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Volumn 26, Issue 4, 2006, Pages 483-530

Anti-angiogenic drugs: From bench to clinical trials

Author keywords

Angiogenesis; Cancer; Clinical trials; Inhibitors; Macular degeneration

Indexed keywords

2 (8 HYDROXY 6 METHOXY 1 OXO 1H 2 BENZOPYRAN 3 YL)PROPIONIC ACID; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 3 [4 METHYL 2 (2 OXO 3 INDOLINYLMETHYLIDENYL) 3 PYRROLYL]PROPIONIC ACID; 4 DEDIMETHYLAMINOSANCYCLINE; 4,4' [CARBONYLBIS[IMINO 1H PYRROLE 4,2 DIYLCARBONYLIMINO(1 METHYL 1H PYRROLE 4,2 DIYL)CARBONYLIMINO]]BIS(1,7 NAPHTHALENESULFONIC ACID); AE 941; AGM 1479; ALPHA INTERFERON; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; BASIC FIBROBLAST GROWTH FACTOR; BATIMASTAT; BB 2626; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CGS 27023A; ERLOTINIB; EVEROLIMUS; FUMAGILLOL CHLOROACETYLCARBAMATE; MARIMASTAT; MONOCLONAL ANTIBODY LM 609; MSI 1256F; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 [2 (1H 1,2,3 TRIAZOL 1 YL)ETHOXY] 4 QUINAZOLINAMINE; PACLITAXEL; PD 166866; PENTOSAN POLYSULFATE; PRINOMASTAT; REBIMASTAT; SEMAXANIB; SOLIMASTAT; SORAFENIB; SQUALAMINE; SU 4984; SUNITINIB; SURAMIN; TANOMASTAT; TECOGALAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VATALANIB;

EID: 33745305095     PISSN: 01986325     EISSN: None     Source Type: Journal    
DOI: 10.1002/med.20059     Document Type: Review
Times cited : (162)

References (424)
  • 1
    • 0032792360 scopus 로고    scopus 로고
    • The rationale and future potential of angiogenesis inhibitors in neoplasia
    • Gasparini G. The rationale and future potential of angiogenesis inhibitors in neoplasia. Drugs 1999;58: 17-38.
    • (1999) Drugs , vol.58 , pp. 17-38
    • Gasparini, G.1
  • 2
    • 0031443206 scopus 로고    scopus 로고
    • A cancer therapy resistant to resistance
    • Kerbel RS. A cancer therapy resistant to resistance. Nature 1997;390:335-336.
    • (1997) Nature , vol.390 , pp. 335-336
    • Kerbel, R.S.1
  • 3
    • 0034665166 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice
    • Brekken RA, Overholser JP, Stastny VA, Waltenberger J, Minna JD, Thorpe PE. Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res 2000;60:5117-5124.
    • (2000) Cancer Res , vol.60 , pp. 5117-5124
    • Brekken, R.A.1    Overholser, J.P.2    Stastny, V.A.3    Waltenberger, J.4    Minna, J.D.5    Thorpe, P.E.6
  • 4
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber HP, Ferrara N. Pharmacology and pharmacodynamics of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res 2005;65:671-680.
    • (2005) Cancer Res , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 5
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, Armanini M, Gillett N, Phillips HS, Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-844.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3    Armanini, M.4    Gillett, N.5    Phillips, H.S.6    Ferrara, N.7
  • 6
    • 2942535898 scopus 로고    scopus 로고
    • Targeted therapy of colorectal cancer: Clinical experience with bevacizumab
    • Fernando NH, Hurwitz HI. Targeted therapy of colorectal cancer: Clinical experience with bevacizumab. Oncologist 2004;9(Suppl 1):11-18.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 1 , pp. 11-18
    • Fernando, N.H.1    Hurwitz, H.I.2
  • 7
    • 0034975263 scopus 로고    scopus 로고
    • Antiangiogenic agents and their promising potential in combined therapy
    • Burke PA, DeNardo SJ. Antiangiogenic agents and their promising potential in combined therapy. Crit Rev Oncol Hematol 2001;39:155-171.
    • (2001) Crit Rev Oncol Hematol , vol.39 , pp. 155-171
    • Burke, P.A.1    DeNardo, S.J.2
  • 8
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L, Meropol NJ, Novotny WF, Lieberman G, Griffing S, Bergsland E. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003;21:60-65.
    • (2003) J Clin Oncol , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6    Griffing, S.7    Bergsland, E.8
  • 9
    • 33745325885 scopus 로고
    • Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-FU-LV) as a first-line therapy in subjects with metastatic CRC
    • Abstract 3645
    • Hurwitz H, Fehrenbacher L, Cartwright T, Hainsworth J, Hein W, Berlin J, Griffing S, Novotny W, Holmgren E, Kabbinavar F. Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-FU-LV) as a first-line therapy in subjects with metastatic CRC. Proc Am Soc Clin Oncol; 22: Abstract 3645.
    • (1922) Proc Am Soc Clin Oncol
    • Hurwitz, H.1    Fehrenbacher, L.2    Cartwright, T.3    Hainsworth, J.4    Hein, W.5    Berlin, J.6    Griffing, S.7    Novotny, W.8    Holmgren, E.9    Kabbinavar, F.10
  • 11
    • 12944313265 scopus 로고    scopus 로고
    • High-dose bevacizumab in combination with FOLFOX4 improves survival in patients with previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200
    • Abstract No: 169a
    • Mitchell EP, Alberts SR, Schwartz MA, Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Benson AB. High-dose bevacizumab in combination with FOLFOX4 improves survival in patients with previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200. Gastrointestinal Cancers Symposium 2005; Abstract No: 169a.
    • (2005) Gastrointestinal Cancers Symposium
    • Mitchell, E.P.1    Alberts, S.R.2    Schwartz, M.A.3    Giantonio, B.J.4    Catalano, P.J.5    Meropol, N.J.6    O'Dwyer, P.J.7    Benson, A.B.8
  • 13
    • 16244379522 scopus 로고    scopus 로고
    • VEGF-targeted therapy in metastatic renal cell carcinoma
    • Rini BI. VEGF-targeted therapy in metastatic renal cell carcinoma. Oncologist 2005;10:191-197.
    • (2005) Oncologist , vol.10 , pp. 191-197
    • Rini, B.I.1
  • 17
    • 1942470411 scopus 로고    scopus 로고
    • 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma
    • Rini BI, Halabi S, Taylor J, Small EJ, Schilsky RL; Cancer and Leukemia Group B. 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin Cancer Res 2004;10:2584-2586.
    • (2004) Clin Cancer Res , vol.10 , pp. 2584-2586
    • Rini, B.I.1    Halabi, S.2    Taylor, J.3    Small, E.J.4    Schilsky, R.L.5
  • 19
    • 33646780432 scopus 로고    scopus 로고
    • E2100: A randomized phase III trial of paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer
    • Late-breaking session
    • Miller KD, Wang M, Gralow J, Dickler M, Cobleigh M, Perez EA, Shenker TN, Davidson NE. E2100: A randomized phase III trial of paclitaxel plus bevacizumab as first-line therapy for locally recurrent or metastatic breast cancer. Proc Am Soc Clin Oncol 2005. Late-breaking session.
    • (2005) Proc Am Soc Clin Oncol
    • Miller, K.D.1    Wang, M.2    Gralow, J.3    Dickler, M.4    Cobleigh, M.5    Perez, E.A.6    Shenker, T.N.7    Davidson, N.E.8
  • 22
    • 22144471081 scopus 로고    scopus 로고
    • Randomized phase II/III trial of paelitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial-E4599
    • Sandler AB, Gray R, Brahmer J, Dowlati A, Sehiller JH, Perry MC, Johnson DH. Randomized phase II/III trial of paelitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial-E4599. J Clin Oncol (Meeting Abstracts) 2005;23:LBA4.
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23
    • Sandler, A.B.1    Gray, R.2    Brahmer, J.3    Dowlati, A.4    Sehiller, J.H.5    Perry, M.C.6    Johnson, D.H.7
  • 23
    • 0035671572 scopus 로고    scopus 로고
    • Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors
    • Barleon B, Reusch P, Totzke F, Herzog C, Keck C, Martiny-Baron G, Marme D. Soluble VEGFR-1 secreted by endothelial cells and monocytes is present in human serum and plasma from healthy donors. Angiogenesis 2001;4:143-154.
    • (2001) Angiogenesis , vol.4 , pp. 143-154
    • Barleon, B.1    Reusch, P.2    Totzke, F.3    Herzog, C.4    Keck, C.5    Martiny-Baron, G.6    Marme, D.7
  • 24
    • 0030726988 scopus 로고    scopus 로고
    • Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth
    • Lin P, Polverini P, Dewhirst M, Shan S, Rao PS, Peters K. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. J Clin Invest 1997;100:2072-2078.
    • (1997) J Clin Invest , vol.100 , pp. 2072-2078
    • Lin, P.1    Polverini, P.2    Dewhirst, M.3    Shan, S.4    Rao, P.S.5    Peters, K.6
  • 25
    • 0031965353 scopus 로고    scopus 로고
    • Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor
    • Lin P, Sankar S, Shan S, Dewhirst MW, Polverini PJ, Quinn TQ, Peters KG. Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor. Cell Growth Differ 1998;9:49-58.
    • (1998) Cell Growth Differ , vol.9 , pp. 49-58
    • Lin, P.1    Sankar, S.2    Shan, S.3    Dewhirst, M.W.4    Polverini, P.J.5    Quinn, T.Q.6    Peters, K.G.7
  • 27
    • 0034655246 scopus 로고    scopus 로고
    • Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ
    • Takayama K, Ueno H, Nakanishi Y, Sakamoto T, Inoue K, Shimizu K, Oohashi H, Hara N. Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ. Cancer Res 2000;60:2169-2177.
    • (2000) Cancer Res , vol.60 , pp. 2169-2177
    • Takayama, K.1    Ueno, H.2    Nakanishi, Y.3    Sakamoto, T.4    Inoue, K.5    Shimizu, K.6    Oohashi, H.7    Hara, N.8
  • 28
    • 0036021883 scopus 로고    scopus 로고
    • Anti-tumor angiogenesis therapy using soluble receptors: Enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor
    • Ogawa T, Takayama K, Takakura N, Kitano S, Ueno H. Anti-tumor angiogenesis therapy using soluble receptors: Enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor. Cancer Gene Ther 2002;9:633-640.
    • (2002) Cancer Gene Ther , vol.9 , pp. 633-640
    • Ogawa, T.1    Takayama, K.2    Takakura, N.3    Kitano, S.4    Ueno, H.5
  • 31
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne AT, Ross L, Holash J, Nakanishi M, Hu L, Hofmann JI, Yancopoulos GD, Jaffe RB. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 2003;9:5721-5728.
    • (2003) Clin Cancer Res , vol.9 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3    Nakanishi, M.4    Hu, L.5    Hofmann, J.I.6    Yancopoulos, G.D.7    Jaffe, R.B.8
  • 35
    • 0035254648 scopus 로고    scopus 로고
    • Angiogenesis: Regulators and clinical applications
    • Liekens S, De Clercq E, Neyts J. Angiogenesis: regulators and clinical applications. Biochem Pharmacol 2001;61:253-270.
    • (2001) Biochem Pharmacol , vol.61 , pp. 253-270
    • Liekens, S.1    De Clercq, E.2    Neyts, J.3
  • 40
    • 0035339880 scopus 로고    scopus 로고
    • High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801
    • Kirkwood JM, Ibrahim JG, Sosman JA, Sondak VK, Agarwala SS, Ernstoff MS, Rao U. High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: Results of intergroup trial E1694/S9512/C509801. J Clin Oncol 2001;19:2370-2380.
    • (2001) J Clin Oncol , vol.19 , pp. 2370-2380
    • Kirkwood, J.M.1    Ibrahim, J.G.2    Sosman, J.A.3    Sondak, V.K.4    Agarwala, S.S.5    Ernstoff, M.S.6    Rao, U.7
  • 41
  • 43
    • 0036676326 scopus 로고    scopus 로고
    • Interferon-alpha therapy in children with malignant diseases: Clinical experience in twenty-four patients treated in a single pediatric oncology unit
    • Kiss C, Kiss M, Szegedi I, Arvai K, Toth J, Olah E. Interferon-alpha therapy in children with malignant diseases: Clinical experience in twenty-four patients treated in a single pediatric oncology unit. Med Pediatr Oncol 2002;39:115-119.
    • (2002) Med Pediatr Oncol , vol.39 , pp. 115-119
    • Kiss, C.1    Kiss, M.2    Szegedi, I.3    Arvai, K.4    Toth, J.5    Olah, E.6
  • 44
    • 0036534376 scopus 로고    scopus 로고
    • Interferon alfa therapy for malignant melanoma: A systematic review of randomized controlled trials
    • Lens MB, Dawes M. Interferon alfa therapy for malignant melanoma: A systematic review of randomized controlled trials. J Clin Oncol 2002;20:1818-1825.
    • (2002) J Clin Oncol , vol.20 , pp. 1818-1825
    • Lens, M.B.1    Dawes, M.2
  • 45
    • 0041384495 scopus 로고    scopus 로고
    • Prospective randomized trial of interferon alfa-2b and interleukin-2 as adjuvant treatment for resected intermediate- and high-risk primary melanoma without clinically detectable node metastasis
    • Hauschild A, Weichenthal M, Balda BR, Becker JC, Wolff HH, Tilgen W, Schulte KW, Ring J, Schadendorf D, Lischner S, Burg G, Dummer R. Prospective randomized trial of interferon alfa-2b and interleukin-2 as adjuvant treatment for resected intermediate- and high-risk primary melanoma without clinically detectable node metastasis. J Clin Oncol 2003;21:2883-2888.
