A therapeutic aptamer inhibits angiogenesis by specifically targeting the heparin binding domain of VEGF165

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 52, 2005, Pages 18902-18907

  Lee, Joon Hwa ^a   Canny, Marella D ^a   De Erkenez, Andrea ^b   Krilleke, Dominik ^b   Ng, Yin Shan ^b   Shima, David T ^b   Pardi, Arthur ^a   Jucker, Fiona ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b Eyetech Research Center   (United States)

^c Dharmacon Inc   (United States)

Author keywords

Age related macular degeneration; Macugen; NMR; RNA

Indexed keywords

APTAMER; HEPARIN BINDING PROTEIN; VASCULOTROPIN 165;

ANGIOGENESIS; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; COMPLEX FORMATION; DIMERIZATION; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR BINDING; RETINA MACULA AGE RELATED DEGENERATION; TISSUE CULTURE;

APTAMERS, NUCLEOTIDE; BINDING SITES; BINDING, COMPETITIVE; CELLS, CULTURED; DIMERIZATION; ENDOTHELIUM, VASCULAR; HEPARIN; HUMANS; MACULAR DEGENERATION; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NEOVASCULARIZATION, PATHOLOGIC; PICHIA; POLYETHYLENE GLYCOLS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; RNA; SIGNAL TRANSDUCTION; THERMODYNAMICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 30044436689     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0509069102     Document Type: Article

References (35)

1. Ferrara, N., Gerber, H. P. & LeCouter, J. (2003) Nat. Med. 9, 669-676.
2. Tammela, T., Enholm, B., Alitola, K. & Paavonen, K. (2005) Cardiovasc. Res. 65, 550-553.
3. Witmer, A. N., Vrensen, G., Van Noorden, C. J. F. & Schlingemann, R. O. (2003) Prog. Retin. Eye Res. 22, 1-29.
4. Ishida, S., Usui, T., Yamashiro, K., Kaji, Y., Amano, S., Ogura, Y., Hida, T., Oguchi, Y., Ambati, J., Miller, J. W., et al. (2003) J. Exp. Med. 198, 483-489.
5. Ng, E. & Adamis, A. (2005) Can. J. Ophthalmol. 40, 352-368.
6. Stauffer, M. E., Skelton, N. J. & Fairbrother, W. J. (2002) J. Biomol. NMR 23, 57-61.
7. Wiesmann, C., Fuh, G., Christinger, H. W., Eigenbrot, C., Wells, J. A. & de Vos, A. M. (1997) Cell 91, 695-704.
8. Ruckman, J., Green, L. S., Beeson, J., Waugh, S., Gillette, W. L., Henninger, D. D., Claesson-Welsh, L. & Janjic, N. (1998) J. Biol. Chem. 273, 20556-20567.
9. Tuerk, C. & Gold, L. (1990) Science 249, 505-510.
10. Nimjee, S., Rusconi, C. & Sullenger, B. (2005) Annu. Rev. Med. 56, 555-583.
11. Bell, C., Lynam, E., Landfair, D. J., Janjic, N. & Wiles, M. (1999) In Vitro Cell Dev. Biol. Anim. 35, 533-542.
12. Gragoudas, E., Adamis, A., Cunningham, E. J., Feinsod, M. & Guyer, D. (2004) N. Engl. J. Med. 351, 2805-2816.
13. Schachat, A. P. (2005) Ophthalmology 112, 531-532.
14. Fine, S., Martin, D. & Kirkpatrick, P. (2005) Nat. Rev. Drug Discov. 4, 187-188.
15. Pervushin, K., Riek, R., Wider, G. & Wüthrich, K. (1997) Proc. Natl. Acad. Sci. USA 94, 12366-12371.
16. Lucerna, M., Mechtcheriakova, D., Kadi, A., Schabbauer, G., Schäfer, R., Gruber, F., Koshelnick, Y., Müller, H.-D., Issbrücker, K., Clauss, M., et al. (2003) J. Biol. Chem. 278, 11433-11440.
17. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J. & Bax, A. (1995) J. Biomol. NMR 6, 277-293.
18. Goddard, T. D. & Kneller, D. G. (2003) SPARKY (University of California, San Francisco).
19. Farmer, B. T., Constantine, K., Goldfarb, V., Friedrichs, M., Wittekind, M., Yanchunas, J. J., Robertson, J. & Mueller, L. (1996) Nat. Struct. Biol. 3, 995-997.
20. Pan, B. & Fairbrother, W. J. (2002) J. Biomol. NMR 22, 189-190.
21. Gorenstein, D. G. (1984) Phosphorous-31 NMR: Principles and Applications (Academic, Orlando, FL).
22. Castagne, C., Murphy, E. C, Gronenborn, A. M. & Delepierre, M. (2000) Eur. J. Biochem. 267, 1223-1229.
23. Jellinek, D., Green, L. S., Bell, C. & Janjic, N. (1994) Biochemistry 33, 10450-10456.
24. Green, L. S., Jellinek, D., Bell, C, Beebe, L. A., Feistner, B. D., Gill, S. C., Jucker, F. M. & Janjic, N. (1995) Chem. Biol. 2, 683-695.
25. Burmeister, P., Lewis, S., Silva, R., Preiss, J., Horwitz, L., Pendergrast, P., McCauley, T., Kurz, J., Epstein, D., Wilson, C. & Keefe, A. (2005) Chem. Biol. 12, 25-33.
26. Gueron, M. & Shulman, R. G. (1975) Proc. Natl. Acad. Sci. USA 72, 3482-3485.
27. Golden, M. C., Collins, B. D., Willis, M. C. & Koch, T. H. (2000) J. Biotechnol. 81, 167-178.
28. Williamson, J. R. (2000) Nat. Struct. Biol 7, 834-837.
29. Hermann, T. & Patel, D. J. (2000) Science 287, 820-825.
30. Cummins, L., Owens, S., Risen, L., Lesnik, E., Freier, S., McGee, D., Guinosso, C. & Cook, P. (1995) Nucleic Acids Res. 23, 2019-2024.
31. Luque, A., Carpizo, D. R. & Iruela-Arispe, M. L. (2003) J. Biol. Chem. 278, 23656-23665.
32. Heroult, M., Bernard-Pierrot, I., Delbe, J., Hamma-Kourbali, Y., Katsoris, P., Varritault, D., Papadimitriou, E., Plouet, J. & Courty, J. (2004) Oncogene 23, 1745-1753.
33. Inoki, I., Shiomi, T., Hashimoto, G., Enomoto, H., Nakamura, H., Makino, K., Ikeda, E., Takata, S., Kobayashi, K. & Okada, Y. (2002) FASEB J. 16, 219-221.
34. Soker, S., Takashima, S., Miao, H. Q., Neufeld, G. & Klagstrun, M. (1998) Cell 92, 735-745.
35. Whitaker, G. B., Limberg, B. & Rosenbaum, J. S. (2001) J. Biol. Chem. 276, 25520-25531.