메뉴 건너뛰기




Volumn 15, Issue 5, 2006, Pages 553-561

Sunitinib malate for the treatment of solid tumours: A review of current clinical data

Author keywords

Antiangiogenic; Antitumour; GIST; Inhibitor; Multitargeted tyrosine kinase; RCC; Solid tumours; SU11248; Sunitinib

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; FLUOROURACIL; GAMMA INTERFERON; INTERLEUKIN 2; KETOCONAZOLE; OCTREOTIDE; PLACEBO; PROTEIN TYROSINE KINASE; RIFAMPICIN; SUNITINIB; TAXANE DERIVATIVE; TRIACYLGLYCEROL LIPASE;

EID: 33646448005     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.15.5.553     Document Type: Review
Times cited : (117)

References (56)
  • 1
    • 22044442973 scopus 로고    scopus 로고
    • Tyrosine kinases as targets for cancer therapy
    • KRAUSE DS, VAN ETTEN RA: Tyrosine kinases as targets for cancer therapy. N. Engl. J. Med. (2005) 353(2):172-187.
    • (2005) N. Engl. J. Med. , vol.353 , Issue.2 , pp. 172-187
    • Krause, D.S.1    Van Etten, R.A.2
  • 2
    • 0038418059 scopus 로고    scopus 로고
    • Signal transduction. Autoinhibition control
    • SCHLESSINGER J: Signal transduction. Autoinhibition control. Science (2003) 300(5620):750-752.
    • (2003) Science , vol.300 , Issue.5620 , pp. 750-752
    • Schlessinger, J.1
  • 3
    • 1542315370 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib
    • MECHTERSHEIMER G, EGERER G, HENSEL M et al.: Gastrointestinal stromal tumours and their response to treatment with the tyrosine kinase inhibitor imatinib. Virchows Arch. (2004) 444(2):108-118.
    • (2004) Virchows Arch. , vol.444 , Issue.2 , pp. 108-118
    • Mechtersheimer, G.1    Egerer, G.2    Hensel, M.3
  • 4
    • 2342557044 scopus 로고    scopus 로고
    • Targeted therapies for non-small-cell lung cancer: Biology, rationale, and preclinical results from a radiation oncology perspective
    • RABEN D, HELFRICH B, BUNN PA Jr: Targeted therapies for non-small-cell lung cancer: biology, rationale, and preclinical results from a radiation oncology perspective. Int. J. Radiat. Oncol. Biol. Phys. (2004) 59(Suppl. 2):27-38.
    • (2004) Int. J. Radiat. Oncol. Biol. Phys. , vol.59 , Issue.SUPPL. 2 , pp. 27-38
    • Raben, D.1    Helfrich, B.2    Bunn Jr., P.A.3
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • VIVANCO I, SAWYERS CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer (2002) 2(7):489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 2442669093 scopus 로고    scopus 로고
    • Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with 'standard of care' therapeutic agents for the treatment of breast cancer
    • ABRAMS TJ, MURRAY LJ, PESENTI E et al.: Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with 'standard of care' therapeutic agents for the treatment of breast cancer. Mol. Cancer Ther. (2003) 2(10):1011-1021.
    • (2003) Mol. Cancer Ther. , vol.2 , Issue.10 , pp. 1011-1021
    • Abrams, T.J.1    Murray, L.J.2    Pesenti, E.3
  • 7
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • MENDEL DB, LAIRD AD, XIN X et al.: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin. Cancer Res. (2003) 9(1):327-337.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.1 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 8
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'FARRELL AM, ABRAMS TJ, YUEN HA et al.: SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood (2003) 101(9):3597-3605.
    • (2003) Blood , vol.101 , Issue.9 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 9
    • 33646464472 scopus 로고    scopus 로고
    • Pfizer, Inc.: Data on file, New York, NY, USA (Unpublished data)
    • PFIZER, INC.: Data on file, New York, NY, USA (2006) (Unpublished data).
    • (2006)
  • 10
    • 9144274970 scopus 로고    scopus 로고
    • SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model
    • MURRAY LJ, ABRAMS TJ, LONG KR et al.: SU11248 inhibits tumor growth and CSF-1R-dependent osteolysis in an experimental breast cancer bone metastasis model. Clin. Exp. Metastasis (2003) 20(8):757-766.
