-
1
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman, J. (1971) Tumor angiogenesis: therapeutic implications. N. Engl. J. Med., 285, 1182-1186.
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
2
-
-
0015311426
-
Anti-angiogenesis: New concept for therapy of solid tumors
-
Folkman, J. (1972) Anti-angiogenesis: new concept for therapy of solid tumors. Ann. Surg., 175, 409-416.
-
(1972)
Ann. Surg.
, vol.175
, pp. 409-416
-
-
Folkman, J.1
-
3
-
-
84959830787
-
Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic implants
-
Algire, G.H. and Chalkley, H.W. (1945) Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic implants. J. Natl Cancer Inst., 6, 73-85.
-
(1945)
J. Natl Cancer Inst.
, vol.6
, pp. 73-85
-
-
Algire, G.H.1
Chalkley, H.W.2
-
4
-
-
0014304893
-
Tumor angiogenesis: Transfilter diffusion studies in the hamster by the transparent chamber technique
-
Greenblatt, M. and Shubi, P. (1968) Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique. J. Natl Cancer Inst., 41, 111-124.
-
(1968)
J. Natl Cancer Inst.
, vol.41
, pp. 111-124
-
-
Greenblatt, M.1
Shubi, P.2
-
5
-
-
0013882422
-
The growth of the blood supply to melanoma transplants in the hamster cheek pouch
-
Warren, B.A. and Shubik, P. (1966) The growth of the blood supply to melanoma transplants in the hamster cheek pouch. Lab. Invest., 15, 464-478.
-
(1966)
Lab. Invest.
, vol.15
, pp. 464-478
-
-
Warren, B.A.1
Shubik, P.2
-
6
-
-
0015008620
-
Isolation of a tumor factor responsible for angiogenesis
-
Folkman, J., Merler, E., Abernathy, C. and Williams, G. (1971) Isolation of a tumor factor responsible for angiogenesis. J. Exp. Med., 133, 275-288.
-
(1971)
J. Exp. Med.
, vol.133
, pp. 275-288
-
-
Folkman, J.1
Merler, E.2
Abernathy, C.3
Williams, G.4
-
7
-
-
0016256685
-
Tumor angiogenesis factor
-
Folkman, J. (1974) Tumor angiogenesis factor. Cancer Res., 34, 2109-2113.
-
(1974)
Cancer Res.
, vol.34
, pp. 2109-2113
-
-
Folkman, J.1
-
8
-
-
0033583670
-
Angiogenesis research is on fast forward
-
Nelson, N.J. (1999) Angiogenesis research is on fast forward. J. Natl Cancer Inst., 91, 820-822.
-
(1999)
J. Natl Cancer Inst.
, vol.91
, pp. 820-822
-
-
Nelson, N.J.1
-
9
-
-
0030772175
-
Clinical trials of antiangiogenic agents
-
Twardowski, P. and Gradishar, W.J. (1997) Clinical trials of antiangiogenic agents. Curr. Opin. Oncol., 9, 584-589.
-
(1997)
Curr. Opin. Oncol.
, vol.9
, pp. 584-589
-
-
Twardowski, P.1
Gradishar, W.J.2
-
10
-
-
0032127699
-
Inhibitors of angiogenesis enter phase III testing
-
Nelson, N.J. (1998) Inhibitors of angiogenesis enter phase III testing. J. Natl Cancer Inst., 90, 960-963.
-
(1998)
J. Natl Cancer Inst.
, vol.90
, pp. 960-963
-
-
Nelson, N.J.1
-
11
-
-
0028830180
-
Clinical trials of antiangiogenic agents
-
Hawkins, M.J. (1995) Clinical trials of antiangiogenic agents. Curr. Opin. Oncol., 7, 90-93.
-
(1995)
Curr. Opin. Oncol.
, vol.7
, pp. 90-93
-
-
Hawkins, M.J.1
-
12
-
-
0030036156
-
Clinical studies with angiogenesis inhibitors: Biological rationale and challenges for their evaluation
-
Gasparini, G. and Presta, M. (1996) Clinical studies with angiogenesis inhibitors: biological rationale and challenges for their evaluation. Ann. Oncol., 7, 441-444.
