overall survival in the treatment of patients with metastatic renal cell cancer
    • Heng DY, Chi KN, Murray N, et al. A population-based study evaluating the impact of sunitinib on overall survival in the treatment of patients with metastatic renal cell cancer. Cancer 2009; 115(4): 776-83.
    • (2009) Cancer , vol.115 , Issue.4 , pp. 776-783
    • Heng, D.Y.1    Chi, K.N.2    Murray, N.3
  • 87
    • 33744513575 scopus 로고    scopus 로고
    • Sorafenib (BAY 43- 9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
    • Adnane L, Trail PA, Taylor I, Wilhelm SM. Sorafenib (BAY 43- 9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol 2006; 407: 597-612.
    • (2006) Methods Enzymol , vol.407 , pp. 597-612
    • Adnane, L.1    Trail, P.A.2    Taylor, I.3    Wilhelm, S.M.4
  • 88
    • 51049098909 scopus 로고    scopus 로고
    • Selected combination therapy with sorafenib: A review of clinical data and perspectives in advanced solid tumors
    • Dal Lago L, D'Hondt V, Awada A. Selected combination therapy with sorafenib: a review of clinical data and perspectives in advanced solid tumors. Oncologist 2008; 13(8): 845-58.
    • (2008) Oncologist , vol.13 , Issue.8 , pp. 845-858
    • Dal Lago, L.1    D'Hondt, V.2    Awada, A.3
  • 89
    • 33744984843 scopus 로고    scopus 로고
    • Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
    • Ratain MJ, Eisen T, Stadler WM, et al. Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 2006; 24(16): 2505-12.
    • (2006) J Clin Oncol , vol.24 , Issue.16 , pp. 2505-2512
    • Ratain, M.J.1    Eisen, T.2    Stadler, W.M.3
  • 90
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356(2): 125-34.
    • (2007) N Engl J Med , vol.356 , Issue.2 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 91
    • 60449094446 scopus 로고    scopus 로고
    • The medical management of metastatic renal cell carcinoma: Integrating new guidelines and recommendations
    • Bellmunt J, Guix M. The medical management of metastatic renal cell carcinoma: integrating new guidelines and recommendations. BJU Int 2009; 103(5): 572-7.
    • (2009) BJU Int , vol.103 , Issue.5 , pp. 572-577
    • Bellmunt, J.1    Guix, M.2
  • 92
    • 60549098640 scopus 로고    scopus 로고
    • Sorafenib: A review of its use in advanced hepatocellular carcinoma
    • Keating GM, Santoro A. Sorafenib: a review of its use in advanced hepatocellular carcinoma. Drugs 2009; 69(2): 223-40.
    • (2009) Drugs , vol.69 , Issue.2 , pp. 223-240
    • Keating, G.M.1    Santoro, A.2
  • 93
    • 63849265332 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in metastatic thyroid cancer
    • Kloos RT, Ringel MD, Knopp MV, et al. Phase II trial of sorafenib in metastatic thyroid cancer. J Clin Oncol 2009; 27(10): 1675-84.
    • (2009) J Clin Oncol , vol.27 , Issue.10 , pp. 1675-1684
    • Kloos, R.T.1    Ringel, M.D.2    Knopp, M.V.3
  • 94
    • 39049095199 scopus 로고    scopus 로고
    • Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma
    • Sonpavde G, Hutson TE, Sternberg CN. Pazopanib, a potent orally administered small-molecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma. Expert Opin Investig Drugs 2008; 17(2): 253-61.
    • (2008) Expert Opin Investig Drugs , vol.17 , Issue.2 , pp. 253-261
    • Sonpavde, G.1    Hutson, T.E.2    Sternberg, C.N.3
  • 95
    • 75749090050 scopus 로고    scopus 로고
    • Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma
    • Hutson TE, Davis ID, Machiels JP, et al. Efficacy and safety of pazopanib in patients with metastatic renal cell carcinoma. J Clin Oncol 2010; 28(3): 475-80.
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 475-480
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.P.3
  • 96
    • 57349179851 scopus 로고    scopus 로고
    • Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy
    • Sloan B, Scheinfeld NS. Pazopanib, a VEGF receptor tyrosine kinase inhibitor for cancer therapy. Curr Opin Investig Drugs 2008; 9(12):1324-35.
    • (2008) Curr Opin Investig Drugs , vol.9 , Issue.12 , pp. 1324-1335
    • Sloan, B.1    Scheinfeld, N.S.2
  • 97
    • 70349782389 scopus 로고    scopus 로고
    • An overview of small-molecule inhibitors of VEGFR signaling
    • Ivy SP, Wick JY, Kaufman BM. An overview of small-molecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol 2009; 6(10): 569-79.
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.10 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 98
    • 34447253095 scopus 로고    scopus 로고
    • Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies
    • Rusnati M, Presta M. Fibroblast growth factors/fibroblast growth factor receptors as targets for the development of anti-angiogenesis strategies Curr Pharm Des 2007; 13(20): 2025-44.
    • (2007) Curr Pharm Des , vol.13 , Issue.20 , pp. 2025-2044
    • Rusnati, M.1    Presta, M.2
  • 99
    • 69249216604 scopus 로고    scopus 로고
    • The role of fibroblast growth factors in tumor growth
    • Korc M, Friesel RE. The role of fibroblast growth factors in tumor growth. Curr Cancer Drug Targets 2009; 9(5): 639-51.
    • (2009) Curr Cancer Drug Targets , vol.9 , Issue.5 , pp. 639-651
    • Korc, M.1    Friesel, R.E.2
  • 100
    • 0031317928 scopus 로고    scopus 로고
    • Fibroblast growth factors and their receptors
    • Galzie Z, Kinsella AR, Smith JA. Fibroblast growth factors and their receptors. Biochem Cell Biol 1997; 75(6): 669-85
    • (1997) Biochem Cell Biol , vol.75 , Issue.6 , pp. 669-685
    • Galzie, Z.1    Kinsella, A.R.2    Smith, J.A.3
  • 101
    • 0033951768 scopus 로고    scopus 로고
    • FGFs, heparan sulfate and FGFRs: Complex interactions essential for development
    • Ornitz DM. FGFs, heparan sulfate and FGFRs: complex interactions essential for development. Bioessays 2000; 22(2): 108-12.
    • (2000) Bioessays , vol.22 , Issue.2 , pp. 108-112
    • Ornitz, D.M.1
  • 102
    • 0034721640 scopus 로고    scopus 로고
    • Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor
    • Lee SH, Schloss DJ, Swain JL. Maintenance of vascular integrity in the embryo requires signaling through the fibroblast growth factor receptor. J Biol Chem 2000; 275(43): 33679-87.
    • (2000) J Biol Chem , vol.275 , Issue.43 , pp. 33679-33687
    • Lee, S.H.1    Schloss, D.J.2    Swain, J.L.3
  • 103
    • 0034009706 scopus 로고    scopus 로고
    • Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGFstimulation of phospholipase C, phospholipase D, phospholipase A, phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
    • Cross MJ, Hodgkin MN, Roberts S, Landgren E, Wakelam MJ, Claesson-Welsh L. Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGFstimulation of phospholipase C, phospholipase D, phospholipase A, phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells. J Cell Sci 2000; 113(Pt 4): 643-51.
    • (2000) J Cell Sci , vol.113 , Issue.PART 4 , pp. 643-651
    • Cross, M.J.1    Hodgkin, M.N.2    Roberts, S.3    Landgren, E.4    Wakelam, M.J.5    Claesson-Welsh, L.6
  • 104
    • 0033520278 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
    • Larsson H, Klint P, Landgren E, Claesson-Welsh L. Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem 1999; 274(36): 25726-34.
    • (1999) J Biol Chem , vol.274 , Issue.36 , pp. 25726-25734
    • Larsson, H.1    Klint, P.2    Landgren, E.3    Claesson-Welsh, L.4
  • 105
    • 0036847930 scopus 로고    scopus 로고
    • Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
    • Hanafusa H, Torii S, Yasunaga T, Nishida E. Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol 2002; 4(11): 850-8.
    • (2002) Nat Cell Biol , vol.4 , Issue.11 , pp. 850-858
    • Hanafusa, H.1    Torii, S.2    Yasunaga, T.3    Nishida, E.4
  • 106
    • 41049103244 scopus 로고    scopus 로고
    • Sprouty proteins, masterminds of receptor tyrosine kinase signaling
    • Cabrita MA, Christofori G. Sprouty proteins, masterminds of receptor tyrosine kinase signaling. Angiogenesis 2008; 11(1): 53-62.
    • (2008) Angiogenesis , vol.11 , Issue.1 , pp. 53-62
    • Cabrita, M.A.1    Christofori, G.2
  • 107
    • 20844461130 scopus 로고    scopus 로고
    • Ghrelin inhibits FGF-2- mediated angiogenesis in vitro and in vivo
    • Conconi MT, Nico B, Guidolin D, et al. Ghrelin inhibits FGF-2- mediated angiogenesis in vitro and in vivo. Peptides 2004; 25(12): 2179-85.
    • (2004) Peptides , vol.25 , Issue.12 , pp. 2179-2185
    • Conconi, M.T.1    Nico, B.2    Guidolin, D.3
  • 108
    • 0037033794 scopus 로고    scopus 로고
    • p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis
    • Matsumoto T, Turesson I, Book M, Gerwins P, Claesson-Welsh L. p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol 2002; 156(1): 149-60.
    • (2002) J Cell Biol , vol.156 , Issue.1 , pp. 149-160
    • Matsumoto, T.1    Turesson, I.2    Book, M.3    Gerwins, P.4    Claesson-Welsh, L.5
  • 109
  • 110
    • 0031425269 scopus 로고    scopus 로고
    • Phase I trial of orally administered pentosan polysulfate in patients with advanced cancer
    • Marshall JL, Wellstein A, Rae J, et al. Phase I trial of orally administered pentosan polysulfate in patients with advanced cancer. Clin Cancer Res 1997; 3(12 Pt 1): 2347-54.
    • (1997) Clin Cancer Res , vol.3 , Issue.12 PART 1 , pp. 2347-2354
    • Marshall, J.L.1    Wellstein, A.2    Rae, J.3
  • 111
    • 33645784293 scopus 로고    scopus 로고
    • The role of pentosan polysulfate in treatment approaches for interstitial cystitis
    • Teichman JMH. The role of pentosan polysulfate in treatment approaches for interstitial cystitis. Rev Urol 2002; 4 (Suppl 1): S21-7.
    • (2002) Rev Urol , vol.4 , Issue.SUPPL 1
    • Teichman, J.M.H.1
  • 112
    • 73349121657 scopus 로고    scopus 로고
    • Phase I trial of metastatic renal cell carcinoma with oral capecitabine and thalidomide
    • Kraemer A, Hauser S, Kim Y, et al. Phase I trial of metastatic renal cell carcinoma with oral capecitabine and thalidomide. Ger Med Sci 2009; 7: Doc04.
    • (2009) Ger Med Sci , vol.7
    • Kraemer, A.1    Hauser, S.2    Kim, Y.3
  • 113
    • 39649111093 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain
    • Margosio B, Rusnati M, Bonezzi K, et al. Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain. Int J Biochem Cell Biol 2008; 40(4): 700-9.
    • (2008) Int J Biochem Cell Biol , vol.40 , Issue.4 , pp. 700-709
    • Margosio, B.1    Rusnati, M.2    Bonezzi, K.3
  • 114
    • 77950551541 scopus 로고    scopus 로고
    • Non-peptidic thrombospondin- 1-mimics as fibroblast growth factor-2 inhibitors: An integrated strategy for the development of new antiangiogenic compounds
    • Colombo G, Margosio B, Ragona L, et al. Non-peptidic thrombospondin- 1-mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds. J Biol Chem 2010; 285(12): 8733-42.
    • (2010) J Biol Chem , vol.285 , Issue.12 , pp. 8733-8742
    • Colombo, G.1    Margosio, B.2    Ragona, L.3
  • 115
    • 2542604364 scopus 로고    scopus 로고
    • Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis
    • Rusnati M, Camozzi M, Moroni E, et al. Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis. Blood 2004; 104(1): 92-9.
    • (2004) Blood , vol.104 , Issue.1 , pp. 92-99
    • Rusnati, M.1    Camozzi, M.2    Moroni, E.3
  • 116
    • 70449389165 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 antagonist and antiangiogenic activity of long-pentraxin 3-derived synthetic peptides
    • Leali D, Alessi P, Coltrini D, Rusnati M, Zetta L, Presta M. Fibroblast growth factor-2 antagonist and antiangiogenic activity of long-pentraxin 3-derived synthetic peptides. Curr Pharm Des 2009; 15(30): 3577-89.
    • (2009) Curr Pharm Des , vol.15 , Issue.30 , pp. 3577-3589
    • Leali, D.1    Alessi, P.2    Coltrini, D.3    Rusnati, M.4    Zetta, L.5    Presta, M.6
  • 117
    • 67650753834 scopus 로고    scopus 로고
    • The role of the Angiopoietins in vascular morphogenesis
    • Thomas M, Augustin HG. The role of the Angiopoietins in vascular morphogenesis. Angiogenesis 2009; 12(2): 125-37.