    • (2003) Clin. Exp. Metastasis , vol.20 , Issue.8 , pp. 757-766
    • Murray, L.J.1    Abrams, T.J.2    Long, K.R.3
  • 11
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • FERRARA N, GERBER HP, LECOUTER J: The biology of VEGF and its receptors. Nat. Med. (2003) 9(6):669-676.
    • (2003) Nat. Med. , vol.9 , Issue.6 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 12
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • HICKLIN DJ, ELLIS LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J. Clin. Oncol. (2005) 23(5):1011-1027.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 14
    • 27644557532 scopus 로고    scopus 로고
    • The role of pericytes in blood-vessel formation and maintenance
    • BERGERS G, SONG S: The role of pericytes in blood-vessel formation and maintenance. Neuro-oncol. (2005) 7(4):452-464.
    • (2005) Neuro-oncol , vol.7 , Issue.4 , pp. 452-464
    • Bergers, G.1    Song, S.2
  • 15
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • BERGERS G, SONG S, MEYER-MORSE N, BERGSLAND E, HANAHAN D: Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. (2003) 111(9):1287-1295.
    • (2003) J. Clin. Invest. , vol.111 , Issue.9 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 16
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • ERBER R, THURNHER A, KATSEN AD et al.: Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. (2004) 18(2):338-340.
    • (2004) FASEB J. , vol.18 , Issue.2 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3
  • 18
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • HEINRICH MC, CORLESS CL, DEMETRI GD et al.: Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J. Clin. Oncol. (2003) 21(23):4342-4349.
    • (2003) J. Clin. Oncol. , vol.21 , Issue.23 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3
  • 19
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • STIREWALT DL, RADICH JP: The role of FLT3 in haematopoietic malignancies. Nat. Rev. Cancer (2003) 3(9):650-665.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.9 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 20
    • 0034693757 scopus 로고    scopus 로고
    • The RET proto-oncogene in human cancers
    • JHIANG SM: The RET proto-oncogene in human cancers. Oncogene (2000) 19(49):5590-5597.
    • (2000) Oncogene , vol.19 , Issue.49 , pp. 5590-5597
    • Jhiang, S.M.1
  • 21
    • 0035266283 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth
    • KARPANEN T, EGEBLAD M, KARKKAINEN MJ et al.: Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res. (2001) 61(5):1786-1790.
    • (2001) Cancer Res. , vol.61 , Issue.5 , pp. 1786-1790
    • Karpanen, T.1    Egeblad, M.2    Karkkainen, M.J.3
  • 22
    • 0347133261 scopus 로고    scopus 로고
    • The role of CSF-1 in normal physiology of mammary gland and breast cancer: An update
    • SAPI E: The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp. Biol. Med. (Maywood) (2004) 229(1):1-11.
    • (2004) Exp. Biol. Med. (Maywood) , vol.229 , Issue.1 , pp. 1-11
    • Sapi, E.1
  • 24
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor β in preclinical models of human small cell lung cancer
    • ABRAMS TJ, LEE LB, MURRAY LJ, PRYER NK, CHERRINGTON JM: SU11248 inhibits KIT and platelet-derived growth factor receptor β in preclinical models of human small cell lung cancer. Mol. Cancer Ther. (2003) 2(5):471-478.
    • (2003) Mol. Cancer Ther. , vol.2 , Issue.5 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3    Pryer, N.K.4    Cherrington, J.M.5
  • 25
    • 0041672482 scopus 로고    scopus 로고
    • SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models
    • SCHUENEMAN AJ, HIMMELFARB E, GENG L et al.: SU11248 maintenance therapy prevents tumor regrowth after fractionated irradiation of murine tumor models. Cancer Res. (2003) 63(14):4009-4016.