-
(1996)
Ann. Oncol.
, vol.7
, pp. 441-444
-
-
Gasparini, G.1
Presta, M.2
-
13
-
-
0021359304
-
Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor
-
Shing, Y., Folkman, J., Sullivan, R., Butterfield, C., Murray, J. and Klagsbrun, M. (1984) Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science, 223, 1296-1299.
-
(1984)
Science
, vol.223
, pp. 1296-1299
-
-
Shing, Y.1
Folkman, J.2
Sullivan, R.3
Butterfield, C.4
Murray, J.5
Klagsbrun, M.6
-
14
-
-
0023157363
-
Angiogenic factors
-
Folkman, J. and Klagsbrun, M. (1987) Angiogenic factors. Science, 235, 442-447.
-
(1987)
Science
, vol.235
, pp. 442-447
-
-
Folkman, J.1
Klagsbrun, M.2
-
15
-
-
0000004505
-
VEGF/VPF: The angiogenesis factor found?
-
Klagsbrun, M. and Soker, S. (1993) VEGF/VPF: the angiogenesis factor found? Curr. biol., 3, 699-702.
-
(1993)
Curr. Biol.
, vol.3
, pp. 699-702
-
-
Klagsbrun, M.1
Soker, S.2
-
16
-
-
0031809572
-
Therapeutic angiogenesis with basic fibroblast growth factor: Technique and early results
-
Sellke, F.W., Laham, R.J., Edelman, E.R., Pearlman, J.D. and Simons, M. (1998) Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results. Ann. Thorac. Surg., 65, 1540-1544.
-
(1998)
Ann. Thorac. Surg.
, vol.65
, pp. 1540-1544
-
-
Sellke, F.W.1
Laham, R.J.2
Edelman, E.R.3
Pearlman, J.D.4
Simons, M.5
-
17
-
-
0343632352
-
Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene
-
Tsurumi, Y., Kearney, M., Chen, D., Silver, M., Takeshita, S., Yang, J., Symes, J.F. and Isner, J.M. (1997) Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene. Circulation. 96 (suppl. II), 382-388.
-
(1997)
Circulation
, vol.96
, Issue.SUPPL. II
, pp. 382-388
-
-
Tsurumi, Y.1
Kearney, M.2
Chen, D.3
Silver, M.4
Takeshita, S.5
Yang, J.6
Symes, J.F.7
Isner, J.M.8
-
18
-
-
0031763144
-
The stimulation of neo-angiogenesis in the ischemic heart by the human growth factor FGF
-
Schumacher, B., von Specht, B.U., Haberstroh, J. and Pecher, P. (1998) The stimulation of neo-angiogenesis in the ischemic heart by the human growth factor FGF. J. Cardiovasc. Surg., 39, 445-153.
-
(1998)
J. Cardiovasc. Surg.
, vol.39
, pp. 445-1153
-
-
Schumacher, B.1
Von Specht, B.U.2
Haberstroh, J.3
Pecher, P.4
-
19
-
-
0033047875
-
VEGFs, receptors and angiogenesis
-
Veikkola, T. and Alitalo, K. (1999) VEGFs, receptors and angiogenesis. Semin. Cancer biol., 9, 211-220.
-
(1999)
Semin. Cancer Biol.
, vol.9
, pp. 211-220
-
-
Veikkola, T.1
Alitalo, K.2
-
20
-
-
0027359953
-
Vascular permeability factor (VPE, VEGF) in tumor biology
-
Senger, D.R., Van De Water, L., Brown, L.F., Nagy, J.A., Yeo, K.-T., Yeo, T.-K., Berse, B., Jackman, R.W., Dvorak, A.M. and Dvorak, H.F. (1993) Vascular permeability factor (VPE, VEGF) in tumor biology. Cancer Melasiasis Rev., 12, 303-324.
-
(1993)
Cancer Melasiasis Rev.
