Hepatocyte growth factor stimulates nitric oxide production through endothelial nitric oxide synthase activation by the phosphoinositide 3-kinase/Akt pathway and possibly by mitogen-activated protein kinase kinase in vascular endothelial cells

Hypertension Research

Volumn 27, Issue 11, 2004, Pages 887-895

  Uruno, Akira ^a   Sugawara, Akira ^a   Kanatsuka, Hiroshi ^a   Arima, Shuji ^a   Taniyama, Yoshihiro ^a   Kudo, Masataka ^a   Takeuchi, Kazuhisa ^a   Ito, Sadayoshi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Endothelial nitric oxide synthase; Hepatocyte growth factor; Mitogen activated protein kinase; Nitric oxide; Phosphoinositide 3 kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RECOMBINANT SCATTER FACTOR; SERINE; THREONINE; TYROSINE; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR SPACE; NONHUMAN; PROTEIN INTERACTION; VASCULAR DISEASE; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; AORTA; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; FLUORESCEIN; HEPATOCYTE GROWTH FACTOR; HUMANS; INDICATORS AND REAGENTS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 14644399898     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.27.887     Document Type: Article

References (35)

1. Bottaro, DP, Rubin JS, Faletto DL, et al: Identification of the hepatocyte growth factor receptor as the c-met protooncogene product. Science 1991; 251: 802-804.
2. Zarnegar R, Michalopoulos GK: The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis. J Cell Biol 1995; 129: 1177-1180.
3. Nakamura Y, Morishita R, Higaki J, et al: Hepatocyte growth factor is a novel member of the endothelium-specific growth factors: additive stimulatory effect of hepatocyte growth factor with basic fibroblast growth factor but not with vascular endothelial growth factor. J Hypertens 1996; 14: 1067-1072.
4. Bussolino F, Di Renzo MF, Ziche M, et al: Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol 1992; 119: 629-641.
5. Grant DS, Kleinman HK, Goldberg ID, et al: Scatter factor induces blood vessel formation in vivo. Proc Natl Acad Sci U S A 1993; 90: 1937-1941.
6. Morishita R: Recent progress in gene therapy for cardiovascular disease. Circ J 2002; 66: 1077-1086.
7. Nakagami H, Morishita R, Yamamoto K, et al: Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells. Hypertension 2001; 37: 581-586.
8. Ziche M, Morbidelli L, Choudhuri R, et al: Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 1997; 99: 2625-2634.
9. Hayashi K, Nakamura S, Morishita R, et al: In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model. Gene Ther 2000; 7: 1664-1671.
10. Maejima Y, Ueba H, Kuroki M, et al: Src family kinases and nitric oxide production are required for hepatocyte growth factor-stimulated endothelial cell growth. Atherosclerosis 2003; 167: 89-95.
11. Makondo K, Kimura K, Kitamura N, et al: Hepatocyte growth factor activates endothelial nitric oxide synthase by Ca (2 +) - and phosphomositide 3-kinase /Akt-dependent phosphorylation in aortic endothelial cells. Biochem J 2003; 374: 63-69.
12. Fulton D, Gratton JP, McCabe TJ, et al: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999; 399: 597-601.
13. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-605.
14. Kojima H, Nakatsubo N, Kikuchi K, et al: Detection and imaging of nitric oxide with novel fluorescent indicators: diaminofluoresceins. Anal Chem 1998; 70: 2446-2453.
15. Sugawara A, Takeuchi K, Uruno A, Kudo M, Sato K, Ito S: Effects of mitogen-activated protein kinase pathway and co-activator CREB-binding protein on peroxisome proliferator-activated receptor-gamma-mediated transcription suppression of angiotensin II type 1 receptor gene. Hypertens Res 2003; 26: 623-628.
16. Nakatsubo N, Kojima H, Kikuchi K, et al: Direct evidence of nitric oxide production from bovine aortic endothelial cells using new fluorescence indicators: diaminofluoresceins. FEBS Lett 1998; 427: 263-266.
17. Tsubouchi H, Niitani Y, Hirono S, et al: Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay. Hepatology 1991; 13: 1-5.
18. Chen ZP, Mitchelhill KI, Michell BJ, et al: AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 1999; 443: 285-289.
19. Michell BJ, Chen Z, Tiganis T, et al: Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. J Biol Chem 2001; 276: 17625-17628.
20. Scotland RS, Morales-Ruiz M, Chen Y, et al: Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circ Res 2002; 90: 904-910.
21. Luo Z, Fujio Y, Kureishi Y, et al: Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest 2000; 106: 493-499.
22. Dudley DT, Pang L, Decker SJ, Bridges AJ, Saltiel AR: A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc Natl Acad Sci U S A 1995; 92: 7686-7689.
23. Favata MF, Horiuchi KY, Manos EJ, et al: Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 1998; 273: 18623-18632.
24. Bernier SG, Haldar S, Michel T: Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase. J Biol Chem 2000; 275: 30707-30715.
25. Hisamoto K, Ohmichi M, Kanda Y, et al: Induction of endothelial nitric-oxide synthase phosphorylation by the raloxifene analog LY 117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells. J Biol Chem 2001; 276: 47642-47649.
26. Chen DB, Bird IM, Zheng J, Magness RR: Membrane estrogen receptor-dependent extracellular signal-regulated kinase pathway mediates acute activation of endothelial nitric oxide synthase by estrogen in uterine artery endothelial cells. Endocrinology 2004; 145: 113-125.
27. Liu W, Liu Y, Lowe WL Jr: The role of phosphatidylinositol 3-kinase and the mitogen-activated protein kinases in insulin-like growth factor-I-mediated effects in vascular endothelial cells. Endocrinology 2001; 142: 1710-1719.
28. Bernatchez PN, Allen BG, Gelinas DS, Guillemette G, Sirois MG: Regulation of VEGF-induced endothelial cell PAF synthesis: role of p42/44 MAPK, p38 MAPK and PI3K pathways. Br J Pharmacol 2001; 134: 1253-1262.
29. Igarashi J, Bernier SG, Michel T: Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase: differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J Biol Chem 2001; 276: 12420-12426.
30. Baumgartner I, Pieczek A, Manor O, et al: Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 1998; 97: 1114-1123.
31. Losordo DW, Vale PR, Symes JF, et al: Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia. Circulation 1998; 98: 2800-2804.
32. Vale PR, Losordo DW, Milliken CE, et al: Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia. Circulation 2000; 102: 965-974.
33. Van Belle E, Witzenbichler B, Chen D, et al: Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis. Circulation 1998; 97 381-390.
34. Nakamura Y, Morishita R, Nakamura S, et al: A vascular modulator, hepatocyte growth factor, is associated with systolic pressure. Hypertension 1996; 28: 409-413.
35. Cooke JP: NO and angiogenesis. Atheroscler Suppl 2003; 4: 53-60.