    • (2003) J Clin Oncol , vol.21 , pp. 2883-2888
    • Hauschild, A.1    Weichenthal, M.2    Balda, B.R.3    Becker, J.C.4    Wolff, H.H.5    Tilgen, W.6    Schulte, K.W.7    Ring, J.8    Schadendorf, D.9    Lischner, S.10    Burg, G.11    Dummer, R.12
  • 46
    • 3242686449 scopus 로고    scopus 로고
    • Adjuvant interferon in high-risk melanoma: The AIM HIGH Study-United Kingdom Coordinating Committee on Cancer Research Randomized Study of Adjuvant Low-Dose Extended-Duration Interferon Alfa-2a in High-Risk Resected Malignant Melanoma
    • Hancock BW, Wheatley K, Harris S, Ives N, Harrison G, Horsman JM, Middleton MR, Thatcher N, Lorigan PC, Marsden JR, Burrows L, Gore M. Adjuvant interferon in high-risk melanoma: The AIM HIGH Study-United Kingdom Coordinating Committee on Cancer Research Randomized Study of Adjuvant Low-Dose Extended-Duration Interferon Alfa-2a in High-Risk Resected Malignant Melanoma. J Clin Oncol 2004;22:53-61.
    • (2004) J Clin Oncol , vol.22 , pp. 53-61
    • Hancock, B.W.1    Wheatley, K.2    Harris, S.3    Ives, N.4    Harrison, G.5    Horsman, J.M.6    Middleton, M.R.7    Thatcher, N.8    Lorigan, P.C.9    Marsden, J.R.10    Burrows, L.11    Gore, M.12
  • 47
    • 1842533233 scopus 로고    scopus 로고
    • A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma
    • Kirkwood JM, Manola J, Ibrahim J, Sondak V, Ernstoff MS, Rao U. A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma. Clin Cancer Res 2004;10:1670-1677.
    • (2004) Clin Cancer Res , vol.10 , pp. 1670-1677
    • Kirkwood, J.M.1    Manola, J.2    Ibrahim, J.3    Sondak, V.4    Ernstoff, M.S.5    Rao, U.6
  • 48
    • 11144236728 scopus 로고    scopus 로고
    • Present status and future prospects for adjuvant therapy of melanoma: Time to build upon the foundation of high-dose interferon alfa-2b
    • Moschos SJ, Kirkwood JM, Konstantinopoulos PA. Present status and future prospects for adjuvant therapy of melanoma: Time to build upon the foundation of high-dose interferon alfa-2b. J Clin Oncol 2004;22:11-14.
    • (2004) J Clin Oncol , vol.22 , pp. 11-14
    • Moschos, S.J.1    Kirkwood, J.M.2    Konstantinopoulos, P.A.3
  • 50
    • 5444220651 scopus 로고    scopus 로고
    • Adjuvant interferon therapy for melanoma: High-dose, low-dose, no dose, which dose?
    • Schuchter LM. Adjuvant interferon therapy for melanoma: High-dose, low-dose, no dose, which dose?. J Clin Oncol. 2004;22:7-10.
    • (2004) J Clin Oncol , vol.22 , pp. 7-10
    • Schuchter, L.M.1
  • 51
    • 0022370712 scopus 로고
    • Suramin binds to platelet-derived growth factor and inhibits its biological activity
    • Hosang M. Suramin binds to platelet-derived growth factor and inhibits its biological activity. J Cell Biochem 1985;29:265-273.
    • (1985) J Cell Biochem , vol.29 , pp. 265-273
    • Hosang, M.1
  • 52
    • 0027489946 scopus 로고
    • Suramin inhibits bFGF-induced endothelial cell proliferation and angio-genesis in the chick chorioallantoic membrane
    • Danesi R, Del BS, Soldani P, Campagni A, La RR, Myers CE, Paparelli A, Del TM. Suramin inhibits bFGF-induced endothelial cell proliferation and angio-genesis in the chick chorioallantoic membrane. Br J Cancer 1993;68:932-938.
    • (1993) Br J Cancer , vol.68 , pp. 932-938
    • Danesi, R.1    Del, B.S.2    Soldani, P.3    Campagni, A.4    La, R.R.5    Myers, C.E.6    Paparelli, A.7    Del, T.M.8
  • 54
    • 0030198685 scopus 로고    scopus 로고
    • Suramin is a potent inhibitor of vascular endothelial growth factor. A contribution to the molecular basis of its antiangiogenic action
    • Waltenberger J, Mayr U, Frank H, Hombach V. Suramin is a potent inhibitor of vascular endothelial growth factor. A contribution to the molecular basis of its antiangiogenic action. J Mol Cell Cardiol 1996;28:1523-1529.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 1523-1529
    • Waltenberger, J.1    Mayr, U.2    Frank, H.3    Hombach, V.4
  • 55
    • 0028318791 scopus 로고
    • Suramin, an anticancer and angiosuppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urokinase-type plasminogen activator
    • Takano S, Gately S, Neville ME, Herblin WF, Gross JL, Engelhard H, Perricone M, Eidsvoog K, Brem S. Suramin, an anticancer and angiosuppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urokinase-type plasminogen activator. Cancer Res 1994;54:2654-2660.
    • (1994) Cancer Res , vol.54 , pp. 2654-2660
    • Takano, S.1    Gately, S.2    Neville, M.E.3    Herblin, W.F.4    Gross, J.L.5    Engelhard, H.6    Perricone, M.7    Eidsvoog, K.8    Brem, S.9
  • 57
    • 0026729378 scopus 로고
    • Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity
    • Pesenti E, Sola F, Mongelli N, Grandi M, Spreatico F. Suramin prevents neovascularisation and tumour growth through blocking of basic fibroblast growth factor activity. Br J Cancer 1992;66:367-372.
    • (1992) Br J Cancer , vol.66 , pp. 367-372
    • Pesenti, E.1    Sola, F.2    Mongelli, N.3    Grandi, M.4    Spreatico, F.5
  • 59
    • 0030763677 scopus 로고    scopus 로고
    • Suramin/epidoxorubicin association in hormone-refractory prostate cancer: Preliminary results of a pilot phase II study
    • Miglietta L, Canobbio L, Granetto C, Vannozzi MO, Esposito M, Boccardo F. Suramin/epidoxorubicin association in hormone-refractory prostate cancer: Preliminary results of a pilot phase II study. J Cancer Res Clin Oncol 1997;123:407-410.
    • (1997) J Cancer Res Clin Oncol , vol.123 , pp. 407-410
    • Miglietta, L.1    Canobbio, L.2    Granetto, C.3    Vannozzi, M.O.4    Esposito, M.5    Boccardo, F.6
  • 60
    • 0030891264 scopus 로고    scopus 로고
    • Suramin in non-small cell lung cancer and advanced breast cancer. Two parallel phase II studies
    • Mirza MR, Jakobsen E, Pfeiffer P, Lindebjerg-Clasen B, Bergh J, Rose C. Suramin in non-small cell lung cancer and advanced breast cancer. Two parallel phase II studies. Acta Oncol 1997;36:171-174.
    • (1997) Acta Oncol , vol.36 , pp. 171-174
    • Mirza, M.R.1    Jakobsen, E.2    Pfeiffer, P.3    Lindebjerg-Clasen, B.4    Bergh, J.5    Rose, C.6
  • 63
    • 0028345444 scopus 로고
    • A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions
    • Braddock PS, Hu DE, Fan TP, Stratford IJ, Harris AL, Bicknell R. A structure-activity analysis of antagonism of the growth factor and angiogenic activity of basic fibroblast growth factor by suramin and related polyanions. Br J Cancer 1994;69:890-898.
    • (1994) Br J Cancer , vol.69 , pp. 890-898
    • Braddock, P.S.1    Hu, D.E.2    Fan, T.P.3    Stratford, I.J.4    Harris, A.L.5    Bicknell, R.6
  • 69
    • 0027787820 scopus 로고
    • Pentosan inhibits angiogenesis in vitro and suppresses prostate tumor growth in vivo
    • Nguyen NM, Lehr JE, Pienta KJ. Pentosan inhibits angiogenesis in vitro and suppresses prostate tumor growth in vivo. Anticancer Res 1993;13:2143-2147.
    • (1993) Anticancer Res , vol.13 , pp. 2143-2147
    • Nguyen, N.M.1    Lehr, J.E.2    Pienta, K.J.3
  • 73
    • 33645784293 scopus 로고    scopus 로고
    • The role of pentosan polysulfate in treatment approaches for interstitial cystitis
    • Teichman JMH. The role of pentosan polysulfate in treatment approaches for interstitial cystitis. Rev Urol 2002;4:S21-S27.
    • (2002) Rev Urol , vol.4
    • Teichman, J.M.H.1
  • 74
    • 0036207871 scopus 로고    scopus 로고
    • Osteoarthritis, genetic and molecular mechanisms
    • Ghosh P, Smith M. Osteoarthritis, genetic and molecular mechanisms. Biogerontology 2002;3:85-88.
    • (2002) Biogerontology , vol.3 , pp. 85-88
    • Ghosh, P.1    Smith, M.2
  • 75
    • 0032943892 scopus 로고    scopus 로고
    • Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells
    • Arora N, Masood R, Zheng T, Cai J, Smith DL, Gill PS. Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells. Cancer Res 1999;59:183-188.
    • (1999) Cancer Res , vol.59 , pp. 183-188
    • Arora, N.1    Masood, R.2    Zheng, T.3    Cai, J.4    Smith, D.L.5    Gill, P.S.6
  • 77
    • 0036554955 scopus 로고    scopus 로고
    • Increased Sophistication of Immunotoxins
    • Frankel AE. Increased Sophistication of Immunotoxins. Clin Cancer Res 2002;8:942-944.
    • (2002) Clin Cancer Res , vol.8 , pp. 942-944
    • Frankel, A.E.1
  • 78
    • 0033396950 scopus 로고    scopus 로고
    • Inhibition of tumor growth and metastasis by targeting tumor associated angiogenesis with antagonists to the receptors of vascular endoithelial growth factor
    • Zhu Z, Witte L. Inhibition of tumor growth and metastasis by targeting tumor associated angiogenesis with antagonists to the receptors of vascular endoithelial growth factor. Invest New Drugs 1999;17:195-212.
    • (1999) Invest New Drugs , vol.17 , pp. 195-212
    • Zhu, Z.1    Witte, L.2
  • 79
    • 0033692912 scopus 로고    scopus 로고
    • Nuclease-resistant synthetic ribozymes: Developing a new class of therapeutics
    • Usman N, Blatt LM. Nuclease-resistant synthetic ribozymes: Developing a new class of therapeutics. J Clin Invest 2000;106:1197-1202.
    • (2000) J Clin Invest , vol.106 , pp. 1197-1202
    • Usman, N.1    Blatt, L.M.2
  • 81
    • 4243323946 scopus 로고    scopus 로고
    • Ribozyme pharmacokinetic screening for predicting pharmacodynamic dosing regimens
    • Rossi J, Couture L, editors. Wymondham, UK: Horizon Scientific Press
    • Parry TJ, Pavco PA, Sandberg JA. Ribozyme pharmacokinetic screening for predicting pharmacodynamic dosing regimens. In: Rossi J, Couture L, editors, Intracellular ribozyme applications: Principles and protocols. Wymondham, UK: Horizon Scientific Press. 1999.
    • (1999) Intracellular Ribozyme Applications: Principles and Protocols
    • Parry, T.J.1    Pavco, P.A.2    Sandberg, J.A.3
  • 86
    • 0035290919 scopus 로고    scopus 로고
    • Angiozyme: A novel angiogenesis inhibitor
    • Weng DE, Usaman N. Angiozyme: A novel angiogenesis inhibitor. Curr Oncol Rep 2001;3:141-146.
    • (2001) Curr Oncol Rep , vol.3 , pp. 141-146
    • Weng, D.E.1    Usaman, N.2
  • 87
    • 1542276244 scopus 로고    scopus 로고
    • Relationship of clinical outcome in metastatic colorectal carcinoma to levels of soluble VEGFR-1: Results of a Phase II trial of ANGIOZYME, a ribozyme targeting the pre-mRNA of VEGFR-1, in combination with chemotherapy
    • Abstract 1025
    • Venook A, Hurwitz H, Cunningham C, Burris H, Aitchison R, Radka S, Pavco P, Capra W, Wolin M, Usman N. Relationship of clinical outcome in metastatic colorectal carcinoma to levels of soluble VEGFR-1: Results of a Phase II trial of ANGIOZYME, a ribozyme targeting the pre-mRNA of VEGFR-1, in combination with chemotherapy. Proc Am Soc Clin Oncol 2003;22:256, Abstract 1025.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 256
    • Venook, A.1    Hurwitz, H.2    Cunningham, C.3    Burris, H.4    Aitchison, R.5    Radka, S.6    Pavco, P.7    Capra, W.8    Wolin, M.9    Usman, N.10
  • 89
    • 0034054325 scopus 로고    scopus 로고
    • Target molecules for anti-angiogenic therapy: From basic research to clinical trials
    • Hagedorn M, Bikfalvi A. Target molecules for anti-angiogenic therapy: From basic research to clinical trials. Crit Rev Oncol Hematol 2000;34:89-110.
