A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration

EMBO Journal

Volumn 19, Issue 15, 2000, Pages 4064-4073

  Gille, Hendrik ^a,b   Kowalski, Joe ^a   Yu, Lanlan ^a   Chen, Helen ^a   Pisabarro, M Teresa ^a   Davis Smyth, Terri ^a,c   Ferrara, Napoleone ^a  

^a GENENTECH INC   (United States)

^b Xantos Biomedicine AG   (Germany)

^c Raven Biotechnologies Inc   (United States)

Author keywords

Flt 1; Juxtamembrane region; KDR; Phosphatidylinositol 3' kinase; VEGF

Indexed keywords

CHIMERIC PROTEIN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; REPRESSOR PROTEIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALIA;

EID: 0034254273     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.15.4064     Document Type: Article

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