    • (2009) Angiogenesis , vol.12 , Issue.2 , pp. 125-137
    • Thomas, M.1    Augustin, H.G.2
  • 118
    • 0036223819 scopus 로고    scopus 로고
    • Stable expression of angiopoietin-1 and other markers by cultured pericytes: Phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo
    • Sundberg C, Kowanetz M, Brown LF, Detmar M, Dvorak HF. Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo. Lab Invest 2002; 82(4): 387-401.
    • (2002) Lab Invest , vol.82 , Issue.4 , pp. 387-401
    • Sundberg, C.1    Kowanetz, M.2    Brown, L.F.3    Detmar, M.4    Dvorak, H.F.5
  • 119
    • 15144358851 scopus 로고    scopus 로고
    • Angiopoietin-2, a natural antagonist for Tie-2 that disrupts in vivo angiogenesis
    • Maisonpierre PC, Suri C, Jones PF, et al. Angiopoietin-2, a natural antagonist for Tie-2 that disrupts in vivo angiogenesis. Science 1997; 277(5322): 55-60.
    • (1997) Science , vol.277 , Issue.5322 , pp. 55-60
    • Maisonpierre, P.C.1    Suri, C.2    Jones, P.F.3
  • 120
    • 0035318510 scopus 로고    scopus 로고
    • Tie receptors: New modulators of angiogenic and lymphangiogenic responses
    • Jones N, Iljin K, Dumont DJ, Alitalo K. Tie receptors: new modulators of angiogenic and lymphangiogenic responses. Nat Rev Mol Cell Biol 2001; 2(4): 257-67.
    • (2001) Nat Rev Mol Cell Biol , vol.2 , Issue.4 , pp. 257-267
    • Jones, N.1    Iljin, K.2    Dumont, D.J.3    Alitalo, K.4
  • 121
    • 2442692715 scopus 로고    scopus 로고
    • The role of the angiopoietins in tumour angiogenesis growth factors
    • Plank MJ, Sleeman BD, Jones PF. The role of the angiopoietins in tumour angiogenesis growth factors. Growth Factors 2004; 22(1): 1-11.
    • (2004) Growth Factors , vol.22 , Issue.1 , pp. 1-11
    • Plank, M.J.1    Sleeman, B.D.2    Jones, P.F.3
  • 122
    • 2542453735 scopus 로고    scopus 로고
    • The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies
    • Fiedler U, Scharpfenecker M, Koidl S, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 2004; 103(11): 4150-6.
    • (2004) Blood , vol.103 , Issue.11 , pp. 4150-4156
    • Fiedler, U.1    Scharpfenecker, M.2    Koidl, S.3
  • 123
    • 33751225092 scopus 로고    scopus 로고
    • Angiopoietins: A link between angiogenesis and inflammation
    • Fiedler U, Augustin HG. Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol 2006; 27(12): 552-8.
    • (2006) Trends Immunol , vol.27 , Issue.12 , pp. 552-558
    • Fiedler, U.1    Augustin, H.G.2
  • 124
    • 64649084437 scopus 로고    scopus 로고
    • Angiopoietin2 is a partial agonist/antagonist of Tie2 signaling in the endothelium
    • Yuan HT, Khankin EV, Karumanchi SA, Parikh SM. Angiopoietin2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol 2009; 29(8): 2011-22.
    • (2009) Mol Cell Biol , vol.29 , Issue.8 , pp. 2011-2022
    • Yuan, H.T.1    Khankin, E.V.2    Karumanchi, S.A.3    Parikh, S.M.4
  • 125
    • 67349263020 scopus 로고    scopus 로고
    • A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis
    • Kim HZ, Jung K, Kim HM, Cheng Y, Koh GY. A designed angiopoietin-2 variant, pentameric COMP-Ang2, strongly activates Tie2 receptor and stimulates angiogenesis. Biochim Biophys Acta 2009; 1793(5): 772-80.
    • (2009) Biochim Biophys Acta , vol.1793 , Issue.5 , pp. 772-780
    • Kim, H.Z.1    Jung, K.2    Kim, H.M.3    Cheng, Y.4    Koh, G.Y.5
  • 126
    • 71349084180 scopus 로고    scopus 로고
    • Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface
    • Hansen TM, Singh H, Tahir TA, Brindle NP. Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface. Cell Signal 2010; 22(3): 527-32.
    • (2010) Cell Signal , vol.22 , Issue.3 , pp. 527-532
    • Hansen, T.M.1    Singh, H.2    Tahir, T.A.3    Brindle, N.P.4
  • 127
    • 34547103275 scopus 로고    scopus 로고
    • Angiopoietin: A TIE(d) balance in tumor angiogenesis
    • Shim WS, Ho IA, Wong PE. Angiopoietin: a TIE(d) balance in tumor angiogenesis. Mol Cancer Res 2007; 5(7): 655-65.
    • (2007) Mol Cancer Res , vol.5 , Issue.7 , pp. 655-665
    • Shim, W.S.1    Ho, I.A.2    Wong, P.E.3
  • 128
    • 27944463086 scopus 로고    scopus 로고
    • Angiogenesis in gliomas: Biology and molecular pathophysiology
    • Fischer I, Gagner JP, Law M, Newcomb EW, Zagzag D. Angiogenesis in gliomas: biology and molecular pathophysiology. Brain Pathol 2005; 15(4): 297-310.
    • (2005) Brain Pathol , vol.15 , Issue.4 , pp. 297-310
    • Fischer, I.1    Gagner, J.P.2    Law, M.3    Newcomb, E.W.4    Zagzag, D.5
  • 129
    • 33744458204 scopus 로고    scopus 로고
    • The dynamic roles of angiopoietins in tumor angiogenesis
    • Yu Q. The dynamic roles of angiopoietins in tumor angiogenesis. Future Oncol 2005; 1(4): 475-84.
    • (2005) Future Oncol , vol.1 , Issue.4 , pp. 475-484
    • Yu, Q.1
  • 130
    • 33847356573 scopus 로고    scopus 로고
    • Markers of angiogenesis and clinical features in patients with sarcoma
    • DuBois S, Demetri G. Markers of angiogenesis and clinical features in patients with sarcoma. Cancer 2007; 109(5): 813-9.
    • (2007) Cancer , vol.109 , Issue.5 , pp. 813-819
    • DuBois, S.1    Demetri, G.2
  • 131
    • 34447525629 scopus 로고    scopus 로고
    • Serum angiopoietin-2 as a clinical marker for lung cancer
    • Park JH, Park KJ, Kim YS, et al. Serum angiopoietin-2 as a clinical marker for lung cancer. Chest 2007; 132(1): 200-6.
    • (2007) Chest , vol.132 , Issue.1 , pp. 200-206
    • Park, J.H.1    Park, K.J.2    Kim, Y.S.3
  • 132
    • 63149188174 scopus 로고    scopus 로고
    • Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma
    • Helfrich I, Edler L, Sucker A, et al. Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma. Clin Cancer Res 2009; 15(4): 1384-92.
    • (2009) Clin Cancer Res , vol.15 , Issue.4 , pp. 1384-1392
    • Helfrich, I.1    Edler, L.2    Sucker, A.3
  • 133
    • 70350619207 scopus 로고    scopus 로고
    • Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer
    • Park JH, Choi H, Kim YB, et al. Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer. Lung Cancer 2009; 66(3): 359-64.
    • (2009) Lung Cancer , vol.66 , Issue.3 , pp. 359-364
    • Park, J.H.1    Choi, H.2    Kim, Y.B.3
  • 134
    • 74549172848 scopus 로고    scopus 로고
    • Angiopoietin-2 promotes disease progression of neuroendocrine tumors
    • Detjen KM, Rieke S, Deters A, et al. Angiopoietin-2 promotes disease progression of neuroendocrine tumors. Clin Cancer Res 2010; 16(2): 420-9.
    • (2010) Clin Cancer Res , vol.16 , Issue.2 , pp. 420-429
    • Detjen, K.M.1    Rieke, S.2    Deters, A.3
  • 135
    • 0038407310 scopus 로고    scopus 로고
    • Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
    • Stoeltzing O, Ahmad SA, Liu W, et al. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res 2003; 63(12): 3370-7.
    • (2003) Cancer Res , vol.63 , Issue.12 , pp. 3370-3377
    • Stoeltzing, O.1    Ahmad, S.A.2    Liu, W.3
  • 137
    • 66349133061 scopus 로고    scopus 로고
    • Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment
    • Holopainen T, Huang H, Chen C, et al. Angiopoietin-1 overexpression modulates vascular endothelium to facilitate tumor cell dissemination and metastasis establishment. Cancer Res 2009; 69(11): 4656-64.
    • (2009) Cancer Res , vol.69 , Issue.11 , pp. 4656-4664
    • Holopainen, T.1    Huang, H.2    Chen, C.3
  • 138
    • 4544290590 scopus 로고    scopus 로고
    • Angiopoietins in tumours: The angiogenic switch
    • Tait CR, Jones PF. Angiopoietins in tumours: the angiogenic switch. J Pathol 2004; 204(1): 1-10.
    • (2004) J Pathol , vol.204 , Issue.1 , pp. 1-10
    • Tait, C.R.1    Jones, P.F.2
  • 139
    • 73649112748 scopus 로고    scopus 로고
    • Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels
    • Falcón BL, Hashizume H, Koumoutsakos P, et al. Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol 2009; 175(5): 2159-70.
    • (2009) Am J Pathol , vol.175 , Issue.5 , pp. 2159-2170
    • Falcón, B.L.1    Hashizume, H.2    Koumoutsakos, P.3
  • 140
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler F, Kozin SV, Tong RT, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004; 6(6): 553-63.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.T.3
  • 141
    • 60749124285 scopus 로고    scopus 로고
    • Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade
    • Huang J, Bae JO, Tsai JP, et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol 2009; 34(1): 79-87.
    • (2009) Int J Oncol , vol.34 , Issue.1 , pp. 79-87
    • Huang, J.1    Bae, J.O.2    Tsai, J.P.3
  • 142
    • 65549129693 scopus 로고    scopus 로고
    • Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases
    • Singh H, Milner CS, Aguilar Hernandez MM, Patel N, Brindle NP. Vascular endothelial growth factor activates the Tie family of receptor tyrosine kinases. Cell Signal 2009; 21(8): 1346-50.
    • (2009) Cell Signal , vol.21 , Issue.8 , pp. 1346-1350
    • Singh, H.1    Milner, C.S.2    Aguilar Hernandez, M.M.3    Patel, N.4    Brindle, N.P.5
  • 143
    • 20544468428 scopus 로고    scopus 로고
    • Angioarrestin: A unique angiopoietin-related protein with anti-angiogenic properties
    • Dhanabal M, Jeffers M, LaRochelle WJ, Lichenstein HS. Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties. Biochem Biophys Res Commun 2005; 333(2): 308-15.
    • (2005) Biochem Biophys Res Commun , vol.333 , Issue.2 , pp. 308-315
    • Dhanabal, M.1    Jeffers, M.2    LaRochelle, W.J.3    Lichenstein, H.S.4
  • 144
    • 73949105871 scopus 로고    scopus 로고
    • A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models
    • Brown JL, Cao ZA, Pinzon-Ortiz M, et al. A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models. Mol Cancer Ther 2010; 9(1): 145-56.
    • (2010) Mol Cancer Ther , vol.9 , Issue.1 , pp. 145-156
    • Brown, J.L.1    Cao, Z.A.2    Pinzon-Ortiz, M.3
  • 145
    • 74549166057 scopus 로고    scopus 로고
    • Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: Studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release
    • Reikvam H, Hatfield KJ, Lassalle P, Kittang AO, Ersvaer E, Bruserud Ø.Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release. Expert Opin Investig Drugs 2010; 19(2): 169-83.
    • (2010) Expert Opin Investig Drugs , vol.19 , Issue.2 , pp. 169-183
    • Reikvam, H.1    Hatfield, K.J.2    Lassalle, P.3    Kittang, A.O.4    Ersvaer, E.5    Bruserud, O.6
  • 146
    • 70249114453 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
    • Herbst RS, Hong D, Chap L, et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol 2009; 27(21): 3557-65.
    • (2009) J Clin Oncol , vol.27 , Issue.21 , pp. 3557-3565
    • Herbst, R.S.1    Hong, D.2    Chap, L.3
  • 147
    • 0038544202 scopus 로고    scopus 로고
    • Platelet-derived growth factor signaling and human cancer
    • Yu J, Ustach C, Kim HR. Platelet-derived growth factor signaling and human cancer. J Biochem Mol Biol 2003; 36(1): 49-59.
    • (2003) J Biochem Mol Biol , vol.36 , Issue.1 , pp. 49-59
    • Yu, J.1    Ustach, C.2    Kim, H.R.3
  • 148
    • 44149090296 scopus 로고    scopus 로고
    • Role of platelet-derived growth factors in physiology and medicine
    • Andrae J, Gallini R, Betsholtz C. Role of platelet-derived growth factors in physiology and medicine. Genes Dev 2008; 22(10): 1276-312.
    • (2008) Genes Dev , vol.22 , Issue.10 , pp. 1276-1312
    • Andrae, J.1    Gallini, R.2    Betsholtz, C.3
  • 149
    • 0034989658 scopus 로고    scopus 로고
    • Developmental roles of platelet- derived growth factors
    • Betsholtz C, Karlsson L, Lindahl P. Developmental roles of platelet- derived growth factors. Bioessays 2001; 23(6): 494-507.