    • (2000) Crit Rev Oncol Hematol , vol.34 , pp. 89-110
    • Hagedorn, M.1    Bikfalvi, A.2
  • 91
    • 0035884609 scopus 로고    scopus 로고
    • Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2
    • Kunkel P, Ulbricht U, Bohlen P, Brockmann MA, Fillbrandt R, Stavrou D, Westphal M, Lamszus K. Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2. Cancer Res 2001;61:6624-6628.
    • (2001) Cancer Res , vol.61 , pp. 6624-6628
    • Kunkel, P.1    Ulbricht, U.2    Bohlen, P.3    Brockmann, M.A.4    Fillbrandt, R.5    Stavrou, D.6    Westphal, M.7    Lamszus, K.8
  • 93
    • 0032145315 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library
    • Zhu Z, Rockwell P, Lu D, Kotanides H, Pytowski B, Hicklin DJ, Bohlen P, Witte L. Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library. Cancer Res 1998;58:3209-3214.
    • (1998) Cancer Res , vol.58 , pp. 3209-3214
    • Zhu, Z.1    Rockwell, P.2    Lu, D.3    Kotanides, H.4    Pytowski, B.5    Hicklin, D.J.6    Bohlen, P.7    Witte, L.8
  • 94
    • 0037386937 scopus 로고    scopus 로고
    • A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma
    • Posey JA, Ng TC, Yang B, Khazaeli MB, Carpenter MD, Fox F, Needle M, Waksal H, LoBuglio AF. A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma. Clin Cancer Res 2003;9:1323-1332.
    • (2003) Clin Cancer Res , vol.9 , pp. 1323-1332
    • Posey, J.A.1    Ng, T.C.2    Yang, B.3    Khazaeli, M.B.4    Carpenter, M.D.5    Fox, F.6    Needle, M.7    Waksal, H.8    Lobuglio, A.F.9
  • 95
    • 0242353266 scopus 로고    scopus 로고
    • Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity
    • Lu D, Shen J, Vil MD, Zhang H, Jimenez X, Bohlen P, Witte L, Zhu Z. Tailoring in vitro selection for a picomolar affinity human antibody directed against vascular endothelial growth factor receptor 2 for enhanced neutralizing activity. J Biol Chem 2003;278:43496-43507.
    • (2003) J Biol Chem , vol.278 , pp. 43496-43507
    • Lu, D.1    Shen, J.2    Vil, M.D.3    Zhang, H.4    Jimenez, X.5    Bohlen, P.6    Witte, L.7    Zhu, Z.8
  • 97
    • 0036279804 scopus 로고    scopus 로고
    • Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics
    • Zhu Z, Bohlen P, Witte L. Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics. Current Cancer Drug Targets 2002;2:135-156.
    • (2002) Current Cancer Drug Targets , vol.2 , pp. 135-156
    • Zhu, Z.1    Bohlen, P.2    Witte, L.3
  • 98
    • 15944419554 scopus 로고    scopus 로고
    • A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3
    • Jimenez X, Lu D, Brennan L, Persaud K, Liu M, Miao H, Witte L, Zhu Z. A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3. Mol Cancer Ther 2005;4:427-434.
    • (2005) Mol Cancer Ther , vol.4 , pp. 427-434
    • Jimenez, X.1    Lu, D.2    Brennan, L.3    Persaud, K.4    Liu, M.5    Miao, H.6    Witte, L.7    Zhu, Z.8
  • 99
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, Tang C, App H, Powell TJ, Kim YH, Schreck R, Wang X, Risau W, Ullrich A, Hirth KP, McMahon G. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999;59:99-106.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3    Tang, C.4    App, H.5    Powell, T.J.6    Kim, Y.H.7    Schreck, R.8    Wang, X.9    Risau, W.10    Ullrich, A.11    Hirth, K.P.12    McMahon, G.13
  • 100
    • 0033231069 scopus 로고    scopus 로고
    • Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
    • Shaheen RM, Davis DW, Liu W, Zebrowski BK, Wilson MR, Bucana CD, McConkey DJ, McMahon G, Ellis LM. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res 1999;59:5412-5416.
    • (1999) Cancer Res , vol.59 , pp. 5412-5416
    • Shaheen, R.M.1    Davis, D.W.2    Liu, W.3    Zebrowski, B.K.4    Wilson, M.R.5    Bucana, C.D.6    McConkey, D.J.7    McMahon, G.8    Ellis, L.M.9
  • 101
    • 0033229939 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas
    • Angelov L, Salhia B, Roncari L, McMahon G, Guha A. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Cancer Res 1999;59:5536-5541.
    • (1999) Cancer Res , vol.59 , pp. 5536-5541
    • Angelov, L.1    Salhia, B.2    Roncari, L.3    McMahon, G.4    Guha, A.5
  • 102
    • 12844265499 scopus 로고    scopus 로고
    • Irradiation combined with SU5416: Microvascular changes and growth delay in a human xenograft glioblastoma tumor line
    • Schuuring J, Bussink J, Bernsen HJ, Peeters W, van Der Kogel AJ. Irradiation combined with SU5416: microvascular changes and growth delay in a human xenograft glioblastoma tumor line. Int J Radiat Oncol Biol Phys 2005;61:529-534.
    • (2005) Int J Radiat Oncol Biol Phys , vol.61 , pp. 529-534
    • Schuuring, J.1    Bussink, J.2    Bernsen, H.J.3    Peeters, W.4    Van Der Kogel, A.J.5
  • 105
    • 0034281007 scopus 로고    scopus 로고
    • Clinical trials referral resource. Current clinical trials administering the antiangiogenesis agent SU5416
    • Via LE, Gore-Langton RE, Pluda JM. Clinical trials referral resource. Current clinical trials administering the antiangiogenesis agent SU5416. Oncology (Williston Park) 2000; 14:1312, 1315-1316, 1321-1323.
    • (2000) Oncology (Williston Park) , vol.14 , pp. 1312
    • Via, L.E.1    Gore-Langton, R.E.2    Pluda, J.M.3
  • 113
    • 0036738403 scopus 로고    scopus 로고
    • Analysis of coagulation cascade and endotelial cell activation during inhibition of vascular endotelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients
    • Kuenen BC, Levi M, Meijer JCM, Kakkar AK, van Hinsbergh VWM, Costéense PJ, Pinedo HM, Hoekman K. Analysis of coagulation cascade and endotelial cell activation during inhibition of vascular endotelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients. Arterioscler Thromb Vase Biol 2002;22:1500-1505.
    • (2002) Arterioscler Thromb Vase Biol , vol.22 , pp. 1500-1505
    • Kuenen, B.C.1    Levi, M.2    Meijer, J.C.M.3    Kakkar, A.K.4    Van Hinsbergh, V.W.M.5    Costéense, P.J.6    Pinedo, H.M.7    Hoekman, K.8
  • 127
    • 0000103504 scopus 로고    scopus 로고
    • Phase I experience with SU6668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies
    • Rosen LS, Rosen PJ, Kabbinavar F, Rosen P, Cropp G, Hannah A. Phase I experience with SU6668, a novel multiple receptor tyrosine kinase inhibitor in patients with advanced malignancies. Proc Am Soc Clin Oncol 2001;20:97a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Rosen, L.S.1    Rosen, P.J.2    Kabbinavar, F.3    Rosen, P.4    Cropp, G.5    Hannah, A.6
  • 129
    • 4644222221 scopus 로고    scopus 로고
    • SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST)
    • Demetri GD, Desai J, Fletcher JA, Morgan JA, Fletcher CDM, Kazanovicz A, Van Den Abbeele A, Baum C, Maki R, Heinrich MC. SU11248, a multi-targeted tyrosine kinase inhibitor, can overcome imatinib (IM) resistance caused by diverse genomic mechanisms in patients (pts) with metastatic gastrointestinal stromal tumor (GIST). J Clin Oncol 2004;22:3001.
    • (2004) J Clin Oncol , vol.22 , pp. 3001
    • Demetri, G.D.1    Desai, J.2    Fletcher, J.A.3    Morgan, J.A.4    Fletcher, C.D.M.5    Kazanovicz, A.6    Van Den Abbeele, A.7    Baum, C.8    Maki, R.9    Heinrich, M.C.10
  • 132
    • 2442669093 scopus 로고    scopus 로고
    • Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer
    • Abrams TJ, Murray LJ, Pesenti E, Holway VW, Colombo T, Lee LB, Cherrington JM, Pryer NK. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with "standard of care" therapeutic agents for the treatment of breast cancer. Mol Cancer Ther 2003;2:1011-1021.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1011-1021
    • Abrams, T.J.1    Murray, L.J.2    Pesenti, E.3    Holway, V.W.4    Colombo, T.5    Lee, L.B.6    Cherrington, J.M.7    Pryer, N.K.8
  • 146
    • 0035217589 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases
    • Solorzano CC, Baker CH, Bruns CJ, Killion JJ, Ellis LM, Wood J, Fidler IJ. Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Cancer Biother Radiopharm 2001;16:359-370.
    • (2001) Cancer Biother Radiopharm , vol.16 , pp. 359-370
    • Solorzano, C.C.1    Baker, C.H.2    Bruns, C.J.3    Killion, J.J.4    Ellis, L.M.5    Wood, J.6    Fidler, I.J.7
  • 147
    • 0036531923 scopus 로고    scopus 로고
    • Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer
    • Baker CH, Solorzano CC, Fidler IJ. Blockade of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling for therapy of metastatic human pancreatic cancer. Cancer Res 2002; 62:1996-2003.
    • (2002) Cancer Res , vol.62 , pp. 1996-2003
    • Baker, C.H.1    Solorzano, C.C.2    Fidler, I.J.3
  • 148
    • 0001341494 scopus 로고    scopus 로고
    • A phase-1 dose-escalating and pharmacokinetic (PK) study of the VEGF-receptor-inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastasis of advanced cancer
    • Drevs J, Mross K, Fuxius S. A phase-1 dose-escalating and pharmacokinetic (PK) study of the VEGF-receptor-inhibitor PTK787/ZK 222584 (PTK/ZK) in patients with liver metastasis of advanced cancer. Proc Am Soc Clin Oncol 2001;20:100a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Drevs, J.1    Mross, K.2    Fuxius, S.3
  • 150
    • 7444222477 scopus 로고    scopus 로고
    • Expanded phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer
    • Steward WP, Thomas A, Morgan B, Wiedenmann B, Bartel C, Vanhoefer U, Trarbach T, Junker U, Laurent D, Lebwohl D. Expanded phase I/II study of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with FOLFOX-4 as first-line treatment for patients with metastatic colorectal cancer. J Clin Oncol (Meeting Abstracts) 2004;22:259.
    • (2004) J Clin Oncol (Meeting Abstracts) , vol.22 , pp. 259
    • Steward, W.P.1    Thomas, A.2    Morgan, B.3    Wiedenmann, B.4    Bartel, C.5    Vanhoefer, U.6    Trarbach, T.7    Junker, U.8    Laurent, D.9    Lebwohl, D.10
  • 151
    • 23844548194 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1)
    • Hecht JR, Trarbach T, Jaeger E, Hainsworth J, Wolff R, Lloyd K, Bodoky G, Borner M, Laurent D, Jacques C. A randomized, double-blind, placebo-controlled, phase III study in patients (Pts) with metastatic adenocarcinoma of the colon or rectum receiving first-line chemotherapy with oxaliplatin/5-fluorouracil/ leucovorin and PTK787/ZK 222584 or placebo (CONFIRM-1). J Clin Oncol (Meeting Abstracts) 2005;23:LBA3.
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23
    • Hecht, J.R.1    Trarbach, T.2    Jaeger, E.3    Hainsworth, J.4    Wolff, R.5    Lloyd, K.6    Bodoky, G.7    Borner, M.8    Laurent, D.9    Jacques, C.10
  • 152
    • 16844371774 scopus 로고    scopus 로고
    • A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM)
    • Reardon D, Friedman H, Yung WKA, Brada M, Conrad C, Provenzale J, Jackson E, Serajuddin H, Chen B, Laurent D. A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM). J Clin Oncol (Meeting Abstracts) 2004;22:110.
    • (2004) J Clin Oncol (Meeting Abstracts) , vol.22 , pp. 110
    • Reardon, D.1    Friedman, H.2    Yung, W.K.A.3    Brada, M.4    Conrad, C.5    Provenzale, J.6    Jackson, E.7    Serajuddin, H.8    Chen, B.9    Laurent, D.10
  • 155
    • 11144223542 scopus 로고    scopus 로고
    • ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity
    • Williams KJ, Telfer BA, Brave S, Kendrew J, Whittaker L, Stratford IJ, Wedge SR. ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity. Clin Cancer Res 2004;10:8587-8593.
    • (2004) Clin Cancer Res , vol.10 , pp. 8587-8593
    • Williams, K.J.1    Telfer, B.A.2    Brave, S.3    Kendrew, J.4    Whittaker, L.5    Stratford, I.J.6    Wedge, S.R.7
  • 156
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F, Caputo R, Damiano V, Caputo R, Troiani T, Vitagliano D, Carlomagno F, Veneziani BM, Fontanini G, Bianco AR, Tortora G. Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res 2003;9:1546-1556.
    • (2003) Clin Cancer Res , vol.9 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3    Caputo, R.4    Troiani, T.5    Vitagliano, D.6    Carlomagno, F.7    Veneziani, B.M.8    Fontanini, G.9    Bianco, A.R.10    Tortora, G.11
  • 157
    • 10844285939 scopus 로고    scopus 로고
    • Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models
    • Taguchi F, Koh Y, Koizumi F, Tamura T, Saijo N, Nishio K. Anticancer effects of ZD6474, a VEGF receptor tyrosine kinase inhibitor, in gefitinib ("Iressa")-sensitive and resistant xenograft models. Cancer Sci 2004;95:984-989.
