Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo

Peptides

Volumn 25, Issue 12, 2004, Pages 2179-2185

  Conconi, Maria Teresa ^a   Nico, Beatrice ^b   Guidolin, Diego ^c   Baiguera, Silvia ^a   Spinazzi, Raffaella ^c   Rebuffat, Piera ^c   Malendowicz, Ludwik K ^d   Vacca, Angelo ^b   Carraro, Gianni ^c   Parnigotto, Pier Paolo ^a   Nussdorfer, Gastone G ^c   Ribatti, Domenico ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY OF BARI MEDICAL SCHOOL   (Italy)

^c UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^d POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Angiogenesis; Antiangiogenesis; FGF 2; Ghrelin; Vinblastine

Indexed keywords

ANGIOGENESIS INHIBITOR; FIBROBLAST GROWTH FACTOR 2; GHRELIN; GROWTH HORMONE RELEASING FACTOR DERIVATIVE; GROWTH HORMONE RELEASING PEPTIDE 6 [3 DEXTRO LYSINE]; GROWTH HORMONE SECRETAGOGUE RECEPTOR; MATRIGEL; MESSENGER RNA; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VINBLASTINE;

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CHICK EMBRYO; CHORIOALLANTOIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN;

ANIMALS; CHICK EMBRYO; CHORIOALLANTOIC MEMBRANE; ENDOTHELIUM, VASCULAR; FEMALE; FIBROBLAST GROWTH FACTOR 2; HUMANS; MICROSCOPY, PHASE-CONTRAST; NEOVASCULARIZATION, PHYSIOLOGIC; PEPTIDE HORMONES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 20844461130     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2004.08.011     Document Type: Article

References (60)

