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Volumn 66, Issue 24, 2006, Pages 11520-11539

Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANGINEX; ANGIOSTATIN; ARGININE DEIMINASE; ARSENIC TRIOXIDE; BEVACIZUMAB; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4 PHOSPHATE; ENDOSTATIN; FUMAGILLOL CHLOROACETYLCARBAMATE; MITOFLAXONE; MN 029; MONOCLONAL ANTIBODY DC101; N ACETYLCOLCHINOL PHOSPHATE; NPI 2358; SEMAXANIB; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE; SU 11657; SU 5474; SUNITINIB; SURAMIN; THALIDOMIDE; THROMBOSPONDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULAR TARGETING AGENT; VASCULOTROPIN ANTIBODY; VATALANIB; VINCA ALKALOID;

EID: 33748869678     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2848     Document Type: Review
Times cited : (231)

References (261)
  • 1
    • 0017171175 scopus 로고
    • Prolonged tumor dormancy by prevention of neovascularization in the vitreous
    • Brem S, Brem H, Folkman J, Finkelstein D, Patz A. Prolonged tumor dormancy by prevention of neovascularization in the vitreous. Cancer Res 1976;36:2807-12.
    • (1976) Cancer Res , vol.36 , pp. 2807-2812
    • Brem, S.1    Brem, H.2    Folkman, J.3    Finkelstein, D.4    Patz, A.5
  • 2
    • 0022648938 scopus 로고
    • How is blood vessel growth regulated in normal and neoplastic tissue?
    • Folkman J. How is blood vessel growth regulated in normal and neoplastic tissue? Cancer Res 1986;46:467-73.
    • (1986) Cancer Res , vol.46 , pp. 467-473
    • Folkman, J.1
  • 3
    • 0033213978 scopus 로고    scopus 로고
    • Tumor development under angiogenic signaling: A dynamic theory of tumor growth, treatment response, and postvascular dormancy
    • Hahnfeldt P, Panigrahy D, Folkman J, Hlatky L. Tumor development under angiogenic signaling: a dynamic theory of tumor growth, treatment response, and postvascular dormancy. Cancer Res 1999;59:4770-5.
    • (1999) Cancer Res , vol.59 , pp. 4770-4775
    • Hahnfeldt, P.1    Panigrahy, D.2    Folkman, J.3    Hlatky, L.4
  • 4
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3:401-10.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 5
    • 33846210737 scopus 로고    scopus 로고
    • The role of microvasculature in metastasis formation
    • Siemann DW, editor, Chichester: John Wiley & Sons, Ltd
    • Stoeltzing O, Ellis LM. The role of microvasculature in metastasis formation. In: Siemann DW, editor. Vascular-targeted therapies in oncology. Chichester: John Wiley & Sons, Ltd.; 2006. p.31-62.
    • (2006) Vascular-targeted therapies in oncology , pp. 31-62
    • Stoeltzing, O.1    Ellis, L.M.2
  • 6
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989;49:6449-65.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 7
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol 2004;14:198-206.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 8
    • 0001836473 scopus 로고
    • A review of the influence of bacterial infection and bacterial products (Coley's toxins) on malignant tumours in man
    • Coley Nauts H, Fowler GA, Bogatko FH. A review of the influence of bacterial infection and bacterial products (Coley's toxins) on malignant tumours in man. Acta Med Scand 1953;274:29-97.
    • (1953) Acta Med Scand , vol.274 , pp. 29-97
    • Coley Nauts, H.1    Fowler, G.A.2    Bogatko, F.H.3
  • 9
    • 0000742387 scopus 로고
    • A critique of tumour resistance
    • Woglem WH. A critique of tumour resistance. J Cancer Res 1923;7:283-311.
    • (1923) J Cancer Res , vol.7 , pp. 283-311
    • Woglem, W.H.1
  • 10
    • 0026011103 scopus 로고
    • Angiogenic attack as a therapeutic strategy for cancer
    • Denekamp J, Hill S. Angiogenic attack as a therapeutic strategy for cancer. Radiother Oncol 1991;Suppl. 20:103-12.
    • (1991) Radiother Oncol , vol.20 , Issue.SUPPL. , pp. 103-112
    • Denekamp, J.1    Hill, S.2
  • 11
    • 0032880236 scopus 로고    scopus 로고
    • The tumour microcirculation as a target in cancer therapy: A clearer perspective
    • Denekamp J. The tumour microcirculation as a target in cancer therapy: a clearer perspective. Eur J Clin Invest 1999;29:733-6.
    • (1999) Eur J Clin Invest , vol.29 , pp. 733-736
    • Denekamp, J.1
  • 12
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004;4:423-36.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 13
    • 0038626211 scopus 로고    scopus 로고
    • Tumor response to radiotherapy regulated by endothelial cell apoptosis
    • Garcia-Barros M, Paris F, Cordon-Cardo C, et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003;300:1155-9.
    • (2003) Science , vol.300 , pp. 1155-1159
    • Garcia-Barros, M.1    Paris, F.2    Cordon-Cardo, C.3
  • 14
    • 0038176480 scopus 로고    scopus 로고
    • Tumor response to ionising radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms on interaction
    • Wachsberger P, Burd R, Dicker AP. Tumor response to ionising radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms on interaction. Clin Cancer Res 2003;9:1957-71.
    • (2003) Clin Cancer Res , vol.9 , pp. 1957-1971
    • Wachsberger, P.1    Burd, R.2    Dicker, A.P.3
  • 15
    • 12244292196 scopus 로고    scopus 로고
    • Differentiation and definition of vascular-targeted therapies
    • Siemann DW, Bibby MC, Dark GG, et al. Differentiation and definition of vascular-targeted therapies. Clin Cancer Res 2005;11:416-20.
    • (2005) Clin Cancer Res , vol.11 , pp. 416-420
    • Siemann, D.W.1    Bibby, M.C.2    Dark, G.G.3
  • 16
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003;9:669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 17
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003;9:677-84.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 18
    • 0036780251 scopus 로고    scopus 로고
    • Clinical translation of angiogenesis inhibitors
    • Kerbel R, Folkman J. Clinical translation of angiogenesis inhibitors. Nat Rev Cancer 2002;2:727-39.
    • (2002) Nat Rev Cancer , vol.2 , pp. 727-739
    • Kerbel, R.1    Folkman, J.2
  • 19
    • 0344874638 scopus 로고    scopus 로고
    • The impact of anti-angiogenic agents on cancer therapy
    • Marmé D. The impact of anti-angiogenic agents on cancer therapy. J Cancer Res Clin Oncol 2003;129:607-20.
    • (2003) J Cancer Res Clin Oncol , vol.129 , pp. 607-620
    • Marmé, D.1
  • 20
    • 0842329999 scopus 로고    scopus 로고
    • Angiogenesis inhibitors in clinical development; where are we now and where are we going?
    • Eskens FA. Angiogenesis inhibitors in clinical development; where are we now and where are we going? Br J Cancer 2004;90:1-7.
    • (2004) Br J Cancer , vol.90 , pp. 1-7
    • Eskens, F.A.1
  • 21
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 22
    • 33846199298 scopus 로고    scopus 로고
    • National Cancer Institute Web site
    • National Cancer Institute Web site: http://www. cancer.gov/ clinicaltrials.
  • 23
    • 0000020762 scopus 로고
    • Thermal radiosensitization in animal tumors: The potential for therapeutic gain
    • Urano M, Douple E, editors, Utrecht: VSP
    • Horsman MR, Overgaard J. Thermal radiosensitization in animal tumors: the potential for therapeutic gain. In: Urano M, Douple E, editors. Hyperthermia and oncology, vol. 2. Utrecht: VSP: 1985. p.113-45.
    • (1985) Hyperthermia and oncology , vol.2 , pp. 113-145
    • Horsman, M.R.1    Overgaard, J.2
  • 24
    • 0032773566 scopus 로고    scopus 로고
    • Tumour vasculature as a target for cancer therapy
    • Chaplin DJ, Dougherty GJ. Tumour vasculature as a target for cancer therapy. Br J Cancer 1999;80:57-64.
    • (1999) Br J Cancer , vol.80 , pp. 57-64
    • Chaplin, D.J.1    Dougherty, G.J.2
  • 25
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004;10:415-27.
    • (2004) Clin Cancer Res , vol.10 , pp. 415-427
    • Thorpe, P.E.1
  • 26
    • 2642571660 scopus 로고    scopus 로고
    • Vascular targeting therapies for treatment of malignant disease
    • Siemann DW, Chaplin DJ, Horsman MR. Vascular targeting therapies for treatment of malignant disease. Cancer 2004;100:2491-9.
    • (2004) Cancer , vol.100 , pp. 2491-2499
    • Siemann, D.W.1    Chaplin, D.J.2    Horsman, M.R.3
  • 27
    • 0037341637 scopus 로고    scopus 로고
    • Antivascular therapy of cancer: DMXAA
    • Baguley BC. Antivascular therapy of cancer: DMXAA. Lancet Oncol 2003;4:141-8.
    • (2003) Lancet Oncol , vol.4 , pp. 141-148
    • Baguley, B.C.1
  • 29
    • 0033883776 scopus 로고    scopus 로고
    • SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
    • Laird AD, Vajkoczy P, Shawver LK, et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res 2000;60:4152-60.
    • (2000) Cancer Res , vol.60 , pp. 4152-4160
    • Laird, A.D.1    Vajkoczy, P.2    Shawver, L.K.3
  • 30
    • 0029944122 scopus 로고    scopus 로고
    • Angiostatin induces and sustains dormancy of primary tumors in mice
    • O'Reilly MS, Holmgren L, Chn C, Folkman J. Angiostatin induces and sustains dormancy of primary tumors in mice. Nat Med 1996;2:689-92.
    • (1996) Nat Med , vol.2 , pp. 689-692
    • O'Reilly, M.S.1    Holmgren, L.2    Chn, C.3    Folkman, J.4
  • 31
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signalling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signalling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002;62:4645-55.
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 32
    • 0036891440 scopus 로고    scopus 로고
    • Combination of vascular targeting agents with thermal or radiation therapy
    • Horsman MR, Murata R. Combination of vascular targeting agents with thermal or radiation therapy. Int J Radiat Oncol Biol Phys 2002;54:1518-23.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 1518-1523
    • Horsman, M.R.1    Murata, R.2
  • 33
    • 17544397865 scopus 로고    scopus 로고
    • Vascular targeting of solid tumours: A major "inverse" volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas
    • Landuyt W, Verdoes O, Darius DO, et al. Vascular targeting of solid tumours: a major "inverse" volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas. Eur J Cancer 2000;36:1833-43.
    • (2000) Eur J Cancer , vol.36 , pp. 1833-1843
    • Landuyt, W.1    Verdoes, O.2    Darius, D.O.3
  • 34
  • 35
    • 20344394640 scopus 로고    scopus 로고
    • The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors
    • Siemann DW, Rojiani AM. The vascular disrupting agent ZD6126 shows increased antitumor efficacy and enhanced radiation response in large, advanced tumors. Int J Radiat Oncol Biol Phys 2005;62:846-53.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 846-853
    • Siemann, D.W.1    Rojiani, A.M.2
  • 36
    • 27744553032 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: Enhancing antitumor efficacy through combination treatment with ZD6126 and ZD6474
    • Shi W, Siemann DW. Targeting the tumor vasculature: enhancing antitumor efficacy through combination treatment with ZD6126 and ZD6474. In Vivo 2005;19:1045-50.
    • (2005) In Vivo , vol.19 , pp. 1045-1050
    • Shi, W.1    Siemann, D.W.2
  • 37
    • 0029087486 scopus 로고
    • Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic acid
    • Ching LM, Xu ZF, Gummer BH, Palmer BD, Joseph WR, Baguley BC. Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic acid. Br J Cancer 1995;72:339-43.
    • (1995) Br J Cancer , vol.72 , pp. 339-343
    • Ching, L.M.1    Xu, Z.F.2    Gummer, B.H.3    Palmer, B.D.4    Joseph, W.R.5    Baguley, B.C.6
  • 38
    • 0031846669 scopus 로고    scopus 로고
    • Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: Concomitant reduction of serum tumour necrosis factor-α and enhancement of anti-tumour activity
    • Ching LM, Browne WL, Tchernegovski R, Gregory T, Baguley BC, Palmer BD. Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of serum tumour necrosis factor-α and enhancement of anti-tumour activity. Br J Cancer 1998;78:336-43.
    • (1998) Br J Cancer , vol.78 , pp. 336-343
    • Ching, L.M.1    Browne, W.L.2    Tchernegovski, R.3    Gregory, T.4    Baguley, B.C.5    Palmer, B.D.6
  • 39
    • 0032895102 scopus 로고    scopus 로고
    • Thalidomide increases both intra-tumoural tumour necrosis factor-α production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid
    • Cao Z, Joseph WR, Browne WL, et al. Thalidomide increases both intra-tumoural tumour necrosis factor-α production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid. Br J Cancer 1999;80:716-23.
    • (1999) Br J Cancer , vol.80 , pp. 716-723
    • Cao, Z.1    Joseph, W.R.2    Browne, W.L.3
  • 40
    • 0034480074 scopus 로고    scopus 로고
    • Synergistic effect of the angiogenesis inhibitor TNP-470 and tumor necrosis factor (TNF) on Bomirski Ab melanoma in hamsters
    • Mysliwski A, Bigda J, Koszalka P, Szmit E. Synergistic effect of the angiogenesis inhibitor TNP-470 and tumor necrosis factor (TNF) on Bomirski Ab melanoma in hamsters. Anticancer Res 2000;20:4643-7.