    • (2001) Bioessays , vol.23 , Issue.6 , pp. 494-507
    • Betsholtz, C.1    Karlsson, L.2    Lindahl, P.3
  • 150
    • 0035015517 scopus 로고    scopus 로고
    • Pericytes: Cell biology and pathology
    • Allt G, Lawrenson JG. Pericytes: cell biology and pathology. Cells Tissues Organs 2001; 169(1): 1-11.
    • (2001) Cells Tissues Organs , vol.169 , Issue.1 , pp. 1-11
    • Allt, G.1    Lawrenson, J.G.2
  • 151
    • 33745069947 scopus 로고    scopus 로고
    • Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents
    • Holash J, Thurston G, Rudge JS, et al. Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents. Cancer Metastasis Rev 2006; 25(2): 243-52.
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.2 , pp. 243-252
    • Holash, J.1    Thurston, G.2    Rudge, J.S.3
  • 152
    • 57649135172 scopus 로고    scopus 로고
    • A role for VEGF as a negative regulator of pericyte function and vessel maturation
    • Greenberg JI, Shields DJ, Barillas SG, et al. A role for VEGF as a negative regulator of pericyte function and vessel maturation. Nature 2008; 456(7223): 809-13.
    • (2008) Nature , vol.456 , Issue.7223 , pp. 809-813
    • Greenberg, J.I.1    Shields, D.J.2    Barillas, S.G.3
  • 153
    • 0036124520 scopus 로고    scopus 로고
    • Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    • Morikawa S, Baluk P, Kaidoh T, Haskell A, Jain RK, McDonald DM. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol 2002; 160(3): 985-1000.
    • (2002) Am J Pathol , vol.160 , Issue.3 , pp. 985-1000
    • Morikawa, S.1    Baluk, P.2    Kaidoh, T.3    Haskell, A.4    Jain, R.K.5    McDonald, D.M.6
  • 154
    • 27644557532 scopus 로고    scopus 로고
    • The role of pericytes in blood-vessel formation and maintenance
    • Bergers G, Song S. The role of pericytes in blood-vessel formation and maintenance. Neuro Oncol 2005; 7(4): 452-64.
    • (2005) Neuro Oncol , vol.7 , Issue.4 , pp. 452-464
    • Bergers, G.1    Song, S.2
  • 155
    • 30944446883 scopus 로고    scopus 로고
    • Lessons from phase III clinical trials on anti-VEGF therapy for cancer
    • Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol 2006; 3(1): 24-40.
    • (2006) Nat Clin Pract Oncol , vol.3 , Issue.1 , pp. 24-40
    • Jain, R.K.1    Duda, D.G.2    Clark, J.W.3    Loeffler, J.S.4
  • 156
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003; 111(9): 1287-95.
    • (2003) J Clin Invest , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 157
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R, Thurnher A, Katsen AD, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004; 18(2): 338-40.
    • (2004) FASEB J , vol.18 , Issue.2 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 158
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-ß regulate pericyte recruitment and influence vascular pattern formation in tumors
    • Abramsson A, Lindblom P, Betsholtz C. Endothelial and nonendothelial sources of PDGF-ß regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 2003; 112(8): 1142-51.
    • (2003) J Clin Invest , vol.112 , Issue.8 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 159
    • 33745271860 scopus 로고    scopus 로고
    • Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer
    • Kim SJ, Uehara H, Yazici S, et al. Targeting platelet-derived growth factor receptor on endothelial cells of multidrug-resistant prostate cancer. J Natl Cancer Inst 2006; 98(11): 783-93.
    • (2006) J Natl Cancer Inst , vol.98 , Issue.11 , pp. 783-793
    • Kim, S.J.1    Uehara, H.2    Yazici, S.3
  • 160
    • 38849202330 scopus 로고    scopus 로고
    • Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    • Pietras K, Pahler J, Bergers G, Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med 2008; 5(1): e19.
    • (2008) PLoS Med , vol.5 , Issue.1
    • Pietras, K.1    Pahler, J.2    Bergers, G.3    Hanahan, D.4
  • 161
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y, Kasman I, Yu L, et al. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009; 15(1): 21-34.
    • (2009) Cancer Cell , vol.15 , Issue.1 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3
  • 162
    • 65249183165 scopus 로고    scopus 로고
    • PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
    • di Tomaso E, London N, Fuja D, et al. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS One 2009; 4(4): e5123.
    • (2009) PLoS One , vol.4 , Issue.4
    • di Tomaso, E.1    London, N.2    Fuja, D.3
  • 163
    • 35848970974 scopus 로고    scopus 로고
    • Playing only one instrument may be not enough: Limitations and future of the antiangiogenic treatment of cancer
    • Quesada AR, Medina MA, Alba E. Playing only one instrument may be not enough: limitations and future of the antiangiogenic treatment of cancer. Bioessays 2007; 29(11): 1159-68.
    • (2007) Bioessays , vol.29 , Issue.11 , pp. 1159-1168
    • Quesada, A.R.1    Medina, M.A.2    Alba, E.3
  • 164
    • 0027528783 scopus 로고
    • Scatter factor induces blood vessel formation in vivo
    • Grant DS, Kleinman HK, Goldberg ID, et al. Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci USA 1993; 90(5): 1937-41.
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.5 , pp. 1937-1941
    • Grant, D.S.1    Kleinman, H.K.2    Goldberg, I.D.3
  • 166
    • 27644543354 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis
    • Abounader R, Laterra J. Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis. Neuro Oncol 2005; 7(4): 436-51.
    • (2005) Neuro Oncol , vol.7 , Issue.4 , pp. 436-451
    • Abounader, R.1    Laterra, J.2
  • 168
    • 14644399898 scopus 로고    scopus 로고
    • Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells
    • Uruno A, Sugawara A, Kanatsuka H, et al. Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells. Hypertens Res 2004; 27(11): 887-95.
    • (2004) Hypertens Res , vol.27 , Issue.11 , pp. 887-895
    • Uruno, A.1    Sugawara, A.2    Kanatsuka, H.3
  • 169
    • 0035793091 scopus 로고    scopus 로고
    • Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
    • Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 2001; 98(1): 247-52.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.1 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3    Mitsuuchi, Y.4    Vande Woude, G.F.5    Testa, J.R.6
  • 170
    • 13944276728 scopus 로고    scopus 로고
    • Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer
    • Ma PC, Jagadeeswaran R, Jagadeesh S, et al. Functional expression and mutations of c-Met and its therapeutic inhibition with SU11274 and small interfering RNA in non-small cell lung cancer. Cancer Res 2005; 65(4): 1479-88.
    • (2005) Cancer Res , vol.65 , Issue.4 , pp. 1479-1488
    • Ma, P.C.1    Jagadeeswaran, R.2    Jagadeesh, S.3
  • 171
    • 65249122512 scopus 로고    scopus 로고
    • Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
    • Eder JP, Vande Woude GF, Boerner SA, LoRusso PM. Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 2009; 15(7): 2207-14.
    • (2009) Clin Cancer Res , vol.15 , Issue.7 , pp. 2207-2214
    • Eder, J.P.1    Vande Woude, G.F.2    Boerner, S.A.3    LoRusso, P.M.4
  • 174
    • 0036188465 scopus 로고    scopus 로고
    • Modulation of the c- Met/hepatocyte growth factor pathway in small cell lung cancer
    • Maulik G, Kijima T, Ma PC, et al. Modulation of the c- Met/hepatocyte growth factor pathway in small cell lung cancer. Clin Cancer Res 2002; 8(2): 620-7.
    • (2002) Clin Cancer Res , vol.8 , Issue.2 , pp. 620-627
    • Maulik, G.1    Kijima, T.2    Ma, P.C.3
  • 175
    • 0031583998 scopus 로고    scopus 로고
    • HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor
    • Date K, Matsumoto K, Shimura H, Tanaka M, Nakamura T. HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett 1997; 420(1): 1-6.
    • (1997) FEBS Lett , vol.420 , Issue.1 , pp. 1-6
    • Date, K.1    Matsumoto, K.2    Shimura, H.3    Tanaka, M.4    Nakamura, T.5
  • 176
    • 34548561684 scopus 로고    scopus 로고
    • Pharmacokinetics and safety of a fully human hepatocyte growth factor antibody, AMG 102, in cynomolgus monkeys
    • Kakkar T, Ma M, Zhuang Y, Patton A, Hu Z, Mounho B. Pharmacokinetics and safety of a fully human hepatocyte growth factor antibody, AMG 102, in cynomolgus monkeys. Pharm Res 2007; 24(10): 1910-8.
    • (2007) Pharm Res , vol.24 , Issue.10 , pp. 1910-1918
    • Kakkar, T.1    Ma, M.2    Zhuang, Y.3    Patton, A.4    Hu, Z.5    Mounho, B.6
  • 177
    • 36749042647 scopus 로고    scopus 로고
    • AMG 102, a fully human antihepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts
    • Jun HT, Sun J, Rex K, et al. AMG 102, a fully human antihepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res 2007; 13(22 Pt 1): 6735-42.
    • (2007) Clin Cancer Res , vol.13 , Issue.22 PART 1 , pp. 6735-6742
    • Jun, H.T.1    Sun, J.2    Rex, K.3
  • 178
    • 33750683969 scopus 로고    scopus 로고
    • A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo
    • Martens T, Schmidt NO, Eckerich C, et al. A novel one-armed anti-c-Met antibody inhibits glioblastoma growth in vivo. Clin Cancer Res 2006; 12(20 Pt 1): 6144-52.
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART 1 , pp. 6144-6152
    • Martens, T.1    Schmidt, N.O.2    Eckerich, C.3
  • 179
    • 49249100382 scopus 로고    scopus 로고
    • MetMAb, the one-armed 5D5 antic- Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
    • Jin H, Yang R, Zheng Z, et al. MetMAb, the one-armed 5D5 antic- Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival. Cancer Res 2008; 68(11): 4360-8.
    • (2008) Cancer Res , vol.68 , Issue.11 , pp. 4360-4368
    • Jin, H.1    Yang, R.2    Zheng, Z.3
  • 180
    • 0034671686 scopus 로고    scopus 로고
    • Notch signaling: From the outside in
    • Mumm JS, Kopan R. Notch signaling: from the outside in. Dev Biol 2000; 228(2): 151-65.
    • (2000) Dev Biol , vol.228 , Issue.2 , pp. 151-165
    • Mumm, J.S.1    Kopan, R.2
  • 181
    • 0034212710 scopus 로고    scopus 로고
    • Notch signaling is essential for vascular morphogenesis in mice
    • Krebs LT, Xue Y, Norton CR, et al. Notch signaling is essential for vascular morphogenesis in mice. Genes Dev 2000; 14(11): 1343-52.
    • (2000) Genes Dev , vol.14 , Issue.11 , pp. 1343-1352
    • Krebs, L.T.1    Xue, Y.2    Norton, C.R.3
  • 182
    • 8644290828 scopus 로고    scopus 로고
    • Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development
    • Gale NW, Dominguez MG, Noguera I, et al. Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci USA 2004; 101(45): 15949-54.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.45 , pp. 15949-15954
    • Gale, N.W.1    Dominguez, M.G.2    Noguera, I.3
  • 183
    • 5444242184 scopus 로고    scopus 로고
    • Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
    • Krebs LT, Shutter JR, Tanigaki K, Honjo T, Stark KL, Gridley T. Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev 2004; 18(20): 2469-73.
    • (2004) Genes Dev , vol.18 , Issue.20 , pp. 2469-2473
    • Krebs, L.T.1    Shutter, J.R.2    Tanigaki, K.3    Honjo, T.4    Stark, K.L.5    Gridley, T.6
  • 184
    • 33847635620 scopus 로고    scopus 로고
    • Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting
    • Lobov IB, Renard RA, Papadopoulos N, et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci USA 2007; 104(9): 3219-24.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.9 , pp. 3219-3224
    • Lobov, I.B.1    Renard, R.A.2    Papadopoulos, N.3
  • 185
    • 33847607880 scopus 로고    scopus 로고
    • The Notch ligand Deltalike4 negatively regulates endothelial tip cell formation and vessel branching
    • Suchting S, Freitas C, le Noble F, et al. The Notch ligand Deltalike4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci USA 2007; 104(9): 3225-30.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.9 , pp. 3225-3230
    • Suchting, S.1    Freitas, C.2    le Noble, F.3
  • 186
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL. Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 2005; 65(19): 8690-7.
    • (2005) Cancer Res , vol.65 , Issue.19 , pp. 8690-8697
    • Patel, N.S.1    Li, J.L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 187
    • 33749012860 scopus 로고    scopus 로고
    • The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions
    • Hainaud P, Contrerès JO, Villemain A, et al. The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. Cancer Res 2006; 66(17): 8501-10.
    • (2006) Cancer Res , vol.66 , Issue.17 , pp. 8501-8510
    • Hainaud, P.1    Contrerès, J.O.2    Villemain, A.3
  • 188
    • 33845907380 scopus 로고    scopus 로고
    • Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
    • Ridgway J, Zhang G, Wu Y, et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 2006; 444(7122): 1083-7.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1083-1087
    • Ridgway, J.1    Zhang, G.2    Wu, Y.3
  • 189
    • 33845642740 scopus 로고    scopus 로고
    • Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate
    • Diez H, Fischer A, Winkler A, et al. Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res 2007; 313(1): 1-9.
    • (2007) Exp Cell Res , vol.313 , Issue.1 , pp. 1-9
    • Diez, H.1    Fischer, A.2    Winkler, A.3
  • 190
    • 33847046849 scopus 로고    scopus 로고
    • Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
    • Hellström M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 2007; 445(7129): 776-80.