, vol.12
, pp. 303-324
-
-
Senger, D.R.1
Van De Water, L.2
Brown, L.F.3
Nagy, J.A.4
Yeo, K.-T.5
Yeo, T.-K.6
Berse, B.7
Jackman, R.W.8
Dvorak, A.M.9
Dvorak, H.F.10
-
21
-
-
0029004025
-
Review: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis
-
Dvorak, H.F., Brown, L.F., Detmar, M. and Dvorak, A.M. (1995) Review: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am. J. Pathol., 146, 1029-1039.
-
(1995)
Am. J. Pathol.
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.F.1
Brown, L.F.2
Detmar, M.3
Dvorak, A.M.4
-
22
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara, N. and Davis-Smyth, T. (1997) The biology of vascular endothelial growth factor. Endocr. Rev., 18, 4-25.
-
(1997)
Endocr. Rev.
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
23
-
-
0032890051
-
Vascular endothelial growth factor: Molecular and biological aspects
-
Ferrara, N. (1999) Vascular endothelial growth factor: molecular and biological aspects. Curr Top. Microbiol. Immunol., 237, 1-30.
-
(1999)
Curr Top. Microbiol. Immunol.
, vol.237
, pp. 1-30
-
-
Ferrara, N.1
-
24
-
-
0028803509
-
Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
-
Alon, T., Hemo, I., Itin, A., Pe'er, J., Stone, J. and Keshet, E. (1995) Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med., 1, 1024-1028.
-
(1995)
Nature Med.
, vol.1
, pp. 1024-1028
-
-
Alon, T.1
Hemo, I.2
Itin, A.3
Pe'er, J.4
Stone, J.5
Keshet, E.6
-
25
-
-
0030806273
-
Conditional switching of Vascular Endothelial Growth Factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal
-
Benjamin, L.E. and Keshet, E. (1997) Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc. Natl Acad. Sci. USA, 94, 8761-8766.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 8761-8766
-
-
Benjamin, L.E.1
Keshet, E.2
-
26
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin, L.E., Golijanin, D., Itin, A., Pode, D. and Keshet, E. (1999) Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J. Clin. Invest., 103, 159-165.
-
(1999)
J. Clin. Invest.
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
Pode, D.4
Keshet, E.5
-
27
-
-
0027197245
-
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
-
Kim, K.J., Li, B., Winer, J., Armanini, M., Gillett, N., Phillips, H.S. and Ferrera, N. (1993) Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature, 362, 841-844.
-
(1993)
Nature
, vol.362
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
Armanini, M.4
Gillett, N.5
Phillips, H.S.6
Ferrera, N.7
-
28
-
-
0031870832
-
Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy
-
Witte, L., Hicklin, D.J., Zhu, Z., Pytowski, B., Kotanides, H., Rockwell, P. and Bohlen, P. (1998) Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy. Cancer Metastasis Rev., 17, 155-161.
-
(1998)
Cancer Metastasis Rev.
, vol.17
, pp. 155-161
-
-
Witte, L.1
Hicklin, D.J.2
Zhu, Z.3
Pytowski, B.4
Kotanides, H.5
Rockwell, P.6
Bohlen, P.7
-
29
-
-
0032907687
-
Vascular Endothelial Growth Factor (VEGF) and its receptors
-
Neufeld, G., Cohen, T., Gengrinovitch, S. and Poltorak, Z. (1999) Vascular endothelial growth factor (VEGF) and its receptors. FASEB J., 13, 9-22.
-
(1999)
FASEB J.
, vol.13
, pp. 9-22
-
-
Neufeld, G.1
Cohen, T.2
Gengrinovitch, S.3
Poltorak, Z.4
-
30
-
-
0032145315
-
Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library
-
Zhu, Z., Rockwell, P., Lu, D., Kotanides, H., Pytowski, B., Hicklin, D.J., Bohlen, P. and Witte, L. (1998) Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single-chain antibodies from a phage display library. Cancer Res., 58, 3209-3214.
-
(1998)
Cancer Res.