    • (2000) Anticancer Res , vol.20 , pp. 4643-4647
    • Mysliwski, A.1    Bigda, J.2    Koszalka, P.3    Szmit, E.4
  • 41
    • 0035254653 scopus 로고    scopus 로고
    • In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
    • Landuyt W, Ahmed B, Nuyts S, et al. In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment. Int J Radiat Oncol Biol Phys 2001;49:443-50.
    • (2001) Int J Radiat Oncol Biol Phys , vol.49 , pp. 443-450
    • Landuyt, W.1    Ahmed, B.2    Nuyts, S.3
  • 42
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark N, Overgaard M, Overgaard J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother Oncol l996;41:31-9.
    • Radiother Oncol l996 , vol.41 , pp. 31-39
    • Nordsmark, N.1    Overgaard, M.2    Overgaard, J.3
  • 43
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
    • Brizel DM, Dodge RK, Clough RW, Dewhirst MW. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 1999;53:113-7.
    • (1999) Radiother Oncol , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3    Dewhirst, M.W.4
  • 44
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hoeckel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56:4509-15.
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hoeckel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 45
    • 0035917618 scopus 로고    scopus 로고
    • Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations
    • Nordsmark N, Alsner J, Keller J, et al. Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br J Cancer 2001;84:1070-5.
    • (2001) Br J Cancer , vol.84 , pp. 1070-1075
    • Nordsmark, N.1    Alsner, J.2    Keller, J.3
  • 46
    • 0034306974 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions
    • Lee C-G, Heijn M, di Tomaso E, et al. Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions. Cancer Res 2000;60:5565-70.
    • (2000) Cancer Res , vol.60 , pp. 5565-5570
    • Lee, C.-G.1    Heijn, M.2    di Tomaso, E.3
  • 47
    • 0043025225 scopus 로고    scopus 로고
    • Arginine deiminase and other anti-angiogenic agents inhibit unfavorable neuroblastoma growth: Potentiation by irradiation
    • Gong H, Pöttgen C, Stüben G, Havers W, Stuschke M, Schweigerer L. Arginine deiminase and other anti-angiogenic agents inhibit unfavorable neuroblastoma growth: potentiation by irradiation. Int J Cancer 2003;106:723-8.
    • (2003) Int J Cancer , vol.106 , pp. 723-728
    • Gong, H.1    Pöttgen, C.2    Stüben, G.3    Havers, W.4    Stuschke, M.5    Schweigerer, L.6
  • 48
    • 0037099598 scopus 로고    scopus 로고
    • PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging
    • Drevs J, Müller-Driver R, Wittig C, et al. PTK787/ZK 222584, a specific vascular endothelial growth factor-receptor tyrosine kinase inhibitor, affects the anatomy of the tumor vascular bed and the functional vascular properties as detected by dynamic enhanced magnetic resonance imaging. Cancer Res 2002;62:4015-22.
    • (2002) Cancer Res , vol.62 , pp. 4015-4022
    • Drevs, J.1    Müller-Driver, R.2    Wittig, C.3
  • 49
  • 50
    • 0034662621 scopus 로고    scopus 로고
    • Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2-blockade, hormone ablation, and chemotherapy
    • Hansen-Algenstaedt N, Stoll BR, Padera TP, et al. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2-blockade, hormone ablation, and chemotherapy. Cancer Res 2000;60:4556-60.
    • (2000) Cancer Res , vol.60 , pp. 4556-4560
    • Hansen-Algenstaedt, N.1    Stoll, B.R.2    Padera, T.P.3
  • 51
    • 12244252749 scopus 로고    scopus 로고
    • Gene therapy delivery of endostatin enhances the treatment efficacy of radiation
    • Shi W, Teschendorf C, Muzyczka N, Siemann DW. Gene therapy delivery of endostatin enhances the treatment efficacy of radiation. Radiother Oncol 2003;66:1-9.
    • (2003) Radiother Oncol , vol.66 , pp. 1-9
    • Shi, W.1    Teschendorf, C.2    Muzyczka, N.3    Siemann, D.W.4
  • 52
    • 17844374383 scopus 로고    scopus 로고
    • Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells
    • Dings RPM, Williams BW, Song CW, Griffioen AW, Mayo KH, Griffin RJ. Anginex synergizes with radiation therapy to inhibit tumor growth by radiosensitizing endothelial cells. Int J Cancer 2005;115:312-9.
    • (2005) Int J Cancer , vol.115 , pp. 312-319
    • Dings, R.P.M.1    Williams, B.W.2    Song, C.W.3    Griffioen, A.W.4    Mayo, K.H.5    Griffin, R.J.6
  • 53
    • 0034099423 scopus 로고    scopus 로고
    • Therapeutic synergy of TNP-470 and ionizing radiation: Effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts
    • Lund EL, Bastholm L, Kristjansen PEG. Therapeutic synergy of TNP-470 and ionizing radiation: effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenografts. Clin Cancer Res 2000;6:971-8.
    • (2000) Clin Cancer Res , vol.6 , pp. 971-978
    • Lund, E.L.1    Bastholm, L.2    Kristjansen, P.E.G.3
  • 54
    • 0035555907 scopus 로고    scopus 로고
    • Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth
    • Hess C, Vuong V, Hegyi I, et al. Effect of VEGF receptor inhibitor PTK787/ZK222548 combined with ionizing radiation on endothelial cells and tumour growth. Br J Cancer 2001;85:2010-6.
    • (2001) Br J Cancer , vol.85 , pp. 2010-2016
    • Hess, C.1    Vuong, V.2    Hegyi, I.3
  • 55
    • 0142217882 scopus 로고    scopus 로고
    • Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas
    • Fenton BM, Paoni SF, Grimwood BG, Ding I. Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas. Int J Radiat Oncol Biol Phys 2003;57:1038-46.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 1038-1046
    • Fenton, B.M.1    Paoni, S.F.2    Grimwood, B.G.3    Ding, I.4
  • 56
    • 0032804144 scopus 로고    scopus 로고
    • Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status
    • Bernsen HJJA, Rijken PFJW, Peters JPW, et al. Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status. J Neurooncol 1999;44:129-36.
    • (1999) J Neurooncol , vol.44 , pp. 129-136
    • Bernsen, H.J.J.A.1    Rijken, P.F.J.W.2    Peters, J.P.W.3
  • 57
    • 4143126815 scopus 로고    scopus 로고
    • Pathophysiological effects of vascular endothelial growth factor receptor-2-blocking antibody plus fractionated radiotherapy on murine mammary tumors
    • Fenton BM, Paoni SF, Ding I. Pathophysiological effects of vascular endothelial growth factor receptor-2-blocking antibody plus fractionated radiotherapy on murine mammary tumors. Cancer Res 2004;64:5712-9.
    • (2004) Cancer Res , vol.64 , pp. 5712-5719
    • Fenton, B.M.1    Paoni, S.F.2    Ding, I.3
  • 58
    • 0026638266 scopus 로고
    • Modifications of the volumetric growth response and steady-state hypoxic fractions of xenografted DLD-2 human colon carcinomas by administration of basic fibroblast growth factor or suramin
    • Leith JT, Papa G, Quaranto L, Michelson S. Modifications of the volumetric growth response and steady-state hypoxic fractions of xenografted DLD-2 human colon carcinomas by administration of basic fibroblast growth factor or suramin. Br J Cancer 1992;66:345-8.
    • (1992) Br J Cancer , vol.66 , pp. 345-348
    • Leith, J.T.1    Papa, G.2    Quaranto, L.3    Michelson, S.4
  • 59
    • 0030971274 scopus 로고    scopus 로고
    • An anti-angiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma
    • Murata R, Nishimura Y, Hiraoka M. An anti-angiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. Int J Radiat Oncol Biol Phys 1997;37:1107-13.
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 1107-1113
    • Murata, R.1    Nishimura, Y.2    Hiraoka, M.3
  • 60
    • 0037085933 scopus 로고    scopus 로고
    • Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response
    • Griffin RJ, Williams BW, Wild R, Cherrington JM, Park H, Song CW. Simultaneous inhibition of the receptor kinase activity of vascular endothelial, fibroblast, and platelet-derived growth factors suppresses tumor growth and enhances tumor radiation response. Cancer Res 2002;62:1702-6.
    • (2002) Cancer Res , vol.62 , pp. 1702-1706
    • Griffin, R.J.1    Williams, B.W.2    Wild, R.3    Cherrington, J.M.4    Park, H.5    Song, C.W.6
  • 61
    • 11144223542 scopus 로고    scopus 로고
    • ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity
    • Williams KJ, Telfer BA, Brave S, et al. ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity. Clin Cancer Res 2004;10:8587-93.
    • (2004) Clin Cancer Res , vol.10 , pp. 8587-8593
    • Williams, K.J.1    Telfer, B.A.2    Brave, S.3
  • 62
    • 0035132923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
    • Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res 2001;61:39-44.
    • (2001) Cancer Res , vol.61 , pp. 39-44
    • Kozin, S.V.1    Boucher, Y.2    Hicklin, D.J.3    Bohlen, P.4    Jain, R.K.5    Suit, H.D.6
  • 63
    • 0029069833 scopus 로고
    • Influence of an anti-angiogenic treatment on 9L gliosarcoma: Oxygenation and response to cytotoxic therapy
    • Teicher BA, Holden SA, Ara G, et al. Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy. Int J Cancer 1995;61:732-7.
    • (1995) Int J Cancer , vol.61 , pp. 732-737
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3
  • 64
    • 0041672462 scopus 로고    scopus 로고
    • Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts
    • Rofstad EK, Henriksen K, Galappathi K, Mathiesen B. Antiangiogenic treatment with thrombospondin-1 enhances primary tumor radiation response and prevents growth of dormant pulmonary micrometastases after curative radiation therapy in human melanoma xenografts. Cancer Res 2003;63:4055-61.
    • (2003) Cancer Res , vol.63 , pp. 4055-4061
    • Rofstad, E.K.1    Henriksen, K.2    Galappathi, K.3    Mathiesen, B.4
  • 65
    • 19944422751 scopus 로고    scopus 로고
    • Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
    • Winkler F, Kozin SV, Tong R, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004;6:553-63.
    • (2004) Cancer Cell , vol.6 , pp. 553-563
    • Winkler, F.1    Kozin, S.V.2    Tong, R.3
  • 66
    • 19944426756 scopus 로고    scopus 로고
    • Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment
    • Ansiaux R, Baudelet C, Jordan BF, et al. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. Clin Cancer Res 2005;11:743-50.
    • (2005) Clin Cancer Res , vol.11 , pp. 743-750
    • Ansiaux, R.1    Baudelet, C.2    Jordan, B.F.3
  • 67
    • 33749256089 scopus 로고    scopus 로고
    • Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: Importance of optimal scheduling to exploit the "normalization" window of the tumor vasculature
    • Segers J, Di Fazio V, Ansiaux R, et al. Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: importance of optimal scheduling to exploit the "normalization" window of the tumor vasculature. Cancer Lett 2006;244:129-35.
    • (2006) Cancer Lett , vol.244 , pp. 129-135
    • Segers, J.1    Di Fazio, V.2    Ansiaux, R.3
  • 68
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain RK. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001;7:987-9.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 69
    • 0025334830 scopus 로고
    • Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: Implications for therapy
    • Boucher Y, Baxter LT, Jain RK. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res 1990;50:4478-84.
    • (1990) Cancer Res , vol.50 , pp. 4478-4484
    • Boucher, Y.1    Baxter, L.T.2    Jain, R.K.3
  • 70
    • 3142631966 scopus 로고    scopus 로고
    • The human tumor microenvironment: Invasive (needle) measurement of oxygen and interstitial fluid pressure
    • Milosevic M, Fyles A, Hedley D, Hill R. The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol 2004;14:249-58.
    • (2004) Semin Radiat Oncol , vol.14 , pp. 249-258
    • Milosevic, M.1    Fyles, A.2    Hedley, D.3    Hill, R.4
  • 71
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004;64:3731-6.
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 72
    • 20944448672 scopus 로고    scopus 로고
    • Trimodal cancer treatment: Beneficial effects of combined antiangiogenesis, radiation, and chemotherapy
    • Huber PE, Bischof M, Jenne J, et al. Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy. Cancer Res 2005;65:3643-55.
    • (2005) Cancer Res , vol.65 , pp. 3643-3655
    • Huber, P.E.1    Bischof, M.2    Jenne, J.3
  • 73
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents
    • Teicher BA, Holden SA, Ara G, et al. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti-angiogenic agents. Int J Cancer 1994;57:920-5.
    • (1994) Int J Cancer , vol.57 , pp. 920-925
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3
  • 74
    • 0001362832 scopus 로고
    • Substantial enhancement of tumor hyperthermic response by tumor necrosis factor
    • Sugahara T, Saito M, editors, London: Taylor and Francis;
    • Kallinowski F, Moehle R, Vaupel P. Substantial enhancement of tumor hyperthermic response by tumor necrosis factor. In: Sugahara T, Saito M, editors. Hyperthermic oncology, vol. I. London: Taylor and Francis; 1989. p.258-9.