    • (2007) Nature , vol.445 , Issue.7129 , pp. 776-780
    • Hellström, M.1    Phng, L.K.2    Hofmann, J.J.3
  • 191
    • 35349012675 scopus 로고    scopus 로고
    • Regulation of vascular morphogenesis by Notch signaling
    • Roca C, Adams RH. Regulation of vascular morphogenesis by Notch signaling. Genes Dev 2007; 21(20): 2511-24.
    • (2007) Genes Dev , vol.21 , Issue.20 , pp. 2511-2524
    • Roca, C.1    Adams, R.H.2
  • 192
    • 58249094059 scopus 로고    scopus 로고
    • Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis
    • Phng LK, Potente M, Leslie JD, et al. Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell 2009; 16(1): 70-82.
    • (2009) Dev Cell , vol.16 , Issue.1 , pp. 70-82
    • Phng, L.K.1    Potente, M.2    Leslie, J.D.3
  • 193
    • 0035753241 scopus 로고    scopus 로고
    • Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis
    • Mailhos C, Modlich U, Lewis J, Harris A, Bicknell R, Ish-Horowicz D. Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 2001; 69(2-3): 135-44.
    • (2001) Differentiation , vol.69 , Issue.2-3 , pp. 135-144
    • Mailhos, C.1    Modlich, U.2    Lewis, J.3    Harris, A.4    Bicknell, R.5    Ish-Horowicz, D.6
  • 194
    • 33845877157 scopus 로고    scopus 로고
    • Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis
    • Noguera-Troise I, Daly C, Papadopoulos NJ, et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature 2006; 444(7122): 1032-7.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1032-1037
    • Noguera-Troise, I.1    Daly, C.2    Papadopoulos, N.J.3
  • 195
    • 34247479498 scopus 로고    scopus 로고
    • Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion
    • Scehnet JS, Jiang W, Kumar SR, et al. Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood 2007; 109(11): 4753-60.
    • (2007) Blood , vol.109 , Issue.11 , pp. 4753-4760
    • Scehnet, J.S.1    Jiang, W.2    Kumar, S.R.3
  • 196
    • 53849106782 scopus 로고    scopus 로고
    • VEGF and Delta-Notch: Interacting signalling pathways in tumour angiogenesis
    • Thurston G, Kitajewski J. VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer 2008; 99(8): 1204-9.
    • (2008) Br J Cancer , vol.99 , Issue.8 , pp. 1204-1209
    • Thurston, G.1    Kitajewski, J.2
  • 197
    • 33745092023 scopus 로고    scopus 로고
    • Notch signaling in the regulation of tumor angiogenesis
    • Rehman AO, Wang CY. Notch signaling in the regulation of tumor angiogenesis. Trends Cell Biol 2006; 16(6): 293-300.
    • (2006) Trends Cell Biol , vol.16 , Issue.6 , pp. 293-300
    • Rehman, A.O.1    Wang, C.Y.2
  • 198
    • 70350236531 scopus 로고    scopus 로고
    • Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties
    • Luistro L, He W, Smith M, et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res 2009; 69(19): 7672-80.
    • (2009) Cancer Res , vol.69 , Issue.19 , pp. 7672-7680
    • Luistro, L.1    He, W.2    Smith, M.3
  • 199
    • 63849310246 scopus 로고    scopus 로고
    • Crosstalk of VEGF and Notch pathways in tumour angiogenesis: Therapeutic implications
    • Li JL, Harris AL. Crosstalk of VEGF and Notch pathways in tumour angiogenesis: therapeutic implications. Front Biosci 2009; 14: 3094-110.
    • (2009) Front Biosci , vol.14 , pp. 3094-3110
    • Li, J.L.1    Harris, A.L.2
  • 200
    • 34548535783 scopus 로고    scopus 로고
    • Anti-Dll4 therapy: Can we block tumour growth by increasing angiogenesis?
    • Sainson RC, Harris AL. Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis? Trends Mol Med 2007; 13(9): 389-95.
    • (2007) Trends Mol Med , vol.13 , Issue.9 , pp. 389-395
    • Sainson, R.C.1    Harris, A.L.2
  • 201
    • 67649998366 scopus 로고    scopus 로고
    • MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice
    • Bonauer A, Carmona G, Iwasaki M, et al. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 2009; 324(5935): 1710-3.
    • (2009) Science , vol.324 , Issue.5935 , pp. 1710-1713
    • Bonauer, A.1    Carmona, G.2    Iwasaki, M.3
  • 202
    • 57349138859 scopus 로고    scopus 로고
    • Hypertension and proteinuria: A classeffect of antiangiogenic therapies
    • Launay-Vacher V, Deray G. Hypertension and proteinuria: a classeffect of antiangiogenic therapies. Anticancer Drugs 2009; 20(1): 81-2.
    • (2009) Anticancer Drugs , vol.20 , Issue.1 , pp. 81-82
    • Launay-Vacher, V.1    Deray, G.2
  • 203
    • 27944456516 scopus 로고    scopus 로고
    • Managing patients treated with bevacizumab combination therapy
    • Gordon MS, Cunningham D. Managing patients treated with bevacizumab combination therapy. Oncology 2005; 69 (Suppl 3): 25-33.
    • (2005) Oncology , vol.69 , Issue.SUPPL 3 , pp. 25-33
    • Gordon, M.S.1    Cunningham, D.2
  • 204
    • 34047219240 scopus 로고    scopus 로고
    • Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer
    • Grothey A. Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer. Oncology (Williston Park) 2006; 20(14 Suppl 10): 21-8.
    • (2006) Oncology (Williston Park) , vol.20 , Issue.14 SUPPL 10 , pp. 21-28
    • Grothey, A.1
  • 205
    • 33750344252 scopus 로고    scopus 로고
    • Bevacizumab in the treatment of metastatic colorectal cancer: Safety profile and management of adverse events
    • Hurwitz H, Saini S. Bevacizumab in the treatment of metastatic colorectal cancer: safety profile and management of adverse events. Semin Oncol 2006; 33(5 Suppl 10): S26-34.
    • (2006) Semin Oncol , vol.33 , Issue.5 SUPPL 10
    • Hurwitz, H.1    Saini, S.2
  • 206
    • 33845313345 scopus 로고    scopus 로고
    • The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review
    • Eskens FA, Verweij J. The clinical toxicity profile of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors; a review. Eur J Cancer 2006; 42(18): 3127-39.
    • (2006) Eur J Cancer , vol.42 , Issue.18 , pp. 3127-3139
    • Eskens, F.A.1    Verweij, J.2
  • 207
    • 70349972023 scopus 로고    scopus 로고
    • Neurological adverse effects caused by cytotoxic and targeted therapies
    • Schiff D, Wen PY, van den Bent MJ. Neurological adverse effects caused by cytotoxic and targeted therapies. Nat Rev Clin Oncol 2009; 6(10): 596-603.
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.10 , pp. 596-603
    • Schiff, D.1    Wen, P.Y.2    van den Bent, M.J.3
  • 208
    • 62949129110 scopus 로고    scopus 로고
    • Intricacies of bevacizumab-induced toxicities and their management
    • Gressett SM, Shah SR. Intricacies of bevacizumab-induced toxicities and their management. Ann Pharmacother 2009; 43(3): 490-501.
    • (2009) Ann Pharmacother , vol.43 , Issue.3 , pp. 490-501
    • Gressett, S.M.1    Shah, S.R.2
  • 209
    • 66949140795 scopus 로고    scopus 로고
    • Understanding and managing the possible adverse effects associated with bevacizumab
    • Shord SS, Bressler LR, Tierney LA, Cuellar S, George A. Understanding and managing the possible adverse effects associated with bevacizumab. Am J Health Syst Pharm 2009; 66(11): 999-1013.
    • (2009) Am J Health Syst Pharm , vol.66 , Issue.11 , pp. 999-1013
    • Shord, S.S.1    Bressler, L.R.2    Tierney, L.A.3    Cuellar, S.4    George, A.5
  • 210
    • 77952531028 scopus 로고    scopus 로고
    • Conjugation of bevacizumab to cationic liposomes enhances their tumor-targeting potential
    • Kuesters GM, Campbell RB. Conjugation of bevacizumab to cationic liposomes enhances their tumor-targeting potential. Nanomedicine (Lond) 2010; 5(2): 181-92.
    • (2010) Nanomedicine (Lond) , vol.5 , Issue.2 , pp. 181-192
    • Kuesters, G.M.1    Campbell, R.B.2
  • 211
    • 38549085315 scopus 로고    scopus 로고
    • Incidence and risk of hypertension with sorafenib in patients with cancer: A systematic review and meta-analysis
    • Wu S, Chen JJ, Kudelka A, Lu J, Zhu X. Incidence and risk of hypertension with sorafenib in patients with cancer: a systematic review and meta-analysis. Lancet Oncol 2008; 9(2): 117-23.
    • (2008) Lancet Oncol , vol.9 , Issue.2 , pp. 117-123
    • Wu, S.1    Chen, J.J.2    Kudelka, A.3    Lu, J.4    Zhu, X.5
  • 212
    • 58149098429 scopus 로고    scopus 로고
    • Risk of hypertension and renal dysfunction with an angiogenesis inhibitor sunitinib: Systematic review and meta-analysis
    • Zhu X, Stergiopoulos K, Wu S. Risk of hypertension and renal dysfunction with an angiogenesis inhibitor sunitinib: systematic review and meta-analysis Acta Oncol 2009; 48(1): 9-17.
    • (2009) Acta Oncol , vol.48 , Issue.1 , pp. 9-17
    • Zhu, X.1    Stergiopoulos, K.2    Wu, S.3
  • 214
    • 58149345018 scopus 로고    scopus 로고
    • Dermatologic symptoms associated with the multikinase inhibitor sorafenib
    • Robert C, Mateus C, Spatz A, Wechsler J, Escudier B. Dermatologic symptoms associated with the multikinase inhibitor sorafenib. J Am Acad Dermatol 2009; 60(2): 299-305.
    • (2009) J Am Acad Dermatol , vol.60 , Issue.2 , pp. 299-305
    • Robert, C.1    Mateus, C.2    Spatz, A.3    Wechsler, J.4    Escudier, B.5
  • 215
    • 52949128348 scopus 로고    scopus 로고
    • Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib
    • Lacouture ME, Wu S, Robert C, et al. Evolving strategies for the management of hand-foot skin reaction associated with the multitargeted kinase inhibitors sorafenib and sunitinib. Oncologist 2008; 13(9): 1001-11.
    • (2008) Oncologist , vol.13 , Issue.9 , pp. 1001-1011
    • Lacouture, M.E.1    Wu, S.2    Robert, C.3
  • 216
    • 67650173972 scopus 로고    scopus 로고
    • Hypothyroidism related to tyrosine kinase inhibitors: An emerging toxic effect of targeted therapy
    • Torino F, Corsello SM, Longo R, Barnabei A, Gasparini G. Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy. Nat Rev Clin Oncol 2009; 6(4): 219-28.
    • (2009) Nat Rev Clin Oncol , vol.6 , Issue.4 , pp. 219-228
    • Torino, F.1    Corsello, S.M.2    Longo, R.3    Barnabei, A.4    Gasparini, G.5
  • 217
    • 74249091926 scopus 로고    scopus 로고
    • Costs of managing adverse events in the treatment of first-line metastatic renal cell carcinoma: Bevacizumab in combination with interferon-alpha2a compared with sunitinib
    • Mickisch G, Gore M, Escudier B, Procopio G, Walzer S, Nuijten M. Costs of managing adverse events in the treatment of first-line metastatic renal cell carcinoma: bevacizumab in combination with interferon-alpha2a compared with sunitinib. Br J Cancer 2010; 102(1): 80-6.
    • (2010) Br J Cancer , vol.102 , Issue.1 , pp. 80-86
    • Mickisch, G.1    Gore, M.2    Escudier, B.3    Procopio, G.4    Walzer, S.5    Nuijten, M.6
  • 218
    • 0031443206 scopus 로고    scopus 로고
    • A cancer therapy resistant to resistance
    • Kerbel, RS. A cancer therapy resistant to resistance. Nature 1997; 390(6658): 335-6.
    • (1997) Nature , vol.390 , Issue.6658 , pp. 335-336
    • Kerbel, R.S.1
  • 219
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • Boehm T, Folkman J, Browder T, O'Reilly MS. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997; 390(6658): 404-7.
    • (1997) Nature , vol.390 , Issue.6658 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 220
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008; 8(8): 592-603.
    • (2008) Nat Rev Cancer , vol.8 , Issue.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 221
    • 43549094700 scopus 로고    scopus 로고
    • New therapeutic directions for advanced pancreatic cancer: Targeting the epidermal growth factor and vascular endothelial growth factor pathways
    • Burris H 3rd, Rocha-Lima C. New therapeutic directions for advanced pancreatic cancer: targeting the epidermal growth factor and vascular endothelial growth factor pathways. Oncologist 2008; 13(3): 289-98.
    • (2008) Oncologist , vol.13 , Issue.3 , pp. 289-298
    • Burris III, H.1    Rocha-Lima, C.2
  • 222
    • 0037251744 scopus 로고    scopus 로고
    • Resistance in the antiangiogenic era: Nay-saying or a word of caution?