, vol.58
, pp. 3209-3214
-
-
Zhu, Z.1
Rockwell, P.2
Lu, D.3
Kotanides, H.4
Pytowski, B.5
Hicklin, D.J.6
Bohlen, P.7
Witte, L.8
-
31
-
-
0033054581
-
Characterization of a new potent, in vivo neutralizing monoclonal antibody to human vascular endothelial growth factor
-
Schlaeppi, J.M., Siemeister, G., Weindel, K., Schnell, C. and Wood, J. (1999) Characterization of a new potent, in vivo neutralizing monoclonal antibody to human vascular endothelial growth factor. J. Cancer Res. Clin. Oncol., 125, 336-342.
-
(1999)
J. Cancer Res. Clin. Oncol.
, vol.125
, pp. 336-342
-
-
Schlaeppi, J.M.1
Siemeister, G.2
Weindel, K.3
Schnell, C.4
Wood, J.5
-
32
-
-
0030856731
-
Humanization of an antivascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
-
Presta, L.G., Chen, H., O'Connor, S.J., Chisholm, V, Meng, Y.G., Krummen, L., Winkler, M. and Ferrara, N. (1997) Humanization of an antivascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res., 57, 4593-4599.
-
(1997)
Cancer Res.
, vol.57
, pp. 4593-4599
-
-
Presta, L.G.1
Chen, H.2
O'Connor, S.J.3
Chisholm, V.4
Meng, Y.G.5
Krummen, L.6
Winkler, M.7
Ferrara, N.8
-
33
-
-
0029915612
-
Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo
-
Ramakrishnan, S., Olson, T.A., Bautch, V.L. and Mohanraj, D. (1996) Vascular endothelial growth factor-toxin conjugate specifically inhibits KDR/flk-1-positive endothelial cell proliferation in vitro and angiogenesis in vivo. Cancer Res., 56, 1324-1330.
-
(1996)
Cancer Res.
, vol.56
, pp. 1324-1330
-
-
Ramakrishnan, S.1
Olson, T.A.2
Bautch, V.L.3
Mohanraj, D.4
-
34
-
-
0030791178
-
Receptor tyrosine kinases as targets for inhibition of angiogenesis
-
Shawver, L.K., Lipson, K.E., Fong, T.A.T., McMahon, G., Plowman, G.D. and Strawn, L.M. (1997) Receptor tyrosine kinases as targets for inhibition of angiogenesis. Drug Dev. Trends, 2, 50-63.
-
(1997)
Drug Dev. Trends
, vol.2
, pp. 50-63
-
-
Shawver, L.K.1
Lipson, K.E.2
Fong, T.A.T.3
McMahon, G.4
Plowman, G.D.5
Strawn, L.M.6
-
35
-
-
0000379427
-
Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor
-
Seo, M.S., Kwak, N., Ozaki, H., Yamada, H., Okamoto, N., Yamada, E., Fabbro, D., Hofmann, F., Wood, J.M. and Campochiaro, P.A. (1999) Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am. J. Pathol., 154, 1743-1753.
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 1743-1753
-
-
Seo, M.S.1
Kwak, N.2
Ozaki, H.3
Yamada, H.4
Okamoto, N.5
Yamada, E.6
Fabbro, D.7
Hofmann, F.8
Wood, J.M.9
Campochiaro, P.A.10
-
36
-
-
0026485002
-
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-mitialed angiogenesis
-
Shweiki, D., Itin, A., Soffer, D. and Keshet, E. (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-mitialed angiogenesis. Nature, 359, 843-845.
-
(1992)
Nature
, vol.359
, pp. 843-845
-
-
Shweiki, D.1
Itin, A.2
Soffer, D.3
Keshet, E.4
-
37
-
-
0029117223
-
Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in c6 glioma cells
-
Ikeda, E., Achen, M.G., Breier, G. and Risau, W. (1995) Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J. Biol. Chem., 270, 19761-19766.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 19761-19766
-
-
Ikeda, E.1
Achen, M.G.2
Breier, G.3
Risau, W.4
-
38
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber, T.G., Osmanian, C., Jacks, T., Housman, D.E., Koch, C.J., Lowe, S.W. and Giaccia, A.J. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature, 379, 88-91.