    • (2003) Cancer Res. , vol.63 , Issue.14 , pp. 4009-4016
    • Schueneman, A.J.1    Himmelfarb, E.2    Geng, L.3
  • 26
    • 33644847440 scopus 로고    scopus 로고
    • Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
    • FAIVRE S, DELBALDO C, VERA K et al.: Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J. Clin. Oncol. (2006) 24(1):25-35.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.1 , pp. 25-35
    • Faivre, S.1    Delbaldo, C.2    Vera, K.3
  • 27
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • MOTZER RJ, MICHAELSON MD, REDMAN BG et al.: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. (2006) 24(1):16-24.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.1 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 28
    • 33646444167 scopus 로고    scopus 로고
    • Population pharmacokinetics (PK) of sunitinib malate (SU11248) and its primary metabolite (SU12662) in oncology patients and healthy volunteers
    • (Abstract B9171)
    • HOUK B, GARRETT M, BELLO C, POLAND B, WAGG J, GAO Y: Population pharmacokinetics (PK) of sunitinib malate (SU11248) and its primary metabolite (SU12662) in oncology patients and healthy volunteers. Clin. Cancer Res. (2005) 11 (Suppl. 24):9074s-9075s (Abstract B9171).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.SUPPL. 24
    • Houk, B.1    Garrett, M.2    Bello, C.3    Poland, B.4    Wagg, J.5    Gao, Y.6
  • 29
    • 33646437882 scopus 로고    scopus 로고
    • The effect of ketoconazole (KETO), a potent CYP3A4 inhibitor, on SU011248 pharmacokinetics (PK) in caucasian and Asian healthy subjects
    • (Abstract 553)
    • WASHINGTON C, ELI M, BELLO C et al.: The effect of ketoconazole (KETO), a potent CYP3A4 inhibitor, on SU011248 pharmacokinetics (PK) in caucasian and Asian healthy subjects. Proc. Am. Soc. Clin. Oncol. (2003) 22:138s (Abstract 553).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22
    • Washington, C.1    Eli, M.2    Bello, C.3
  • 30
    • 33646108821 scopus 로고    scopus 로고
    • Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: Results from a Phase I study in healthy subjects
    • BELLO C, SHERMAN L, ZHOU J et al.: Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: results from a Phase I study in healthy subjects. Anticancer Drugs (2006) 17(3):353-358.
    • (2006) Anticancer Drugs , vol.17 , Issue.3 , pp. 353-358
    • Bello, C.1    Sherman, L.2    Zhou, J.3
  • 31
    • 0344442746 scopus 로고    scopus 로고
    • Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease
    • JANZEN NK, KIM HL, FIGLIN RA, BELLDEGRUN AS: Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. Urol. Clin. North Am. (2003) 30(4):843-852.
    • (2003) Urol. Clin. North Am. , vol.30 , Issue.4 , pp. 843-852
    • Janzen, N.K.1    Kim, H.L.2    Figlin, R.A.3    Belldegrun, A.S.4
  • 32
    • 23744445106 scopus 로고    scopus 로고
    • Novel approaches in the therapy of metastatic renal cell carcinoma
    • LAM JS, LEPPERT JT, BELLDEGRUN AS, FIGLIN RA: Novel approaches in the therapy of metastatic renal cell carcinoma. World J. Urol. (2005) 23(3):202-212.
    • (2005) World J. Urol. , vol.23 , Issue.3 , pp. 202-212
    • Lam, J.S.1    Leppert, J.T.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 34
    • 23744431849 scopus 로고    scopus 로고
    • Chemotherapy in metastatic renal cell cancer
    • LILLEBY W, FOSSA SD: Chemotherapy in metastatic renal cell cancer. World J. Urol. (2005) 23(3):175-179.
    • (2005) World J. Urol. , vol.23 , Issue.3 , pp. 175-179
    • Lilleby, W.1    Fossa, S.D.2
  • 36
    • 0142219359 scopus 로고    scopus 로고
    • Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: Exploiting the hypoxia-induced pathway
    • PANTUCK AJ, ZENG G, BELLDEGRUN AS, FIGLIN RA: Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway. Clin. Cancer Res. (2003) 9(13):4641-4652.
    • (2003) Clin. Cancer Res. , vol.9 , Issue.13 , pp. 4641-4652
    • Pantuck, A.J.1    Zeng, G.2    Belldegrun, A.S.3    Figlin, R.A.4
  • 37
    • 14644415949 scopus 로고    scopus 로고
    • Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma
    • RINI BI, SMALL EJ: Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma. J. Clin. Oncol. (2005) 23(5):1028-1043.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.5 , pp. 1028-1043
    • Rini, B.I.1    Small, E.J.2
  • 38
    • 33646462684 scopus 로고    scopus 로고
    • Sunitinib malate (SU11248) shows antitumor activity in patients with metastatic renal cell carcinoma: Updated results from Phase II trials
    • (Abstract 797)
    • MOTZER R, RINI B, MICHAELSON M et al.: Sunitinib malate (SU11248) shows antitumor activity in patients with metastatic renal cell carcinoma: updated results from Phase II trials. Eur. J. Cancer Suppl. (2005) 3(2):227 (Abstract 797).