    • Sweeney CJ, Miller KD, Sledge GW Jr. Resistance in the antiangiogenic era: nay-saying or a word of caution? Trends Mol Med 2003; 9(1): 24-9.
    • (2003) Trends Mol Med , vol.9 , Issue.1 , pp. 24-29
    • Sweeney, C.J.1    Miller, K.D.2    Sledge Jr., G.W.3
  • 223
    • 55949096784 scopus 로고    scopus 로고
    • Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies
    • Shojaei F, Ferrara N. Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies. Drug Resist Updat 2008; 11(6): 219-30.
    • (2008) Drug Resist Updat , vol.11 , Issue.6 , pp. 219-230
    • Shojaei, F.1    Ferrara, N.2
  • 224
    • 67349129399 scopus 로고    scopus 로고
    • Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies
    • Rapisarda A, Melillo G. Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies. Drug Resist Updat 2009; 12(3): 74-80.
    • (2009) Drug Resist Updat , vol.12 , Issue.3 , pp. 74-80
    • Rapisarda, A.1    Melillo, G.2
  • 225
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in latestage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, Hanahan D. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in latestage pancreatic islet tumors. Cancer Cell 2005; 8(4): 299-309.
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 226
    • 34547346812 scopus 로고    scopus 로고
    • Challenges of antiangiogenic cancer therapy: Trials and errors, and renewed hope
    • Medina MA, Muñoz-Chápuli R, Quesada AR. Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope. J Cell Mol Med 2007; 11(3): 374-82.
    • (2007) J Cell Mol Med , vol.11 , Issue.3 , pp. 374-382
    • Medina, M.A.1    Muñoz-Chápuli, R.2    Quesada, A.R.3
  • 227
    • 60649106195 scopus 로고    scopus 로고
    • Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis
    • Pàez-Ribes M, Allen E, Hudock J, et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 2009; 15(3): 220-31.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 220-231
    • Pàez-Ribes, M.1    Allen, E.2    Hudock, J.3
  • 228
    • 60649087564 scopus 로고    scopus 로고
    • Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis
    • Ebos JM, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG, Kerbel RS. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 2009; 15(3): 232-9.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 232-239
    • Ebos, J.M.1    Lee, C.R.2    Cruz-Munoz, W.3    Bjarnason, G.A.4    Christensen, J.G.5    Kerbel, R.S.6
  • 229
    • 60649116477 scopus 로고    scopus 로고
    • Silencing or fueling metastasis with VEGF inhibitors: Antiangiogenesis revisited
    • Loges S, Mazzone M, Hohensinner P, Carmeliet P. Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisited. Cancer Cell 2009; 15(3): 167-70.
    • (2009) Cancer Cell , vol.15 , Issue.3 , pp. 167-170
    • Loges, S.1    Mazzone, M.2    Hohensinner, P.3    Carmeliet, P.4
  • 230
    • 0035865363 scopus 로고    scopus 로고
    • Redefining the target: Chemotherapeutics as antiangiogenics
    • Miller KD, Sweeney CJ, Sledge GW Jr. Redefining the target: chemotherapeutics as antiangiogenics. J Clin Oncol 2001; 19(4): 1195-206.
    • (2001) J Clin Oncol , vol.19 , Issue.4 , pp. 1195-1206
    • Miller, K.D.1    Sweeney, C.J.2    Sledge Jr., G.W.3
  • 231
    • 23844483271 scopus 로고    scopus 로고
    • Cyclophosphamidemethotrexate 'metronomic' chemotherapy for the palliative treatment of metastatic breast cancer. A comparative pharmacoeconomic evaluation
    • Bocci G, Tuccori M, Emmenegger U, et al. Cyclophosphamidemethotrexate 'metronomic' chemotherapy for the palliative treatment of metastatic breast cancer. A comparative pharmacoeconomic evaluation. Ann Oncol 2005; 16(8): 1243-52.
    • (2005) Ann Oncol , vol.16 , Issue.8 , pp. 1243-1252
    • Bocci, G.1    Tuccori, M.2    Emmenegger, U.3
  • 232
    • 33745976468 scopus 로고    scopus 로고
    • Current status of angiogenesis inhibitors combined with radiation therapy
    • Nieder C, Wiedenmann N, Andratschke N, Molls M. Current status of angiogenesis inhibitors combined with radiation therapy. Cancer Treat Rev 2006; 32(5): 348-64.
    • (2006) Cancer Treat Rev , vol.32 , Issue.5 , pp. 348-364
    • Nieder, C.1    Wiedenmann, N.2    Andratschke, N.3    Molls, M.4
  • 233
    • 33748869678 scopus 로고    scopus 로고
    • Pathophysiologic effects of vasculartargeting agents and the implications for combination with conventional therapies
    • Horsman MR, Siemann DW. Pathophysiologic effects of vasculartargeting agents and the implications for combination with conventional therapies. Cancer Res 2006; 66(24): 11520-39.
    • (2006) Cancer Res , vol.66 , Issue.24 , pp. 11520-11539
    • Horsman, M.R.1    Siemann, D.W.2
  • 234
    • 58149179239 scopus 로고    scopus 로고
    • The interaction of radiation therapy and antiangiogenic therapy
    • O'Reilly MS. The interaction of radiation therapy and antiangiogenic therapy. Cancer J 2008; 14(4): 207-13.
    • (2008) Cancer J , vol.14 , Issue.4 , pp. 207-213
    • O'Reilly, M.S.1
  • 235
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 2006; 312(5777): 1171-5.
    • (2006) Science , vol.312 , Issue.5777 , pp. 1171-1175
    • Kerbel, R.S.1
  • 236
    • 0036252329 scopus 로고    scopus 로고
    • Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model
    • Jung YD, Mansfield PF, Akagi M, et al. Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model. Eur J Cancer 2002; 38(8): 1133-40.
    • (2002) Eur J Cancer , vol.38 , Issue.8 , pp. 1133-1140
    • Jung, Y.D.1    Mansfield, P.F.2    Akagi, M.3
  • 237
    • 20344374749 scopus 로고    scopus 로고
    • Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and docetaxel in a human prostate cancer PC-3 model
    • Muramaki M, Miyake H, Hara I, Kamidono S. Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and docetaxel in a human prostate cancer PC-3 model. Int J Oncol 2005; 26(3): 623-8.
    • (2005) Int J Oncol , vol.26 , Issue.3 , pp. 623-628
    • Muramaki, M.1    Miyake, H.2    Hara, I.3    Kamidono, S.4
  • 238
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001; 7(9): 987-9.
    • (2001) Nat Med , vol.7 , Issue.9 , pp. 987-989
    • Jain, R.K.1
  • 239
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005; 307(5706): 58-62.
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 240
    • 35748970483 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization
    • Fukumura D, Jain RK. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res 2007; 74(2-3): 72-84.
    • (2007) Microvasc Res , vol.74 , Issue.2-3 , pp. 72-84
    • Fukumura, D.1    Jain, R.K.2
  • 241
    • 62749193771 scopus 로고    scopus 로고
    • Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature
    • Wu J, Long Q, Xu S, Padhani AR. Study of tumor blood perfusion and its variation due to vascular normalization by anti-angiogenic therapy based on 3D angiogenic microvasculature. J Biomech 2009; 42(6): 712-21.
    • (2009) J Biomech , vol.42 , Issue.6 , pp. 712-721
    • Wu, J.1    Long, Q.2    Xu, S.3    Padhani, A.R.4
  • 243
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai T, Mancuso M, Hashizume H, et al. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004; 165(1): 35-52.
    • (2004) Am J Pathol , vol.165 , Issue.1 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3
  • 244
    • 32944478893 scopus 로고    scopus 로고
    • Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors
    • Nakahara T, Norberg SM, Shalinsky DR, Hu-Lowe DD, McDonald DM. Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors. Cancer Res 2006; 66(3): 1434-45.
    • (2006) Cancer Res , vol.66 , Issue.3 , pp. 1434-1445
    • Nakahara, T.1    Norberg, S.M.2    Shalinsky, D.R.3    Hu-Lowe, D.D.4    McDonald, D.M.5
  • 245
    • 40949141801 scopus 로고    scopus 로고
    • Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide
    • Zhou Q, Guo P, Gallo JM. Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res 2008; 14(5): 1540-9.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1540-1549
    • Zhou, Q.1    Guo, P.2    Gallo, J.M.3
  • 246
    • 35848934106 scopus 로고    scopus 로고
    • Supra-additive antitumor effect of sunitinib malate (SU11248, Sutent) combined with docetaxel. A new therapeutic perspective in hormone refractory prostate cancer
    • Guérin O, Formento P, Lo Nigro C, et al. Supra-additive antitumor effect of sunitinib malate (SU11248, Sutent) combined with docetaxel. A new therapeutic perspective in hormone refractory prostate cancer. J Cancer Res Clin Oncol 2008; 134(1): 51-7.
    • (2008) J Cancer Res Clin Oncol , vol.134 , Issue.1 , pp. 51-57
    • Guérin, O.1    Formento, P.2    Lo Nigro, C.3
  • 247
    • 57749092182 scopus 로고    scopus 로고
    • Combination of antiangiogenesis with chemotherapy for more effective cancer treatment
    • Ma J, Waxman DJ. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol Cancer Ther 2008; 7(12): 3670-84.
    • (2008) Mol Cancer Ther , vol.7 , Issue.12 , pp. 3670-3684
    • Ma, J.1    Waxman, D.J.2
  • 248
    • 49249113484 scopus 로고    scopus 로고
    • Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity
    • Azad NS, Posadas EM, Kwitkowski VE, et al. Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. J Clin Oncol 2008; 26(22): 3709-14.
    • (2008) J Clin Oncol , vol.26 , Issue.22 , pp. 3709-3714
    • Azad, N.S.1    Posadas, E.M.2    Kwitkowski, V.E.3
  • 249
    • 63149101547 scopus 로고    scopus 로고
    • Hand-foot skin reaction increases with cumulative sorafenib dose and with combination anti-vascular endothelial growth factor therapy
    • Azad NS, Aragon-Ching JB, Dahut WL, et al. Hand-foot skin reaction increases with cumulative sorafenib dose and with combination anti-vascular endothelial growth factor therapy. Clin Cancer Res 2009; 15(4): 1411-6.
    • (2009) Clin Cancer Res , vol.15 , Issue.4 , pp. 1411-1416
    • Azad, N.S.1    Aragon-Ching, J.B.2    Dahut, W.L.3
  • 250
    • 76349087360 scopus 로고    scopus 로고
    • Combination therapy: Intermittent sorafenib with bevacizumab yields activity and decreased toxicity
    • Lee JM, Sarosy GA, Annunziata CM, et al. Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity. Br J Cancer 2010; 102(3): 495-9.
    • (2010) Br J Cancer , vol.102 , Issue.3 , pp. 495-499
    • Lee, J.M.1    Sarosy, G.A.2    Annunziata, C.M.3
  • 251
    • 73449100517 scopus 로고    scopus 로고
    • Vascular endothelial growth factor plus epidermal growth factor receptor dual targeted therapy in metastatic colorectal cancer: Synergy or antagonism?
    • Marshall JL. Vascular endothelial growth factor plus epidermal growth factor receptor dual targeted therapy in metastatic colorectal cancer: Synergy or antagonism? J Oncol 2009; 2009: 937305.
    • (2009) J Oncol , vol.2009 , pp. 937305
    • Marshall, J.L.1
  • 252
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 2009; 27(5): 672-80.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 253
    • 71649094684 scopus 로고    scopus 로고
    • Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: A phase II study
    • Reardon DA, Desjardins A, Vredenburgh JJ, et al. Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. Br J Cancer 2009; 101(12): 1986-94.
    • (2009) Br J Cancer , vol.101 , Issue.12 , pp. 1986-1994
    • Reardon, D.A.1    Desjardins, A.2    Vredenburgh, J.J.3
  • 254
    • 64049095783 scopus 로고    scopus 로고
    • Novel agents for renal cell carcinoma require novel selection paradigms to optimise first-line therapy
    • Schmidinger M, Zielinski CC. Novel agents for renal cell carcinoma require novel selection paradigms to optimise first-line therapy. Cancer Treat Rev 2009; 35(3): 289-96.
    • (2009) Cancer Treat Rev , vol.35 , Issue.3 , pp. 289-296
    • Schmidinger, M.1    Zielinski, C.C.2
  • 255
    • 46949084994 scopus 로고    scopus 로고
    • Medscape. Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: Tools or decorations?
    • Sessa C, Guibal A, Del Conte G, Rüegg C; Medscape. Biomarkers of angiogenesis for the development of antiangiogenic therapies in oncology: tools or decorations? Nat Clin Pract Oncol 2008; 5(7): 378-91.
    • (2008) Nat Clin Pract Oncol , vol.5 , Issue.7 , pp. 378-391
    • Sessa, C.1    Guibal, A.2    del Conte, G.3    Rüegg, C.4
  • 256
    • 67651005852 scopus 로고    scopus 로고
    • Good and bad news for an antiangiogenic
    • Honey K. Good and bad news for an antiangiogenic. J Clin Invest 2009; 119(6): 1400.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1400
    • Honey, K.1
  • 257
    • 33746548452 scopus 로고    scopus 로고
    • Predicting benefit from anti-angiogenic agents in malignancy
    • Jubb AM, Oates AJ, Holden S, Koeppen H. Predicting benefit from anti-angiogenic agents in malignancy. Nat Rev Cancer 2006; 6(8): 626-35.