    • (1989) Hyperthermic oncology , vol.1 , pp. 258-259
    • Kallinowski, F.1    Moehle, R.2    Vaupel, P.3
  • 75
    • 0029936902 scopus 로고    scopus 로고
    • Combined treatment of IL-α and TNF-α potentiates the antitumour effect of hyperthermia
    • Lin JC, Park HJ, Song CW. Combined treatment of IL-α and TNF-α potentiates the antitumour effect of hyperthermia. Int J Hyperthermia 1996;12:335-44.
    • (1996) Int J Hyperthermia , vol.12 , pp. 335-344
    • Lin, J.C.1    Park, H.J.2    Song, C.W.3
  • 76
    • 0028852080 scopus 로고
    • Anti-vascular approaches to solid tumour therapy: Evaluation of vinblastine and flavone acetic acid
    • Hill SA, Sampson LE, Chaplin DJ. Anti-vascular approaches to solid tumour therapy: evaluation of vinblastine and flavone acetic acid. Int J Cancer 1995;63:119-23.
    • (1995) Int J Cancer , vol.63 , pp. 119-123
    • Hill, S.A.1    Sampson, L.E.2    Chaplin, D.J.3
  • 77
    • 0029902597 scopus 로고    scopus 로고
    • Anti-vascular approaches to solid tumour therapy: Evaluation of tubulin binding agents
    • Chaplin DJ, Pettit GR, Parkins CS, Hill SA. Anti-vascular approaches to solid tumour therapy: evaluation of tubulin binding agents. Br J Cancer 1996;74:S86-8.
    • (1996) Br J Cancer , vol.74
    • Chaplin, D.J.1    Pettit, G.R.2    Parkins, C.S.3    Hill, S.A.4
  • 79
    • 0033572313 scopus 로고    scopus 로고
    • Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown
    • Lew YS, Brown SL, Griffin RJ, Song CW, Kim JH. Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown. Cancer Res 1999;59:6033-7.
    • (1999) Cancer Res , vol.59 , pp. 6033-6037
    • Lew, Y.S.1    Brown, S.L.2    Griffin, R.J.3    Song, C.W.4    Kim, J.H.5
  • 80
    • 0034490275 scopus 로고    scopus 로고
    • Use of arsenic trioxide as an antivascular and thermosensitizing agent in solid tumors
    • Griffin RJ, Lee SH, Rood KL, et al. Use of arsenic trioxide as an antivascular and thermosensitizing agent in solid tumors. Neoplasia 2000;2:555-60.
    • (2000) Neoplasia , vol.2 , pp. 555-560
    • Griffin, R.J.1    Lee, S.H.2    Rood, K.L.3
  • 82
    • 0024555010 scopus 로고
    • Reduction of tumor blood flow by flavone acetic acid: A possible component of therapy
    • Bibby M, Double JA, Loadman PM, Duke CV. Reduction of tumor blood flow by flavone acetic acid: a possible component of therapy. J Natl Cancer Inst 1989;81:216-20.
    • (1989) J Natl Cancer Inst , vol.81 , pp. 216-220
    • Bibby, M.1    Double, J.A.2    Loadman, P.M.3    Duke, C.V.4
  • 83
    • 0031858141 scopus 로고    scopus 로고
    • Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4- acetic acid (DMXAA) by the combination with 5-hydroxytryptamine and bioreductive drugs
    • Lash CJ, Li AE, Rutland M, Baguley BC, Zwi LJ, Wilson WR. Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4- acetic acid (DMXAA) by the combination with 5-hydroxytryptamine and bioreductive drugs. Br J Cancer 1998;78:439-45.
    • (1998) Br J Cancer , vol.78 , pp. 439-445
    • Lash, C.J.1    Li, A.E.2    Rutland, M.3    Baguley, B.C.4    Zwi, L.J.5    Wilson, W.R.6
  • 84
    • 0035131992 scopus 로고    scopus 로고
    • Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues
    • Murata R, Overgaard J, Horsman MR. Comparative effects of combretastatin A-4 disodium phosphate and 5,6-dimethylxanthenone-4-acetic acid on blood perfusion in a murine tumour and normal tissues. Int J Radiat Biol 2001;77:195-204.
    • (2001) Int J Radiat Biol , vol.77 , pp. 195-204
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 85
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • Siemann DW, Mercer E, Lepler S, Rojiani AM. Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy. Int J Cancer 2002;99:1-6.
    • (2002) Int J Cancer , vol.99 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 86
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity towards tumor vasculature
    • Dark GD, Hill SA, Prise VE, Tozer GM, Pettit GR, Chaplin DJ. Combretastatin A-4, an agent that displays potent and selective toxicity towards tumor vasculature. Cancer Res 1997;57:1829-34.
    • (1997) Cancer Res , vol.57 , pp. 1829-1834
    • Dark, G.D.1    Hill, S.A.2    Prise, V.E.3    Tozer, G.M.4    Pettit, G.R.5    Chaplin, D.J.6
  • 87
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • Tozer GM, Prise VE, Wilson J, et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues. Cancer Res 1999;59:1626-34.
    • (1999) Cancer Res , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 88
    • 0037115398 scopus 로고    scopus 로고
    • ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature
    • Davis PD, Dougherty GJ, Blakey DC, et al. ZD6126: a novel vascular-targeting agent that causes selective destruction of tumor vasculature. Cancer Res 2002;62:7247-53.
    • (2002) Cancer Res , vol.62 , pp. 7247-7253
    • Davis, P.D.1    Dougherty, G.J.2    Blakey, D.C.3
  • 89
    • 0036569804 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by the novel vascular targeting agent ZD6126
    • Siemann DW, Rojiani AM. Enhancement of radiation therapy by the novel vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 2002;53:164-71.
    • (2002) Int J Radiat Oncol Biol Phys , vol.53 , pp. 164-171
    • Siemann, D.W.1    Rojiani, A.M.2
  • 90
    • 0142155561 scopus 로고    scopus 로고
    • Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
    • Horsman MR, Murata R. Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response. Int J Radiat Oncol Biol Phys 2003;57:1047-55.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 1047-1055
    • Horsman, M.R.1    Murata, R.2
  • 91
    • 0242329757 scopus 로고    scopus 로고
    • Microvascular mechanisms by which the combretastatin A-4 derivative AC7770 (AVE8062) induces tumour blood flow stasis
    • Hori K, Saito S. Microvascular mechanisms by which the combretastatin A-4 derivative AC7770 (AVE8062) induces tumour blood flow stasis. Br J Cancer 2003;89:1334-44.
    • (2003) Br J Cancer , vol.89 , pp. 1334-1344
    • Hori, K.1    Saito, S.2
  • 92
    • 0142121501 scopus 로고    scopus 로고
    • Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with antivascular drug and cytoloxic drugs: Implications for the evaluation of therapeutic efficacy of AC7700 (AVE8062)
    • Hori K, Saito S, Sato Y, et al. Differential relationship between changes in tumour size and microcirculatory functions induced by therapy with antivascular drug and cytoloxic drugs: implications for the evaluation of therapeutic efficacy of AC7700 (AVE8062). Eur J Cancer 2003;39:1957-66.
    • (2003) Eur J Cancer , vol.39 , pp. 1957-1966
    • Hori, K.1    Saito, S.2    Sato, Y.3
  • 93
    • 0036324914 scopus 로고    scopus 로고
    • Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503
    • Hill SA, Tozer GM, Pettit GR, Chaplin DJ. Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503. Anticancer Res 2002;22:1453-8.
    • (2002) Anticancer Res , vol.22 , pp. 1453-1458
    • Hill, S.A.1    Tozer, G.M.2    Pettit, G.R.3    Chaplin, D.J.4
  • 94
    • 0036875993 scopus 로고    scopus 로고
    • Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-I phosphate
    • Howell SE, Cooper PA, Thompson MJ, et al. Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-I phosphate. Anticancer Res 2002;22:3933-40.
    • (2002) Anticancer Res , vol.22 , pp. 3933-3940
    • Howell, S.E.1    Cooper, P.A.2    Thompson, M.J.3
  • 95
    • 0038576983 scopus 로고    scopus 로고
    • Oxi4503, a novel vascular targeting agent: Effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate
    • Hua J, Sheng Y, Pinney KG. Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate. Anticancer Res 2003;23:1433-40.
    • (2003) Anticancer Res , vol.23 , pp. 1433-1440
    • Hua, J.1    Sheng, Y.2    Pinney, K.G.3
  • 96
    • 3843090808 scopus 로고    scopus 로고
    • Combretastatin family member Oxi4503 induces tumor vascular collapse through the induction of endothelial apoptosis
    • Sheng Y, Hua J, Pinney KG, et al. Combretastatin family member Oxi4503 induces tumor vascular collapse through the induction of endothelial apoptosis. Int J Cancer 2004;111:604-10.
    • (2004) Int J Cancer , vol.111 , pp. 604-610
    • Sheng, Y.1    Hua, J.2    Pinney, K.G.3
  • 97
    • 27944450310 scopus 로고    scopus 로고
    • Preclinical studies of the novel vascular disrupting agent MN-029
    • Shi W, Siemann DW. Preclinical studies of the novel vascular disrupting agent MN-029. Anticancer Res 2005;25:3899-904.
    • (2005) Anticancer Res , vol.25 , pp. 3899-3904
    • Shi, W.1    Siemann, D.W.2
  • 98
    • 0034962379 scopus 로고    scopus 로고
    • Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumours
    • Murata R, Siemann DW, Overgaard J, Horsman MR. Interaction between combretastatin A-4 disodium phosphate and radiation in murine tumours. Radiother Oncol 2001;60:155-61.
    • (2001) Radiother Oncol , vol.60 , pp. 155-161
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 99
    • 0035158004 scopus 로고    scopus 로고
    • Potentiation of the anti-tumor effect of hyperthermia by combining with the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid
    • Murata R, Overgaard J, Horsman MR. Potentiation of the anti-tumor effect of hyperthermia by combining with the vascular targeting agent 5,6-dimethylxanthenone-4-acetic acid. Int J Hyperthermia 2001;17:508-19.
    • (2001) Int J Hyperthermia , vol.17 , pp. 508-519
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 100
    • 0035064594 scopus 로고    scopus 로고
    • Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    • Galbraith SM, Chaplin DJ, Lee F, et al. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res 2001;21:93-102.
    • (2001) Anticancer Res , vol.21 , pp. 93-102
    • Galbraith, S.M.1    Chaplin, D.J.2    Lee, F.3
  • 101
    • 0037085753 scopus 로고    scopus 로고
    • The tumor vascular targeting agent combretastatin A-4 phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    • Kanthou C, Tozer GM. The tumor vascular targeting agent combretastatin A-4 phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells. Blood 2002;99:2060-9.
    • (2002) Blood , vol.99 , pp. 2060-2069
    • Kanthou, C.1    Tozer, G.M.2
  • 102
    • 0036278972 scopus 로고    scopus 로고
    • Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models
    • Blakey DC, Westwood FH, Walker M, et al. Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models. Clin Cancer Res 2002;8:1974-83.
    • (2002) Clin Cancer Res , vol.8 , pp. 1974-1983
    • Blakey, D.C.1    Westwood, F.H.2    Walker, M.3
  • 103
    • 0029982830 scopus 로고    scopus 로고
    • Tumor necrosis factor α-induced vascular leakage involves PECAM1 phosphorylation
    • Ferrero E, Villa A, Ferrero ME, et al. Tumor necrosis factor α-induced vascular leakage involves PECAM1 phosphorylation. Cancer Res 1996;56:3211-5.
    • (1996) Cancer Res , vol.56 , pp. 3211-3215
    • Ferrero, E.1    Villa, A.2    Ferrero, M.E.3
  • 104
    • 0035417875 scopus 로고    scopus 로고
    • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
    • Tozer GM, Prise VE, Wilson J, et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res 2001;61:6413-22.
    • (2001) Cancer Res , vol.61 , pp. 6413-6422
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 105
    • 0348014917 scopus 로고    scopus 로고
    • Arsenic trioxide enhances radiation response of 9L glioma in the rat brain
    • Kim JH, Lew YS, Kolozsvary A, Ryu S, Brown SL. Arsenic trioxide enhances radiation response of 9L glioma in the rat brain. Radiat Res 2003;160:662-6.
    • (2003) Radiat Res , vol.160 , pp. 662-666
    • Kim, J.H.1    Lew, Y.S.2    Kolozsvary, A.3    Ryu, S.4    Brown, S.L.5
  • 106
    • 0037778194 scopus 로고    scopus 로고
    • Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging
    • Robinson SP, McIntyre DJO, Checkley D, et al. Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging. Br J Cancer 2003;88:1592-7.
    • (2003) Br J Cancer , vol.88 , pp. 1592-1597
    • Robinson, S.P.1    McIntyre, D.J.O.2    Checkley, D.3
  • 107
    • 0042386691 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging
    • Galbraith SM, Maxwell RJ, Lodge MA, et al. Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging. J Clin Oncol 2003;21:2831-42.
    • (2003) J Clin Oncol , vol.21 , pp. 2831-2842
    • Galbraith, S.M.1    Maxwell, R.J.2    Lodge, M.A.3
  • 108
    • 2542523230 scopus 로고    scopus 로고
    • Magnetic resonance imaging measurements of the response of murine and human tumors to the vascular-targeting agent ZD6126
    • Evelhoch JL, LoRusso PM, He Z, et al. Magnetic resonance imaging measurements of the response of murine and human tumors to the vascular-targeting agent ZD6126. Clin Cancer Res 2004;10:3650-7.
