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Volumn , Issue , 2009, Pages

Vascular endothelial growth factor plus epidermal growth factor receptor dual targeted therapy in metastatic colorectal cancer: Synergy or antagonism?

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; VANDETANIB; VASCULOTROPIN;

EID: 73449100517     PISSN: 16878450     EISSN: 16878469     Source Type: Journal    
DOI: 10.1155/2009/937305     Document Type: Review
Times cited : (17)

References (61)
  • 2
    • 36348963081 scopus 로고    scopus 로고
    • Combining chemotherapy and targeted therapies in metastatic colorectal cancer
    • Rodriguez J., Zarate R., Bandres E., Combining chemotherapy and targeted therapies in metastatic colorectal cancer World Journal of Gastroenterology 2007 13 44 5867 5876
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.44 , pp. 5867-5876
    • Rodriguez, J.1    Zarate, R.2    Bandres, E.3
  • 4
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero A. F., Maurel J., Fehrenbacher L., EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer Journal of Clinical Oncology 2008 26 14 2311 2319
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 5
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer The New England Journal of Medicine 2004 351 4 337 345
    • (2004) The New England Journal of Medicine , vol.351 , Issue.4 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 6
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E., Khne C.-H., Hitre E., Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer The New England Journal of Medicine 2009 360 14 1408 1417
    • (2009) The New England Journal of Medicine , vol.360 , Issue.14 , pp. 1408-1417
    • Van Cutsem, E.1    Khne, C.-H.2    Hitre, E.3
  • 7
    • 55249110754 scopus 로고    scopus 로고
    • Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Pooled safety results
    • Peeters M., Wilson G., Ducreux M., Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): pooled safety results Journal of Clinical Oncology 2008 26 15S 4064
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.S , pp. 4064
    • Peeters, M.1    Wilson, G.2    Ducreux, M.3
  • 9
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
    • Van Cutsem E., Peeters M., Siena S., Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer Journal of Clinical Oncology 2007 25 13 1658 1664
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.13 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 10
    • 38049044037 scopus 로고    scopus 로고
    • An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy
    • Van Cutsem E., Siena S., Humblet Y., An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy Annals of Oncology 2008 19 1 92 98
    • (2008) Annals of Oncology , vol.19 , Issue.1 , pp. 92-98
    • Van Cutsem, E.1    Siena, S.2    Humblet, Y.3
  • 12
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the eastern cooperative oncology group study E3200
    • Giantonio B. J., Catalano P. J., Meropol N. J., Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the eastern cooperative oncology group study E3200 Journal of Clinical Oncology 2007 25 12 1539 1544
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 13
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer The New England Journal of Medicine 2004 350 23 2335 2342
    • (2004) The New England Journal of Medicine , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 14
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar F. F., Schulz J., McCleod M., Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial Journal of Clinical Oncology 2005 23 16 3697 3705
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.16 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 15
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz L. B., Meropol N. J., Loehrer P. J. Sr., Needle M. N., Kopit J., Mayer R. J., Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor Journal of Clinical Oncology 2004 22 7 1201 1208
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 16
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J., Targeting RAS signalling pathways in cancer therapy Nature Reviews Cancer 2003 3 1 11 22
    • (2003) Nature Reviews Cancer , vol.3 , Issue.1 , pp. 11-22
    • Downward, J.1
  • 17
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R. G., Wolf M., Peeters M., Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer Journal of Clinical Oncology 2008 26 10 1626 1634
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.10 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 18