    • (2004) Cancer Sci , vol.95 , pp. 984-989
    • Taguchi, F.1    Koh, Y.2    Koizumi, F.3    Tamura, T.4    Saijo, N.5    Nishio, K.6
  • 158
    • 0141542201 scopus 로고    scopus 로고
    • A phase I study of an oral VEGF receptor tyrosine kinase inhibitor ZD6474, in Japanese patients with solid tumors
    • Abstract 778
    • Minami H, Ebi H, Tahara M, Sasaki Y, Yamamoto N, Yamada Y, Tamura T, Saijo N. A phase I study of an oral VEGF receptor tyrosine kinase inhibitor ZD6474, in Japanese patients with solid tumors. Proc Am Soc Clin Oncol 2003;22: Abstract 778.
    • (2003) Proc Am Soc Clin Oncol , vol.22
    • Minami, H.1    Ebi, H.2    Tahara, M.3    Sasaki, Y.4    Yamamoto, N.5    Yamada, Y.6    Tamura, T.7    Saijo, N.8
  • 162
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • Wilhelm S, Chien DS. BAY 43-9006: Preclinical data. Curr Pharm Des 2002;8:2255-2257.
    • (2002) Curr Pharm des , vol.8 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.S.2
  • 169
    • 0037112181 scopus 로고    scopus 로고
    • Randomized discontinuation design: Application to cytostatic antineoplastic agents
    • Rosner GL, Stadler W, Ratain MJ. Randomized discontinuation design: Application to cytostatic antineoplastic agents. J Clin Onc 2002;20:4478-4484.
    • (2002) J Clin Onc , vol.20 , pp. 4478-4484
    • Rosner, G.L.1    Stadler, W.2    Ratain, M.J.3
  • 170
    • 4644276593 scopus 로고    scopus 로고
    • Preliminary antitumor activity of BAY 43-9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT)
    • Ratain MJ, Flaherty KT, Stadler WM, O'Dwyer P, Kaye S, Xiong H, Patnaik A, Gore M, Lee RJ, Eisen T. Preliminary antitumor activity of BAY 43-9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT). J Clin Oncol (Meeting Abstracts) 2004;22:4501.
    • (2004) J Clin Oncol (Meeting Abstracts) , vol.22 , pp. 4501
    • Ratain, M.J.1    Flaherty, K.T.2    Stadler, W.M.3    O'Dwyer, P.4    Kaye, S.5    Xiong, H.6    Patnaik, A.7    Gore, M.8    Lee, R.J.9    Eisen, T.10
  • 172
    • 23844558595 scopus 로고    scopus 로고
    • Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
    • Escudier B, Szczylik C, Eisen T, Stadler WM, Schwartz B, Shan M, Bukowski RM. Randomized phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC). J Clin Oncol (Meeting Abstracts) 2005;23:LBA4510.
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23
    • Escudier, B.1    Szczylik, C.2    Eisen, T.3    Stadler, W.M.4    Schwartz, B.5    Shan, M.6    Bukowski, R.M.7
  • 173
    • 0034799139 scopus 로고    scopus 로고
    • A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor
    • Ciardiello F, Tortora G. A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor. Clin Cancer Res 2001;7:2958-2970.
    • (2001) Clin Cancer Res , vol.7 , pp. 2958-2970
    • Ciardiello, F.1    Tortora, G.2
  • 174
    • 0034754136 scopus 로고    scopus 로고
    • Epidermal growth factor receptor biology (IMC-C225)
    • Kim ES, Khuri FR, Herbst RS. Epidermal growth factor receptor biology (IMC-C225). Curr Opin Oncol 2001;13:506-513.
    • (2001) Curr Opin Oncol , vol.13 , pp. 506-513
    • Kim, E.S.1    Khuri, F.R.2    Herbst, R.S.3
  • 175
    • 21744454494 scopus 로고    scopus 로고
    • The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression
    • Luwor RB, Lu Y, Li X, Mendelsohn J, Fan Z. The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression. Oncogene 2005;24:4433-4441.
    • (2005) Oncogene , vol.24 , pp. 4433-4441
    • Luwor, R.B.1    Lu, Y.2    Li, X.3    Mendelsohn, J.4    Fan, Z.5
  • 176
    • 0037862765 scopus 로고    scopus 로고
    • Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Van Cutsem E. 2003. Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer. Proc Am Soc Clin Oncol 2002;22:252.
    • (2002) Proc Am Soc Clin Oncol , vol.22 , pp. 252
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3    Khayat, D.4    Bleiberg, H.5    Santoro, A.6    Bets, D.7    Mueser, M.8    Harstrick, A.9    Van Cutsem, E.10
  • 179
    • 0003000030 scopus 로고    scopus 로고
    • Continued response following treatment with IMC-225, an EGFr MoAb, combined with RT in advanced head and neck malignancies
    • Bonner JA, Ezekiel MP, Robert F, Meredith RF, Spencer SA, Waksal HW. Continued response following treatment with IMC-225, an EGFr MoAb, combined with RT in advanced head and neck malignancies. Proc Am Soc Clin Oncol 2000;19:4.
    • (2000) Proc Am Soc Clin Oncol , vol.19 , pp. 4
    • Bonner, J.A.1    Ezekiel, M.P.2    Robert, F.3    Meredith, R.F.4    Spencer, S.A.5    Waksal, H.W.6
  • 180
    • 0000229081 scopus 로고    scopus 로고
    • Efficacy and safety of the anti-epidermal growth factor receptor antibody (EGFR) IMC-C225 in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy
    • Hong WK, Arquette M, Nabell L, Needle MN, Waksal HW, Herbst RS. Efficacy and safety of the anti-epidermal growth factor receptor antibody (EGFR) IMC-C225 in combination with cisplatin in patients with recurrent squamous cell carcinoma of the head and neck (SCCHN) refractory to cisplatin containing chemotherapy. Proc Am Soc Clin Oncol 2001;21:224.
    • (2001) Proc Am Soc Clin Oncol , vol.21 , pp. 224
    • Hong, W.K.1    Arquette, M.2    Nabell, L.3    Needle, M.N.4    Waksal, H.W.5    Herbst, R.S.6
  • 182
    • 0347187211 scopus 로고    scopus 로고
    • Cetuximab (C225) in combination with bi-weekly irinotecan (CPT-11), infusional 5-fluorouracil (5-FU), and folinic acid (FA) in patients with metastatic colorectal cancer (CRC) expressing the epidermal growth factor receptor (EGFR). Preliminary safety and efficacy results
    • Van Laethem J-L, Raoul J-L, Mitry E, Brezault C, Husseini F, Cals L, Vedovato JC, Mueser MM, Rougier P. Cetuximab (C225) in combination with bi-weekly irinotecan (CPT-11), infusional 5-fluorouracil (5-FU), and folinic acid (FA) in patients with metastatic colorectal cancer (CRC) expressing the epidermal growth factor receptor (EGFR). Preliminary safety and efficacy results. Proc Am Soc Clin Oncol 2003; 22:264.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 264
    • Van Laethem, J.-L.1    Raoul, J.-L.2    Mitry, E.3    Brezault, C.4    Husseini, F.5    Cals, L.6    Vedovato, J.C.7    Mueser, M.M.8    Rougier, P.9
  • 183
    • 0001391575 scopus 로고    scopus 로고
    • Phase II study of anti-epidermal growth factor receptor (EGFR) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer
    • Abbruzzese JL, Rosenberg A, Xiong Q, LoBuglio A, Schmidt W, Wolff R, Needle M, Waksal H. Phase II study of anti-epidermal growth factor receptor (EGFR) antibody cetuximab (IMC-C225) in combination with gemcitabine in patients with advanced pancreatic cancer. Proc Am Soc Clin Oncol 2001;21:130.
    • (2001) Proc Am Soc Clin Oncol , vol.21 , pp. 130
    • Abbruzzese, J.L.1    Rosenberg, A.2    Xiong, Q.3    Lobuglio, A.4    Schmidt, W.5    Wolff, R.6    Needle, M.7    Waksal, H.8
  • 184
    • 10444220480 scopus 로고    scopus 로고
    • Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with or without cetuximab
    • Bonner JA, Giralt J, Harari PM, Cohen R, Jones C, Sur RK, Rabin D, Azarnia N, Needle MN, Ang KK. Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carcinoma of head and neck: A phase III study of high dose radiation therapy with or without cetuximab. J Clin Oncol (Meeting Abstracts) 2004;22:5507.
    • (2004) J Clin Oncol (Meeting Abstracts) , vol.22 , pp. 5507
    • Bonner, J.A.1    Giralt, J.2    Harari, P.M.3    Cohen, R.4    Jones, C.5    Sur, R.K.6    Rabin, D.7    Azarnia, N.8    Needle, M.N.9    Ang, K.K.10
  • 188
    • 27644463443 scopus 로고    scopus 로고
    • A phase II study of cetuximab (C225) in combination with chemoradiation (CRT) in patients (PTS) with stage IIIA/B non-small cell lung cancer (NSCLC): An interim overall toxicity report of the RTOG 0324 Trial
    • Werner-Wasik M, Swann S, Curran W, Robert F, Komaki R, Lee CP, Jafar S, Share R, Choy H, Blumenschein G. A phase II study of cetuximab (C225) in combination with chemoradiation (CRT) in patients (PTS) with stage IIIA/B non-small cell lung cancer (NSCLC): An interim overall toxicity report of the RTOG 0324 Trial. J Clin Oncol (Meeting Abstracts) 2005;23:7135.
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , pp. 7135
    • Werner-Wasik, M.1    Swann, S.2    Curran, W.3    Robert, F.4    Komaki, R.5    Lee, C.P.6    Jafar, S.7    Share, R.8    Choy, H.9    Blumenschein, G.10
  • 190
    • 1642442499 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitors: A new prospective in the treatment of lung cancer
    • Tiseo M, Loprevite M, Ardizzoni A. Epidermal growth factor receptor inhibitors: A new prospective in the treatment of lung cancer. Curr Med Chem Anti-Cane Agents 2004;4:139-148.
    • (2004) Curr Med Chem Anti-Cane Agents , vol.4 , pp. 139-148
    • Tiseo, M.1    Loprevite, M.2    Ardizzoni, A.3
  • 191
    • 1142305741 scopus 로고    scopus 로고
    • Disease-related symptoms in advanced non-small cell lung cancer (NSCLC) as measured by the Lung Cancer Subscale (LCS) of the FACT-L questionnaire: Clinically meaningful improvements with gefitinib (IRESSA, ZD 1839)
    • Cella D, Natale RB, Lynch TJ, Lee C, Carbone D, Douillard JY, Kay A, Wolf M, Heyes A, Ward J. Disease-related symptoms in advanced non-small cell lung cancer (NSCLC) as measured by the Lung Cancer Subscale (LCS) of the FACT-L questionnaire: Clinically meaningful improvements with gefitinib (IRESSA, ZD 1839). Proc Am Soc Clin Oncol 2003;22:629.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 629
    • Cella, D.1    Natale, R.B.2    Lynch, T.J.3    Lee, C.4    Carbone, D.5    Douillard, J.Y.6    Kay, A.7    Wolf, M.8    Heyes, A.9    Ward, J.10
  • 192
    • 0042213489 scopus 로고    scopus 로고
    • A II study of gefitinib (ZD 1839, Iressa™) combination with Folfox-4 (IFOX) in patients with unresectable or metastatic colorectal cancer
    • Cho CD, Fisher GA, Halsey J, Jambalos CN, Advani RH, Wakelee H, Lum BL, Sikic BI. A II study of gefitinib (ZD 1839, Iressa™) combination with Folfox-4 (IFOX) in patients with unresectable or metastatic colorectal cancer. Proc Am Soc Clin Oncol 2003;22:265.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 265
    • Cho, C.D.1    Fisher, G.A.2    Halsey, J.3    Jambalos, C.N.4    Advani, R.H.5    Wakelee, H.6    Lum, B.L.7    Sikic, B.I.8
  • 193
    • 0346057793 scopus 로고    scopus 로고
    • Extensive experience of disease control with gefitinib and the role of prognostic markers
    • Cortes-Funes H, Soto-Parra H. Extensive experience of disease control with gefitinib and the role of prognostic markers. Br J Cancer 2003;89:S3-S8.
    • (2003) Br J Cancer , vol.89
    • Cortes-Funes, H.1    Soto-Parra, H.2
  • 194
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD 1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen EE, Rosen F, Stadler WM, Recant W, Stenson K, Huo D, Vokes EE. Phase II trial of ZD 1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003;21:1980-1987.
    • (2003) J Clin Oncol , vol.21 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3    Recant, W.4    Stenson, K.5    Huo, D.6    Vokes, E.E.7
  • 196
    • 1842633680 scopus 로고    scopus 로고
    • Gefitinib, a novel, orally administered agent for the treatment of cancer
    • Ranson M, Wardell S. Gefitinib, a novel, orally administered agent for the treatment of cancer. J Clin Pharm Ther 2004;29:95-103.
    • (2004) J Clin Pharm Ther , vol.29 , pp. 95-103
    • Ranson, M.1    Wardell, S.2
  • 198
    • 0042804495 scopus 로고    scopus 로고
    • Gefitinib ('Iressa', ZD 1839) is active in acquired tamoxifen (TAM)-resistant oestrogen receptor (ER)-positive and ER-negative breast cancer: Results from a Phase II study
    • Robertson JFR, Gutteridge E, Cheung K, Owers R, Koehler M, Hamilton L, Gee J, Nicholson RI. Gefitinib ('Iressa', ZD 1839) is active in acquired tamoxifen (TAM)-resistant oestrogen receptor (ER)-positive and ER-negative breast cancer: Results from a Phase II study. Proc Am Soc Clin Oncol 2003;22: Abstract 23.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 23
    • Robertson, J.F.R.1    Gutteridge, E.2    Cheung, K.3    Owers, R.4    Koehler, M.5    Hamilton, L.6    Gee, J.7    Nicholson, R.I.8
  • 204
    • 17844390172 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions
    • Pao W, Miller VA. Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions. J Clin Oncol 2005;23:2556-2568.