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
Osmanian, C.2
Jacks, T.3
Housman, D.E.4
Koch, C.J.5
Lowe, S.W.6
Giaccia, A.J.7
-
40
-
-
0032053767
-
Signaling angiogenesis and lymphangiogenesis
-
Korpelainen, E.I. and Alitalo, K. (1998) Signaling angiogenesis and lymphangiogenesis. Curr. Opin. Cell Biol., 10, 159-164.
-
(1998)
Curr. Opin. Cell Biol.
, vol.10
, pp. 159-164
-
-
Korpelainen, E.I.1
Alitalo, K.2
-
41
-
-
0026695259
-
Tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors
-
Dumont, D.J., Yamaguchi, T.P., Conlon, R.A., Rossant, J. and Breitman, M.L. (1992) tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene, 7, 1471-1480.
-
(1992)
Oncogene
, vol.7
, pp. 1471-1480
-
-
Dumont, D.J.1
Yamaguchi, T.P.2
Conlon, R.A.3
Rossant, J.4
Breitman, M.L.5
-
42
-
-
0030460424
-
Isolation of Angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning
-
Davis, S., Aldrich, T.H., Jones, P.F., Acheson, A., Compton, D.L., Vivek, J., Ryan, T., Bruno, J., Radjiewski, C., Maisonpierre, P.C. and Yancopoulos, G.D. (1996) Isolation of Angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell, 87, 1161-1169.
-
(1996)
Cell
, vol.87
, pp. 1161-1169
-
-
Davis, S.1
Aldrich, T.H.2
Jones, P.F.3
Acheson, A.4
Compton, D.L.5
Vivek, J.6
Ryan, T.7
Bruno, J.8
Radjiewski, C.9
Maisonpierre, P.C.10
Yancopoulos, G.D.11
-
43
-
-
0030480322
-
Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis
-
Suri, C., Jones, P.F., Patan, S., Bartunkova, S., Maisonpierre, P.C., Davis, S., Sato, T.N. and Yancopoulos, G.D. (1996) Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell, 87, 1171-1180.
-
(1996)
Cell
, vol.87
, pp. 1171-1180
-
-
Suri, C.1
Jones, P.F.2
Patan, S.3
Bartunkova, S.4
Maisonpierre, P.C.5
Davis, S.6
Sato, T.N.7
Yancopoulos, G.D.8
-
44
-
-
15144358851
-
Angiopoietin-2. A natural antagonist for Tie2 that disrupts in vivo angiogenesis
-
Maisonpierre, P.C., Suri, C., Jones, P.F. et al. (1997) Angiopoietin-2. a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science, 277, 55-60.
-
(1997)
Science
, vol.277
, pp. 55-60
-
-
Maisonpierre, P.C.1
Suri, C.2
Jones, P.F.3
-
45
-
-
0033580889
-
Vessel cooption, regression and growth in tumors mediated by angiopoietins and VEGF
-
Holash, J., Maisonpierre, P.C., Compton, D., Boland, P., Alexander, C.R., Zagzag, D., Yancopoulos, G.D. and Wiegand, S.J. (1999) Vessel cooption, regression and growth in tumors mediated by angiopoietins and VEGF. Science, 284, 1994-1998.
-
(1999)
Science
, vol.284
, pp. 1994-1998
-
-
Holash, J.1
Maisonpierre, P.C.2
Compton, D.3
Boland, P.4
Alexander, C.R.5
Zagzag, D.6
Yancopoulos, G.D.7
Wiegand, S.J.8
-
46
-
-
0030851764
-
Signaling vascular morphogenesis and maintenance
-
Hanahan, D. (1997) Signaling vascular morphogenesis and maintenance. Science, 111, 48-50.
-
(1997)
Science
, vol.111
, pp. 48-50
-
-
Hanahan, D.1
-
47
-
-
0032893263
-
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization and growth of multiple tumor types
-
Fong, T.A., Shawver, L.K., Sun, L., Tang, C., App, H., Powell, T.J., Kim, Y.H., Schreck, R., Wang, X., Risau, W., Ullrich, A., Hirth, K.P. and McMahon, G. (1999) SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization and growth of multiple tumor types. Cancer Res., 59, 99-106.