    • (2004) Clin Cancer Res , vol.10 , pp. 3650-3657
    • Evelhoch, J.L.1    LoRusso, P.M.2    He, Z.3
  • 109
    • 22044437369 scopus 로고    scopus 로고
    • Mechanisms of tumor vascular shutdown induced by 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Increased tumor vascular permeability
    • Zhao L, Ching L-M, Kestell P, Kelland LR, Baguley BC. Mechanisms of tumor vascular shutdown induced by 5,6-dimethylxanthenone-4-acetic acid (DMXAA): increased tumor vascular permeability. Int J Cancer 2005;116:322-6.
    • (2005) Int J Cancer , vol.116 , pp. 322-326
    • Zhao, L.1    Ching, L.-M.2    Kestell, P.3    Kelland, L.R.4    Baguley, B.C.5
  • 110
    • 27744607653 scopus 로고    scopus 로고
    • Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure
    • Ferretti S, Allegrini PR, O'Reilly T, et al. Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure. Clin Cancer Res 2005;11:7773-84.
    • (2005) Clin Cancer Res , vol.11 , pp. 7773-7784
    • Ferretti, S.1    Allegrini, P.R.2    O'Reilly, T.3
  • 111
    • 33644536374 scopus 로고    scopus 로고
    • Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumours
    • Skliarenko JV, Lunt SJ, Gordon ML, Vitkin A, Milosevic M, Hill RP. Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumours. Cancer Res 2006;66:2074-80.
    • (2006) Cancer Res , vol.66 , pp. 2074-2080
    • Skliarenko, J.V.1    Lunt, S.J.2    Gordon, M.L.3    Vitkin, A.4    Milosevic, M.5    Hill, R.P.6
  • 113
    • 27644466314 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate induces rapid regression of tumor neu vessels and growth through interference with vascular endothelial-cadherin signalling
    • Vincent L, Kermani P, Young LM, et al. Combretastatin A4 phosphate induces rapid regression of tumor neu vessels and growth through interference with vascular endothelial-cadherin signalling. J Clin Invest 2005;115:2992-3006.
    • (2005) J Clin Invest , vol.115 , pp. 2992-3006
    • Vincent, L.1    Kermani, P.2    Young, L.M.3
  • 114
    • 0024421136 scopus 로고
    • Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma
    • Sun J-R, Brown JM. Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma. Cancer Res 1989;49:5664-70.
    • (1989) Cancer Res , vol.49 , pp. 5664-5670
    • Sun, J.-R.1    Brown, J.M.2
  • 115
    • 0032758736 scopus 로고    scopus 로고
    • In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
    • Grosios K, Holwell SE, McGown AT, Pettie GR, Bibby MC. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug. Br J Cancer 1999;81:1318-27.
    • (1999) Br J Cancer , vol.81 , pp. 1318-1327
    • Grosios, K.1    Holwell, S.E.2    McGown, A.T.3    Pettie, G.R.4    Bibby, M.C.5
  • 116
    • 0036891515 scopus 로고    scopus 로고
    • The development of combretastatin A4 phosphate as a vascular targeting agent
    • Chaplin DJ, Hill SA. The development of combretastatin A4 phosphate as a vascular targeting agent. Int J Radiat Oncol Biol Phys 2002;54:1491-6.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 1491-1496
    • Chaplin, D.J.1    Hill, S.A.2
  • 118
    • 0031770618 scopus 로고    scopus 로고
    • The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors
    • Horsman MR, Ehrnrooth E, Ladekarl M, Overgaard J. The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors. Int J Radiat Oncol Biol Phys 1998;42:895-8.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 895-898
    • Horsman, M.R.1    Ehrnrooth, E.2    Ladekarl, M.3    Overgaard, J.4
  • 119
    • 12244296444 scopus 로고    scopus 로고
    • Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma
    • Wachsberger PR, Bird R, Marero N, et al. Effect of the tumor vascular-damaging agent, ZD6126, on the radioresponse of U87 glioblastoma. Clin Cancer Res 2005;11:835-42.
    • (2005) Clin Cancer Res , vol.11 , pp. 835-842
    • Wachsberger, P.R.1    Bird, R.2    Marero, N.3
  • 120
    • 0035204801 scopus 로고    scopus 로고
    • Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia
    • Eikesdal HP, Bjerkvig R, Raleigh JA, Mella O, Dahl O, Tumor vasculature is targeted by the combination of combretastatin A-4 and hyperthermia. Radiother Oncol 2001;61:313-20.
    • (2001) Radiother Oncol , vol.61 , pp. 313-320
    • Eikesdal, H.P.1    Bjerkvig, R.2    Raleigh, J.A.3    Mella, O.4    Dahl, O.5
  • 121
    • 14844325322 scopus 로고    scopus 로고
    • Tumour parameters affected by combretastatin A-4 phosphate therapy in a human colorectal xenograft model in nude mice
    • El-Emir E, Boxer GM, Petrie IA, et al. Tumour parameters affected by combretastatin A-4 phosphate therapy in a human colorectal xenograft model in nude mice. Eur J Cancer 2005;41:799-806.
    • (2005) Eur J Cancer , vol.41 , pp. 799-806
    • El-Emir, E.1    Boxer, G.M.2    Petrie, I.A.3
  • 122
    • 20344378675 scopus 로고    scopus 로고
    • Tumor physiologic response to corebretastatin A4 phosphate assessed by MRI
    • Zhao D, Jiang L, Hahn EW, Mason RP. Tumor physiologic response to corebretastatin A4 phosphate assessed by MRI. Int J Radiat Oncol Biol Phys 2005;62:872-80.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 872-880
    • Zhao, D.1    Jiang, L.2    Hahn, E.W.3    Mason, R.P.4
  • 123
    • 0025771650 scopus 로고
    • Are cancer cells acidic?
    • Griffiths JH. Are cancer cells acidic? Br J Cancer 1991;64:425-7.
    • (1991) Br J Cancer , vol.64 , pp. 425-427
    • Griffiths, J.H.1
  • 125
    • 33646417630 scopus 로고    scopus 로고
    • The effects of the vascular disrupting agents combretastatin A-4 disodium phosphate, 5,6-dimethylxanthenone-4-acetic acid, and ZD6126 in a murine tumour: A comparative assessment using MRI and MRS
    • Breidahl T, Nielsen FU, Stodkilde-Jorgensen H, Maxwell RJ, Horsman MR. The effects of the vascular disrupting agents combretastatin A-4 disodium phosphate, 5,6-dimethylxanthenone-4-acetic acid, and ZD6126 in a murine tumour: a comparative assessment using MRI and MRS. Acta Oncol 2006;45:306-16.
    • (2006) Acta Oncol , vol.45 , pp. 306-316
    • Breidahl, T.1    Nielsen, F.U.2    Stodkilde-Jorgensen, H.3    Maxwell, R.J.4    Horsman, M.R.5
  • 127
    • 0031748452 scopus 로고    scopus 로고
    • Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status
    • Beauregard DA, Thelwall PE, Chaplin DJ, Hill SA, Adams GE, Brindle KM. Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status. Br J Cancer 1998;77:1761-7.
    • (1998) Br J Cancer , vol.77 , pp. 1761-1767
    • Beauregard, D.A.1    Thelwall, P.E.2    Chaplin, D.J.3    Hill, S.A.4    Adams, G.E.5    Brindle, K.M.6
  • 128
    • 17444376781 scopus 로고    scopus 로고
    • Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin
    • Gorski DH, Mauceri HJ, Salloum RM, et al. Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Res 1998;58:5686-9.
    • (1998) Cancer Res , vol.58 , pp. 5686-5689
    • Gorski, D.H.1    Mauceri, H.J.2    Salloum, R.M.3
  • 130
    • 12944331952 scopus 로고    scopus 로고
    • Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model
    • Griscelli F, Li H, Cheong C, et al. Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model. Proc Natl Acad Sci U S A 2000;97:6698-703.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6698-6703
    • Griscelli, F.1    Li, H.2    Cheong, C.3
  • 131
    • 0033758044 scopus 로고    scopus 로고
    • Antitumor interaction of short-course endostatin and ionizing radiation
    • Hanna NN, Seetharam S, Mauceri HJ, et al. Antitumor interaction of short-course endostatin and ionizing radiation. Cancer J 2000;6:287-93.
    • (2000) Cancer J , vol.6 , pp. 287-293
    • Hanna, N.N.1    Seetharam, S.2    Mauceri, H.J.3
  • 132
    • 0033564974 scopus 로고    scopus 로고
    • Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation
    • Gorski DH, Beckett MA, Jaskowiak NT, et al. Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Res 1999;59:3374-8.
    • (1999) Cancer Res , vol.59 , pp. 3374-3378
    • Gorski, D.H.1    Beckett, M.A.2    Jaskowiak, N.T.3
  • 133
    • 0036371621 scopus 로고    scopus 로고
    • Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance
    • Guptra VK, Jaskowiak NT, Beckett MA, et al. Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance. Cancer J 2002;8:47-54.
    • (2002) Cancer J , vol.8 , pp. 47-54
    • Guptra, V.K.1    Jaskowiak, N.T.2    Beckett, M.A.3
  • 134
    • 1242293097 scopus 로고    scopus 로고
    • Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium
    • Lu B, Geng L, Musiek A, et al. Broad spectrum receptor tyrosine kinase inhibitor, SU6668, sensitizes radiation via targeting survival pathway of vascular endothelium. Int J Radiat Oncol Biol Phys 2004;58:844-50.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 844-850
    • Lu, B.1    Geng, L.2    Musiek, A.3
  • 135
    • 0041672482 scopus 로고    scopus 로고
    • SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
    • Schueneman AA, Himmelfarb K, Geng L, et al. SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res 2003;63:4009-16.
    • (2003) Cancer Res , vol.63 , pp. 4009-4016
    • Schueneman, A.A.1    Himmelfarb, K.2    Geng, L.3
  • 136
    • 13844266132 scopus 로고    scopus 로고
    • Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice
    • Zips D, Hessel F, Krause M, et al. Impact of adjuvant inhibition of vascular endothelial growth factor receptor tyrosine kinases on tumor growth delay and local tumor control after fractionated irradiation in human squamous cell carcinomas in nude mice. Int J Radiat Oncol Biol Phys 2005;61:908-14.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 908-914
    • Zips, D.1    Hessel, F.2    Krause, M.3
  • 137
    • 18244419396 scopus 로고    scopus 로고
    • Combined effects of angiostatin and ionizing radiation in antitumor therapy
    • Mauceri HJ, Hanna NN, Beckett MA, et al. Combined effects of angiostatin and ionizing radiation in antitumor therapy. Nature 1998;394:287-91.
    • (1998) Nature , vol.394 , pp. 287-291
    • Mauceri, H.J.1    Hanna, N.N.2    Beckett, M.A.3
  • 138
    • 0035866771 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy
    • Geng L, Donnelly E, McMahon G, et al. Inhibition of vascular endothelial growth factor receptor signaling leads to reversal of tumor resistance to radiotherapy. Cancer Res 2001;61:2413-9.
    • (2001) Cancer Res , vol.61 , pp. 2413-2419
    • Geng, L.1    Donnelly, E.2    McMahon, G.3
  • 139
    • 0036145292 scopus 로고    scopus 로고
    • The antiangiogenic agents SU5416 and SU6668 increase antitumor effects of fractionated irradiation
    • Ning S, Laird D, Cherrington JM, Knox SJ. The antiangiogenic agents SU5416 and SU6668 increase antitumor effects of fractionated irradiation. Radiat Res 2002;157:45-51.
    • (2002) Radiat Res , vol.157 , pp. 45-51
    • Ning, S.1    Laird, D.2    Cherrington, J.M.3    Knox, S.J.4
  • 140
    • 10744223116 scopus 로고    scopus 로고
    • Experimental study on different combination schedules of VEGF-receptor inhibitor PTK787/ZK222584 and fractionated irradiation
    • Zips D, Krause M, Hessel F, et al. Experimental study on different combination schedules of VEGF-receptor inhibitor PTK787/ZK222584 and fractionated irradiation. Anticancer Res 2003;23:3869-76.
    • (2003) Anticancer Res , vol.23 , pp. 3869-3876
    • Zips, D.1    Krause, M.2    Hessel, F.3
  • 141
    • 33646915238 scopus 로고    scopus 로고
    • VEGF associated tyrosine kinase inhibition increases the tumor response to single and fractionated dose radiotherapy
    • Brazelle WD, Shi W, Siemann DW. VEGF associated tyrosine kinase inhibition increases the tumor response to single and fractionated dose radiotherapy. Int J Radiat Oncol Biol Phys 2006;65:836-41.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 836-841
    • Brazelle, W.D.1    Shi, W.2    Siemann, D.W.3
  • 142
    • 23044500424 scopus 로고    scopus 로고
    • Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma
    • Damiano V, Melisi D, Bianco C, et al. Cooperative antitumor effect of multitargeted kinase inhibitor ZD6474 and ionizing radiation in glioblastoma. Clin Cancer Res 2005;11:5639-44.
    • (2005) Clin Cancer Res , vol.11 , pp. 5639-5644
    • Damiano, V.1    Melisi, D.2    Bianco, C.3
  • 143
    • 28044461236 scopus 로고    scopus 로고
    • Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion
    • Kaliski A, Maggiorella L, Cengel KA, et al. Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion. Mol Cancer Ther 2005;4:1717-28.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1717-1728
    • Kaliski, A.1    Maggiorella, L.2    Cengel, K.A.3
  • 144
    • 0018425119 scopus 로고
    • Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity
    • Steel GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. Int J Radiat Oncol Biol Phys 1979;5:85-91.