    • (2005) J Clin Oncol , vol.23 , pp. 2556-2568
    • Pao, W.1    Miller, V.A.2
  • 205
    • 5644303684 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC)
    • Shepherd F, Pereira J, Ciuleanu TE, Tan EH, Hirsh V, Thongprasert S, Bezjak A, Tu D, Santabarbara P, Seymour L. A randomized placebo-controlled trial of erlotinib in patients with advanced non-small cell lung cancer (NSCLC) following failure of 1st line or or 2nd line chemotherapy. A National Cancer Institute of Canada Clinical Trials Group (NCIC). J Clin Oncol (Meeting Abstracts) 2004;22:7022.
    • (2004) J Clin Oncol (Meeting Abstracts) , vol.22 , pp. 7022
    • Shepherd, F.1    Pereira, J.2    Ciuleanu, T.E.3    Tan, E.H.4    Hirsh, V.5    Thongprasert, S.6    Bezjak, A.7    Tu, D.8    Santabarbara, P.9    Seymour, L.10
  • 207
    • 27644460508 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCIC-CTG]
    • Moore MJ, Goldstein D, Hamm J, Figer A, Hecht J, Gallinger S, Au H, Ding K, Christy-Bittel J, Parulekar W. Erlotinib plus gemcitabine compared to gemcitabine alone in patients with advanced pancreatic cancer. A phase III trial of the National Cancer Institute of Canada Clinical Trials Group [NCIC-CTG]. J Clin Oncol (Meeting Abstracts) 2005;23:1.
    • (2005) J Clin Oncol , vol.23 , pp. 1
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.5    Gallinger, S.6    Au, H.7    Ding, K.8    Christy-Bittel, J.9    Parulekar, W.10
  • 208
    • 0141534352 scopus 로고    scopus 로고
    • Development of the epidermal growth factor receptor inhibitor Tarceva (OSI-774)
    • Grunwald V, Hidalgo M. Development of the epidermal growth factor receptor inhibitor Tarceva (OSI-774). Adv Exp Med Biol 2003;532:235-246.
    • (2003) Adv Exp Med Biol , vol.532 , pp. 235-246
    • Grunwald, V.1    Hidalgo, M.2
  • 209
    • 1542648232 scopus 로고    scopus 로고
    • Clinical experience with the HER1/EGFR tyrosine kinase inhibitor erlotinib
    • Sandler A. Clinical experience with the HER1/EGFR tyrosine kinase inhibitor erlotinib. Oncology 2003;11:17-22.
    • (2003) Oncology , vol.11 , pp. 17-22
    • Sandler, A.1
  • 210
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004;22:77-85.
    • (2004) J Clin Oncol , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarwala, S.S.5    Siu, L.L.6
  • 219
    • 0035569894 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human HT-29 colon carcinoma and human CaKi1 renal cell carcinoma xenografts
    • Teicher BA, Menon K, Alvarez E, Galbreath E, Shih C, Faul MM. Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human HT-29 colon carcinoma and human CaKi1 renal cell carcinoma xenografts. Anticancer Res 2001;21:3175-3184.
    • (2001) Anticancer Res , vol.21 , pp. 3175-3184
    • Teicher, B.A.1    Menon, K.2    Alvarez, E.3    Galbreath, E.4    Shih, C.5    Faul, M.M.6
  • 220
    • 0035210102 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in murine lewis lung carcinoma and human Calu-6 non-small-cell lung carcinoma xenografts
    • Teicher BA, Menon K, Alvarez E, Galbreath E, Shih C, Faul MM. Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in murine lewis lung carcinoma and human Calu-6 non-small-cell lung carcinoma xenografts. Cancer Chemother Pharmacol 2001;48:473-480.
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 473-480
    • Teicher, B.A.1    Menon, K.2    Alvarez, E.3    Galbreath, E.4    Shih, C.5    Faul, M.M.6
  • 221
    • 0034888620 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human hepatocellular and gastric cancer xenografts
    • Teicher BA, Menon K, Alvarez E, Liu P, Shih C, Faul MM. Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human hepatocellular and gastric cancer xenografts. In Vivo 2001;15:185-193.
    • (2001) In Vivo , vol.15 , pp. 185-193
    • Teicher, B.A.1    Menon, K.2    Alvarez, E.3    Liu, P.4    Shih, C.5    Faul, M.M.6
  • 223
    • 0036021216 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human breast cancer and ovarian cancer xenografts
    • Teicher BA, Menon K, Alvarez E, Shih C, Faul MM. Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human breast cancer and ovarian cancer xenografts. Invest New Drugs 2002;20:241-251.
    • (2002) Invest New Drugs , vol.20 , pp. 241-251
    • Teicher, B.A.1    Menon, K.2    Alvarez, E.3    Shih, C.4    Faul, M.M.5
  • 225
    • 0025204095 scopus 로고
    • Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
    • Ingber D, Fujita T, Kishimoto S, Sudo K, Kanamaru T, Brem H, Folkman J. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990;348:555-557.
    • (1990) Nature , vol.348 , pp. 555-557
    • Ingber, D.1    Fujita, T.2    Kishimoto, S.3    Sudo, K.4    Kanamaru, T.5    Brem, H.6    Folkman, J.7
  • 226
    • 0035572017 scopus 로고    scopus 로고
    • A re-evaluation of fumagillin selectivity towards endothelial cells
    • Rodriguez-Nieto S, Medina MA, Quesada AR. A re-evaluation of fumagillin selectivity towards endothelial cells. Anticancer Res 2001;21:3457-3460.
    • (2001) Anticancer Res , vol.21 , pp. 3457-3460
    • Rodriguez-Nieto, S.1    Medina, M.A.2    Quesada, A.R.3
  • 227
    • 0028176358 scopus 로고
    • A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells
    • Abe J, Zhou W, Takuwa N, Taguchi J, Kurokawa K, Kumada M, Takuwa Y. A fumagillin derivative angiogenesis inhibitor, AGM-1470, inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Cancer Res 1994;54:3407-3412.
    • (1994) Cancer Res , vol.54 , pp. 3407-3412
    • Abe, J.1    Zhou, W.2    Takuwa, N.3    Taguchi, J.4    Kurokawa, K.5    Kumada, M.6    Takuwa, Y.7
  • 228
    • 0031171961 scopus 로고    scopus 로고
    • Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovulicin
    • Griffith EC, Su Z, Turk BE, Chen S, Chang YH, Wu Z, Biemann K, Liu JO. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovulicin. Chem Biol 1997;4:461-471.
    • (1997) Chem Biol , vol.4 , pp. 461-471
    • Griffith, E.C.1    Su, Z.2    Turk, B.E.3    Chen, S.4    Chang, Y.H.5    Wu, Z.6    Biemann, K.7    Liu, J.O.8
  • 229
    • 0033617532 scopus 로고    scopus 로고
    • Effects of angiogenesis inhibitors on multistage earcinogenesis in mice
    • Bergers G, Javaherian K, Lo K.-M, Forkman J, Hanahan D. Effects of angiogenesis inhibitors on multistage earcinogenesis in mice. Science 1999;284:808-812.
    • (1999) Science , vol.284 , pp. 808-812
    • Bergers, G.1    Javaherian, K.2    Lo, K.-M.3    Forkman, J.4    Hanahan, D.5
  • 230
    • 0034099423 scopus 로고    scopus 로고
    • Therapeutic synergy of TNP-470 and Ionizing radiation: Effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenographs
    • Lund EL, Bastholm L, Krisjansen PEG. Therapeutic synergy of TNP-470 and Ionizing radiation: Effects on tumor growth, vessel morphology, and angiogenesis in human glioblastoma multiforme xenographs. Clin Cancer Res 2000;6:971-978.
    • (2000) Clin Cancer Res , vol.6 , pp. 971-978
    • Lund, E.L.1    Bastholm, L.2    Krisjansen, P.E.G.3
  • 235
    • 0032767386 scopus 로고    scopus 로고
    • Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma
    • Stadler WM, Kuzel T, Shapiro C, Sosman J, Clark J, Vogelzang NJ. Multi-institutional study of the angiogenesis inhibitor TNP-470 in metastatic renal carcinoma. J Clin Oncol 1999;17:2541-2545.
    • (1999) J Clin Oncol , vol.17 , pp. 2541-2545
    • Stadler, W.M.1    Kuzel, T.2    Shapiro, C.3    Sosman, J.4    Clark, J.5    Vogelzang, N.J.6
  • 242
    • 18144399578 scopus 로고    scopus 로고
    • MTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S, Faivre S, Aguirre D, Raymond E. MTOR-targeted therapy of cancer with rapamycin derivatives. Annals Oncol 2005;16:525-537.
    • (2005) Annals Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 244
    • 0036225178 scopus 로고    scopus 로고
    • Inhibitors of mammalian target of rapamycin as novel antitumor agents: From bench to clinic
    • Huang S, Houghton PJ. Inhibitors of mammalian target of rapamycin as novel antitumor agents: From bench to clinic. Curr Opin Investig Drugs 2002;3:295-304.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 295-304
    • Huang, S.1    Houghton, P.J.2
  • 245
    • 0036146486 scopus 로고    scopus 로고
    • Early clinical experience with a novel rapamycin derivative
    • Nashan B. Early clinical experience with a novel rapamycin derivative.
    • (2002) Ther Drug Monit , vol.24 , pp. 53-58
    • Nashan, B.1
  • 250
    • 0030998660 scopus 로고    scopus 로고
    • Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma
    • Dong Z, Kumar R, Yang X, Fidler IJ. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell 1997;88:801-810.
    • (1997) Cell , vol.88 , pp. 801-810
    • Dong, Z.1    Kumar, R.2    Yang, X.3    Fidler, I.J.4
  • 252
    • 0003092713 scopus 로고    scopus 로고
    • Angiostatin and endostatin: Endothelial cell-specific endogenous inhibitors of angiogenesis and tumor growth
    • Sim BK. Angiostatin and endostatin: Endothelial cell-specific endogenous inhibitors of angiogenesis and tumor growth. Angiogenesis 1998;2:37-48.
    • (1998) Angiogenesis , vol.2 , pp. 37-48
    • Sim, B.K.1
  • 253
    • 33745328553 scopus 로고    scopus 로고
    • Multiple signaling is involved in endostatin-mediated apoptosis in ECV 304 endothelial cells
    • Ren B, Wang Y, Ndebele K, Zhi Q, Chen FH, Wang YZ, Parangi S. Multiple signaling is involved in endostatin-mediated apoptosis in ECV 304 endothelial cells. Front Biosci 2005;10:1089-1097.
    • (2005) Front Biosci , vol.10 , pp. 1089-1097
    • Ren, B.1    Wang, Y.2    Ndebele, K.3    Zhi, Q.4    Chen, F.H.5    Wang, Y.Z.6    Parangi, S.7
  • 254
    • 0037120985 scopus 로고    scopus 로고
    • First clinical trials of endostatin yield lukewarm results
    • Twombly R. First clinical trials of endostatin yield lukewarm results. J Natl Cancer Inst 2002;94:1520-1521.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1520-1521
    • Twombly, R.1
  • 256
    • 0037440123 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors
    • Dresen A, Geiger P, Pluda J, Fogler W, Schiller JH, Wilding G. Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol 2003;21:223-231.
    • (2003) J Clin Oncol , vol.21 , pp. 223-231
    • Dresen, A.1    Geiger, P.2    Pluda, J.3    Fogler, W.4    Schiller, J.H.5    Wilding, G.6
  • 261
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman J. Role of angiogenesis in tumor growth and metastasis. Semin Oncol 2002;29:15-18.
    • (2002) Semin Oncol , vol.29 , pp. 15-18
    • Folkman, J.1
  • 263
    • 2942622489 scopus 로고    scopus 로고
    • Inhibition of B16BL6 tumor progression by coadministration of recombinant angiostatin K1-3 and endostatin genes with cationic liposomes
    • Kim KS, Kim HS, Park JS, Kwon YG, Park YS. Inhibition of B16BL6 tumor progression by coadministration of recombinant angiostatin K1-3 and endostatin genes with cationic liposomes. Cancer Gene Ther 2004;11:441-449.
    • (2004) Cancer Gene Ther , vol.11 , pp. 441-449
    • Kim, K.S.1    Kim, H.S.2    Park, J.S.3    Kwon, Y.G.4    Park, Y.S.5
  • 264
    • 12744281278 scopus 로고    scopus 로고
    • Endostatin cDNA/Cationic liposome complexes as a promising therapy to prevent lung metastases in osteosarcoma: Study in a human-like rat orthotopic tumor
    • Dutour A, Monteil J, Paraf F, Charissoux JL, Kaletta C, Sauer B, Naujoks K, Rigaud M. Endostatin cDNA/Cationic liposome complexes as a promising therapy to prevent lung metastases in osteosarcoma: Study in a human-like rat orthotopic tumor. Mol Ther 2005;11:311-319.
