p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis

Journal of Cell Biology

Volumn 156, Issue 1, 2002, Pages 149-160

  Matsumoto, Taro ^a   Turesson, Ingela ^a   Book, Majlis ^a   Gerwins, Pär ^a   Claesson Welsh, Lena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Angiogenesis; Differentiation; Fibroblast growth factor; p38 mitogen activated protein kinase; Vascular endothelial growth factor

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGEN; FIBROBLAST GROWTH FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH RECEPTOR;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CATTLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CHORIOALLANTOIS; CONTROLLED STUDY; DNA SYNTHESIS; ENDOTHELIUM CELL; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MORPHOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; STRESS;

ANIMALS; APOPTOSIS; CALCIUM-BINDING PROTEINS; CAPILLARIES; CATTLE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; CHICK EMBRYO; DNA; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FIBROBLAST GROWTH FACTOR 2; IMIDAZOLES; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOKINES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOGENESIS; MUTATION; NEOVASCULARIZATION, PHYSIOLOGIC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEINS; PYRIDINES; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ANIMALIA; BOS TAURUS; BOVINAE;

EID: 0037033794     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200103096     Document Type: Article

References (60)

1. Essential role of p38α MAP kinase in placental but not embryonic cardiovascular development
2. Requirement of vascular integrin αvβ3 for angiogenesis
3. Integrins and signal transduction pathways: The road taken
4. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
5. Signal transduction and biological function of placenta growth factor in primary human trophoblast
6. Endothelial cell apoptosis in angiogenesis and vessel regression
7. Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
8. Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis
9. Angiogenesis in cancer, vascular, rheumatoid and other disease
10. Anglogenesis in vitro
11. Induction of angiogenesis during the transition from hyperplasia to neoplasia
12. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
13. Differential expression and activation of p38 mitogen-activated protein kinase α, β, γ, and δ in inflammatory cell lineages
14. Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: Role of extracellular matrix
15. Integrin α2β1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the α2 cytoplasmic tail
16. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β)
17. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38δ
18. Gene expression profiling in an in vitro model of angiogenesis
19. Signal transduction by fibroblast growth factor receptors
20. Notch signaling is essential for vascular morphogenesis in mice
21. Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures
22. Induction of apoptotic cell death in vascular endothelial cells cultured in three-dimensional collagen lattice
23. Protein kinase cascades activated by stress and inflammatory cytokines
24. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
25. The primary structure of p38γ: A new member of p38 group of MAP kinases
26. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
27. Requirement of the MADS-box transcription factor MEF2C for vascular development
28. Defective IL-12 production in mitogen-activated protein MAP) kinase kinase 3 (Mkk3)-deficient mice
29. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: Inhibition by overexpression of Bcl-2 and Abl
30. Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK
31. In vitro rapid organization of endothelial cells into capillary-like networks is promoted by collagen matrices
32. Basic fibroblast growth factor induces angiogenesis in vitro
33. Induction of epithelial tubular morphogenesis in vitro by fibroblast-derived soluble factors
34. Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells
35. Essential role for p38α mitogen-activated protein kinase in placental angiogenesis
36. The p38 signal transduction pathway: Activation and function
37. Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro
38. Endothelial cell apoptosis in capillary network remodeling
39. Phosphoinositide 3 kinase is critical for survival, mitogenesis and migration but not for differentiation of endothelial cells
40. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
41. Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase
42. Mechanisms of angiogenesis
43. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
44. Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin
45. Autocrinological role of basic fibroblast growth factor on tube formation of vascular endothelial cells in vitro
46. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
47. Requirement for p38α in erythropoietin expression: A role for stress kinases in erythropoiesis
48. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
49. Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene
50. Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells
51. Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium
52. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
53. Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
54. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
55. Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged 1
56. Mekk3 is essential for early embryonic cardiovascular development
57. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
58. MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor
59. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor
60. An antisense oligonucleotide to the notch ligand Jagged enhances fibroblast growth factor-induced angiogenesis in vitro