-
(1999)
Cancer Res.
, vol.59
, pp. 99-106
-
-
Fong, T.A.1
Shawver, L.K.2
Sun, L.3
Tang, C.4
App, H.5
Powell, T.J.6
Kim, Y.H.7
Schreck, R.8
Wang, X.9
Risau, W.10
Ullrich, A.11
Hirth, K.P.12
McMahon, G.13
-
48
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon, E.R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
49
-
-
0029837761
-
How tumors become angiogenic
-
Bouck, N., Stellmach, V. and Hsu, S.C. (1996) How tumors become angiogenic. Adv. Cancer Res., 69, 135-174.
-
(1996)
Adv. Cancer Res.
, vol.69
, pp. 135-174
-
-
Bouck, N.1
Stellmach, V.2
Hsu, S.C.3
-
50
-
-
0030576517
-
Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
-
Hanahan, D. and Folkman, J. (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 86, 353-364.
-
(1996)
Cell
, vol.86
, pp. 353-364
-
-
Hanahan, D.1
Folkman, J.2
-
51
-
-
0029171892
-
Angiogenesis inhibitors generated by tumors
-
Folkman, J. (1995) Angiogenesis inhibitors generated by tumors. Mol. Med., 1, 120-122.
-
(1995)
Mol. Med.
, vol.1
, pp. 120-122
-
-
Folkman, J.1
-
52
-
-
0028060380
-
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
-
Dameron, K.M., Volpert, O.V., Tainsky, M.A. and Bouck, N. (1994) Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science, 265, 1582-1584.
-
(1994)
Science
, vol.265
, pp. 1582-1584
-
-
Dameron, K.M.1
Volpert, O.V.2
Tainsky, M.A.3
Bouck, N.4
-
53
-
-
0027290714
-
Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity
-
Tolsma, S.S., Volpert, O.V., Good, D.J., Frazier, W.A., Polverini, P.J. and Bouck, N. (1993) Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity. J. Cell. Biol., 122, 497-511.
-
(1993)
J. Cell. Biol.
, vol.122
, pp. 497-511
-
-
Tolsma, S.S.1
Volpert, O.V.2
Good, D.J.3
Frazier, W.A.4
Polverini, P.J.5
Bouck, N.6
-
54
-
-
0024510578
-
Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumours in mice
-
Dvorak, H.F. and Gresser, I. (1989) Microvascular injury in pathogenesis of interferon-induced necrosis of subcutaneous tumours in mice. J. Natl Cancer Inst., 81, 497-502.
-
(1989)
J. Natl Cancer Inst.
, vol.81
, pp. 497-502
-
-
Dvorak, H.F.1
Gresser, I.2
-
55
-
-
0029075603
-
Interferons a and p down-regulate the expression of basic fibroblast growth factor in human carcinomas
-
Singh, R.K., Gutman, M., Bucana, C.D., Sanchez, R., Llansa, N. and Fidler, I.J. (1995) Interferons a and p down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc. Natl Acad. Sci. USA, 92, 4562-4566.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 4562-4566
-
-
Singh, R.K.1
Gutman, M.2
Bucana, C.D.3
Sanchez, R.4
Llansa, N.5
Fidler, I.J.6
-
56
-
-
0026525407
-
Interferon α-2a therapy for life-threatening hemangiomas of infancy
-
Ezekowitz, R.A., Mulliken, J.B. and Folkman, J. (1992) Interferon α-2a therapy for life-threatening hemangiomas of infancy. N. Engl. J. Med., 326, 1456-1463.
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1456-1463
-
-
Ezekowitz, R.A.1
Mulliken, J.B.2
Folkman, J.3
-
57
-
-
0027236943
-
The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis
-
Clapp, C., Martial, A., Guzman, R.C., Rentier-Delrue, F. and Weiner, R.I. (1993) The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis. Endocrinology, 133, 1292-1299.