    • (1979) Int J Radiat Oncol Biol Phys , vol.5 , pp. 85-91
    • Steel, G.G.1    Peckham, M.J.2
  • 145
    • 0018727288 scopus 로고
    • Terminology in the description of drug-radiation interactions
    • Steel GG. Terminology in the description of drug-radiation interactions. Int J Radiat Oncol Biol Phys 1979;5:1145-50.
    • (1979) Int J Radiat Oncol Biol Phys , vol.5 , pp. 1145-1150
    • Steel, G.G.1
  • 146
    • 84960987950 scopus 로고
    • The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
    • Gray LH, Conger AD, Ebert M, et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953;26:638-48.
    • (1953) Br J Radiol , vol.26 , pp. 638-648
    • Gray, L.H.1    Conger, A.D.2    Ebert, M.3
  • 147
    • 1842659804 scopus 로고    scopus 로고
    • The oxygen effect and tumour microenvironment
    • Steel GG, editor, 3rd ed. London: Edward Arnold;
    • Horsman MR, Overgaard J. The oxygen effect and tumour microenvironment. In: Steel GG, editor. Basic clinical radiobiology for radiation oncologists. 3rd ed. London: Edward Arnold; 2002. p. 158-68.
    • (2002) Basic clinical radiobiology for radiation oncologists , pp. 158-168
    • Horsman, M.R.1    Overgaard, J.2
  • 149
    • 0014378592 scopus 로고
    • The growth of transplanted murine tumours in pre-irradiated sites
    • Hewitt HB, Blake ER. The growth of transplanted murine tumours in pre-irradiated sites. Br J Cancer 1968;22:808-24.
    • (1968) Br J Cancer , vol.22 , pp. 808-824
    • Hewitt, H.B.1    Blake, E.R.2
  • 150
    • 20444435955 scopus 로고    scopus 로고
    • Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition
    • Zips D, Eicheler W, Geyer P, et al. Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition. Cancer Res 2005;65:5374-9.
    • (2005) Cancer Res , vol.65 , pp. 5374-5379
    • Zips, D.1    Eicheler, W.2    Geyer, P.3
  • 151
    • 0038756364 scopus 로고    scopus 로고
    • SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro
    • Abdollahi A, Lipson KE, Han X, et al. SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro. Cancer Res 2003;63:3755-63.
    • (2003) Cancer Res , vol.63 , pp. 3755-3763
    • Abdollahi, A.1    Lipson, K.E.2    Han, X.3
  • 152
    • 0031742231 scopus 로고    scopus 로고
    • Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy
    • Li L, Rojiani A, Siemann DW. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. Int J Radiat Oncol Biol Phys 1998;42:899-903.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 899-903
    • Li, L.1    Rojiani, A.2    Siemann, D.W.3
  • 153
    • 0032950870 scopus 로고    scopus 로고
    • Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate
    • Chaplin DJ, Pettit GR, Hill SA. Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate. Anticancer Res 1999;19:189-96.
    • (1999) Anticancer Res , vol.19 , pp. 189-196
    • Chaplin, D.J.1    Pettit, G.R.2    Hill, S.A.3
  • 154
    • 0031775298 scopus 로고    scopus 로고
    • Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
    • Wilson WW, Li AE, Cowan D, Siim BG. Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid. Int J Radiat Oncol Biol Phys 1998;42:905-8.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 905-908
    • Wilson, W.W.1    Li, A.E.2    Cowan, D.3    Siim, B.G.4
  • 155
    • 0034759198 scopus 로고    scopus 로고
    • Improved tumor response by combining radiation and the vascular damaging drug 5,6-dimethylxanthenone-4- acetic acid
    • Murata R, Siemann DW, Overgaard J, Horsman MR. Improved tumor response by combining radiation and the vascular damaging drug 5,6-dimethylxanthenone-4- acetic acid. Radiat Res 2001;156:503-9.
    • (2001) Radiat Res , vol.156 , pp. 503-509
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 156
    • 0033119240 scopus 로고    scopus 로고
    • Tumor necrosis factor-α sensitizes prostate cancer cells to γ-irradiation-induced apoptosis
    • Kimura K, Bowen C, Spiegel S, Gelmann EP. Tumor necrosis factor-α sensitizes prostate cancer cells to γ-irradiation-induced apoptosis. Cancer Res 1999;59:1606-14.
    • (1999) Cancer Res , vol.59 , pp. 1606-1614
    • Kimura, K.1    Bowen, C.2    Spiegel, S.3    Gelmann, E.P.4
  • 158
    • 33846265446 scopus 로고    scopus 로고
    • Combining combretastatin A-4 disodium phosphate and radiation in a fractionated schedule to improve local tumour control in mice
    • Murata R, Overgaard J, Horsman MR. Combining combretastatin A-4 disodium phosphate and radiation in a fractionated schedule to improve local tumour control in mice. Radiother Oncol 2000;56:S98.
    • (2000) Radiother Oncol , vol.56
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 159
    • 0142170363 scopus 로고    scopus 로고
    • Combination studies with combretastatin and radiation: Effects in early and late responding tissues
    • Horsman MR, Murata R, Overgaard J. Combination studies with combretastatin and radiation: effects in early and late responding tissues. Radiother Oncol 2002;64:550.
    • (2002) Radiother Oncol , vol.64 , pp. 550
    • Horsman, M.R.1    Murata, R.2    Overgaard, J.3
  • 160
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T, Butterfield CE, Kraling BM, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res 2000;60:1878-86.
    • (2000) Cancer Res , vol.60 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kraling, B.M.3
  • 161
    • 0036152447 scopus 로고    scopus 로고
    • Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts
    • Klement G, Huang P, Mayer B, et al. Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant human breast cancer xenografts. Clin Cancer Res 2002;8:221-32.
    • (2002) Clin Cancer Res , vol.8 , pp. 221-232
    • Klement, G.1    Huang, P.2    Mayer, B.3
  • 162
    • 0036532055 scopus 로고    scopus 로고
    • Combined anti-fetal liver kinase 1 monoclonal antibody and continuous low-dose doxorubicin inhibits angiogenesis and growth of human soft tissue sarcoma xenografts by induction of endothelial cell apoptosis
    • Zhang L, Yu D, Hicklin DJ, Hannay JAF, Ellis LM, Pollock RE. Combined anti-fetal liver kinase 1 monoclonal antibody and continuous low-dose doxorubicin inhibits angiogenesis and growth of human soft tissue sarcoma xenografts by induction of endothelial cell apoptosis. Cancer Res 2002;62:2034-42.
    • (2002) Cancer Res , vol.62 , pp. 2034-2042
    • Zhang, L.1    Yu, D.2    Hicklin, D.J.3    Hannay, J.A.F.4    Ellis, L.M.5    Pollock, R.E.6
  • 163
    • 25144488561 scopus 로고    scopus 로고
    • Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: A complementation antiangiogenic strategy
    • Yap R, Veliceasa D, Emmenegger U, et al. Metronomic low-dose chemotherapy boosts CD95-dependent antiangiogenic effect of the thrombospondin peptide ABT-510: a complementation antiangiogenic strategy. Clin Cancer Res 2005;11:6678-85.
    • (2005) Clin Cancer Res , vol.11 , pp. 6678-6685
    • Yap, R.1    Veliceasa, D.2    Emmenegger, U.3
  • 164
    • 0343953078 scopus 로고    scopus 로고
    • Combination of angiogenesis inhibitor TNP-470 with cytotoxic drugs in experimental therapy of nasopharyngeal carcinoma
    • Qian CN, Min HQ, Lin HL, Hong MH. Combination of angiogenesis inhibitor TNP-470 with cytotoxic drugs in experimental therapy of nasopharyngeal carcinoma. Ann Otol Rhinol Laryngol 2000;109:641-5.
    • (2000) Ann Otol Rhinol Laryngol , vol.109 , pp. 641-645
    • Qian, C.N.1    Min, H.Q.2    Lin, H.L.3    Hong, M.H.4
  • 165
    • 0042807635 scopus 로고    scopus 로고
    • Combination therapy with paclitaxel and thalidomide inhibits angiogenesis and growth of human colon cancer xenograft in mice
    • Fujii T, Tachibana M, Dhar DK, et al. Combination therapy with paclitaxel and thalidomide inhibits angiogenesis and growth of human colon cancer xenograft in mice. Anticancer Res 2003;23:2405-12.
    • (2003) Anticancer Res , vol.23 , pp. 2405-2412
    • Fujii, T.1    Tachibana, M.2    Dhar, D.K.3
  • 166
    • 23044432250 scopus 로고    scopus 로고
    • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model
    • Zhang X, Galardi E, Duquette M, Lawler J, Parangi S. Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. Clin Cancer Res 2005;11:5622-30.
    • (2005) Clin Cancer Res , vol.11 , pp. 5622-5630
    • Zhang, X.1    Galardi, E.2    Duquette, M.3    Lawler, J.4    Parangi, S.5
  • 167
    • 0037312485 scopus 로고    scopus 로고
    • Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma
    • Inoue K, Chikazawa M, Fukata S, Yoshikawa C, Shuin T. Docetaxel enhances the therapeutic effect of the angiogenesis inhibitor TNP-470 (AGM-1470) in metastatic human transitional cell carcinoma. Clin Cancer Res 2003;9:886-99.
    • (2003) Clin Cancer Res , vol.9 , pp. 886-899
    • Inoue, K.1    Chikazawa, M.2    Fukata, S.3    Yoshikawa, C.4    Shuin, T.5
  • 168
    • 0035881312 scopus 로고    scopus 로고
    • Nontoxic doses of suramin enhance activity of paclitaxel against lung metastases
    • Song S, Wientjes MG, Walsh C, Au JL-S. Nontoxic doses of suramin enhance activity of paclitaxel against lung metastases. Cancer Res 2001;61:6145-50.
    • (2001) Cancer Res , vol.61 , pp. 6145-6150
    • Song, S.1    Wientjes, M.G.2    Walsh, C.3    Au, J.L.-S.4
  • 169
    • 4644265735 scopus 로고    scopus 로고
    • Low-dose suramin enhanced paclitaxel activity in chemotherapy-naive and paclitaxel-pretreated human breast xenograft tumors
    • Song S, Yu B, Wei Y, Wientjes MG, Au JL-S. Low-dose suramin enhanced paclitaxel activity in chemotherapy-naive and paclitaxel-pretreated human breast xenograft tumors. Clin Cancer Res 2004;10:6058-65.
    • (2004) Clin Cancer Res , vol.10 , pp. 6058-6065
    • Song, S.1    Yu, B.2    Wei, Y.3    Wientjes, M.G.4    Au, J.L.-S.5
  • 170
    • 0034761804 scopus 로고    scopus 로고
    • Nontoxic doses of suramin enhance activity of doxorubicin in prostate tumors
    • Zhang Y, Song S, Yang F, Au JL-S, Wientjes MG. Nontoxic doses of suramin enhance activity of doxorubicin in prostate tumors. J Pharmacol Exp Ther 2001;299:426-33.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 426-433
    • Zhang, Y.1    Song, S.2    Yang, F.3    Au, J.L.-S.4    Wientjes, M.G.5
  • 171
    • 20444480653 scopus 로고    scopus 로고
    • Low dose suramin as a chemosensitizer of bladder cancer to mitomycin C
    • Xin Y, Lyness G, Chen D, Song S, Wientjes MG, Au JL-S. Low dose suramin as a chemosensitizer of bladder cancer to mitomycin C. J Urol 2005;174:322-7.
    • (2005) J Urol , vol.174 , pp. 322-327
    • Xin, Y.1    Lyness, G.2    Chen, D.3    Song, S.4    Wientjes, M.G.5    Au, J.L.-S.6
  • 172
    • 21044446644 scopus 로고    scopus 로고
    • Synergistic anti-tumor effect of recombinant human endostatin adenovirus combined with gemcitabine
    • Wu Y, Yang L, Hu B, et al. Synergistic anti-tumor effect of recombinant human endostatin adenovirus combined with gemcitabine. Anticancer Drugs 2005;16:551-7.
    • (2005) Anticancer Drugs , vol.16 , pp. 551-557
    • Wu, Y.1    Yang, L.2    Hu, B.3
  • 173
    • 24344460527 scopus 로고    scopus 로고
    • Thalidomide enhances the anti-tumor activity of standard chemotherapy in a human melanoma xenotransplatation model
    • Heere-Ress E, Boehm J, Thallinger C, et al. Thalidomide enhances the anti-tumor activity of standard chemotherapy in a human melanoma xenotransplatation model. J Invest Dermatol 2005;125:201-6.
    • (2005) J Invest Dermatol , vol.125 , pp. 201-206
    • Heere-Ress, E.1    Boehm, J.2    Thallinger, C.3
  • 174
    • 0033927807 scopus 로고    scopus 로고
    • Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the anti-vascular endothelial growth factor receptor monoclonal antibody DC101 and paclitaxel
    • Inoue K, Slaton JW, Davis DW, et al. Treatment of human metastatic transitional cell carcinoma of the bladder in a murine model with the
    • (2000) Clin Cancer Res , vol.6 , pp. 2635-2643
    • Inoue, K.1    Slaton, J.W.2    Davis, D.W.3
  • 175
    • 0036840759 scopus 로고    scopus 로고
    • Vascular endothelial growth factor immunoneutralization plus paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer
    • Hu L, Hofmann J, Zaloudek C, Ferrara N, Hamilton T, Jaffe RB. Vascular endothelial growth factor immunoneutralization plus paclitaxel markedly reduces tumor burden and ascites in athymic mouse model of ovarian cancer. Am J Pathol 2002;161:1917-24.