    • (2005) Mol Ther , vol.11 , pp. 311-319
    • Dutour, A.1    Monteil, J.2    Paraf, F.3    Charissoux, J.L.4    Kaletta, C.5    Sauer, B.6    Naujoks, K.7    Rigaud, M.8
  • 265
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: Trials and tribulations. Science 2002;295:2387-2392.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 266
    • 0036170808 scopus 로고    scopus 로고
    • MMP inhibitors: Glimmers of hope amidst clinical failures
    • Dove A. MMP inhibitors: Glimmers of hope amidst clinical failures. Nature Med 2002;8:95.
    • (2002) Nature Med , vol.8 , pp. 95
    • Dove, A.1
  • 267
    • 0036716282 scopus 로고    scopus 로고
    • Strategies for MMP inhibition in cancer: Innovations for the post-trial era
    • Overall CM, Lopez-Otin C. Strategies for MMP inhibition in cancer: Innovations for the post-trial era. Nat Rev Cancer 2002;2:657-672.
    • (2002) Nat Rev Cancer , vol.2 , pp. 657-672
    • Overall, C.M.1    Lopez-Otin, C.2
  • 269
    • 0033652601 scopus 로고    scopus 로고
    • Marimastat: The clinical development of a matrix metalloproteinase inhibitor
    • Sieward WP, Thomas AL. Marimastat: The clinical development of a matrix metalloproteinase inhibitor. Expert Opin Investig Drugs 2000;9:2913-2922.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2913-2922
    • Sieward, W.P.1    Thomas, A.L.2
  • 270
    • 0035424135 scopus 로고    scopus 로고
    • Marimastat as first-line therapy for patients with unresectable pancreatic cancer: A randomized trial
    • Marimastat Pancreatic Cancer Study Group
    • Bramhall SR, Rosemurgy A, Brown PD, Bowry C, Buckels JA. Marimastat Pancreatic Cancer Study Group. Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial. J Clin Oncol 2001;19:3447-3455.
    • (2001) J Clin Oncol , vol.19 , pp. 3447-3455
    • Bramhall, S.R.1    Rosemurgy, A.2    Brown, P.D.3    Bowry, C.4    Buckels, J.A.5
  • 271
    • 0037112183 scopus 로고    scopus 로고
    • Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: A trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer
    • Shepherd FA, Giaccone G, Seymour L, Debruyne C, Bezjak A, Hirsh V, Smylie M, Rubin S, Martins H, Lamont A, Krzakowski M, Sadura A, Zee B. Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: A trial of the National Cancer Institute of Canada-Clinical Trials Group and the European Organization for Research and Treatment of Cancer. J Clin Oncol 2002;20:4434-4439.
    • (2002) J Clin Oncol , vol.20 , pp. 4434-4439
    • Shepherd, F.A.1    Giaccone, G.2    Seymour, L.3    Debruyne, C.4    Bezjak, A.5    Hirsh, V.6    Smylie, M.7    Rubin, S.8    Martins, H.9    Lamont, A.10    Krzakowski, M.11    Sadura, A.12    Zee, B.13
  • 272
    • 16544372352 scopus 로고    scopus 로고
    • Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: Eastern Cooperative Oncology Group trial E2196
    • Sparano JA, Bernardo P, Stephenson P, Gradishar WJ, Ingle JN, Zucker S, Davidson NE. Randomized phase III trial of marimastat versus placebo in patients with metastatic breast cancer who have responding or stable disease after first-line chemotherapy: Eastern Cooperative Oncology Group trial E2196. J Clin Oncol 2004;22:4683-4690.
    • (2004) J Clin Oncol , vol.22 , pp. 4683-4690
    • Sparano, J.A.1    Bernardo, P.2    Stephenson, P.3    Gradishar, W.J.4    Ingle, J.N.5    Zucker, S.6    Davidson, N.E.7
  • 275
    • 0000603394 scopus 로고    scopus 로고
    • Phase I study of the matrix metalloproteinase inhibitor AG340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors
    • D'Olimpio J, Hande K, Collier M, Michelson G, Paradiso L, Clendeninn N. Phase I study of the matrix metalloproteinase inhibitor AG340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors. Proc Am Soc Clin Oncol 1999;18: Abstract 615.
    • (1999) Proc Am Soc Clin Oncol , vol.18 , pp. 615
    • D'Olimpio, J.1    Hande, K.2    Collier, M.3    Michelson, G.4    Paradiso, L.5    Clendeninn, N.6
  • 276
    • 0033864065 scopus 로고    scopus 로고
    • Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. A novel pharmacological approach for tissue remodelling-related diseases
    • Scatena R. Prinomastat, a hydroxamate-based matrix metalloproteinase inhibitor. A novel pharmacological approach for tissue remodelling-related diseases. Expert Opin Investig Drugs 2000;9:2159-2165.
    • (2000) Expert Opin Investig Drugs , vol.9 , pp. 2159-2165
    • Scatena, R.1
  • 277
    • 0036118399 scopus 로고    scopus 로고
    • Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer
    • Bonomi P. Matrix metalloproteinases and matrix metalloproteinase inhibitors in lung cancer. Semin Oncol 2002;29:78-86.
    • (2002) Semin Oncol , vol.29 , pp. 78-86
    • Bonomi, P.1
  • 281
    • 0142029001 scopus 로고    scopus 로고
    • Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy
    • Behrendt CE, Ruiz RB. Venous thromboembolism among patients with advanced lung cancer randomized to prinomastat or placebo, plus chemotherapy. Thromb Haemost 2003;90:734-737.
    • (2003) Thromb Haemost , vol.90 , pp. 734-737
    • Behrendt, C.E.1    Ruiz, R.B.2
  • 283
    • 0035208166 scopus 로고    scopus 로고
    • The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on posttraumatic proliferative vitreoretinopathy
    • Ozerdem U, Mach-Hotacre B, Keefe K, Pham T, Soules K, Appelt K, Freeman WR. The effect of prinomastat (AG3340), a synthetic inhibitor of matrix metalloproteinases, on posttraumatic proliferative vitreoretinopathy. Ophthalmic Res 2001;33:20-23.
    • (2001) Ophthalmic Res , vol.33 , pp. 20-23
    • Ozerdem, U.1    Mach-Hotacre, B.2    Keefe, K.3    Pham, T.4    Soules, K.5    Appelt, K.6    Freeman, W.R.7
  • 289
    • 0036334059 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials
    • Bloomston M, Zervos EE, Rosemurgy AS. Matrix metalloproteinases and their role in pancreatic cancer: A review of preclinical studies and clinical trials. Ann Surg Oncol 2002;9:668-674.
    • (2002) Ann Surg Oncol , vol.9 , pp. 668-674
    • Bloomston, M.1    Zervos, E.E.2    Rosemurgy, A.S.3
  • 291
    • 0033853171 scopus 로고    scopus 로고
    • Anti-angiogenic agents: Clinical trial design and therapies in development
    • Deplanque G, Harris AL. Anti-angiogenic agents: Clinical trial design and therapies in development. Eur J Cancer 2000;36:1713-1724.
    • (2000) Eur J Cancer , vol.36 , pp. 1713-1724
    • Deplanque, G.1    Harris, A.L.2
  • 292
    • 0033863530 scopus 로고    scopus 로고
    • Ongoing trials with matrix metalloproteinase inhibitors
    • Brown PD. Ongoing trials with matrix metalloproteinase inhibitors. Expert Opin Investig Drugs 2002;9:2167-2177.
    • (2002) Expert Opin Investig Drugs , vol.9 , pp. 2167-2177
    • Brown, P.D.1
  • 293
    • 1642391046 scopus 로고    scopus 로고
    • A phase I and pharmacological study of the matrix metalloproteinase inhibitor BB-3644 in patients with solid tumours
    • Wall L, Talbot DC, Bradbury P, Jodrell DI. A phase I and pharmacological study of the matrix metalloproteinase inhibitor BB-3644 in patients with solid tumours. Br J Cancer 2004;90:800-804.
    • (2004) Br J Cancer , vol.90 , pp. 800-804
    • Wall, L.1    Talbot, D.C.2    Bradbury, P.3    Jodrell, D.I.4
  • 295
    • 0032170034 scopus 로고    scopus 로고
    • Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor receptors in a human colon adenocarcinoma (Colo 205) cell line
    • Lombard M, Wallace T, Kubicek MF, Petzold GL, Mitchell MA, Hendges SK, Wilks JW. Synthetic matrix metalloproteinase inhibitors and tissue inhibitor of metalloproteinase (TIMP)-2, but not TIMP-1, inhibit shedding of tumor necrosis factor receptors in a human colon adenocarcinoma (Colo 205) cell line. Cancer Res 1998;58:4001-4007.
    • (1998) Cancer Res , vol.58 , pp. 4001-4007
    • Lombard, M.1    Wallace, T.2    Kubicek, M.F.3    Petzold, G.L.4    Mitchell, M.A.5    Hendges, S.K.6    Wilks, J.W.7
  • 299
    • 0036229815 scopus 로고    scopus 로고
    • BMS-275291. Bristol-Myers Squibb
    • Poulaki V. BMS-275291. Bristol-Myers Squibb. Curr Opin Investig Drugs 2002;3:500-504.
    • (2002) Curr Opin Investig Drugs , vol.3 , pp. 500-504
    • Poulaki, V.1
  • 301
    • 21044453902 scopus 로고    scopus 로고
    • Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR. 18., Humphrey JS, Voi M, Galbraith S, Hann K, Seymour L, Shepherd FA
    • Leighl NB, Paz-Ares L, Douillard JY, Peschel C, Arnold A, Depierre A, Santoro A, Betticher DC, Gatzemeier U, Jassem J, Crawford J, Tu D, Bezjak A. Randomized Phase III Study of Matrix Metalloproteinase Inhibitor BMS-275291 in Combination With Paclitaxel and Carboplatin in Advanced Non-Small-Cell Lung Cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR. 18., Humphrey JS, Voi M, Galbraith S, Hann K, Seymour L, Shepherd FA. J Clin Oncol 2005;23:2831-2839.
    • (2005) J Clin Oncol , vol.23 , pp. 2831-2839
    • Leighl, N.B.1    Paz-Ares, L.2    Douillard, J.Y.3    Peschel, C.4    Arnold, A.5    Depierre, A.6    Santoro, A.7    Betticher, D.C.8    Gatzemeier, U.9    Jassem, J.10    Crawford, J.11    Tu, D.12    Bezjak, A.13
  • 303
    • 0002593621 scopus 로고    scopus 로고
    • CGS27023a, a potent and orally active matrix metalloprotease inhibitor with anti-tumour activity
    • Wood J, Schnell C, Cozens R. CGS27023a, a potent and orally active matrix metalloprotease inhibitor with anti-tumour activity. Proc Am Assoc Cancer Res 1998;39:83A.
    • (1998) Proc Am Assoc Cancer Res , vol.39
    • Wood, J.1    Schnell, C.2    Cozens, R.3
  • 304
    • 0037231197 scopus 로고    scopus 로고
    • Anti-tumor angiogenic effect of a matrix metalloproteinase inhibitor MMI270
    • Nakamura ES, Koizumi K, Yamaura T, Saiki I. Anti-tumor angiogenic effect of a matrix metalloproteinase inhibitor MMI270. Anticancer Res 2003;23:411-417.
    • (2003) Anticancer Res , vol.23 , pp. 411-417
    • Nakamura, E.S.1    Koizumi, K.2    Yamaura, T.3    Saiki, I.4
  • 306
    • 11244354290 scopus 로고    scopus 로고
    • A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MM 1270 (previously termed CGS27023A) with 5-FU and folinic acid
    • Eatock M, Cassidy J, Johnson J, Morrison R, Devlin M, Blackey R, Owen S, Choi L, Twelves C. A dose-finding and pharmacokinetic study of the matrix metalloproteinase inhibitor MM 1270 (previously termed CGS27023A) with 5-FU and folinic acid. Cancer Chemother Pharmacol 2005;55:39-46.
    • (2005) Cancer Chemother Pharmacol , vol.55 , pp. 39-46
    • Eatock, M.1    Cassidy, J.2    Johnson, J.3    Morrison, R.4    Devlin, M.5    Blackey, R.6    Owen, S.7    Choi, L.8    Twelves, C.9
  • 307
    • 0037100983 scopus 로고    scopus 로고
    • A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall SR, Schulz J, Nemunaitis J, Brown PD, Baillet M, Buckels JA. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br J Cancer 2002;87:161-167.
    • (2002) Br J Cancer , vol.87 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 309
    • 0036499078 scopus 로고    scopus 로고
    • Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme
    • Groves MD, Puduvalli VK, Hess KR, Jaeckle KA, Peterson P, Yung WK, Levin VA. Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J Clin Oncol 2002;20:1383-1388.
    • (2002) J Clin Oncol , vol.20 , pp. 1383-1388
    • Groves, M.D.1    Puduvalli, V.K.2    Hess, K.R.3    Jaeckle, K.A.4    Peterson, P.5    Yung, W.K.6    Levin, V.A.7
  • 310
    • 2342637653 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors
    • Ramnath N, Creaven PJ. Matrix metalloproteinase inhibitors. Curr Oncol Rep 2004;6:96-102.
    • (2004) Curr Oncol Rep , vol.6 , pp. 96-102
    • Ramnath, N.1    Creaven, P.J.2
  • 311
    • 0032864675 scopus 로고    scopus 로고
    • MMP inhibition in prostate cancer
    • Lokeshwar BL. MMP inhibition in prostate cancer. Ann N Y Acad Sci 1999;878:271-289.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 271-289
    • Lokeshwar, B.L.1
  • 312
    • 0032837305 scopus 로고    scopus 로고
    • CMT-3, a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer
    • Selzer MG, Zhu B, Block NL, Zhu B, Lokeshwar BL. CMT-3, a chemically modified tetracycline, inhibits bony metastases and delays the development of paraplegia in a rat model of prostate cancer. Ann N Y Acad Sci 1999;878:678-682.