1. G. Albertin, G. Carraro, P.P. Parnigotto, M.T. Conconi, A. Ziolkowska, and L.K. Malendowicz Human skin keratinocytes and fibroblasts express adrenomedullin and its receptors, and adrenonomedullin enhances their growth in vitro by stimulating proliferation and inhibiting apoptosis Int J Mol Med 11 2003 635 639
2. Baiguera S, Conconi MT, Guidolin D, Mazzocchi G, Malendowicz LK, Parnigotto PP, et al. Ghrelin inhibits in vitro angiogenic activity of rat brain microvascular endothelial cells. Int J Mol Med, 2004, in press.
3. A. Baird, P. Mormede, and P. Bohlen Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggests its identity with macrophage-derived growth factor Biochem Biophys Res Commun 126 1985 358 364
4. G. Baldanzi, N. Filigheddu, S. Cutrupi, F. Catapano, S. Bonissoni, and A. Fubini Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK/2 and PI3-kinase/AKT J Cell Biol 159 2001 1029 1037
5. C. Basilico, and D. Moscatelli The FGF family of growth factors and angiogenesis Adv Cancer Res 59 1992 115 165
6. 14-ghrelin Eur J Pharmacol 476 2003 87 95
7. A.S. Belloni, C. Macchi, P. Rebuffat, M.T. Conconi, L.K. Malendowicz, and P.P. Parnigotto Effect of ghrelin on the apoptosis deletion rate of different types of cells cultured in vitro Int J Mol Med 14 2004 165 167
8. G. Bisi, V. Podio, M.R. Valetto, F. Broglio, G. Bertuccio, and G. Aimaretti Cardiac effects of hexarelin in hypopituitary adults Eur J Pharmacol 381 1999 31 38
9. S. Blotnick, G.E. Peoples, M.R. Freeman, T.J. Eberlein, and M. Klagsbrun T lymphocytes synthesize and export heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor, mitogens for vascular cells and fibroblasts: differential production and release by CD4+ and CD8+ T cells Proc Natl Acad Sci USA 91 1994 2890 2894
10. V. Bodard, M. Febbraio, A. Demers, N. McNicoll, P. Pohankova, and A. Perreault CD36 mediates the cardiovascular action of growth hormone-releasing peptides in the heart Circ Res 90 2002 844 849
11. F. Broglio, C. Gottero, E. Arvat, and E. Ghigo Endocrine and non-endocrine actions of ghrelin Horm Res 59 2003 109 117
12. G. Carraro, G. Albertin, A. Abudukerimu, F. Aragona, and G.G. Nussdorfer Growth hormone secretagogue receptor subtypes 1a and 1b are expressed in the human adrenal cortex Int J Mol Med 13 2004 295 298
13. P. Cassoni, C. Ghé, T. Marrocco, E. Tarabra, E. Allia, and F. Catapano Expression of ghrelin and biological activity of specific receptors for ghrelin and des-acyl ghrelin in human prostate neoplasms and related cell lines Eur J Endocrinol 150 2004 173 184
14. P. Cassoni, M. Papotti, C. Ghè, F. Catapano, A. Sapino, and A. Graziani Identification, characterization and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogue and analogs in human breast carcinomas and cell lines J Clin Endocrinol Metab 86 2001 1738 1745
15. P. Dell'Era, M. Presta, and G. Ragnotti Nuclear localization of endogenous basic fibroblast growth factor in cultured endothelial cells Exp Cell Res 192 1991 505 510
16. D. Donovan, N.J. Brown, E.T. Bishop, and C.E. Lewis Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo Angiogenesis 4 2001 113 121
17. M.S. Duxbury, T. Waseem, H. Ito, M.K. Robinson, M.J. Zinner, and S.W. Ashley Ghrelin promotes pancreatic adrenocarcinoma cellular proliferation and invasiveness Biochem Biophys Res Commun 309 2003 464 468
18. M. Enomoto, N. Nagaya, M. Uematsu, H. Okumura, E. Nakagawa, and F. Ono Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans Clin Sci 105 2003 431 435
19. J. Folkman Tumor angiogenesis: therapeutic implications New Engl J Med 285 1971 1182 1186
20. E. Ghigo, E. Arvat, R. Giordano, F. Broglio, L. Gianotti, and M. Maccario Biologic activities of growth hormone secretagogue in humans Endocrine 14 2001 87 93
21. S. Gnanapavan, B. Kola, S.A. Bustin, D.G. Morris, P. McGree, and P. Fairclough The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans J Clin Endocrinol Metab 87 2002 2988 2991
22. O. Gualillo, F. Lago, J. Gomez-Reino, F.F. Casanueva, and C. Dieguez Ghrelin, a widespread hormone: insights into molecular and cellular regulation of its expression and mechanism of action FEBS Lett 552 2003 105 109
23. A.D. Howard, S.C. Feighner, D.F. Cully, J.P. Arena, P.A. Liberator, and C.I. Rosenblum A receptor in pituitary and hypothalamus that functions in growth hormone release Science 273 1996 974 977
24. P.L. Jeffrey, A.C. Herington, and L.K. Chopin The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer Cytokine Growth Factor Rev 14 2003 113 122
25. 121I- His(9)]-ghrelin, a novel radioligand for localizing GHS orphan receptors in human and rat tissues: up-regulation of receptors with atherosclerosis Br J Pharmacol 134 2001 143 149
26. R. Kerbel, and J. Folkman Clinical translation of angiogenesis inhibitors Nat Rev Cancer 2 2002 723 739
27. M.K. King, D.M. Gay, L.C. Pan, J.H. McElmurray III, J.W. Hendrick, and C. Pierie Treatment with a growth hormone secretagogue in a model of developing heart failure: effects on ventricular and myocyte function Circulation 103 2001 308 313
28. M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone acylated peptide from stomach Nature 402 1999 656 660
29. M. Kojima, H. Hosoda, H. Matsuo, and K. Kangawa Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor Trends Endocrinol Metab 12 2001 118 122
30. M. Korbonits, M. Kojima, K. Kangawa, and A.B. Grossman Presence of ghrelin in normal and adenomatous human pituitary Endocrine 14 2001 101 104