    • (2006) Nat Rev Cancer , vol.6 , Issue.8 , pp. 626-635
    • Jubb, A.M.1    Oates, A.J.2    Holden, S.3    Koeppen, H.4
  • 258
    • 5044226920 scopus 로고    scopus 로고
    • The role of imaging in the clinical development of antiangiogenic agents
    • Morgan B, Horsfield MA, Steward WP. The role of imaging in the clinical development of antiangiogenic agents. Hematol Oncol Clin North Am 2004; 18(5): 1183-206.
    • (2004) Hematol Oncol Clin North Am , vol.18 , Issue.5 , pp. 1183-1206
    • Morgan, B.1    Horsfield, M.A.2    Steward, W.P.3
  • 260
    • 33846168055 scopus 로고    scopus 로고
    • Targeted in vivo imaging of angiogenesis: Present status and perspectives
    • Choe YS, Lee KH. Targeted in vivo imaging of angiogenesis: present status and perspectives. Curr Pharm Des 2007; 13(1): 17-31.
    • (2007) Curr Pharm Des , vol.13 , Issue.1 , pp. 17-31
    • Choe, Y.S.1    Lee, K.H.2
  • 261
    • 35148855707 scopus 로고    scopus 로고
    • Molecular imaging can accelerate anti-angiogenic drug development and testing
    • Iagaru A, Chen X, Gambhir SS. Molecular imaging can accelerate anti-angiogenic drug development and testing. Nat Clin Pract Oncol 2007; 4(10): 556-7.
    • (2007) Nat Clin Pract Oncol , vol.4 , Issue.10 , pp. 556-557
    • Iagaru, A.1    Chen, X.2    Gambhir, S.S.3
  • 262
    • 73649131641 scopus 로고    scopus 로고
    • Radionuclide imaging of tumor angiogenesis
    • Dijkgraaf I, Boerman OC. Radionuclide imaging of tumor angiogenesis. Cancer Biother Radiopharm 2009; 24(6): 637-47.
    • (2009) Cancer Biother Radiopharm , vol.24 , Issue.6 , pp. 637-647
    • Dijkgraaf, I.1    Boerman, O.C.2
  • 264
    • 38149006909 scopus 로고    scopus 로고
    • Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
    • Gao D, Nolan DJ, Mellick AS, Bambino K, McDonnell K, Mittal V. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 2008; 319(5860): 195-8.
    • (2008) Science , vol.319 , Issue.5860 , pp. 195-198
    • Gao, D.1    Nolan, D.J.2    Mellick, A.S.3    Bambino, K.4    McDonnell, K.5    Mittal, V.6
  • 265
    • 74849085724 scopus 로고    scopus 로고
    • Role of endothelial progenitor cells in breast cancer angiogenesis: From fundamental research to clinical ramifications
    • Le Bourhis X, Romon R, Hondermarck H. Role of endothelial progenitor cells in breast cancer angiogenesis: from fundamental research to clinical ramifications. Breast Cancer Res Treat 2010; 120(1): 17-24.
    • (2010) Breast Cancer Res Treat , vol.120 , Issue.1 , pp. 17-24
    • Le Bourhis, X.1    Romon, R.2    Hondermarck, H.3
  • 266
    • 33750286135 scopus 로고    scopus 로고
    • The multifaceted circulating endothelial cell in cancer: Towards marker and target identification
    • Bertolini F, Shaked Y, Mancuso P, Kerbel RS. The multifaceted circulating endothelial cell in cancer: towards marker and target identification. Nat Rev Cancer 2006; 6(11): 835-45.
    • (2006) Nat Rev Cancer , vol.6 , Issue.11 , pp. 835-845
    • Bertolini, F.1    Shaked, Y.2    Mancuso, P.3    Kerbel, R.S.4
  • 267
    • 19944432454 scopus 로고    scopus 로고
    • Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: Implications for cellular surrogate marker analysis of antiangiogenesis
    • Shaked Y, Bertolini F, Man S, et al. Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis: implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell 2005; 7(1): 101-11.
    • (2005) Cancer Cell , vol.7 , Issue.1 , pp. 101-111
    • Shaked, Y.1    Bertolini, F.2    Man, S.3
  • 268
    • 33846880876 scopus 로고    scopus 로고
    • Biomarkers for monitoring antiangiogenic therapy
    • Bhatt RS, Seth P, Sukhatme VP. Biomarkers for monitoring antiangiogenic therapy. Clin Cancer Res 2007; 3(2 Pt 2): 777s- 780s.
    • (2007) Clin Cancer Res , vol.3 , Issue.2 PART 2
    • Bhatt, R.S.1    Seth, P.2    Sukhatme, V.P.3
  • 269
    • 0031766152 scopus 로고    scopus 로고
    • Occular neovascularization: An epidemiological review
    • Lee P, Wang CC, Adamis AP. Occular neovascularization: an epidemiological review. Surv Ophthalmol 1998; 43(3): 245-269.
    • (1998) Surv Ophthalmol , vol.43 , Issue.3 , pp. 245-269
    • Lee, P.1    Wang, C.C.2    Adamis, A.P.3
  • 271
    • 70350704800 scopus 로고    scopus 로고
    • Current molecular understanding and future treatment strategies for pathologic ocular neovascularization
    • Tolentino MJ. Current molecular understanding and future treatment strategies for pathologic ocular neovascularization. Curr Mol Med 2009; 9(8): 973-81.
    • (2009) Curr Mol Med , vol.9 , Issue.8 , pp. 973-981
    • Tolentino, M.J.1
  • 272
    • 33845251640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor biology: Clinical implications for ocular treatments
    • Bhisitkul RB. Vascular endothelial growth factor biology: clinical implications for ocular treatments. Br J Ophthalmol 2006; 90(12); 1542-7.
    • (2006) Br J Ophthalmol , vol.90 , Issue.12 , pp. 1542-1547
    • Bhisitkul, R.B.1
  • 273
    • 0028123090 scopus 로고
    • Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy
    • Adamis AP, Miller JW, Bernal MT, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994; 118(4): 445-50.
    • (1994) Am J Ophthalmol , vol.118 , Issue.4 , pp. 445-450
    • Adamis, A.P.1    Miller, J.W.2    Bernal, M.T.3
  • 274
    • 0036970074 scopus 로고    scopus 로고
    • Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion
    • Boyd SR, Zachary I, Chakravarthy U, et al. Correlation of increased vascular endothelial growth factor with neovascularization and permeability in ischemic central vein occlusion. Arch Ophthalmol 2002; 120(12): 1644-50.
    • (2002) Arch Ophthalmol , vol.120 , Issue.12 , pp. 1644-1650
    • Boyd, S.R.1    Zachary, I.2    Chakravarthy, U.3
  • 275
    • 33646256581 scopus 로고    scopus 로고
    • Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion
    • Noma H, Minamoto A, Funatsu H, et al. Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 2006; 244(3): 309-15.
    • (2006) Graefes Arch Clin Exp Ophthalmol , vol.244 , Issue.3 , pp. 309-315
    • Noma, H.1    Minamoto, A.2    Funatsu, H.3
  • 276
    • 0037900481 scopus 로고    scopus 로고
    • Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
    • Rakic JM, Lambert V, Devy L, et al. Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci 2003; 44(7): 3186-93.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , Issue.7 , pp. 3186-3193
    • Rakic, J.M.1    Lambert, V.2    Devy, L.3
  • 277
    • 70649094281 scopus 로고    scopus 로고
    • Neovascular age-related macular degeneration: Intraocular cytokines and growth factors and the influence of therapy with ranibizumab
    • Funk M, Karl D, Georgopoulos M, et al. Neovascular age-related macular degeneration: intraocular cytokines and growth factors and the influence of therapy with ranibizumab. Ophthalmology 2009; 116(12): 2393-9.
    • (2009) Ophthalmology , vol.116 , Issue.12 , pp. 2393-2399
    • Funk, M.1    Karl, D.2    Georgopoulos, M.3
  • 278
    • 62649161064 scopus 로고    scopus 로고
    • Intraocular concentrations of growth factors and cytokines in retinal vein occlusion and the effect of therapy with bevacizumab
    • Funk M, Kriechbaum K, Prager F, et al. Intraocular concentrations of growth factors and cytokines in retinal vein occlusion and the effect of therapy with bevacizumab. Invest Ophthalmol Vis Sci 2009; 50(3): 1025-32.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.3 , pp. 1025-1032
    • Funk, M.1    Kriechbaum, K.2    Prager, F.3
  • 279
    • 0028130747 scopus 로고
    • Mechanisms of retinal and choroidal neovascularization
    • D'Amore PA. Mechanisms of retinal and choroidal neovascularization. Invest Ophthalmol Vis Sci 1994; 35(12): 3974-9.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , Issue.12 , pp. 3974-3979
    • D'Amore, P.A.1
  • 280
    • 67649386575 scopus 로고    scopus 로고
    • Age-related macular degeneration: An immunologically driven disease
    • Nussenblatt RB, Liu B, Li Z. Age-related macular degeneration: an immunologically driven disease. Curr Opin Investig Drugs 2009; 10(5): 434-42.
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.5 , pp. 434-442
    • Nussenblatt, R.B.1    Liu, B.2    Li, Z.3
  • 281
    • 30044436689 scopus 로고    scopus 로고
    • A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165
    • Lee JH, Canny MD, De Erkenez A, et al. A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165. Proc Natl Acad Sci USA 2005; 102(52): 18902-7.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.52 , pp. 18902-18907
    • Lee, J.H.1    Canny, M.D.2    De Erkenez, A.3
  • 282
    • 33748474191 scopus 로고    scopus 로고
    • Evolving European guidance on the medical management of neovascular age related macular degeneration
    • Chakravarthy U, Soubrane G, Bandello F, et al. Evolving European guidance on the medical management of neovascular age related macular degeneration. Br J Ophthalmol 2006; 90(9): 1188-96.
    • (2006) Br J Ophthalmol , vol.90 , Issue.9 , pp. 1188-1196
    • Chakravarthy, U.1    Soubrane, G.2    Bandello, F.3
  • 283
    • 46949111802 scopus 로고    scopus 로고
    • Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: A systematic review and economic evaluation
    • Colquitt JL, Jones J, Tan SC, Takeda A, Clegg AJ, Price A. Ranibizumab and pegaptanib for the treatment of age-related macular degeneration: a systematic review and economic evaluation. Health Technol Assess 2008; 12(16): iii-iv, ix-201.
    • (2008) Health Technol Assess , vol.12 , Issue.16
    • Colquitt, J.L.1    Jones, J.2    Tan, S.C.3    Takeda, A.4    Clegg, A.J.5    Price, A.6
  • 284
    • 35549009324 scopus 로고    scopus 로고
    • The economic implications of the use of anti-vascular endothelial growth factor drugs in age-related macular degeneration
    • Azad R, Chandra P, Gupta R. The economic implications of the use of anti-vascular endothelial growth factor drugs in age-related macular degeneration. Indian J Ophthalmol 2007; 55(6): 441-3.
    • (2007) Indian J Ophthalmol , vol.55 , Issue.6 , pp. 441-443
    • Azad, R.1    Chandra, P.2    Gupta, R.3
  • 285
    • 33745386921 scopus 로고    scopus 로고
    • Intravitreal avastin: The low cost alternative to lucentis?
    • Rosenfeld PJ. Intravitreal avastin: the low cost alternative to lucentis? Am J Ophthalmol 2006; 142(1): 141-3.
    • (2006) Am J Ophthalmol , vol.142 , Issue.1 , pp. 141-143
    • Rosenfeld, P.J.1
  • 286
    • 34447519933 scopus 로고    scopus 로고
    • Clinical update: New treatments for age-related macular degeneration
    • Wong TY, Liew G, Mitchell P. Clinical update: new treatments for age-related macular degeneration. Lancet 2007; 370(9583): 204-6.
    • (2007) Lancet , vol.370 , Issue.9583 , pp. 204-206
    • Wong, T.Y.1    Liew, G.2    Mitchell, P.3
  • 287
    • 52949129894 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor pharmacotherapy for age-related macular degeneration: A report by the American Academy of Ophthalmology
    • Ip MS, Scott IU, Brown GC, et al. Anti-vascular endothelial growth factor pharmacotherapy for age-related macular degeneration: a report by the American Academy of Ophthalmology. Ophthalmology 2008; 115(10): 1837-46.
    • (2008) Ophthalmology , vol.115 , Issue.10 , pp. 1837-1846
    • Ip, M.S.1    Scott, I.U.2    Brown, G.C.3
  • 288
    • 57949094834 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study
    • Brown DM, Michels M, Kaiser PK, et al. Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: Two-year results of the ANCHOR study. Ophthalmology 2009; 116(1): 57-65.e5.
    • (2009) Ophthalmology , vol.116 , Issue.1
    • Brown, D.M.1    Michels, M.2    Kaiser, P.K.3
  • 289
    • 65549113426 scopus 로고    scopus 로고
    • Safety and efficacy of intravitreal anti- VEGF injections for age-related macular degeneration
    • Jeganathan VS, Verma N. Safety and efficacy of intravitreal anti- VEGF injections for age-related macular degeneration. Curr Opin Ophthalmol 2009; 20(3): 223-5.