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti S., Sartore-Bianchi A., Di Nicolantonio F., Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies Cancer Research 2007 67 6 2643 2648
    • (2007) Cancer Research , vol.67 , Issue.6 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 19
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S., Garrett C. R., Meropol N. J., Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab Journal of Clinical Oncology 2007 25 22 3230 3237
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.22 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3
  • 20
    • 38649099966 scopus 로고    scopus 로고
    • KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
    • Livre A., Bachet J.-B., Boige V., KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab Journal of Clinical Oncology 2008 26 3 374 379
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.3 , pp. 374-379
    • Livre, A.1    Bachet, J.-B.2    Boige, V.3
  • 22
    • 55249109460 scopus 로고    scopus 로고
    • Relationship of efficacy with KRAS status (wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer (mCRC), treated with irinotecan (q2w) and escalating doses of cetuximab (q1w): The EVEREST experience (preliminary data)
    • Tejpar S., Peeters M., Humblet Y., Relationship of efficacy with KRAS status (wild type versus mutant) in patients with irinotecan-refractory metastatic colorectal cancer (mCRC), treated with irinotecan (q2w) and escalating doses of cetuximab (q1w): the EVEREST experience (preliminary data) Journal of Clinical Oncology 2008 26 15S 4001
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.S , pp. 4001
    • Tejpar, S.1    Peeters, M.2    Humblet, Y.3
  • 23
    • 60549117062 scopus 로고    scopus 로고
    • Correlation of KRAS status (wild type [wt] vs. mutant [mt]) with efficacy to first-line cetuximab in a study of cetuximab single agent followed by cetuximab + FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC)
    • Cervantes T., Macarulla T., Martinelli E., Correlation of KRAS status (wild type [wt] vs. mutant [mt]) with efficacy to first-line cetuximab in a study of cetuximab single agent followed by cetuximab + FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) Journal of Clinical Oncology 2008 26 4129
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 4129
    • Cervantes, T.1    MacArulla, T.2    Martinelli, E.3
  • 24
    • 55249126998 scopus 로고    scopus 로고
    • Role of KRAS mutation in predicting response, progression-free survival, and overall survival in irinotecan-refractory patients treated with cetuximab plus irinotecan for a metastatic colorectal cancer: Analysis of 281 individual data from published series
    • Di Fiore F., Van Cutsem E., Laurent-Puig P., Role of KRAS mutation in predicting response, progression-free survival, and overall survival in irinotecan-refractory patients treated with cetuximab plus irinotecan for a metastatic colorectal cancer: analysis of 281 individual data from published series Journal of Clinical Oncology 2008 26 4035
    • (2008) Journal of Clinical Oncology , vol.26 , pp. 4035
    • Di Fiore, F.1    Van Cutsem, E.2    Laurent-Puig, P.3
  • 25
    • 39349083477 scopus 로고    scopus 로고
    • EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer
    • Finocchiaro G., Cappuzzo F., Jnne P. A., EGFR, HER2 and Kras as predictive factors for cetuximab sensitivity in colorectal cancer Journal of Clinical Oncology 2007 25 18S 4021
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.S , pp. 4021
    • Finocchiaro, G.1    Cappuzzo, F.2    Jnne, P.A.3
  • 26
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C., Bondarenko I., Makhson A., Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer Journal of Clinical Oncology 2009 27 5 663 671
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 27
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • Herbst R. S., Johnson D. H., Mininberg E., Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer Journal of Clinical Oncology 2005 23 11 2544 2555
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.11 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 28
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardiello F., Bianco R., Damiano V., Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells Clinical Cancer Research 2000 6 9 3739 3747 (Pubitemid 30694960)
    • (2000) Clinical Cancer Research , vol.6 , Issue.9 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3    Fontanini, G.4    Caputo, R.5    Pomatico, G.6    De Placido, S.7    Bianco, A.R.8    Mendelsohn, J.9    Tortora, G.10
