Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

Genes and Development

Volumn 18, Issue 20, 2004, Pages 2469-2473

  Krebs, Luke T ^a   Shutter, John R ^b   Tanigaki, Kenji ^c   Honjo, Tasuku ^c   Stark, Kevin L ^b   Gridley, Thomas ^a  

^a JACKSON LABORATORY   (United States)

^b AMGEN INC   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Arteriovenous malformation; Dll4; Haploinsufficiency; Notch signaling; RBP J; Vascular remodeling

Indexed keywords

LIGAND; MUTANT PROTEIN; NOTCH RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOVENOUS MALFORMATION; ARTERY; ARTICLE; BLOOD VESSEL; CELL LINEAGE; CONTROLLED STUDY; DISEASE COURSE; EMBRYO; ENDOTHELIUM CELL; GENE FUNCTION; GENE INACTIVATION; GENE MUTATION; HETEROZYGOSITY; HOMOZYGOSITY; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; BLOOD VESSELS; DNA PRIMERS; DNA-BINDING PROTEINS; ENDOTHELIAL CELLS; GENE DOSAGE; GENOTYPE; HISTOLOGICAL TECHNIQUES; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; IMMUNOHISTOCHEMISTRY; LIGANDS; MEMBRANE PROTEINS; MICE; MUTATION; NUCLEAR PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

ANIMALIA; VERTEBRATA;

EID: 5444242184     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1239204     Document Type: Article

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