    • (2005) Eur. J. Cancer Suppl. , vol.3 , Issue.2 , pp. 227
    • Motzer, R.1    Rini, B.2    Michaelson, M.3
  • 39
    • 33646454525 scopus 로고    scopus 로고
    • Soluble protein biomarkers of pharmacodynamic activity of the multitargeted tyrosine kinase inhibitor SU11248 in patients with metastatic renal cell carcinoma
    • Anaheim, USA (16 - 20 April) (Abstract 464)
    • DEPRIMO SE, BELLO CL, SMERAGLIA J et al.: Soluble protein biomarkers of pharmacodynamic activity of the multitargeted tyrosine kinase inhibitor SU11248 in patients with metastatic renal cell carcinoma. 96th Annual Meeting of the American Association for Cancer Research, Anaheim, USA (16 - 20 April 2005) (Abstract 464).
    • (2005) 96th Annual Meeting of the American Association for Cancer Research
    • Deprimo, S.E.1    Bello, C.L.2    Smeraglia, J.3
  • 40
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-α as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • MOTZER RJ, BACIK J, MURPHY BA, RUSSO P, MAZUMDAR M: Interferon-α as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J. Clin. Oncol. (2002) 20(1):289-296.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.1 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3    Russo, P.4    Mazumdar, M.5
  • 41
    • 0033056820 scopus 로고    scopus 로고
    • Cytokines in metastatic renal cell carcinoma: Is it useful to switch to interleukin-2 or interferon after failure of a first treatment?
    • Groupe Francais d'Immunotherape
    • ESCUDIER B, CHEVREAU C, LASSET C et al.: Cytokines in metastatic renal cell carcinoma: is it useful to switch to interleukin-2 or interferon after failure of a first treatment? Groupe Francais d'Immunotherape. J. Clin. Oncol. (1999) 17(7):2039-2043.
    • (1999) J. Clin. Oncol. , vol.17 , Issue.7 , pp. 2039-2043
    • Escudier, B.1    Chevreau, C.2    Lasset, C.3
  • 42
    • 23944476156 scopus 로고    scopus 로고
    • PDGFRA mutations in gastrointestinal stromal tumors: Frequency, spectrum and in vitro sensitivity to imatinib
    • CORLESS CL, SCHROEDER A, GRIFFITH D et al.: PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib. J. Clin. Oncol. (2005) 23(23):5357-5364.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.23 , pp. 5357-5364
    • Corless, C.L.1    Schroeder, A.2    Griffith, D.3
  • 43
    • 20044362947 scopus 로고    scopus 로고
    • State-of-the art therapy for gastrointestinal stromal tumors
    • BLANKE CD, CORLESS CL: State-of-the art therapy for gastrointestinal stromal tumors. Cancer Invest. (2005) 23(3):274-280.
    • (2005) Cancer Invest. , vol.23 , Issue.3 , pp. 274-280
    • Blanke, C.D.1    Corless, C.L.2
  • 44
    • 0037103424 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
    • DEMETRI GD, VON MEHREN M, BLANKE CD et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. (2002) 347(7):472-480.
    • (2002) N. Engl. J. Med. , vol.347 , Issue.7 , pp. 472-480
    • Demetri, G.D.1    Von Mehren, M.2    Blanke, C.D.3
  • 45
    • 24944529613 scopus 로고    scopus 로고
    • Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: A European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study
    • VAN GLABBEKE M, VERWEIJ J, CASALI PG et al.: Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study. J. Clin. Oncol. (2005) 23(24):5795-5804.
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5795-5804
    • Van Glabbeke, M.1    Verweij, J.2    Casali, P.G.3
  • 46
    • 33646463104 scopus 로고    scopus 로고
    • Patients with imatinib mesylate-resistant GIST exhibit durable responses to sunitinb malate (SU11248)
    • European Cancer Conference (ECCO 13), Paris, France 30 October - 3 November 2005 (Abstract 1456)
    • MORGAN JA, DEMETRI GD, FLETCHER JA et al.: Patients with imatinib mesylate-resistant GIST exhibit durable responses to sunitinb malate (SU11248). European Cancer Conference (ECCO 13), Paris, France 30 October - 3 November 2005. Eur. J. Cancer Suppl. (2005) 3(2):421 (Abstract 1456).