  • 29
    • 17944370631 scopus 로고    scopus 로고
    • Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
    • Shaheen R. M., Ahmad S. A., Liu W., Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors British Journal of Cancer 2001 85 4 584 589
    • (2001) British Journal of Cancer , vol.85 , Issue.4 , pp. 584-589
    • Shaheen, R.M.1    Ahmad, S.A.2    Liu, W.3
  • 30
    • 0036252329 scopus 로고    scopus 로고
    • Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model
    • Jung Y. D., Mansfield P. F., Akagi M., Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model European Journal of Cancer 2002 38 8 1133 1140
    • (2002) European Journal of Cancer , vol.38 , Issue.8 , pp. 1133-1140
    • Jung, Y.D.1    Mansfield, P.F.2    Akagi, M.3
  • 31
    • 0001223491 scopus 로고    scopus 로고
    • Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
    • Petit A. M., Rak J., Hung M.-C., Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors The American Journal of Pathology 1997 151 6 1523 1530
    • (1997) The American Journal of Pathology , vol.151 , Issue.6 , pp. 1523-1530
    • Petit, A.M.1    Rak, J.2    Hung, M.-C.3
  • 32
    • 0037386774 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
    • Ciardiello F., Caputo R., Damiano V., Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase Clinical Cancer Research 2003 9 4 1546 1556
    • (2003) Clinical Cancer Research , vol.9 , Issue.4 , pp. 1546-1556
    • Ciardiello, F.1    Caputo, R.2    Damiano, V.3
  • 33
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • Saltz L. B., Lenz H.-J., Kindler H. L., Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study Journal of Clinical Oncology 2007 25 29 4557 4561
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.29 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.-J.2    Kindler, H.L.3
  • 34
    • 0030818926 scopus 로고    scopus 로고
    • Phase II trial of irinotecan in patients with metastatic colorectal carcinoma
    • Pitot H. C., Wender D. B., OConnell M. J., Phase II trial of irinotecan in patients with metastatic colorectal carcinoma Journal of Clinical Oncology 1997 15 8 2910 2919
    • (1997) Journal of Clinical Oncology , vol.15 , Issue.8 , pp. 2910-2919
    • Pitot, H.C.1    Wender, D.B.2    Oconnell, M.J.3
  • 35
    • 0027194943 scopus 로고
    • Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer
    • Shimada Y., Yoshino M., Wakui A., Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer Journal of Clinical Oncology 1993 11 5 909 913
    • (1993) Journal of Clinical Oncology , vol.11 , Issue.5 , pp. 909-913
    • Shimada, Y.1    Yoshino, M.2    Wakui, A.3
  • 36
    • 34547852270 scopus 로고    scopus 로고
    • Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastastic colorectal cancer
    • Meyerhardt J. A., Stuart K., Fuchs C. S., Phase II study of FOLFOX, bevacizumab and erlotinib as first-line therapy for patients with metastastic colorectal cancer Annals of Oncology 2007 18 7 1185 1189
    • (2007) Annals of Oncology , vol.18 , Issue.7 , pp. 1185-1189
    • Meyerhardt, J.A.1    Stuart, K.2    Fuchs, C.S.3
  • 37
    • 33748752619 scopus 로고    scopus 로고
    • A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: Results from the eastern cooperative oncology group study E2200
    • Giantonio B. J., Levy D. E., ODwyer P. J., Meropol N. J., Catalano P. J., Benson A. B. III, A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the eastern cooperative oncology group study E2200 Annals of Oncology 2006 17 9 1399 1403
    • (2006) Annals of Oncology , vol.17 , Issue.9 , pp. 1399-1403
    • Giantonio, B.J.1    Levy, D.E.2    Odwyer, P.J.3    Meropol, N.J.4    Catalano, P.J.5    Iii B. B, A.6
  • 38
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: A randomized phase III study
    • Saltz L. B., Clarke S., Daz-Rubio E., Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study Journal of Clinical Oncology 2008 26 12 2013 2019
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Daz-Rubio, E.3
  • 39
    • 65649132497 scopus 로고    scopus 로고
    • A phase III, multicenter, placebo-controlled, double-blind, randomized clinical trial to evaluate the efficacy of bevacizumab (Avastin) in combination with erlotinib (Tarceva) compared with erlotinib alone for treatment of advanced non-small cell lung cancer after failure of standard first-line chemotherapy (BETA)