    • (2002) Am J Pathol , vol.161 , pp. 1917-1924
    • Hu, L.1    Hofmann, J.2    Zaloudek, C.3    Ferrara, N.4    Hamilton, T.5    Jaffe, R.B.6
  • 176
    • 2442492932 scopus 로고    scopus 로고
    • Carboplatin selectively induces the VEGF stress response in endothelial cells: Potentiation of antitumor activity by combination treatment with antibody to VEGF
    • Wild R, Dings RPM, Subramanian I, Ramakrishnan S. Carboplatin selectively induces the VEGF stress response in endothelial cells: potentiation of antitumor activity by combination treatment with antibody to VEGF. Int J Cancer 2004;110:343-51.
    • (2004) Int J Cancer , vol.110 , pp. 343-351
    • Wild, R.1    Dings, R.P.M.2    Subramanian, I.3    Ramakrishnan, S.4
  • 177
    • 4444254354 scopus 로고    scopus 로고
    • Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: An experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine
    • Bocci G, Danesi R, Marangoni G, et al. Antiangiogenic versus cytotoxic therapeutic approaches to human pancreas cancer: an experimental study with a vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor and gemcitabine. Eur J Pharmacol 2004;498:9-18.
    • (2004) Eur J Pharmacol , vol.498 , pp. 9-18
    • Bocci, G.1    Danesi, R.2    Marangoni, G.3
  • 178
    • 12344312012 scopus 로고    scopus 로고
    • Anti-angiogenic therapy for human pancreatic carcinoma xenografts in nude mice
    • Jia L, Zhang M-H, Yuan S-Z, Huang W-G. Anti-angiogenic therapy for human pancreatic carcinoma xenografts in nude mice. World J Gastroenterol 2005;11:447-50.
    • (2005) World J Gastroenterol , vol.11 , pp. 447-450
    • Jia, L.1    Zhang, M.-H.2    Yuan, S.-Z.3    Huang, W.-G.4
  • 179
    • 0036795180 scopus 로고    scopus 로고
    • Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer
    • Fox WD, Higgins B, Maiese KM, et al. Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer. Clin Cancer Res 2002;8:3226-31.
    • (2002) Clin Cancer Res , vol.8 , pp. 3226-3231
    • Fox, W.D.1    Higgins, B.2    Maiese, K.M.3
  • 180
    • 0032806309 scopus 로고    scopus 로고
    • Importance of VEGF for breast cancer angiogenesis in vivo: Implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin
    • Börgstrom P, Gold DP, Hillan KJ, Ferrara N. Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res 1999;19:4203-14.
    • (1999) Anticancer Res , vol.19 , pp. 4203-4214
    • Börgstrom, P.1    Gold, D.P.2    Hillan, K.J.3    Ferrara, N.4
  • 181
    • 0029875694 scopus 로고    scopus 로고
    • Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470
    • Devineni D, Klein-Szanto A, Gallo JM. Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470. Cancer Res 1996;56:1983-7.
    • (1996) Cancer Res , vol.56 , pp. 1983-1987
    • Devineni, D.1    Klein-Szanto, A.2    Gallo, J.M.3
  • 182
    • 0035878997 scopus 로고    scopus 로고
    • Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470
    • Ma J, Pulfer S, Li S, Chu J, Reed K, Gallo JM. Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470. Cancer Res 2001;61:5491-8.
    • (2001) Cancer Res , vol.61 , pp. 5491-5498
    • Ma, J.1    Pulfer, S.2    Li, S.3    Chu, J.4    Reed, K.5    Gallo, J.M.6
  • 183
    • 0019349297 scopus 로고
    • Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells
    • Teicher BA, Lazo JS, Sartorelli AC. Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Res 1981;41:73-81.
    • (1981) Cancer Res , vol.41 , pp. 73-81
    • Teicher, B.A.1    Lazo, J.S.2    Sartorelli, A.C.3
  • 184
    • 0019491278 scopus 로고
    • Response of Chinese hamster ovary cells to anti-cancer drugs under aerobic and hypoxic conditions
    • Tannock I, Guttman P. Response of Chinese hamster ovary cells to anti-cancer drugs under aerobic and hypoxic conditions. Br J Cancer 1981;43:245-8.
    • (1981) Br J Cancer , vol.43 , pp. 245-248
    • Tannock, I.1    Guttman, P.2
  • 185
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease
    • Wike-Hooley JL, Haveman J, Reinhold HS. The relevance of tumour pH to the treatment of malignant disease. Radiother Oncol 1984;2:343-66.
    • (1984) Radiother Oncol , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 186
    • 0024207211 scopus 로고
    • Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay
    • Grau C, Overgaard J. Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay. Radiother Oncol 1988;13:301-9.
    • (1988) Radiother Oncol , vol.13 , pp. 301-309
    • Grau, C.1    Overgaard, J.2
  • 187
    • 0025974326 scopus 로고
    • The influence of microenvironmental factors on the activity of radiation and drugs
    • Durand RE. The influence of microenvironmental factors on the activity of radiation and drugs. Int J Radiat Oncol Biol Phys 1991;20:253-8.
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , pp. 253-258
    • Durand, R.E.1
  • 188
    • 0026694762 scopus 로고
    • Effect of etoposide, carmustine, vincristine, 5-fluorouracil, or methotrexate on radiobiologically oxic and hypoxic cells in a C3H mouse mammary carcinoma
    • Grau C, Overgaard J. Effect of etoposide, carmustine, vincristine, 5-fluorouracil, or methotrexate on radiobiologically oxic and hypoxic cells in a C3H mouse mammary carcinoma. Cancer Chemother Pharmacol 1992;30:277-80.
    • (1992) Cancer Chemother Pharmacol , vol.30 , pp. 277-280
    • Grau, C.1    Overgaard, J.2
  • 189
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 2004;350:2335-42.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 190
    • 0025894741 scopus 로고
    • Induction of tumour hypoxia by FAA and TNF: Interaction with bioreductive drugs
    • Edwards HS, Bremner JCM, Stratford IJ. Induction of tumour hypoxia by FAA and TNF: interaction with bioreductive drugs. Int J Radiat Biol 1991;60:373-7.
    • (1991) Int J Radiat Biol , vol.60 , pp. 373-377
    • Edwards, H.S.1    Bremner, J.C.M.2    Stratford, I.J.3
  • 191
    • 0027331857 scopus 로고
    • Enhancement of mitomycin-C cytotoxicity by combination with flavone acetic acid in a marine tumour
    • Parkins CS, Denekamp J, Chaplin DJ. Enhancement of mitomycin-C cytotoxicity by combination with flavone acetic acid in a marine tumour. Anticancer Res 1993;13:1437-42.
    • (1993) Anticancer Res , vol.13 , pp. 1437-1442
    • Parkins, C.S.1    Denekamp, J.2    Chaplin, D.J.3
  • 192
    • 0028234390 scopus 로고
    • Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid
    • Cliffe S, Taylor ML, Rutland M, Baguley BC, Hill RP, Wilson WR. Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid. Int J Radiat Oncol Biol Phys 1994;29:373-7.
    • (1994) Int J Radiat Oncol Biol Phys , vol.29 , pp. 373-377
    • Cliffe, S.1    Taylor, M.L.2    Rutland, M.3    Baguley, B.C.4    Hill, R.P.5    Wilson, W.R.6
  • 193
    • 0029935930 scopus 로고    scopus 로고
    • Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide, and AQ4N
    • Wilson WR, Denny WA, Pullen SM, et al. Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide, nitracrine N-oxide, and AQ4N. Br J Cancer 1996;74:S43-7.
    • (1996) Br J Cancer , vol.74
    • Wilson, W.R.1    Denny, W.A.2    Pullen, S.M.3
  • 194
    • 0028027951 scopus 로고
    • Enhancement of chlorambucil cytotoxicity by combination with flavone acetic acid in a murine tumour
    • Parkins CS, Chadwick JA, Chaplin DJ. Enhancement of chlorambucil cytotoxicity by combination with flavone acetic acid in a murine tumour. Anticancer Res 1994;14:1603-8.
    • (1994) Anticancer Res , vol.14 , pp. 1603-1608
    • Parkins, C.S.1    Chadwick, J.A.2    Chaplin, D.J.3
  • 195
    • 0031016945 scopus 로고    scopus 로고
    • Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid
    • Pruijn FB, van Daalen M, Holford NHG, Wilson WR. Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid. Cancer Chemother Pharmacol 1997;39:541-6.
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 541-546
    • Pruijn, F.B.1    van Daalen, M.2    Holford, N.H.G.3    Wilson, W.R.4
  • 196
    • 0036215178 scopus 로고    scopus 로고
    • Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma
    • Li L, Rojiani AM, Siemann DW. Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Acta Oncol 2002;41:91-7.
    • (2002) Acta Oncol , vol.41 , pp. 91-97
    • Li, L.1    Rojiani, A.M.2    Siemann, D.W.3
  • 197
    • 0034109559 scopus 로고    scopus 로고
    • Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma
    • Grosios K, Loadman PM, Swaine DJ, Pettit GR, Bibby MC. Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma. Anticancer Res 2000;20:229-34.
    • (2000) Anticancer Res , vol.20 , pp. 229-234
    • Grosios, K.1    Loadman, P.M.2    Swaine, D.J.3    Pettit, G.R.4    Bibby, M.C.5
  • 198
    • 0036891109 scopus 로고    scopus 로고
    • Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126
    • Siemann DW, Rojiani AM. Antitumor efficacy of conventional anticancer drugs is enhanced by the vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys 2002;54:1512-7.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 1512-1517
    • Siemann, D.W.1    Rojiani, A.M.2
  • 199
    • 0038297388 scopus 로고    scopus 로고
    • Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo
    • Morinaga Y, Suga Y, Ehara S, Harada K, Nihei Y, Suzuki M. Combination effect of AC-7700, a novel combretastatin A-4 derivative, and cisplatin against murine and human tumors in vivo. Cancer Sci 2003;94:200-4.
    • (2003) Cancer Sci , vol.94 , pp. 200-204
    • Morinaga, Y.1    Suga, Y.2    Ehara, S.3    Harada, K.4    Nihei, Y.5    Suzuki, M.6
  • 200
    • 0018380464 scopus 로고
    • Blood flow and heat transfer in Walker 256 mammary carcinoma
    • Jain RK, Grantham FH, Gullino PM. Blood flow and heat transfer in Walker 256 mammary carcinoma. J Natl Cancer Inst 1979;62:927-33,
    • (1979) J Natl Cancer Inst , vol.62 , pp. 927-933
    • Jain, R.K.1    Grantham, F.H.2    Gullino, P.M.3
  • 202
    • 0017380828 scopus 로고
    • The influence of hypoxia and acidity on the hyperthermic response of malignant cells in vitro
    • Overgaard J, Bichel P. The influence of hypoxia and acidity on the hyperthermic response of malignant cells in vitro. Radiology 1977;123:511-4.
    • (1977) Radiology , vol.123 , pp. 511-514
    • Overgaard, J.1    Bichel, P.2
  • 203
    • 0018373096 scopus 로고
    • Response of cells to hyperthermia under acute and chronic hypoxic conditions
    • Gerweck LE, Nygaard TG, Burlett M. Response of cells to hyperthermia under acute and chronic hypoxic conditions. Cancer Res 1979;39:966-72.
    • (1979) Cancer Res , vol.39 , pp. 966-972
    • Gerweck, L.E.1    Nygaard, T.G.2    Burlett, M.3
  • 204
    • 0016799986 scopus 로고
    • Effect of heat and ionizing radiation on normal and neoplastic tissue of the C3H mouse
    • Thrall DE, Gillette EL, Dewey WC. Effect of heat and ionizing radiation on normal and neoplastic tissue of the C3H mouse. Radiat Res 1975;63:363-77.
    • (1975) Radiat Res , vol.63 , pp. 363-377
    • Thrall, D.E.1    Gillette, E.L.2    Dewey, W.C.3
  • 205
    • 0018169929 scopus 로고
    • The effect of vascular occlusion on the thermal sensitization of a mouse tumor
    • Hill SA, Denekamp J. The effect of vascular occlusion on the thermal sensitization of a mouse tumor. Br J Radiol 1978;51:997-1002.
    • (1978) Br J Radiol , vol.51 , pp. 997-1002
    • Hill, S.A.1    Denekamp, J.2
  • 206
    • 0024531650 scopus 로고
    • Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo
    • Horsman MR, Christensen KL, Overgaard J. Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. Int J Hyperthermia 1989;5:123-36.
    • (1989) Int J Hyperthermia , vol.5 , pp. 123-136
    • Horsman, M.R.1    Christensen, K.L.2    Overgaard, J.3
  • 207
    • 0026666932 scopus 로고
    • Use of nitroprusside to increase tissue temperature during local hyperthermia in normal and tumor-bearing dogs
    • Prescott DM, Samulski TV, Dewhirst MW, et al. Use of nitroprusside to increase tissue temperature during local hyperthermia in normal and tumor-bearing dogs. Int J Radiat Oncol Biol Phys 1992;23:377-85.