-
(1993)
Endocrinology
, vol.133
, pp. 1292-1299
-
-
Clapp, C.1
Martial, A.2
Guzman, R.C.3
Rentier-Delrue, F.4
Weiner, R.I.5
-
58
-
-
0027970092
-
Angiostatin: A novel angiogenesis inhihitor that mediates the suppression of melastases by a Lewis lung carcinoma
-
O'Reilly, M.S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R.A., Moses, M., Lane, S.W., Cao, Y., Sage, E.H. and Folkman, J. (1994) Angiostatin: a novel angiogenesis inhihitor that mediates the suppression of melastases by a Lewis lung carcinoma. Cell, 79, 315-328.
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.S.1
Holmgren, L.2
Shing, Y.3
Chen, C.4
Rosenthal, R.A.5
Moses, M.6
Lane, S.W.7
Cao, Y.8
Sage, E.H.9
Folkman, J.10
-
59
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly, M.S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W.S., Flynn, E., Birkhead, J.R., Olsen, B.R. and Folkman, J. (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell, 88, 277-285.
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
Fukai, N.4
Vasios, G.5
Lane, W.S.6
Flynn, E.7
Birkhead, J.R.8
Olsen, B.R.9
Folkman, J.10
-
60
-
-
0032906102
-
VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo
-
Zhai, Y., Ni, J., Jiang, G.W., Lu, J., Xing, L., Lincoln, C., Carter, K.C., Janat, F., Kozak, D., Xu, S., Rojas, L., Aggarwal, B.B., Ruben, S., Li, L.Y., Gentz, R. and Yu, G.L. (1999) VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo. FASEB J., 13, 181-189.
-
(1999)
FASEB J.
, vol.13
, pp. 181-189
-
-
Zhai, Y.1
Ni, J.2
Jiang, G.W.3
Lu, J.4
Xing, L.5
Lincoln, C.6
Carter, K.C.7
Janat, F.8
Kozak, D.9
Xu, S.10
Rojas, L.11
Aggarwal, B.B.12
Ruben, S.13
Li, L.Y.14
Gentz, R.15
Yu, G.L.16
-
61
-
-
0032445492
-
Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth
-
Pike, S.E., Yao, L., Jones, K.D., Cherney, B., Appella, E., Sakaguchi, K., Nakhasi, H., Teruya-Feldstein, J., Wirth, P., Gupta, G. and Tosato, G. (1998) Vasostatin, a calreticulin fragment, inhibits angiogenesis and suppresses tumor growth. J. Exp. Med., 188, 2349-2356.
-
(1998)
J. Exp. Med.
, vol.188
, pp. 2349-2356
-
-
Pike, S.E.1
Yao, L.2
Jones, K.D.3
Cherney, B.4
Appella, E.5
Sakaguchi, K.6
Nakhasi, H.7
Teruya-Feldstein, J.8
Wirth, P.9
Gupta, G.10
Tosato, G.11
-
62
-
-
0038757017
-
METH-1, a human ortholog of ADAMTS-1 and METH-2 are members of a new family of proteins with angio-inhibitory activity
-
Vazquez, F., Hastings, G., Ortega, M.A., Lane, T.F., Oikemus, S., Lombardo, M. and Iruela-Arispe, M.L. (1999) METH-1, a human ortholog of ADAMTS-1 and METH-2 are members of a new family of proteins with angio-inhibitory activity. J. Biol. Chem., 274, 23349-23357.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 23349-23357
-
-
Vazquez, F.1
Hastings, G.2
Ortega, M.A.3
Lane, T.F.4
Oikemus, S.5
Lombardo, M.6
Iruela-Arispe, M.L.7
-
63
-
-
0029098320
-
A potent inhibitor of endothelial cell proliferation is generated by proteolylic cleavage of the chemokine platelet factor 4
-
Gupta, S.K., Hassel, T. and Singh, J.P. (1995) A potent inhibitor of endothelial cell proliferation is generated by proteolylic cleavage of the chemokine platelet factor 4. Proc. Nalt Acad. Sci. USA, 92, 7799-7803.