    • (2005) Eur. J. Cancer Suppl. , vol.3 , Issue.2 , pp. 421
    • Morgan, J.A.1    Demetri, G.D.2    Fletcher, J.A.3
  • 47
    • 33646458478 scopus 로고    scopus 로고
    • Sunitinib malate (SU11248) prolongs progression-free and overall survival for GIST patients after failure of imatinib mesylate therapy: Update of a Phase III trial
    • (Abstract 716)
    • DEMETRI GD, VAN OOSTEROM A, GARRETT C et al.: Sunitinib malate (SU11248) prolongs progression-free and overall survival for GIST patients after failure of imatinib mesylate therapy: update of a Phase III trial. Eur. J. Cancer Suppl. (2005) 3(2):203 (Abstract 716).
    • (2005) Eur. J. Cancer Suppl. , vol.3 , Issue.2 , pp. 203
    • Demetri, G.D.1    Van Oosterom, A.2    Garrett, C.3
  • 48
    • 0034925637 scopus 로고    scopus 로고
    • Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells
    • PRICE DJ, MIRALEM T, JIANG S, STEINBERG R, AVRAHAM H: Role of vascular endothelial growth factor in the stimulation of cellular invasion and signaling of breast cancer cells. Cell Growth Differ. (2001) 12(3):129-135.
    • (2001) Cell Growth Differ. , vol.12 , Issue.3 , pp. 129-135
    • Price, D.J.1    Miralem, T.2    Jiang, S.3    Steinberg, R.4    Avraham, H.5
  • 49
    • 0031910169 scopus 로고    scopus 로고
    • Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops
    • DE JONG JS, VAN DIEST PJ, VAN DER VALK P, BAAK JP: Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: an inventory in search of autocrine and paracrine loops. J. Pathol. (1998) 184(1):44-52.
    • (1998) J. Pathol. , vol.184 , Issue.1 , pp. 44-52
    • De Jong, J.S.1    Van Diest, P.J.2    Van Der Valk, P.3    Baak, J.P.4
  • 50
    • 0031906775 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in digestive neuroendocrine tumours
    • TERRIS B, SCOAZEC JY, RUBBIA L et al.: Expression of vascular endothelial growth factor in digestive neuroendocrine tumours. Histopathology (1998) 32(2):133-138.
    • (1998) Histopathology , vol.32 , Issue.2 , pp. 133-138
    • Terris, B.1    Scoazec, J.Y.2    Rubbia, L.3
  • 51
    • 0028856096 scopus 로고
    • Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis
    • CHRISTOFORI G, NAIK P, HANAHAN D: Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol. Endocrinol. (1995) 9(12):1760-1770.
    • (1995) Mol. Endocrinol. , vol.9 , Issue.12 , pp. 1760-1770
    • Christofori, G.1    Naik, P.2    Hanahan, D.3
  • 52
    • 0027269918 scopus 로고
    • Expression of growth factor peptides and their receptors in neuroendocrine tumors of the digestive system
    • CHAUDHRY A, FUNA K, OBERG K: Expression of growth factor peptides and their receptors in neuroendocrine tumors of the digestive system. Acta Oncol. (1993) 32(2):107-114.
    • (1993) Acta Oncol. , vol.32 , Issue.2 , pp. 107-114
    • Chaudhry, A.1    Funa, K.2    Oberg, K.3
  • 53
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • YANG JC, HAWORTH L, SHERRY RM et al.: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med. (2003) 349(5):427-434.
    • (2003) N. Engl. J. Med. , vol.349 , Issue.5 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 54
    • 19644375361 scopus 로고    scopus 로고
    • Gastric GI stromal tumors (GISTs): The role of surgery in the era of targeted therapy
    • (Discussion 207)
    • HEINRICH MC, CORLESS CL: Gastric GI stromal tumors (GISTs): the role of surgery in the era of targeted therapy. J. Surg. Oncol. (2005) 90(3):195-207 (Discussion 207).
    • (2005) J. Surg. Oncol. , vol.90 , Issue.3 , pp. 195-207
    • Heinrich, M.C.1    Corless, C.L.2
  • 55
    • 20944442418 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumors in children and young adults: A clinicopathologic, molecular, and genomic study of 15 cases and review of the literature
    • PRAKASH S, SARRAN L, SOCCI N et al.: Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. J. Pediatr. Hematol. Oncol. (2005) 27(4):179-187.
    • (2005) J. Pediatr. Hematol. Oncol. , vol.27 , Issue.4 , pp. 179-187
    • Prakash, S.1    Sarran, L.2    Socci, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.