    • (1992) Int J Radiat Oncol Biol Phys , vol.23 , pp. 377-385
    • Prescott, D.M.1    Samulski, T.V.2    Dewhirst, M.W.3
  • 208
    • 0020682146 scopus 로고
    • Effect of hyperglycemia on the thermal response of murine normal and tumor tissue
    • Urano M, Montoya V, Booth A. Effect of hyperglycemia on the thermal response of murine normal and tumor tissue. Cancer Res 1983;43:453-5.
    • (1983) Cancer Res , vol.43 , pp. 453-455
    • Urano, M.1    Montoya, V.2    Booth, A.3
  • 209
    • 0036119967 scopus 로고    scopus 로고
    • 4An rat glioma: Lack of interaction with the angiogenesis inhibitor batimastat
    • 4An rat glioma: lack of interaction with the angiogenesis inhibitor batimastat. Int J Hyperthermia 2002;18:141-52.
    • (2002) Int J Hyperthermia , vol.18 , pp. 141-152
    • Eikesdal, H.P.1    Bjorkhaug, S.T.2    Dahl, O.3
  • 210
    • 0029117784 scopus 로고
    • Enhancement effect of an anti-angiogenic agent, TNP-470, on hyperthermia-induced growth suppression of human esophageal and gastric cancers transplantable to nude mice
    • Yano T, Tanase M, Watanabe A, et al. Enhancement effect of an anti-angiogenic agent, TNP-470, on hyperthermia-induced growth suppression of human esophageal and gastric cancers transplantable to nude mice. Anticancer Res 1995;15:1355-8.
    • (1995) Anticancer Res , vol.15 , pp. 1355-1358
    • Yano, T.1    Tanase, M.2    Watanabe, A.3
  • 211
    • 0030043649 scopus 로고    scopus 로고
    • Combined effects of an angiogenesis inhibitor (TNP-470) and hyperthermia
    • Nishimura Y, Murata R, Hiraoka M. Combined effects of an angiogenesis inhibitor (TNP-470) and hyperthermia. Br J Cancer 1996;73:270-4.
    • (1996) Br J Cancer , vol.73 , pp. 270-274
    • Nishimura, Y.1    Murata, R.2    Hiraoka, M.3
  • 212
    • 0242442486 scopus 로고    scopus 로고
    • Arsenic trioxide induces selective tumour vascular damage via oxidative stress and increases thermosensitivity of tumours
    • Griffin RJ, Monzen H, Williams BW, Park H, Lee SH, Song CW. Arsenic trioxide induces selective tumour vascular damage via oxidative stress and increases thermosensitivity of tumours. Int J Hyperthermia 2003;19:575-89.
    • (2003) Int J Hyperthermia , vol.19 , pp. 575-589
    • Griffin, R.J.1    Monzen, H.2    Williams, B.W.3    Park, H.4    Lee, S.H.5    Song, C.W.6
  • 213
    • 0034923996 scopus 로고    scopus 로고
    • Improving local tumor control by combining vascular targeting drugs, mild hyperthermia, and radiation
    • Horsman MR, Murata R, Overgaard J. Improving local tumor control by combining vascular targeting drugs, mild hyperthermia, and radiation. Acta Oncol 2001;40:497-503.
    • (2001) Acta Oncol , vol.40 , pp. 497-503
    • Horsman, M.R.1    Murata, R.2    Overgaard, J.3
  • 215
    • 0035889331 scopus 로고    scopus 로고
    • Combretastatin A-4 disodium phosphate: A vascular targeting agent that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy
    • Murata R, Overgaard J, Horsman MR. Combretastatin A-4 disodium phosphate: a vascular targeting agent that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy. Int J Radiat Oncol Biol Phys 2001;51:1018-24.
    • (2001) Int J Radiat Oncol Biol Phys , vol.51 , pp. 1018-1024
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 216
    • 0000411749 scopus 로고
    • Rationale and problems in the design of clinical trials
    • Overgaard J, editor, London; Taylor and Francis
    • Overgaard J. Rationale and problems in the design of clinical trials. In Overgaard J, editor. Hyperthermic oncology vol. 2. London; Taylor and Francis: 1985. p.325-38.
    • (1985) Hyperthermic oncology , vol.2 , pp. 325-338
    • Overgaard, J.1
  • 217
    • 2242446580 scopus 로고    scopus 로고
    • Overcoming tumour radioresistance resulting from hypoxia
    • Steel GG, editor, 3rd ed. London: Edward Arnold;
    • Horsman MR, Overgaard J. Overcoming tumour radioresistance resulting from hypoxia. In: Steel GG, editor. Basic clinical radiobiology for radiation oncologists. 3rd ed. London: Edward Arnold; 2002. p.169-81.
    • (2002) Basic clinical radiobiology for radiation oncologists , pp. 169-181
    • Horsman, M.R.1    Overgaard, J.2
  • 218
    • 3042644639 scopus 로고    scopus 로고
    • Tumour-specific enhancement of thermoradiotherapy at mild temperatures by the vascular targeting agent 5,6-dimethylxanthenone-4- acetic acid
    • Murata R, Horsman MJR. Tumour-specific enhancement of thermoradiotherapy at mild temperatures by the vascular targeting agent 5,6-dimethylxanthenone-4- acetic acid. Int J Hyperthermia 2004;20:393-404.
    • (2004) Int J Hyperthermia , vol.20 , pp. 393-404
    • Murata, R.1    Horsman, M.J.R.2
  • 219
    • 0022999180 scopus 로고
    • Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in vitro: Comparison to ionizing radiation
    • Henderson BW, Miller AC. Effects of scavengers of reactive oxygen and radical species on cell survival following photodynamic treatment in vitro: comparison to ionizing radiation. Radiat Res 1986;108:196-205.
    • (1986) Radiat Res , vol.108 , pp. 196-205
    • Henderson, B.W.1    Miller, A.C.2
  • 220
    • 0032761526 scopus 로고    scopus 로고
    • Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD1666285 and PD173074: Implications for combination treatment with photodynamic therapy
    • Dimitroff CJ, Klohs W, Sharma A, et al. Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD1666285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs 1999;17:121-5.
    • (1999) Invest New Drugs , vol.17 , pp. 121-125
    • Dimitroff, C.J.1    Klohs, W.2    Sharma, A.3
  • 221
    • 26444525737 scopus 로고    scopus 로고
    • Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models
    • Zhou Q, Olivo M, Lye KYK, Moore S, Sharma A, Chowbay B. Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models. Cancer Chemother Pharmacol 2005;56:569-77.
    • (2005) Cancer Chemother Pharmacol , vol.56 , pp. 569-577
    • Zhou, Q.1    Olivo, M.2    Lye, K.Y.K.3    Moore, S.4    Sharma, A.5    Chowbay, B.6
  • 222
    • 0030002174 scopus 로고    scopus 로고
    • Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents
    • Pedley RB, Boden JA, Boden R, et al. Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents. Cancer Res 1996;56:3293-300.
    • (1996) Cancer Res , vol.56 , pp. 3293-3300
    • Pedley, R.B.1    Boden, J.A.2    Boden, R.3
  • 223
    • 0035874889 scopus 로고    scopus 로고
    • Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin A-4 3-O-phosphate
    • Pedley RB, Hill SA, Boxer GM, et al. Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin A-4 3-O-phosphate. Cancer Res 2001;61:4716-22.
    • (2001) Cancer Res , vol.61 , pp. 4716-4722
    • Pedley, R.B.1    Hill, S.A.2    Boxer, G.M.3
  • 224
    • 0033567097 scopus 로고    scopus 로고
    • Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent
    • Pedley RB, Sharma SK, Boxer GM, et al. Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent. Cancer Res 1999;59:3998-4003.
    • (1999) Cancer Res , vol.59 , pp. 3998-4003
    • Pedley, R.B.1    Sharma, S.K.2    Boxer, G.M.3
  • 225
    • 33846217088 scopus 로고    scopus 로고
    • Vasculature-disrupting strategies combined with bacterial spores targeting hypoxic regions of solid tumors
    • Siemann DW, editor, Chichester: John Wiley & Sons, Ltd
    • Ahn G-O, Brown JM. Vasculature-disrupting strategies combined with bacterial spores targeting hypoxic regions of solid tumors. In: Siemann DW, editor. Vascular-targeted therapies in oncology. Chichester: John Wiley & Sons, Ltd.; 2006. p.261-76.
    • (2006) Vascular-targeted therapies in oncology , pp. 261-276
    • Ahn, G.-O.1    Brown, J.M.2
  • 226
    • 0023676391 scopus 로고
    • Anti-tumor effects of tumor necrosis factor alone or combined with radiotherapy
    • Sersa G, Willingham V, Milas L. Anti-tumor effects of tumor necrosis factor alone or combined with radiotherapy. Int J Cancer 1988;42:129-34.
    • (1988) Int J Cancer , vol.42 , pp. 129-134
    • Sersa, G.1    Willingham, V.2    Milas, L.3
  • 227
    • 0025350957 scopus 로고
    • Tumor necrosis factor as an adjunct to fractionated radiotherapy in the treatment of murine tumors
    • Nishiguchi I, Willingham V, Milas L. Tumor necrosis factor as an adjunct to fractionated radiotherapy in the treatment of murine tumors. Int J Radiat Oncol Biol Phys 1990;18:555-8.
    • (1990) Int J Radiat Oncol Biol Phys , vol.18 , pp. 555-558
    • Nishiguchi, I.1    Willingham, V.2    Milas, L.3
  • 228
    • 0029777311 scopus 로고    scopus 로고
    • Tumor necrosis factor α (TNF-α) gene therapy targeted by ionizing radiation selectively damages tumor vasculature
    • Mauceri HJ, Hanna NN, Wayne JD, Hallahan DE, Hellman S, Weichselbaum RR. Tumor necrosis factor α (TNF-α) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. Cancer Res 1996;56:4311-4.
    • (1996) Cancer Res , vol.56 , pp. 4311-4314
    • Mauceri, H.J.1    Hanna, N.N.2    Wayne, J.D.3    Hallahan, D.E.4    Hellman, S.5    Weichselbaum, R.R.6
  • 230
    • 0036682021 scopus 로고    scopus 로고
    • Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor
    • Lew YS, Kolozsvary A, Brown SL, Kim JH. Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor. Cancer Res 2002;62:4202-5.
    • (2002) Cancer Res , vol.62 , pp. 4202-4205
    • Lew, Y.S.1    Kolozsvary, A.2    Brown, S.L.3    Kim, J.H.4
  • 231
    • 0035254653 scopus 로고    scopus 로고
    • In vivo antitumor effect of vascular targeting combined with ionising radiation or anti-angiogenesis treatment
    • Landuyt W, Ahmed B, Nuyts S, et al. In vivo antitumor effect of vascular targeting combined with ionising radiation or anti-angiogenesis treatment. Int J Radiat Oncol Biol Phys 2001;49:443-50.
    • (2001) Int J Radiat Oncol Biol Phys , vol.49 , pp. 443-450
    • Landuyt, W.1    Ahmed, B.2    Nuyts, S.3
  • 232
    • 4444280232 scopus 로고    scopus 로고
    • Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xcnograft model
    • Raben D, Bianco C, Damiano V, et al. Antitumor activity of ZD6126, a novel vascular-targeting agent, is enhanced when combined with ZD1839, an epidermal growth factor receptor tyrosine kinase inhibitor, and potentiates the effects of radiation in a human non-small cell lung cancer xcnograft model. Mol Cancer Ther 2004;3:977-83.
    • (2004) Mol Cancer Ther , vol.3 , pp. 977-983
    • Raben, D.1    Bianco, C.2    Damiano, V.3
  • 233
    • 33846204064 scopus 로고    scopus 로고
    • Combined modality approaches using vasculature-disrupting agents
    • Siemann DW, editor, Chichester: John Wiley & Sons, Ltd
    • Shi W, Horsman MR, Siemann DW. Combined modality approaches using vasculature-disrupting agents. In: Siemann DW, editor. Vascular-targeted therapies in oncology. Chichester: John Wiley & Sons, Ltd.; 2006. p.123-36.
    • (2006) Vascular-targeted therapies in oncology , pp. 123-136
    • Shi, W.1    Horsman, M.R.2    Siemann, D.W.3
  • 234
    • 0029147793 scopus 로고
    • Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma
    • Teicher BA, Holden SA, Dupuis NP, et al. Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma. Breast Cancer Res Treat 1995;36:227-36.
    • (1995) Breast Cancer Res Treat , vol.36 , pp. 227-236
    • Teicher, B.A.1    Holden, S.A.2    Dupuis, N.P.3
  • 235
    • 0028104250 scopus 로고
    • Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-470) and cytotoxic agents in mice
    • Kato T, Sato K, Kakinuma H, Matsuda Y. Enhanced suppression of tumor growth by combination of angiogenesis inhibitor O-(chloroacetyl-carbamoyl) fumagillol (TNP-470) and cytotoxic agents in mice. Cancer Res 1994;54:5143-7.
    • (1994) Cancer Res , vol.54 , pp. 5143-5147
    • Kato, T.1    Sato, K.2    Kakinuma, H.3    Matsuda, Y.4
  • 236
    • 0031205740 scopus 로고    scopus 로고
    • Efficacy of CDDP and AGM-1470 chemotherapy against lung metastasis in rat osteosarcoma depends on the timing of combined administration
    • Morishita T, Mii Y, Miyauchi Y, et al. Efficacy of CDDP and AGM-1470 chemotherapy against lung metastasis in rat osteosarcoma depends on the timing of combined administration. Jpn J Clin Oncol 1997;27:236-9.