    • Hainsworth J., Herbst R., A phase III, multicenter, placebo-controlled, double-blind, randomized clinical trial to evaluate the efficacy of bevacizumab (Avastin) in combination with erlotinib (Tarceva) compared with erlotinib alone for treatment of advanced non-small cell lung cancer after failure of standard first-line chemotherapy (BETA) Journal of Thoracic Oncology 2008 3 11 S302
    • (2008) Journal of Thoracic Oncology , vol.3 , Issue.11 , pp. 302
    • Hainsworth, J.1    Herbst, R.2
  • 40
    • 62349097073 scopus 로고    scopus 로고
    • Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A phase I/II study
    • Cohen E. E., Davis D. W., Karrison T. G., Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a phase I/II study The Lancet Oncology 2009 10 3 247 257
    • (2009) The Lancet Oncology , vol.10 , Issue.3 , pp. 247-257
    • Cohen, E.E.1    Davis, D.W.2    Karrison, T.G.3
  • 41
    • 66249112918 scopus 로고    scopus 로고
    • S0536: SWOG phase II trial of carboplatin (C), paclitaxel (P), cetuximab (CX) and bevacizumab (B) followed by cetuximab and bevacizumab in advanced non-small cell lung cancer (NSCLC)
    • Kim E. S., Herbst R. S., Moon J., S0536: SWOG phase II trial of carboplatin (C), paclitaxel (P), cetuximab (CX) and bevacizumab (B) followed by cetuximab and bevacizumab in advanced non-small cell lung cancer (NSCLC) Journal of Thoracic Oncology 2008 3 11 S266
    • (2008) Journal of Thoracic Oncology , vol.3 , Issue.11 , pp. 266
    • Kim, E.S.1    Herbst, R.S.2    Moon, J.3
  • 43
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht J. R., Mitchell E., Chidiac T., A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer Journal of Clinical Oncology 2009 27 5 672 680
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 44
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A., Figer A., Seymour M., Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer Journal of Clinical Oncology 2000 18 16 2938 2947
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.16 , pp. 2938-2947
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 45
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone. as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard J. Y., Cunningham D., Roth A. D., Irinotecan combined with fluorouracil compared with fluorouracil alone. as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial The Lancet 2000 355 9209 1041 1047
    • (2000) The Lancet , vol.355 , Issue.9209 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 46
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C., Andr T., Achille E., FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study Journal of Clinical Oncology 2004 22 2 229 237
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.2 , pp. 229-237
    • Tournigand, C.1    Andr, T.2    Achille, E.3
  • 47
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J., Koopman M., Cats A., Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer The New England Journal of Medicine 2009 360 6 563 572
    • (2009) The New England Journal of Medicine , vol.360 , Issue.6 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 48
    • 0035444798 scopus 로고    scopus 로고
    • Kirsten ras mutations in patients with colorectal cancer: The RASCAL II study
    • Andreyev H. J. N., Norman A. R., Cunningham D., Kirsten ras mutations in patients with colorectal cancer: the RASCAL II study British Journal of Cancer 2001 85 5 692 696
    • (2001) British Journal of Cancer , vol.85 , Issue.5 , pp. 692-696
    • Andreyev, H.J.N.1    Norman, A.R.2    Cunningham, D.3
  • 49
    • 0036739336 scopus 로고    scopus 로고
    • Specific codon 13 K- ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K- ras mutations are associated with mucinous histotype
    • Bazan V., Migliavacca M., Zanna I., Specific codon 13 K- ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K- ras mutations are associated with mucinous histotype Annals of Oncology 2002 13 9 1438 1446
    • (2002) Annals of Oncology , vol.13 , Issue.9 , pp. 1438-1446
    • Bazan, V.1    Migliavacca, M.2    Zanna, I.3
  • 50
    • 0035863495 scopus 로고    scopus 로고
    • K- ras and p16 aberrations confer poor prognosis in human colorectal cancer
    • Esteller M., Gonzlez S., Risques R. A., K- ras and p16 aberrations confer poor prognosis in human colorectal cancer Journal of Clinical Oncology 2001 19 2 299 304
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.2 , pp. 299-304
    • Esteller, M.1    Gonzlez, S.2    Risques, R.A.3
  • 51
    • 36348985348 scopus 로고    scopus 로고
    • Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer
    • Zhang W., Yang D., Capanu M., Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer Journal of Clinical Oncology 2007 25 18S 4128
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.S , pp. 4128
    • Zhang, W.1    Yang, D.2    Capanu, M.3
  • 52
    • 35848958839 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) A61G polymorphism and EGF gene expression in normal colon tissue from patients with colorectal cancer
    • Spindler K.-L. G., Nielsen J. N., Ornskov D., Brandslund I., Jakobsen A., Epidermal growth factor (EGF) A61G polymorphism and EGF gene expression in normal colon tissue from patients with colorectal cancer Acta Oncologica 2007 46 8 1113 1117
    • (2007) Acta Oncologica , vol.46 , Issue.8 , pp. 1113-1117
    • Spindler, K.-L.G.1    Nielsen, J.N.2    Ornskov, D.3    Brandslund, I.4    Jakobsen, A.5
  • 53
    • 41149140325 scopus 로고    scopus 로고
    • Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer
    • Graziano F., Ruzzo A., Loupakis F., Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer Journal of Clinical Oncology 2008 26 9 1427 1434
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.9 , pp. 1427-1434
    • Graziano, F.1    Ruzzo, A.2    Loupakis, F.3
  • 54
    • 59949097532 scopus 로고    scopus 로고
    • Panitumumab (pmab) regimen evaluation in colorectal cancer to estimate primary response to treatment (PRECEPT): Effect of KRAS mutation status on second-line treatment (tx) with pmab and FOLFIRI
    • Cohn A., Smith D. A., Neubauer M. A., Panitumumab (pmab) regimen evaluation in colorectal cancer to estimate primary response to treatment (PRECEPT): effect of KRAS mutation status on second-line treatment (tx) with pmab and FOLFIRI Journal of Clinical Oncology 2008 26 15S 4127
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.S , pp. 4127
    • Cohn, A.1    Smith, D.A.2    Neubauer, M.A.3
  • 55
    • 34547464547 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Company, Princeton, NJ, USA, 2008
    • Erbitux0x000AE (cetuximab), Full Prescribing Information. Bristol-Myers Squibb Company, Princeton, NJ, USA, 2008
    • Full Prescribing Information
  • 56
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F., Martini M., Molinari F., Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer Journal of Clinical Oncology 2008 26 35 5705 5712
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.35 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 57
    • 51249089269 scopus 로고    scopus 로고
    • Potential value of PTEN in predicting cetuximab response in colorectal cancer: An exploratory study
    • Razis E., Briasoulis E., Vrettou E., Potential value of PTEN in predicting cetuximab response in colorectal cancer: an exploratory study BMC Cancer 2008 8, article 234
    • (2008) BMC Cancer , vol.8234
    • Razis, E.1    Briasoulis, E.2    Vrettou, E.3
  • 59
    • 0037194728 scopus 로고    scopus 로고
    • Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
    • Rajagopalan H., Bardelli A., Lengauer C., Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status Nature 2002 418 6901 934
    • (2002) Nature , vol.418 , Issue.6901 , pp. 934
    • Rajagopalan, H.1    Bardelli, A.2    Lengauer, C.3
  • 60
    • 33644836082 scopus 로고    scopus 로고
    • Cancer and leukemia group b/southwest oncology group trial 80405: A phase III trial of chemotherapy and biologics for patients with untreated advanced colorectal adenocarcinoma
    • Venook A. P., Blanke C. D., Niedzwiecki D., Cancer and leukemia group b/southwest oncology group trial 80405: a phase III trial of chemotherapy and biologics for patients with untreated advanced colorectal adenocarcinoma Clinical Colorectal Cancer 2005 5 4 292 294
    • (2005) Clinical Colorectal Cancer , vol.5 , Issue.4 , pp. 292-294
    • Venook, A.P.1    Blanke, C.D.2    Niedzwiecki, D.3
  • 61
    • 77953641347 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with cetuximab plus irinotecan in irinotecan-refractory colorectal cancer (CRC) patients who have progressed on a bevacizumab-containing regiment (the BOND 2.5 study)
    • Segal N. H., Reidy-Lagunes D., Capanu M., Phase II study of bevacizumab in combination with cetuximab plus irinotecan in irinotecan-refractory colorectal cancer (CRC) patients who have progressed on a bevacizumab-containing regiment (the BOND 2.5 study) Journal of Clinical Oncology 2009 27 15S 4087
    • (2009) Journal of Clinical Oncology , vol.27 , Issue.S , pp. 4087
    • Segal, N.H.1    Reidy-Lagunes, D.2    Capanu, M.3


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