    • (1999) Ann N Y Acad Sci , vol.878 , pp. 678-682
    • Selzer, M.G.1    Zhu, B.2    Block, N.L.3    Zhu, B.4    Lokeshwar, B.L.5
  • 314
    • 0035040972 scopus 로고    scopus 로고
    • Cytotoxic activity and inhibition of tumor cell invasion by derivatives of a chemically modified tetracycline CMT-3 (COL-3)
    • Lokeshwar BL, Escatel E, Zhu B. Cytotoxic activity and inhibition of tumor cell invasion by derivatives of a chemically modified tetracycline CMT-3 (COL-3). Curr Med Chem 2001;8:271-279.
    • (2001) Curr Med Chem , vol.8 , pp. 271-279
    • Lokeshwar, B.L.1    Escatel, E.2    Zhu, B.3
  • 315
    • 0037051090 scopus 로고    scopus 로고
    • Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model
    • Lokeshwar BL, Selzer MG, Zhu BQ, Block NL, Golub LM. Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model. Int J Cancer 2002;98:297-309.
    • (2002) Int J Cancer , vol.98 , pp. 297-309
    • Lokeshwar, B.L.1    Selzer, M.G.2    Zhu, B.Q.3    Block, N.L.4    Golub, L.M.5
  • 319
    • 0034528012 scopus 로고    scopus 로고
    • Shark cartilage extracts as antiangiogenic agents: Smart drinks or bitter pills?
    • Gingras D, Renaud A, Mousseau N, Beliveau R. Shark cartilage extracts as antiangiogenic agents: Smart drinks or bitter pills?. Cancer Metastasis Rev 2000;19:83-86.
    • (2000) Cancer Metastasis Rev , vol.19 , pp. 83-86
    • Gingras, D.1    Renaud, A.2    Mousseau, N.3    Beliveau, R.4
  • 321
    • 0036692153 scopus 로고    scopus 로고
    • The antiangiogenic agent Neovastat (AE-941) induces endothelial cell apoptosis
    • Boivin D, Gendron S, Beaulieu E, Gingras D, Beliveau R. The antiangiogenic agent Neovastat (AE-941) induces endothelial cell apoptosis. Mol Cancer Ther 2002;1:795-802.
    • (2002) Mol Cancer Ther , vol.1 , pp. 795-802
    • Boivin, D.1    Gendron, S.2    Beaulieu, E.3    Gingras, D.4    Beliveau, R.5
  • 322
    • 0036211156 scopus 로고    scopus 로고
    • Antiangiogenic and antimetastatic properties of Neovastat (AE-941), an orally active extract derived from cartilage tissue
    • Dupont E, Falardeau P, Mousa, Dimitriadou V, Pepin MC, Wang T, Alaoui-Jamali MA. Antiangiogenic and antimetastatic properties of Neovastat (AE-941), an orally active extract derived from cartilage tissue. Clin Exp Metast 2002;19:145-153.
    • (2002) Clin Exp Metast , vol.19 , pp. 145-153
    • Dupont, E.1    Falardeau, P.2    Mousa3    Dimitriadou, V.4    Pepin, M.C.5    Wang, T.6    Alaoui-Jamali, M.A.7
  • 325
    • 0035207897 scopus 로고    scopus 로고
    • Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials
    • Falardeau P, Champagne P, Poyet P, Hariton C, Dupont E. Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol 2001;28:620-625.
    • (2001) Semin Oncol , vol.28 , pp. 620-625
    • Falardeau, P.1    Champagne, P.2    Poyet, P.3    Hariton, C.4    Dupont, E.5
  • 326
    • 0043136374 scopus 로고    scopus 로고
    • AE-941, a multifunctional antiangiogenic compound: Trials in renal cell carcinoma
    • Bukowski RM. AE-941, a multifunctional antiangiogenic compound: Trials in renal cell carcinoma. Expert Opin Investig Drugs 2003;12:1403-1411.
    • (2003) Expert Opin Investig Drugs , vol.12 , pp. 1403-1411
    • Bukowski, R.M.1
  • 329
    • 33745310809 scopus 로고    scopus 로고
    • A phase III study of AE-941 with induction chemotherapy (IC) and concomitant chemoradiotherapy (CRT) for stage III non-small cell Lung cancer (NSCLC) (NCI T99-0046, RTOG 02-70, MDA 99-303): An interim report of toxicity and response
    • Lu C, Komaki R, Herbst RS, Evans WK, Lee JJ, Truong M, Moore CA, Choy H, Bleyer A, Fisch MJ. A phase III study of AE-941 with induction chemotherapy (IC) and concomitant chemoradiotherapy (CRT) for stage III non-small cell Lung cancer (NSCLC) (NCI T99-0046, RTOG 02-70, MDA 99-303): An interim report of toxicity and response. J Clin Oncol (Meeting Abstracts) 2005;23:7144.
    • (2005) J Clin Oncol (Meeting Abstracts) , vol.23 , pp. 7144
    • Lu, C.1    Komaki, R.2    Herbst, R.S.3    Evans, W.K.4    Lee, J.J.5    Truong, M.6    Moore, C.A.7    Choy, H.8    Bleyer, A.9    Fisch, M.J.10
  • 330
    • 0036771851 scopus 로고    scopus 로고
    • Neovastat (AE-941), an inhibitor of angiogenesis: Randomized phase I/II clinical trial results in patients with plaque psoriasis
    • Sauder DN, Dekoven J, Champagne P, Croteau D, Dupont E. Neovastat (AE-941), an inhibitor of angiogenesis: Randomized phase I/II clinical trial results in patients with plaque psoriasis. J Am Acad Dermatol 2002;47:535-541.
    • (2002) J Am Acad Dermatol , vol.47 , pp. 535-541
    • Sauder, D.N.1    Dekoven, J.2    Champagne, P.3    Croteau, D.4    Dupont, E.5
  • 332
    • 0038191064 scopus 로고    scopus 로고
    • Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways
    • Philip S, Kundu GC. Osteopontin induces nuclear factor kappa B-mediated promatrix metalloproteinase-2 activation through I kappa B alpha/IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. J Biol Chem 2003;278:14487-14497.
    • (2003) J Biol Chem , vol.278 , pp. 14487-14497
    • Philip, S.1    Kundu, G.C.2
  • 340
    • 0033760662 scopus 로고    scopus 로고
    • Vitaxin applied molecular evolution
    • Mikecz K. Vitaxin applied molecular evolution. Curr Opin Investig Drugs 2000;1:199-203.
    • (2000) Curr Opin Investig Drugs , vol.1 , pp. 199-203
    • Mikecz, K.1
  • 342
    • 0036839554 scopus 로고    scopus 로고
    • Integrin alpha v beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases
    • Wilder R. Integrin alpha v beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases. Ann Rheum Dis 2002;61(Suppl 2):ii 96-99.
    • (2002) Ann Rheum Dis , vol.61 , Issue.SUPPL. 2
    • Wilder, R.1
  • 344
    • 0036682030 scopus 로고    scopus 로고
    • Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts
    • Burke PA, DeNardo SJ, Miers LA, Lamborn KR, Matzku S, DeNardo GL. Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts. Cancer Res 2002;62:4263-4272.
    • (2002) Cancer Res , vol.62 , pp. 4263-4272
    • Burke, P.A.1    Denardo, S.J.2    Miers, L.A.3    Lamborn, K.R.4    Matzku, S.5    Denardo, G.L.6
  • 347
    • 0035957050 scopus 로고    scopus 로고
    • Solution structures and integrin binding activities of an RGD peptide with two isomers
    • Assa-Munt N, Jia X, Laakkonen P, Ruoslahti E. Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry 2001;40:2373-2378.
    • (2001) Biochemistry , vol.40 , pp. 2373-2378
    • Assa-Munt, N.1    Jia, X.2    Laakkonen, P.3    Ruoslahti, E.4
  • 348
    • 0347155579 scopus 로고    scopus 로고
    • Phase 1 and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alpha v beta 3 and alpha v beta 5 in patients with advanced solid tumours
    • Eskens FA, Dumez H, Hoekstra R, Perschl A, Brindley C, Bottcher S, Wynendaele W, Drevs J, Verweij J, van Oosterom AT. Phase 1 and pharmacokinetic study of continuous twice weekly intravenous administration of Cilengitide (EMD 121974), a novel inhibitor of the integrins alpha v beta 3 and alpha v beta 5 in patients with advanced solid tumours. Eur J Cancer 2003;39:917-926.
    • (2003) Eur J Cancer , vol.39 , pp. 917-926
    • Eskens, F.A.1    Dumez, H.2    Hoekstra, R.3    Perschl, A.4    Brindley, C.5    Bottcher, S.6    Wynendaele, W.7    Drevs, J.8    Verweij, J.9    Van Oosterom, A.T.10
  • 349
    • 0346158521 scopus 로고    scopus 로고
    • Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour
    • Raguse JD, Gath HJ, Bier J, Riess H, Oettle H. Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour. Oral Oncol 2004;40:228-230.
    • (2004) Oral Oncol , vol.40 , pp. 228-230
    • Raguse, J.D.1    Gath, H.J.2    Bier, J.3    Riess, H.4    Oettle, H.5
  • 353
    • 0034200865 scopus 로고    scopus 로고
    • Effects of the novel alphav integrin antagonist SM256 and cis-platinum on growth of murine squamous cell carcinoma PAM LY8
    • Van Waes C, Enamorado-Ayala I, Hecht D, Sulica L, Chen Z, Batt DG, Mousa S. Effects of the novel alphav integrin antagonist SM256 and cis-platinum on growth of murine squamous cell carcinoma PAM LY8. Int J Oncol 2000;16:1189-1195.
    • (2000) Int J Oncol , vol.16 , pp. 1189-1195
    • Van Waes, C.1    Enamorado-Ayala, I.2    Hecht, D.3    Sulica, L.4    Chen, Z.5    Batt, D.G.6    Mousa, S.7
  • 354
    • 0037420818 scopus 로고    scopus 로고
    • Nonpeptide RGD antagonists: A novel class of mimetics, the 5,8-disubstituted 1-azabicyclo|5.2.0| nonan-2-one lactam
    • Bourguet E, Baneres JL, Parello J, Lusinchi X, Girard JP, Vidal JP. Nonpeptide RGD antagonists: A novel class of mimetics, the 5,8-disubstituted 1-azabicyclo|5.2.0| nonan-2-one lactam. Bioorg Med Chem Lett 2003;13:1561-1564.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1561-1564
    • Bourguet, E.1    Baneres, J.L.2    Parello, J.3    Lusinchi, X.4    Girard, J.P.5    Vidal, J.P.6
  • 355
    • 0036734093 scopus 로고    scopus 로고
    • A reevaluation of integrins as regulators of angiogenesis
    • Hynes RO. A reevaluation of integrins as regulators of angiogenesis. Nat Med 2002;8:918-921.
    • (2002) Nat Med , vol.8 , pp. 918-921
    • Hynes, R.O.1
  • 356
    • 0029758257 scopus 로고    scopus 로고
    • Rediscovering thalidomide: A review of its mechanism of action, side effects, and potential uses
    • Tseng S, Pak G, Washenik K, Pomeranz MK, Shupack JL. Rediscovering thalidomide: A review of its mechanism of action, side effects, and potential uses. J Am Acad Dermatol 1996;35:969-979.
    • (1996) J Am Acad Dermatol , vol.35 , pp. 969-979
    • Tseng, S.1    Pak, G.2    Washenik, K.3    Pomeranz, M.K.4    Shupack, J.L.5
  • 357
    • 0013805310 scopus 로고
    • Further observation with thalidomide in lepra reactions
    • Sheskin J. Further observation with thalidomide in lepra reactions. Lepr Rev 1965;36:183-187.
    • (1965) Lepr Rev , vol.36 , pp. 183-187
    • Sheskin, J.1
  • 359
    • 0029925419 scopus 로고    scopus 로고
    • Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade
    • Geitz H, Handt S, Zwingenberger K. Thalidomide selectively modulates the density of cell surface molecules involved in the adhesion cascade. Immunopharmacol 1996;31:213-221.
    • (1996) Immunopharmacol , vol.31 , pp. 213-221
    • Geitz, H.1    Handt, S.2    Zwingenberger, K.3
  • 360
    • 22044444554 scopus 로고    scopus 로고
    • Thalidomide-induced anti-angiogenic action is mediated by ceramide through depletion of VEGF receptors, and antagonized by sphingosine-1-phosphate
    • Yabu T, Tomimoto H, Taguchi Y, Yamaoka S, Igarashi Y, Okazaki T. Thalidomide-induced anti-angiogenic action is mediated by ceramide through depletion of VEGF receptors, and antagonized by sphingosine-1-phosphate. Blood 2005;106:125-134.
    • (2005) Blood , vol.106 , pp. 125-134
    • Yabu, T.1    Tomimoto, H.2    Taguchi, Y.3    Yamaoka, S.4    Igarashi, Y.5    Okazaki, T.6
  • 362
    • 0001955290 scopus 로고    scopus 로고
    • Efficacy of low dose thalidomide in multiple myeloma
    • Durie BG, Stepan DE. Efficacy of low dose thalidomide in multiple myeloma. Elec J Oncol 2000;1:1-8.