    • (2009) Curr Opin Ophthalmol , vol.20 , Issue.3 , pp. 223-225
    • Jeganathan, V.S.1    Verma, N.2
  • 290
    • 65549162660 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration
    • Ciulla TA, Rosenfeld PJ. Antivascular endothelial growth factor therapy for neovascular age-related macular degeneration. Curr Opin Ophthalmol 2009; 20(3): 158-65.
    • (2009) Curr Opin Ophthalmol , vol.20 , Issue.3 , pp. 158-165
    • Ciulla, T.A.1    Rosenfeld, P.J.2
  • 291
    • 60849083238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor Trap-Eye for diabetic macular oedema
    • Kaiser PK. Vascular endothelial growth factor Trap-Eye for diabetic macular oedema. Br J Ophthalmol 2009; 93(2): 135-6.
    • (2009) Br J Ophthalmol , vol.93 , Issue.2 , pp. 135-136
    • Kaiser, P.K.1
  • 292
    • 70349330817 scopus 로고    scopus 로고
    • VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration
    • Dixon JA, Oliver SC, Olson JL, Mandava N. VEGF Trap-Eye for the treatment of neovascular age-related macular degeneration. Expert Opin Investig Drugs 2009; 18(10): 1573-80.
    • (2009) Expert Opin Investig Drugs , vol.18 , Issue.10 , pp. 1573-1580
    • Dixon, J.A.1    Oliver, S.C.2    Olson, J.L.3    Mandava, N.4
  • 294
    • 33846388442 scopus 로고    scopus 로고
    • A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents
    • Hosseini H, Nejabat M. A potential therapeutic strategy for inhibition of corneal neovascularization with new anti-VEGF agents. Med Hypotheses 2007; 68(4): 799-801.
    • (2007) Med Hypotheses , vol.68 , Issue.4 , pp. 799-801
    • Hosseini, H.1    Nejabat, M.2
  • 295
    • 73449096791 scopus 로고    scopus 로고
    • Effect of subconjuctival and intraocular bevacizumab injection on angiogenic gene expression levels in a mouse model of corneal neovascularization
    • Dratviman-Storobinsky O, Lubin BC, Hasanreisoglu M, Goldenberg-Cohen N. Effect of subconjuctival and intraocular bevacizumab injection on angiogenic gene expression levels in a mouse model of corneal neovascularization. Mol Vis 2009; 15: 2326-38.
    • (2009) Mol Vis , vol.15 , pp. 2326-2338
    • Dratviman-Storobinsky, O.1    Lubin, B.C.2    Hasanreisoglu, M.3    Goldenberg-Cohen, N.4
  • 296
    • 76749160293 scopus 로고    scopus 로고
    • Effect of subconjunctival and intraocular bevacizumab injections on corneal neovascularization in a mouse model
    • Avisar I, Weinberger D, Kremer I. Effect of subconjunctival and intraocular bevacizumab injections on corneal neovascularization in a mouse model. Curr Eye Res 2010; 35(2): 108-15.
    • (2010) Curr Eye Res , vol.35 , Issue.2 , pp. 108-115
    • Avisar, I.1    Weinberger, D.2    Kremer, I.3
  • 297
    • 70549086876 scopus 로고    scopus 로고
    • Proliferative retinopathies: Angiogenesis that blinds
    • Sapieha P, Hamel D, Shao Z, et al. Proliferative retinopathies: angiogenesis that blinds. Int J Biochem Cell Biol 2010; 42(1): 5-12.
    • (2010) Int J Biochem Cell Biol , vol.42 , Issue.1 , pp. 5-12
    • Sapieha, P.1    Hamel, D.2    Shao, Z.3
  • 299
    • 34948859043 scopus 로고    scopus 로고
    • Targeted pharmacotherapy of retinal diseases with ranibizumab
    • Campochiaro PA. Targeted pharmacotherapy of retinal diseases with ranibizumab. Drugs Today (Barc) 2007; 43(8): 529-37.
    • (2007) Drugs Today (Barc) , vol.43 , Issue.8 , pp. 529-537
    • Campochiaro, P.A.1
  • 301
    • 77950535778 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery
    • Li Z, Van Bergen T, Van de Veire S, et al. Inhibition of vascular endothelial growth factor reduces scar formation after glaucoma filtration surgery. Invest Ophthalmol Vis Sci 2009; 50(11): 5217-25.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.11 , pp. 5217-5225
    • Li, Z.1    Van Bergen, T.2    Van de Veire, S.3
  • 302
    • 67649949015 scopus 로고    scopus 로고
    • Postoperative use of bevacizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbit
    • Memarzadeh F, Varma R, Lin LT, et al. Postoperative use of bevacizumab as an antifibrotic agent in glaucoma filtration surgery in the rabbit. Invest Ophthalmol Vis Sci 2009; 50(7): 3233-7.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.7 , pp. 3233-3237
    • Memarzadeh, F.1    Varma, R.2    Lin, L.T.3
  • 303
    • 66149122289 scopus 로고    scopus 로고
    • Angiogenesis: Trabeculectomy and bevacizumab
    • Jue A. Angiogenesis: trabeculectomy and bevacizumab. Semin Ophthalmol 2009; 24(2): 122-5.
    • (2009) Semin Ophthalmol , vol.24 , Issue.2 , pp. 122-125
    • Jue, A.1
  • 304
    • 34548187262 scopus 로고    scopus 로고
    • Neovascular glaucoma
    • Hayreh SS. Neovascular glaucoma. Prog Retin Eye Res 2007; 26(5): 470-85.
    • (2007) Prog Retin Eye Res , vol.26 , Issue.5 , pp. 470-485
    • Hayreh, S.S.1
  • 305
    • 43549124122 scopus 로고    scopus 로고
    • Ocular complications associated with diabetes mellitus
    • quiz 58, 60
    • Watkinson S, Seewoodhary R. Ocular complications associated with diabetes mellitus. Nurs Stand 2008; 22(27): 51-7; quiz 58, 60.
    • (2008) Nurs Stand , vol.22 , Issue.27 , pp. 51-57
    • Watkinson, S.1    Seewoodhary, R.2
  • 306
    • 66149135266 scopus 로고    scopus 로고
    • Neovascular glaucoma: Etiology, diagnosis and prognosis
    • Shazly TA, Latina MA. Neovascular glaucoma: etiology, diagnosis and prognosis. Semin Ophthalmol 2009; 24(2): 113-21.
    • (2009) Semin Ophthalmol , vol.24 , Issue.2 , pp. 113-121
    • Shazly, T.A.1    Latina, M.A.2
  • 307
    • 34547483451 scopus 로고    scopus 로고
    • Bevacizumab (Avastin) for the treatment of neovascular glaucoma
    • Chilov MN, Grigg JR, Playfair TJ. Bevacizumab (Avastin) for the treatment of neovascular glaucoma. Clin Exp Ophthalmol 2007; 35(5): 494-6.
    • (2007) Clin Exp Ophthalmol , vol.35 , Issue.5 , pp. 494-496
    • Chilov, M.N.1    Grigg, J.R.2    Playfair, T.J.3
  • 308
    • 56249105395 scopus 로고    scopus 로고
    • Short-term intraocular pressure changes immediately after intravitreal injections of anti-vascular endothelial growth factor agents
    • Kim JE, Mantravadi AV, Hur EY, Covert DJ. Short-term intraocular pressure changes immediately after intravitreal injections of anti-vascular endothelial growth factor agents. Am J Ophthalmol 2008; 146(6): 930-4.e1.
    • (2008) Am J Ophthalmol , vol.146 , Issue.6
    • Kim, J.E.1    Mantravadi, A.V.2    Hur, E.Y.3    Covert, D.J.4
  • 309
    • 74549191872 scopus 로고    scopus 로고
    • Shortterm effect of intravitreal injection of Ranibizumab (Lucentis) on intraocular pressure
    • Gismondi M, Salati C, Salvetat ML, Zeppieri M, Brusini P. Shortterm effect of intravitreal injection of Ranibizumab (Lucentis) on intraocular pressure. J Glaucoma 2009; 18(9): 658-61.
    • (2009) J Glaucoma , vol.18 , Issue.9 , pp. 658-661
    • Gismondi, M.1    Salati, C.2    Salvetat, M.L.3    Zeppieri, M.4    Brusini, P.5
  • 310
    • 59849119842 scopus 로고    scopus 로고
    • Intracameral bevacizumab in the treatment of neovascular glaucoma and exudative retinal detachment after brachytherapy in choroidal melanoma
    • Vásquez LM, Somani S, Altomare F, Simpson ER. Intracameral bevacizumab in the treatment of neovascular glaucoma and exudative retinal detachment after brachytherapy in choroidal melanoma. Can J Ophthalmol 2009; 44(1): 106-7.
    • (2009) Can J Ophthalmol , vol.44 , Issue.1 , pp. 106-107
    • Vásquez, L.M.1    Somani, S.2    Altomare, F.3    Simpson, E.R.4
  • 311
    • 76649136646 scopus 로고    scopus 로고
    • Course of intraocular pressure after intravitreal injection of 0.05 mL ranibizumab (Lucentis)
    • Sharei V, Höhn F, Köhler T, Hattenbach LO, Mirshahi A. Course of intraocular pressure after intravitreal injection of 0.05 mL ranibizumab (Lucentis). Eur J Ophthalmol 2010; 20(1): 174-9.
    • (2010) Eur J Ophthalmol , vol.20 , Issue.1 , pp. 174-179
    • Sharei, V.1    Höhn, F.2    Köhler, T.3    Hattenbach, L.O.4    Mirshahi, A.5
  • 312
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407(6801): 249-57.
    • (2000) Nature , vol.407 , Issue.6801 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 314
    • 0035051834 scopus 로고    scopus 로고
    • Angiogenesis in the pathogenesis of inflammatory joint and lung diseases
    • Walsh DA, Pearson CI. Angiogenesis in the pathogenesis of inflammatory joint and lung diseases. Arthritis Res 2001; 3(3): 147-53.
    • (2001) Arthritis Res , vol.3 , Issue.3 , pp. 147-153
    • Walsh, D.A.1    Pearson, C.I.2
  • 315
    • 65549127738 scopus 로고    scopus 로고
    • The vasculature in rheumatoid arthritis: Cause or consequence?
    • Paleolog EM. The vasculature in rheumatoid arthritis: cause or consequence? Int J Exp Pathol 2009; 90(3): 249-61.
    • (2009) Int J Exp Pathol , vol.90 , Issue.3 , pp. 249-261
    • Paleolog, E.M.1
  • 316
    • 67649344520 scopus 로고    scopus 로고
    • Angiogenesis inhibitors for the treatment of chronic autoimmune inflammatory arthritis
    • Schoettler N, Brahn E. Angiogenesis inhibitors for the treatment of chronic autoimmune inflammatory arthritis. Curr Opin Investig Drugs 2009; 10(5): 425-33.
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.5 , pp. 425-433
    • Schoettler, N.1    Brahn, E.2
  • 317
    • 18144391498 scopus 로고    scopus 로고
    • Hypoxia and angiogenesis in rheumatoid arthritis
    • Taylor PC, Sivakumar B. Hypoxia and angiogenesis in rheumatoid arthritis. Curr Opin Rheumatol 2005; 17(3): 293-8.
    • (2005) Curr Opin Rheumatol , vol.17 , Issue.3 , pp. 293-298
    • Taylor, P.C.1    Sivakumar, B.2
  • 318
    • 0242335590 scopus 로고    scopus 로고
    • Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis
    • Giatromanolaki A, Sivridis E, Maltezos E, et al. Upregulated hypoxia inducible factor-1alpha and -2alpha pathway in rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 2003; 5(4): R193-201.
    • (2003) Arthritis Res Ther , vol.5 , Issue.4
    • Giatromanolaki, A.1    Sivridis, E.2    Maltezos, E.3
  • 319
    • 77149139874 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications
    • Westra J, Molema G, Kallenberg CG. Hypoxia-inducible factor-1 as regulator of angiogenesis in rheumatoid arthritis - therapeutic implications. Curr Med Chem 2009; 17(3): 254-63.
    • (2009) Curr Med Chem , vol.17 , Issue.3 , pp. 254-263
    • Westra, J.1    Molema, G.2    Kallenberg, C.G.3
  • 320
    • 0034671575 scopus 로고    scopus 로고
    • Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha / anti-CD4 therapy
    • Williams RO, Marinova-Mutafchieva L, Feldmann M, Maini RN. Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha / anti-CD4 therapy. J Immunol 2000; 165(12): 7240-5.
    • (2000) J Immunol , vol.165 , Issue.12 , pp. 7240-7245
    • Williams, R.O.1    Marinova-Mutafchieva, L.2    Feldmann, M.3    Maini, R.N.4
  • 321
    • 0034814370 scopus 로고    scopus 로고
    • Neutralization of vascular endothelial growth factor prevents collageninduced arthritis and ameliorates established disease in mice
    • Sone H, Kawakami Y, Sakauchi M, et al. Neutralization of vascular endothelial growth factor prevents collageninduced arthritis and ameliorates established disease in mice. Biochem Biophys Res Commun 2001; 281(2): 562-8.
    • (2001) Biochem Biophys Res Commun , vol.281 , Issue.2 , pp. 562-568
    • Sone, H.1    Kawakami, Y.2    Sakauchi, M.3
  • 322
    • 10744228170 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGFRII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis
    • De Bandt M, Ben Mahdi MH, Ollivier V, et al. Blockade of vascular endothelial growth factor receptor I (VEGF-RI), but not VEGFRII, suppresses joint destruction in the K/BxN model of rheumatoid arthritis. J Immunol 2003; 171(9): 4853-9.