    • (1997) Jpn J Clin Oncol , vol.27 , pp. 236-239
    • Morishita, T.1    Mii, Y.2    Miyauchi, Y.3
  • 237
    • 0031766695 scopus 로고    scopus 로고
    • Inhibition of liver metastasis of pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin
    • Shishido T, Yasoshima T, Denno K, Muyaiya M, Sato N, Hirata K. Inhibition of liver metastasis of pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin. Jpn J Cancer Res 1998;89:963-9.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 963-969
    • Shishido, T.1    Yasoshima, T.2    Denno, K.3    Muyaiya, M.4    Sato, N.5    Hirata, K.6
  • 238
    • 0033055383 scopus 로고    scopus 로고
    • Delay in administration of CDDP until completion of AGM-1740 treatment enhances antimetastatic and antitumor effects
    • Morishita T, Miyauchi Y, Mii Y, et al. Delay in administration of CDDP until completion of AGM-1740 treatment enhances antimetastatic and antitumor effects. Clin Exp Metastasis 1999;17:15-8.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 15-18
    • Morishita, T.1    Miyauchi, Y.2    Mii, Y.3
  • 239
    • 0029971486 scopus 로고    scopus 로고
    • Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma
    • Teicher BA, Holden SA, Ara G, Korbut T, Menon K. Comparison of several antiangiogenic regimens alone and with cytotoxic therapies in the Lewis lung carcinoma. Cancer Chemother Pharmacol 1996;38:169-77.
    • (1996) Cancer Chemother Pharmacol , vol.38 , pp. 169-177
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3    Korbut, T.4    Menon, K.5
  • 240
    • 0030920374 scopus 로고    scopus 로고
    • Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents
    • Kakeji Y, Teicher BA. Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents. Invest New Drugs 1997;15:39-48.
    • (1997) Invest New Drugs , vol.15 , pp. 39-48
    • Kakeji, Y.1    Teicher, B.A.2
  • 241
    • 0033752751 scopus 로고    scopus 로고
    • Treatment of murine angiosarcoma with etoposide, TNP-70, and prednisolone
    • Ma G, Masuzawa M, Hamada Y, et al. Treatment of murine angiosarcoma with etoposide, TNP-70, and prednisolone. J Dermatol Sci 2000;24:126-33.
    • (2000) J Dermatol Sci , vol.24 , pp. 126-133
    • Ma, G.1    Masuzawa, M.2    Hamada, Y.3
  • 242
    • 4544220102 scopus 로고    scopus 로고
    • Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KOTCC-1 model
    • Muramaki M, Miyake H, Hara J, Kawabata G, Kamidono S. Synergistic inhibition of tumor growth and metastasis by combined treatment with TNP-470 and gemcitabine in a human bladder cancer KOTCC-1 model. J Urol 2004;172:1485-9.
    • (2004) J Urol , vol.172 , pp. 1485-1489
    • Muramaki, M.1    Miyake, H.2    Hara, J.3    Kawabata, G.4    Kamidono, S.5
  • 243
    • 0018746150 scopus 로고
    • Suramin enhancement of the chemotherapeutic actions of cyclophosphamide or adriamycin of intramuscularly-implanted Ehrlich carcinoma
    • Osswald H, Youssef M. Suramin enhancement of the chemotherapeutic actions of cyclophosphamide or adriamycin of intramuscularly-implanted Ehrlich carcinoma. Cancer Lett 1979;6:337-43.
    • (1979) Cancer Lett , vol.6 , pp. 337-343
    • Osswald, H.1    Youssef, M.2
  • 244
    • 0029056794 scopus 로고
    • Complete inhibition of human ovarian cancer xenografts in nude mice by suramin and cis-diammine-dichloroplatinum(II)
    • Kikuchi Y, Hirata J, Hisano A, Tode T, Kita T, Nagata I. Complete inhibition of human ovarian cancer xenografts in nude mice by suramin and cis-diammine-dichloroplatinum(II). Gynecol Oncol 1995;58:11-5.
    • (1995) Gynecol Oncol , vol.58 , pp. 11-15
    • Kikuchi, Y.1    Hirata, J.2    Hisano, A.3    Tode, T.4    Kita, T.5    Nagata, I.6
  • 245
    • 0036450557 scopus 로고    scopus 로고
    • Angiostatin potentiates cyclophosphamide treatment of metastatic disease
    • Mauceri MJ, Seetharam S, Bechett MA, et al. Angiostatin potentiates cyclophosphamide treatment of metastatic disease. Cancer Chemother Pharmacol 2002;50:412-8.
    • (2002) Cancer Chemother Pharmacol , vol.50 , pp. 412-418
    • Mauceri, M.J.1    Seetharam, S.2    Bechett, M.A.3
  • 246
    • 0036902458 scopus 로고    scopus 로고
    • Enhanced antitumour efficacy by combining conventional chemotherapy with angiostatin or endostatin in a liver metastasis model
    • te Velde EA, Vogten JM, Gebbink MFGB, van Gorp JM, Voest EE, Borel Rinkes IHM. Enhanced antitumour efficacy by combining conventional chemotherapy with angiostatin or endostatin in a liver metastasis model. Br J Surg 2002;89:1302-9.
    • (2002) Br J Surg , vol.89 , pp. 1302-1309
    • te Velde, E.A.1    Vogten, J.M.2    Gebbink, M.F.G.B.3    van Gorp, J.M.4    Voest, E.E.5    Borel Rinkes, I.H.M.6
  • 247
    • 0034234555 scopus 로고    scopus 로고
    • Endostatin, an antiangiogenic drug, induces tumor stabilisation after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma
    • Bertolini I, Fusetti L, Mancuso P, et al. Endostatin, an antiangiogenic drug, induces tumor stabilisation after chemotherapy or anti-CD20 therapy in a NOD/SCID mouse model of human high-grade non-Hodgkin lymphoma. Blood 2000;96:282-7.
    • (2000) Blood , vol.96 , pp. 282-287
    • Bertolini, I.1    Fusetti, L.2    Mancuso, P.3
  • 248
    • 0042692888 scopus 로고    scopus 로고
    • Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts
    • Abraham D, Abri S, Hofmann M, Höltl W, Aharinejad S. Low dose carboplatin combined with angiostatic agents prevents metastasis in human testicular germ cell tumor xenografts. J Urol 2003;170:1388-93.
    • (2003) J Urol , vol.170 , pp. 1388-1393
    • Abraham, D.1    Abri, S.2    Hofmann, M.3    Höltl, W.4    Aharinejad, S.5
  • 249
    • 33646242264 scopus 로고    scopus 로고
    • Adeno-assoeiated virus-mediated delivery of a mutant endostatin in combination with carboplatin treatment inhibits orthotopic growth of ovarian cancer and improves long-term survival
    • Subramanian IV, Nguyen TMB, Truskinovsky AM, Tolar J, Blazar BR, Kamakrishnan S. Adeno-assoeiated virus-mediated delivery of a mutant endostatin in combination with carboplatin treatment inhibits orthotopic growth of ovarian cancer and improves long-term survival. Cancer Res 2006;66:4319-28.
    • (2006) Cancer Res , vol.66 , pp. 4319-4328
    • Subramanian, I.V.1    Nguyen, T.M.B.2    Truskinovsky, A.M.3    Tolar, J.4    Blazar, B.R.5    Kamakrishnan, S.6
  • 250
    • 0036042545 scopus 로고    scopus 로고
    • Potentiation of the antitumour effect of cyclophosphamide in mice by thalidomide
    • Ding Q, Kestell P, Baguley BC, et al. Potentiation of the antitumour effect of cyclophosphamide in mice by thalidomide. Cancer Chemother Pharmaeol 2002;50:186-92.
    • (2002) Cancer Chemother Pharmaeol , vol.50 , pp. 186-192
    • Ding, Q.1    Kestell, P.2    Baguley, B.C.3
  • 251
    • 0037439824 scopus 로고    scopus 로고
    • The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin
    • Dings RPM, Yokoyama Y, Ramakrishnan S, Griffioen AW, Mayo KH. The designed angiostatic peptide anginex synergistically improves chemotherapy and antiangiogenesis therapy with angiostatin. Cancer Res 2003;63:382-5.
    • (2003) Cancer Res , vol.63 , pp. 382-385
    • Dings, R.P.M.1    Yokoyama, Y.2    Ramakrishnan, S.3    Griffioen, A.W.4    Mayo, K.H.5
  • 252
    • 1442359994 scopus 로고    scopus 로고
    • Thrombospondin-1 plus irinotecan: A novel anti-angiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice
    • Allegrini G, Goulette FA, Darnowski JW, Calabresi P. Thrombospondin-1 plus irinotecan: a novel anti-angiogenic-chemotherapeutic combination that inhibits the growth of advanced human colon tumor xenografts in mice. Cancer Chemother Pharmacol 2004;53:261-6.
    • (2004) Cancer Chemother Pharmacol , vol.53 , pp. 261-266
    • Allegrini, G.1    Goulette, F.A.2    Darnowski, J.W.3    Calabresi, P.4
  • 253
    • 0034894341 scopus 로고    scopus 로고
    • Combination antiangiogenic therapy: Increased efficacy in a murine model of Wilms tumor
    • Soffer SZ, Moore JT, Kim E, et al. Combination antiangiogenic therapy: increased efficacy in a murine model of Wilms tumor. J Pediatr Surg 2001;36:1177-81.
    • (2001) J Pediatr Surg , vol.36 , pp. 1177-1181
    • Soffer, S.Z.1    Moore, J.T.2    Kim, E.3
  • 254
    • 0038235987 scopus 로고    scopus 로고
    • Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11
    • Wildiers H, Guelens G, De Boeck G, et al. Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. Br J Cancer 2003;88:1979-86.
    • (2003) Br J Cancer , vol.88 , pp. 1979-1986
    • Wildiers, H.1    Guelens, G.2    De Boeck, G.3
  • 255
    • 10744223595 scopus 로고    scopus 로고
    • The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically
    • Garofolo A, Naumova E, Manenti L, et al. The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Clin Cancer Res 2003;9:3476-85.
    • (2003) Clin Cancer Res , vol.9 , pp. 3476-3485
    • Garofolo, A.1    Naumova, E.2    Manenti, L.3
  • 256
    • 0030013209 scopus 로고    scopus 로고
    • In vivo effects of tumor necrosis factor-α or flavone acetic acid in combination with doxorubicin on multidrug-resistant B16 melanoma
    • D'Alessandro N, Borsellino N. In vivo effects of tumor necrosis factor-α or flavone acetic acid in combination with doxorubicin on multidrug-resistant B16 melanoma. Anticancer Drugs 1996;7:281-7.
    • (1996) Anticancer Drugs , vol.7 , pp. 281-287
    • D'Alessandro, N.1    Borsellino, N.2
  • 257
    • 0037222218 scopus 로고    scopus 로고
    • Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
    • Siim BG, Lee AE, Shalal-Zwain S, Pruijn FB, McKeage MJ, Wilson WR. Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemother Pharmacol 2003;51:43-52.
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 43-52
    • Siim, B.G.1    Lee, A.E.2    Shalal-Zwain, S.3    Pruijn, F.B.4    McKeage, M.J.5    Wilson, W.R.6
  • 258
    • 0034472914 scopus 로고    scopus 로고
    • Combretastatins novel vascular targeting drugs for improving anti-cancer therapy
    • Horsman MR, Murata R, Breidahl T, et al. Combretastatins novel vascular targeting drugs for improving anti-cancer therapy. Adv Exp Med Biol 2000;476:311-23.
    • (2000) Adv Exp Med Biol , vol.476 , pp. 311-323
    • Horsman, M.R.1    Murata, R.2    Breidahl, T.3
  • 259
    • 0346023954 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence
    • Wildiers H, Ahmed B, Guetens G, et al. Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence. Eur J Cancer 2004;40:284-90.
    • (2004) Eur J Cancer , vol.40 , pp. 284-290
    • Wildiers, H.1    Ahmed, B.2    Guetens, G.3
  • 260
    • 9344239900 scopus 로고    scopus 로고
    • Sensitization of tumor-associated endothelial cell apoptosis by the novel vascular-targeting agent ZD6126 in combination with cisplatin
    • Goto H, Yano S, Matsumori Y, Ogawa H, Blakey DC, Sone S. Sensitization of tumor-associated endothelial cell apoptosis by the novel vascular-targeting agent ZD6126 in combination with cisplatin. Clin Cancer Res 2004;10:7671-6.
    • (2004) Clin Cancer Res , vol.10 , pp. 7671-7676
    • Goto, H.1    Yano, S.2    Matsumori, Y.3    Ogawa, H.4    Blakey, D.C.5    Sone, S.6
  • 261
    • 0037562506 scopus 로고    scopus 로고
    • Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model
    • Shnyder SD, Cooper PA, Pettit GR, Lippert JW III, Bibby MC. Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model. Anticancer Res 2003;23:1619-24.
    • (2003) Anticancer Res , vol.23 , pp. 1619-1624
    • Shnyder, S.D.1    Cooper, P.A.2    Pettit, G.R.3    Lippert III, J.W.4    Bibby, M.C.5


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