31. K. Lamaszus, N.O. Schmidt, S. Ergün, and M. Westphal Isolation and culture of human neuromicrovascular endothelial cells for the study of angiogenesis in vitro J Neurosci Res 55 1999 370 381
32. M.A. Lazarczyk, M. Lazarczyk, and T. Grzela Ghrelin: a recently discovered gut-brain peptide Int J Mol Med 12 2003 279 287
33. V. Locatelli, G. Rossoni, F. Schweiger, A. Torsello, V. De Gennaro-Colonna, and M. Bernareggi Growth hormone-independent cardioprotective effects of hexarelin in the rat Endocrinology 140 1999 4024 4031
34. K.K. McKee, O.C. Palynha, S.D. Feighner, D.L. Hreniuk, C.P. Tan, and M.S. Phillips Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors Mol Endocrinol 11 1997 415 423
35. G. Mazzocchi, G. Neri, M. Rucinski, P. Rebuffat, R. Spinazzi, and L.K. Malendowicz Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects Peptides 25 2004 1269 1277
36. G. Mazzocchi, G.P. Rossi, G. Neri, L.K. Malendowicz, G. Albertin, and G.G. Nussdorfer 11β-Hydroxysteroid dehydrogenase expression and activity in the human adrenal cortex FASEB J 12 1998 1533 1539
37. 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland J Endocrinol Invest 24 2001 RC7 RC9
38. N. Nagaya, and K. Kangawa Ghrelin a novel growth hormone-releasing peptide, in the treatment of chronic heart failure Regul Pept 114 2003 71 77
39. N. Nagaya, M. Kojima, M. Uematsu, M. Yamagishi, H. Hosoda, and H. Oya Hemodynamic and hormonal effects of human ghrelin in healthy volunteers Am J Physiol 280 2001 R1483 R1487
40. N. Nagaya, M. Uematsu, M. Kojima, Y. Ikeda, F. Yoshihara, and W. Shimizu Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure Circulation 104 2001 1430 1435
41. H. Norrelund, T.K. Hansen, H. Orskov, H. Hosoda, M. Kojima, and K. Kangawa Ghrelin immunoreactivity in human plasma is suppressed by somatostatin Clin Endocrinol 57 2002 539 546
42. M.A. Nugent, and R.V. Iosso Fibroblast growth factor-2 Int J Biochem Cell Biol 32 2000 115 120
43. H. Okumura, N. Nagaya, M. Enomoto, E. Nakagawa, H. Oya, and K. Kangawa Vasodilatory effect of ghrelin, an endogenous peptide from the stomach J Cardiovasc Pharmacol 39 2002 779 783
44. J.J. Pang, R.K. Xu, X.B. Xu, J.M. Cao, C. Ni, and W.L. Zhu Hexarelin protects rat cardiomyocytes from angiotensin II-induced apoptosis in vitro Am J Physiol 286 2004 1063 1069
45. M. Papotti, C. Ghè, P. Cassoni, F. Catapano, R. Deghenghi, and E. Ghigo Growth hormone secretagogue binding sites in peripheral human tissues J Clin Endocrinol Metab 85 2000 3803 3807
46. I. Petterson, G. Muccioli, R. Granata, R. Deghenghi, E. Ghigo, and C. Ohlsson Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 J Endocrinol 175 2002 201 209
47. D. Ribatti, C. Urbinati, B. Nico, M. Rusnati, L. Roncali, and M. Presta Endogenous basic fibroblast growth factor is implicated in the vascularization of the chick chorioallantoic membrane Dev Biol 170 1995 39 49
48. D. Ribatti, A. Gualandris, M. Bastaki, A. Vacca, M. Iurlaro, and L. Roncali New model for the study of angiogenesis and antiangiogenesis in the chick embryo chorioallantoic membrane: the gelatin sponge/chorioallantoic membrane assay J Vasc Res 34 1997 455 463
49. D. Ribatti, M. Bertossi, B. Nico, A. Vacca, R. Ria, and A. Riva Role of basic fibroblast growth factor in the formation of the capillary plexus in the chick embryo chorioallantoic membrane. An in situ hybridization, immunohistochemical and ultrastructural study J Submicrosc Cytol Pathol 30 1998 127 136
50. D. Ribatti, D. Guidolin, M.T. Conconi, B. Nico, S. Baiguera, and P.P. Parnigotto Vinblastine inhibits the angiogenic response induced by andrenomedullin in vitro and in vivo Oncogene 22 2003 6458 6461
51. D. Ribatti, A. Vacca, and F. Dammacco The role of the vascular phase in solid tumor growth: a historical review Neoplasia 1 1999 293 302
52. A.E. Rigamonti, A.I. Pincelli, B. Corrà, R. Viarengo, S.M. Bonomo, and D. Galimberti Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients J Endocrinol 175 2002 R1 R5
53. K. Sturm, C.G. Mac Intosh, B.J. Parker, J. Wishart, M. Horowitz, and I.M. Chapman Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin, and other gastrointestinal hormones in undernourished older women and well-nourished young and older women J Clin Endocrinol Metab 88 2003 3747 3755
54. K. Takaya, H. Ariyasu, N. Kanamoto, H. Iwakura, A. Yoshimoto, and M. Hazada Ghrelin strongly stimulates growth hormone release in humans J Clin Endocrinol Metab 85 2000 4908 4911
55. A. Tivesten, E. Bollano, K. Caidahl, V. Kujacic, X.Y. Sun, and T. Hedner The growth hormone secretagogue hexarelin improves cardiac function in rats after experimental myocardial infarction Endocrinology 141 2000 60 66
56. C. Tortorella, C. Macchi, R. Spinazzi, L.K. Malendowicz, M. Trejter, and G.G. Nussdorfer Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is expressed in the human adrenal cortex Int J Mol Med 12 2003 213 217
57. K. Toshinai, Y. Date, N. Murakami, M. Shimada, M.S. Mondal, and T. Shimbara Ghrelin-induced food intake is mediated via the orexin pathway Endocrinology 144 2003 1506 1512
58. A. Vacca, M. Iurlaro, D. Ribatti, M. Minischetti, B. Nico, and R. Ria Antiangiogenesis is produced by nontoxic doses of vinblastine Blood 94 1999 4143 4155
59. M. Volante, E. Allia, E. Fulcheri, P. Cassoni, E. Ghigo, and G. Muccioli Ghrelin in fetal thyroid and follicular tumors and cell lines Am J Pathol 162 2003 645 654
60. K.E. Wiley, and A.P. Davenport Comparison of vasodilators in human internal mammary artery: ghrelin is a potent physiological antagonist of endothelin-1 Br J Pharmacol 136 2002 1146 1152