    • (2000) Elec J Oncol , vol.1 , pp. 1-8
    • Durie, B.G.1    Stepan, D.E.2
  • 367
    • 18144368906 scopus 로고    scopus 로고
    • Phase II trial of GM-CSF+thalidomide in patients with androgen-independent metastatic prostate cancer
    • Dreicer R, Klein EA, Elson P, Peereboom D, Byzova T, Plow EF. Phase II trial of GM-CSF+thalidomide in patients with androgen-independent metastatic prostate cancer. Urol Oncol 2005;23:82-86.
    • (2005) Urol Oncol , vol.23 , pp. 82-86
    • Dreicer, R.1    Klein, E.A.2    Elson, P.3    Peereboom, D.4    Byzova, T.5    Plow, E.F.6
  • 371
    • 0037435522 scopus 로고    scopus 로고
    • Phase I study of thalidomide for the treatment of plexiform neurofibroma in neurofibromatosis 1
    • Gupta A, Cohen BH, Ruggieri P, Packer RJ, Phillips PC. Phase I study of thalidomide for the treatment of plexiform neurofibroma in neurofibromatosis 1. Neurology 2003;60:130-132.
    • (2003) Neurology , vol.60 , pp. 130-132
    • Gupta, A.1    Cohen, B.H.2    Ruggieri, P.3    Packer, R.J.4    Phillips, P.C.5
  • 378
    • 0030039682 scopus 로고    scopus 로고
    • The role of calcium in the regulation of invasion and angiogenesis
    • Alessandro R, Masiero L, Liotta LA, Kohn EC. The role of calcium in the regulation of invasion and angiogenesis. In Vivo 1996;10:153-160.
    • (1996) In Vivo , vol.10 , pp. 153-160
    • Alessandro, R.1    Masiero, L.2    Liotta, L.A.3    Kohn, E.C.4
  • 380
    • 0033985524 scopus 로고    scopus 로고
    • Carboxyamido-triazole inhibits angiogenesis by blocking the calcium-mediated nitric-oxide synthase-vascular endothelial growth factor pathway
    • Bauer KS, Cude KJ, Dixon SC, Kruger EA, Figg WD. Carboxyamido-triazole inhibits angiogenesis by blocking the calcium-mediated nitric-oxide synthase-vascular endothelial growth factor pathway. J Pharmacol Exp Ther 2000;292:31-37.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 31-37
    • Bauer, K.S.1    Cude, K.J.2    Dixon, S.C.3    Kruger, E.A.4    Figg, W.D.5
  • 381
    • 0034089155 scopus 로고    scopus 로고
    • Carboxyamido-triazole induces apoptosis in bovine aortic endothelial and human glioma cells
    • Ge S, Rempel SA, Divine G, Mikkelsen T. Carboxyamido-triazole induces apoptosis in bovine aortic endothelial and human glioma cells. Clin Cancer Res 2000;6:1248-1254.
    • (2000) Clin Cancer Res , vol.6 , pp. 1248-1254
    • Ge, S.1    Rempel, S.A.2    Divine, G.3    Mikkelsen, T.4
  • 382
    • 0028040432 scopus 로고
    • Calcium influx modulates expression of matrix metalloproteinase-2 (72 kDa type IV collagenase, gelatinase A) expression
    • Kohn EC, Jacobs W, Kim YS, Alessandro R, Stetler-Stevenson WG, Liotta LA. Calcium influx modulates expression of matrix metalloproteinase-2 (72 kDa type IV collagenase, gelatinase A) expression. J Biol Chem 1994;269:21505-21511.
    • (1994) J Biol Chem , vol.269 , pp. 21505-21511
    • Kohn, E.C.1    Jacobs, W.2    Kim, Y.S.3    Alessandro, R.4    Stetler-Stevenson, W.G.5    Liotta, L.A.6
  • 390
    • 0035523960 scopus 로고    scopus 로고
    • The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species
    • Yin L, Ohno T, Weichselbaum R, Kharbanda S, Kufe D. The novel isocoumarin 2-(8-hydroxy-6-methoxy-1-oxo-1H-2-benzopyran-3-yl) propionic acid (NM-3) induces lethality of human carcinoma cells by generation of reactive oxygen species. Mol Cancer Ther 2001;1:43-48.
    • (2001) Mol Cancer Ther , vol.1 , pp. 43-48
    • Yin, L.1    Ohno, T.2    Weichselbaum, R.3    Kharbanda, S.4    Kufe, D.5
  • 393
    • 0035132923 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
    • Kozin SV, Boucher Y, Hicklin DJ, Bohlen P, Jain RK, Suit HD. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res 2001;61:39-44.
    • (2001) Cancer Res , vol.61 , pp. 39-44
    • Kozin, S.V.1    Boucher, Y.2    Hicklin, D.J.3    Bohlen, P.4    Jain, R.K.5    Suit, H.D.6
  • 395
    • 0024332082 scopus 로고
    • Antitumor effects of an antiangiogenic polysaccharide from an Arthrobacter species with or without a steroid
    • Tanaka NG, Sakamoto N, Inoue K, Korenaga H, Kadoya S, Ogawa H, Osada Y. Antitumor effects of an antiangiogenic polysaccharide from an Arthrobacter species with or without a steroid. Cancer Res 1989;49:6727-6730.
    • (1989) Cancer Res , vol.49 , pp. 6727-6730
    • Tanaka, N.G.1    Sakamoto, N.2    Inoue, K.3    Korenaga, H.4    Kadoya, S.5    Ogawa, H.6    Osada, Y.7
  • 396
    • 0035219752 scopus 로고    scopus 로고
    • The bacterial polysaccharide tecogalan blocks growth of breast cancer cells in vivo
    • Yunmbam MK, Wellstein A. The bacterial polysaccharide tecogalan blocks growth of breast cancer cells in vivo. Oncol Rep 2001;8:161-164.
    • (2001) Oncol Rep , vol.8 , pp. 161-164
    • Yunmbam, M.K.1    Wellstein, A.2
  • 397
    • 0033803875 scopus 로고    scopus 로고
    • The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities
    • Yoshikawa H, Ishibashi T, Hata Y, Inomata H, Sueishi K. The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities. Ophthalmic Res 2000;32:261-269.
    • (2000) Ophthalmic Res , vol.32 , pp. 261-269
    • Yoshikawa, H.1    Ishibashi, T.2    Hata, Y.3    Inomata, H.4    Sueishi, K.5
  • 399
    • 0035865363 scopus 로고    scopus 로고
    • Redefining the target: Chemotherapeutics as antiangiogenics
    • Miller KD, Sweeney CJ, Sledge GW Jr. Redefining the target: Chemotherapeutics as antiangiogenics. J Clin Oncol 2001;19:1195-206.
    • (2001) J Clin Oncol , vol.19 , pp. 1195-1206
    • Miller, K.D.1    Sweeney, C.J.2    Sledge Jr., G.W.3
  • 400
    • 0035080016 scopus 로고    scopus 로고
    • Docetaxel (Taxotere) in combination with platinums in patients with non-small cell lung cancer: Trial data and implications for clinical management
    • Belani C, Lynch T. Docetaxel (Taxotere) in combination with platinums in patients with non-small cell lung cancer: Trial data and implications for clinical management. Semin Oncol 2001;28:10-14.
    • (2001) Semin Oncol , vol.28 , pp. 10-14
    • Belani, C.1    Lynch, T.2
  • 401
    • 0035257923 scopus 로고    scopus 로고
    • Docetaxel (Taxotere) plus trastuzumab (Herceptin) in breast cancer
    • Burris HA III. Docetaxel (Taxotere) plus trastuzumab (Herceptin) in breast cancer. Semin Oncol 2001;28:38-44.
    • (2001) Semin Oncol , vol.28 , pp. 38-44
    • Burris III, H.A.1
  • 402
    • 0035046962 scopus 로고    scopus 로고
    • Taxanes in lung cancer: A review with focus on the European experience
    • Calderoni A, Cerny T. Taxanes in lung cancer: A review with focus on the [European experience. Crit Rev Oncol Hematol 2001;38:105-127.
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 105-127
    • Calderoni, A.1    Cerny, T.2
  • 403
    • 0035111779 scopus 로고    scopus 로고
    • Taxanes in combined modality therapy for solid tumors
    • Choy H. Taxanes in combined modality therapy for solid tumors. Crit Rev Oncol Hematol 2001;37:237-247.
    • (2001) Crit Rev Oncol Hematol , vol.37 , pp. 237-247
    • Choy, H.1
  • 404
    • 0032808776 scopus 로고    scopus 로고
    • Recent progress in the clinical development of docetaxel (Taxotere)
    • Hortobagyi GN. Recent progress in the clinical development of docetaxel (Taxotere). Semin Oncol 1999;26:32-36.
    • (1999) Semin Oncol , vol.26 , pp. 32-36
    • Hortobagyi, G.N.1
  • 406
    • 0032900181 scopus 로고    scopus 로고
    • Combination of taxanes with radiation: Preclinical studies
    • Milas L, Milas MM, Mason KA. Combination of taxanes with radiation: Preclinical studies. Semin Radiat Oncol 1999;9:12-26.
    • (1999) Semin Radiat Oncol , vol.9 , pp. 12-26
    • Milas, L.1    Milas, M.M.2    Mason, K.A.3
  • 407
    • 0036167369 scopus 로고    scopus 로고
    • Biological basis for chemo-radiotherapy interactions
    • Hennequin C, Favaudon V. Biological basis for chemo-radiotherapy interactions. Eur J Cancer 2002;38:223-230.
    • (2002) Eur J Cancer , vol.38 , pp. 223-230
    • Hennequin, C.1    Favaudon, V.2
  • 408
    • 0032945705 scopus 로고    scopus 로고
    • Taxanes as radiosensitizers for head and neck cancer
    • Herscher LL, Cook J. Taxanes as radiosensitizers for head and neck cancer. Curr Opin Oncol 1999;11:183-186.
    • (1999) Curr Opin Oncol , vol.11 , pp. 183-186
    • Herscher, L.L.1    Cook, J.2
  • 410
    • 0037430246 scopus 로고    scopus 로고
    • Comparison of antiangiogenic activities using paclitaxel (taxol) and docetaxel (taxotere)
    • Grant DS, Williams TL, Zahaczewsky M, Dicker AP. Comparison of antiangiogenic activities using paclitaxel (taxol) and docetaxel (taxotere). Int J Cancer 2003;104:121-129.
    • (2003) Int J Cancer , vol.104 , pp. 121-129
    • Grant, D.S.1    Williams, T.L.2    Zahaczewsky, M.3    Dicker, A.P.4
  • 411
    • 0034092011 scopus 로고    scopus 로고
    • Tumor angiogenesis: Past, present and near future
    • Kerbel RS. Tumor angiogenesis: Past, present and near future. Carcinogenesis 2000;21:505-515.
    • (2000) Carcinogenesis , vol.21 , pp. 505-515
    • Kerbel, R.S.1
  • 412
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 413
    • 0035352721 scopus 로고    scopus 로고
    • Angiogenesis: Pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs
    • Fox SB, Gasparini G, Harris AL. Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol 2001;2:278-289.
    • (2001) Lancet Oncol , vol.2 , pp. 278-289
    • Fox, S.B.1    Gasparini, G.2    Harris, A.L.3
  • 417
    • 1642472018 scopus 로고    scopus 로고
    • Antiangiogenic therapy and tumor progression
    • Blagosklonny MV. Antiangiogenic therapy and tumor progression. Cancer Cell 2004;5:13-17.
    • (2004) Cancer Cell , vol.5 , pp. 13-17
    • Blagosklonny, M.V.1
  • 418
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai T, Mancuso M, Hashizume H, Baffert F, Haskell A, Baluk P, Hu-Lowe DD, Shalinsky DR, Thurston G, Yancopoulos GD, McDonald DM. Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004;165:35-52.
    • (2004) Am J Pathol , vol.165 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3    Baffert, F.4    Haskell, A.5    Baluk, P.6    Hu-Lowe, D.D.7    Shalinsky, D.R.8    Thurston, G.9    Yancopoulos, G.D.10    McDonald, D.M.11
  • 419
    • 13944260479 scopus 로고    scopus 로고
    • Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants
    • Vosseler S, Mirancea N, Bohlen P, Mueller MM, Fusenig NE. Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants. Cancer Res 2005;65:1294-1305.
    • (2005) Cancer Res , vol.65 , pp. 1294-1305
    • Vosseler, S.1    Mirancea, N.2    Bohlen, P.3    Mueller, M.M.4    Fusenig, N.E.5
  • 420
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong RT, Boucher Y, Kozin SV, Winkler F, Hicklin DJ, Jain RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 2004;64:3731-3736.
    • (2004) Cancer Res , vol.64 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 421
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy. Science 2005;307:58-62.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 423
    • 0037373826 scopus 로고    scopus 로고
    • The First International Conference on Vascular Targeting: Meeting overview
    • Thorpe PE, Chaplin DJ, Blajey DC. The First International Conference on Vascular Targeting: Meeting overview. Cancer Res 2003;63:1144-1147.
    • (2003) Cancer Res , vol.63 , pp. 1144-1147
    • Thorpe, P.E.1    Chaplin, D.J.2    Blajey, D.C.3
  • 424
    • 0036136731 scopus 로고    scopus 로고
    • Angioprevention: Angiogenesis is a common and key target for cancer chemopreventive agents
    • Tosetti F, Ferrari N, De Flora S, Albini A. Angioprevention: Angiogenesis is a common and key target for cancer chemopreventive agents. FASEB J 2002;16:2-14.
    • (2002) FASEB J , vol.16 , pp. 2-14
    • Tosetti, F.1    Ferrari, N.2    De Flora, S.3    Albini, A.4


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