    • (2003) J Immunol , vol.171 , Issue.9 , pp. 4853-4859
    • De Bandt, M.1    Ben Mahdi, M.H.2    Ollivier, V.3
  • 323
    • 59749103950 scopus 로고    scopus 로고
    • Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model
    • Choi ST, Kim JH, Seok JY, Park YB, Lee SK. Therapeutic effect of anti-vascular endothelial growth factor receptor I antibody in the established collagen-induced arthritis mouse model. Clin Rheumatol 2009; 28(3): 333-7.
    • (2009) Clin Rheumatol , vol.28 , Issue.3 , pp. 333-337
    • Choi, S.T.1    Kim, J.H.2    Seok, J.Y.3    Park, Y.B.4    Lee, S.K.5
  • 324
    • 1942453816 scopus 로고    scopus 로고
    • Angiogenesis inhibition by the novel VEGF receptor tyrosine kinase inhibitor, PTK787/ZK222584, causes significant anti-arthritic effects in models of rheumatoid arthritis
    • Grosios K, Wood J, Esser R, Raychaudhuri A, Dawson J. Angiogenesis inhibition by the novel VEGF receptor tyrosine kinase inhibitor, PTK787/ZK222584, causes significant anti-arthritic effects in models of rheumatoid arthritis. Inflamm Res 2004; 53(4): 133-42.
    • (2004) Inflamm Res , vol.53 , Issue.4 , pp. 133-142
    • Grosios, K.1    Wood, J.2    Esser, R.3    Raychaudhuri, A.4    Dawson, J.5
  • 325
    • 74849095453 scopus 로고    scopus 로고
    • Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis
    • Kong JS, Yoo SA, Kim JW, et al. Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis. Arthritis Rheum 2010; 62(1): 179-90.
    • (2010) Arthritis Rheum , vol.62 , Issue.1 , pp. 179-190
    • Kong, J.S.1    Yoo, S.A.2    Kim, J.W.3
  • 326
    • 4344623431 scopus 로고    scopus 로고
    • Angiogenesis in osteoarthritis and spondylosis: Successful repair with undesirable outcomes
    • Walsh DA. Angiogenesis in osteoarthritis and spondylosis: successful repair with undesirable outcomes. Curr Opin Rheumatol 2004; 16(5): 609-15.
    • (2004) Curr Opin Rheumatol , vol.16 , Issue.5 , pp. 609-615
    • Walsh, D.A.1
  • 327
    • 12344290643 scopus 로고    scopus 로고
    • Osteoarthritis, angiogenesis and inflammation
    • Bonnet CS, Walsh DA. Osteoarthritis, angiogenesis and inflammation. Rheumatology (Oxford) 2005; 44(1): 7-16.
    • (2005) Rheumatology (Oxford) , vol.44 , Issue.1 , pp. 7-16
    • Bonnet, C.S.1    Walsh, D.A.2
  • 328
    • 55249093872 scopus 로고    scopus 로고
    • Angiogenesis in osteoarthritis
    • Ashraf S, Walsh DA. Angiogenesis in osteoarthritis. Curr Opin Rheumatol 2008; 20(5): 573-80.
    • (2008) Curr Opin Rheumatol , vol.20 , Issue.5 , pp. 573-580
    • Ashraf, S.1    Walsh, D.A.2
  • 329
    • 56349097770 scopus 로고    scopus 로고
    • Application of angiogenesis to clinical dermatology
    • Fried LE, Arbiser JL. Application of angiogenesis to clinical dermatology. Adv Dermatol 2008; 24: 89-103.
    • (2008) Adv Dermatol , vol.24 , pp. 89-103
    • Fried, L.E.1    Arbiser, J.L.2
  • 330
    • 70350736092 scopus 로고    scopus 로고
    • Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis
    • Arbiser JL, Bonner MY, Berrios RL. Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis. Curr Mol Med 2009; 9(8): 929-34.
    • (2009) Curr Mol Med , vol.9 , Issue.8 , pp. 929-934
    • Arbiser, J.L.1    Bonner, M.Y.2    Berrios, R.L.3
  • 332
    • 0027980960 scopus 로고
    • Overexpression of vascular permeability factor/ vascular endothelial growth factor and its receptors in psoriasis
    • Detmar M, Brown LF, Claffey KP, et al. Overexpression of vascular permeability factor/ vascular endothelial growth factor and its receptors in psoriasis. J Exp Med 1994; 180(3): 1141-6.
    • (1994) J Exp Med , vol.180 , Issue.3 , pp. 1141-1146
    • Detmar, M.1    Brown, L.F.2    Claffey, K.P.3
  • 333
    • 0033387917 scopus 로고    scopus 로고
    • Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis
    • Bhushan M, McLaughlin B, Weiss JB, Griffiths CE. Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis. Br J Dermatol 1999; 141(6): 1054-60.
    • (1999) Br J Dermatol , vol.141 , Issue.6 , pp. 1054-1060
    • Bhushan, M.1    McLaughlin, B.2    Weiss, J.B.3    Griffiths, C.E.4
  • 334
    • 43049148701 scopus 로고    scopus 로고
    • Angiogenesis: The new potential target for the therapy of psoriasis?
    • Heidenreich R, Röcken M, Ghoreschi K. Angiogenesis: the new potential target for the therapy of psoriasis? Drug News Perspect 2008; 21(2): 97-105.
    • (2008) Drug News Perspect , vol.21 , Issue.2 , pp. 97-105
    • Heidenreich, R.1    Röcken, M.2    Ghoreschi, K.3
  • 335
    • 76049112722 scopus 로고    scopus 로고
    • Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: An approach of vascular development chronology in psoriasis
    • Henno A, Blacher S, Lambert CA, et al. Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: An approach of vascular development chronology in psoriasis. J Dermatol Sci 2010; 57(3): 162-169.
    • (2010) J Dermatol Sci , vol.57 , Issue.3 , pp. 162-169
    • Henno, A.1    Blacher, S.2    Lambert, C.A.3
  • 336
    • 71049114213 scopus 로고    scopus 로고
    • The role of angiogenesis in the pathogenesis of psoriasis
    • Chua RA, Arbiser JL. The role of angiogenesis in the pathogenesis of psoriasis. Autoimmunity 2009; 42(7): 574-9.
    • (2009) Autoimmunity , vol.42 , Issue.7 , pp. 574-579
    • Chua, R.A.1    Arbiser, J.L.2
  • 337
    • 33847279025 scopus 로고    scopus 로고
    • Pathogenesis and therapy of psoriasis
    • Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007; 445(7130): 866-73.
    • (2007) Nature , vol.445 , Issue.7130 , pp. 866-873
    • Lowes, M.A.1    Bowcock, A.M.2    Krueger, J.G.3
  • 338
    • 70349416933 scopus 로고    scopus 로고
    • Tetracycline actions relevant to rosacea treatment
    • Korting HC, Schöllmann C. Tetracycline actions relevant to rosacea treatment. Skin Pharmacol Physiol 2009; 22(6): 287-94.
    • (2009) Skin Pharmacol Physiol , vol.22 , Issue.6 , pp. 287-294
    • Korting, H.C.1    Schöllmann, C.2
  • 339
    • 0035675207 scopus 로고    scopus 로고
    • Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NFkappa B-dependent manner
    • Loewe R, Pillinger M, de Martin R, et al. Dimethylfumarate inhibits tumor-necrosis-factor-induced CD62E expression in an NFkappa B-dependent manner. J Invest Dermatol 2001; 117(6): 1363-8.
    • (2001) J Invest Dermatol , vol.117 , Issue.6 , pp. 1363-1368
    • Loewe, R.1    Pillinger, M.2    de Martin, R.3
  • 340
    • 76049107574 scopus 로고    scopus 로고
    • Topical application of antiangiogenic peptides based on pigment epithelium-derived factor can improve psoriasis
    • Abe R, Yamagishi SI, Fujita Y, et al. Topical application of antiangiogenic peptides based on pigment epithelium-derived factor can improve psoriasis. J Dermatol Sci 2010; 57(3): 183-191.
    • (2010) J Dermatol Sci , vol.57 , Issue.3 , pp. 183-191
    • Abe, R.1    Yamagishi, S.I.2    Fujita, Y.3
  • 341
    • 75849142549 scopus 로고    scopus 로고
    • Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis
    • Schonthaler HB, Huggenberger R, Wculek SK, Detmar M, Wagner EF. Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci USA 2009; 106(50): 21264-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.50 , pp. 21264-21269
    • Schonthaler, H.B.1    Huggenberger, R.2    Wculek, S.K.3    Detmar, M.4    Wagner, E.F.5
  • 342
    • 66449131988 scopus 로고    scopus 로고
    • Complete remission of psoriasis following bevacizumab therapy for colon cancer
    • Akman A, Yilmaz E, Mutlu H, Ozdogan M. Complete remission of psoriasis following bevacizumab therapy for colon cancer. Clin Exp Dermatol 2009; 34(5): e202-4.
    • (2009) Clin Exp Dermatol , vol.34 , Issue.5
    • Akman, A.1    Yilmaz, E.2    Mutlu, H.3    Ozdogan, M.4
  • 343
    • 2642545746 scopus 로고    scopus 로고
    • Emerging drugs for endometriosis
    • Fedele L, Berlanda N. Emerging drugs for endometriosis. Expert Opin Emerg Drugs 2004; 9(1): 167-77.
    • (2004) Expert Opin Emerg Drugs , vol.9 , Issue.1 , pp. 167-177
    • Fedele, L.1    Berlanda, N.2
  • 344
    • 59849120875 scopus 로고    scopus 로고
    • Mechanistic and therapeutic implications of angiogenesis in endometriosis
    • Taylor RN, Yu J, Torres PB, et al. Mechanistic and therapeutic implications of angiogenesis in endometriosis. Reprod Sci 2009; 16(2): 140-6.
    • (2009) Reprod Sci , vol.16 , Issue.2 , pp. 140-146
    • Taylor, R.N.1    Yu, J.2    Torres, P.B.3
  • 346
    • 35748942563 scopus 로고    scopus 로고
    • Angiogenesis and antiangiogenic therapy in endometriosis
    • Becker CM, D'Amato RJ. Angiogenesis and antiangiogenic therapy in endometriosis. Microvasc Res 2007; 74(2-3): 121-30.
    • (2007) Microvasc Res , vol.74 , Issue.2-3 , pp. 121-130
    • Becker, C.M.1    D'Amato, R.J.2
  • 347
    • 58149347223 scopus 로고    scopus 로고
    • Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity
    • Ledoux S, Queguiner I, Msika S, et al. Angiogenesis associated with visceral and subcutaneous adipose tissue in severe human obesity. Diabetes 2008; 57(12): 3247-57.
    • (2008) Diabetes , vol.57 , Issue.12 , pp. 3247-3257
    • Ledoux, S.1    Queguiner, I.2    Msika, S.3
  • 348
    • 42349093844 scopus 로고    scopus 로고
    • Angiogenesis and obesity
    • Lijnen HR. Angiogenesis and obesity. Cardiovasc Res 2008; 78(2): 286-93.
    • (2008) Cardiovasc Res , vol.78 , Issue.2 , pp. 286-293
    • Lijnen, H.R.1
  • 349
    • 75849165542 scopus 로고    scopus 로고
    • Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
    • Cao Y. Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases. Nat Rev Drug Discov 2010; 9(2): 107-15.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.2 , pp. 107-115
    • Cao, Y.1
  • 350
    • 73349141136 scopus 로고    scopus 로고
    • The role of hypoxia in atherosclerosis
    • Hultén LM, Levin M. The role of hypoxia in atherosclerosis. Curr Opin Lipidol 2009; 20(5): 409-14.
    • (2009) Curr Opin Lipidol , vol.20 , Issue.5 , pp. 409-414
    • Hultén, L.M.1    Levin, M.2
  • 351
    • 40849086607 scopus 로고    scopus 로고
    • Hypoxia, hypoxiainducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis
    • Sluimer JC, Gasc JM, van Wanroij JL, et al. Hypoxia, hypoxiainducible transcription factor, and macrophages in human atherosclerotic plaques are correlated with intraplaque angiogenesis. J Am Coll Cardiol 2008; 51(13): 1258-65.
    • (2008) J Am Coll Cardiol , vol.51 , Issue.13 , pp. 1258-1265
    • Sluimer, J.C.1    Gasc, J.M.2    van Wanroij, J.L.3
  • 352
    • 66749187756 scopus 로고    scopus 로고
    • Novel concepts in atherogenesis: Angiogenesis and hypoxia in atherosclerosis
    • Sluimer JC, Daemen MJ. Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol 2009; 218(1): 7-29.
    • (2009) J Pathol , vol.218 , Issue.1 , pp. 7-29
    • Sluimer, J.C.1    Daemen, M.J.2
  • 353
    • 52049095030 scopus 로고    scopus 로고
    • Angiogenesis and inflammation in carotid atherosclerosis
    • Krupinski J, Font A, Luque A, Turu M, Slevin M. Angiogenesis and inflammation in carotid atherosclerosis. Front Biosci 2008; 13: 6472-82.
    • (2008) Front Biosci , vol.13 , pp. 6472-6482
    • Krupinski, J.1    Font, A.2    Luque, A.3    Turu, M.4    Slevin, M.5


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