-
(1995)
Proc. Nalt Acad. Sci. USA
, vol.92
, pp. 7799-7803
-
-
Gupta, S.K.1
Hassel, T.2
Singh, J.P.3
-
64
-
-
0033578910
-
Antiangiogenic activity of the cleaved conformation of the Serpin Antithrombin III
-
O'Reilly, M.S., Pirie-Shepherd, S., Lane, W.S. and Folkman, J. (1999) Antiangiogenic activity of the cleaved conformation of the Serpin Antithrombin III.Science, 285, 1926-1928.
-
(1999)
Science
, vol.285
, pp. 1926-1928
-
-
O'Reilly, M.S.1
Pirie-Shepherd, S.2
Lane, W.S.3
Folkman, J.4
-
65
-
-
0001549862
-
Pieces of eight: Bioactive fragments of extracellular ptoeins as regulators of angiogenesis
-
Sage, E.H. (1999) Pieces of eight: bioactive fragments of extracellular ptoeins as regulators of angiogenesis. Trends Biol. Sci., 1, 182.
-
(1999)
Trends Biol. Sci.
, vol.1
, pp. 182
-
-
Sage, E.H.1
-
66
-
-
0028822834
-
Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
-
Rak, J., Mitsuhashi, Y., Bayko, L., Filmus, J., Sasazuki, T. and Kerbel, R.S. (1995) Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res., 55, 4575-4580.
-
(1995)
Cancer Res.
, vol.55
, pp. 4575-4580
-
-
Rak, J.1
Mitsuhashi, Y.2
Bayko, L.3
Filmus, J.4
Sasazuki, T.5
Kerbel, R.S.6
-
67
-
-
0001223491
-
Neutralizing antibodies against EGF and ErbB-2/neu receptor tyrosine kinases down-regulate VEGF production by tumor cells in vitro and in vivo: Angiogenic implications for signal transduction therapy of solid tumors
-
Viloria-Petit, A.M., Rak, J., Hung, M.-C., Rockwell, P., Goldstein, N. and Kerbel, R.S. (1997) Neutralizing antibodies against EGF and ErbB-2/neu receptor tyrosine kinases down-regulate VEGF production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors. Am. J. Pathol., 151, 1523-1530.
-
(1997)
Am. J. Pathol.
, vol.151
, pp. 1523-1530
-
-
Viloria-Petit, A.M.1
Rak, J.2
Hung, M.-C.3
Rockwell, P.4
Goldstein, N.5
Kerbel, R.S.6
-
68
-
-
0032972944
-
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
-
Perrotte, P., Matsumoto, T., Inoue, K., Kuniyasu, H., Eve, B.Y., Hicklin, D.J., Radinsky, R. and Dinney, C.P. (1999) Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin. Cancer Res., 5, 257-265.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 257-265
-
-
Perrotte, P.1
Matsumoto, T.2
Inoue, K.3
Kuniyasu, H.4
Eve, B.Y.5
Hicklin, D.J.6
Radinsky, R.7
Dinney, C.P.8
-
69
-
-
0031858958
-
Establishing a link between oncogenes and tumor angiogenesis
-
Kerbel, R.S., Viloria-Petit, A.M., Okada, F. and Rak, J.W. (1998) Establishing a link between oncogenes and tumor angiogenesis. Mol. Med., 4, 286-295.
-
(1998)
Mol. Med.
, vol.4
, pp. 286-295
-
-
Kerbel, R.S.1
Viloria-Petit, A.M.2
Okada, F.3
Rak, J.W.4
-
70
-
-
0029920054
-
Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein
-
Siemeister, G., Weindel, K., Mohrs, K., Barleon, B., Martiny-Baron, G. and Marme, D. (1996) Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein. Cancer Res., 56, 2299-2301.
-
(1996)
Cancer Res.
, vol.56
, pp. 2299-2301
-
-
Siemeister, G.1
Weindel, K.2
Mohrs, K.3
Barleon, B.4
Martiny-Baron, G.5
Marme, D.6
-
71
-
-
0028929991
-
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
-
Wizigmann-Voos, S., Breier, G., Risau, W. and Plate, K.H. (1995) Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res., 55, 1358-1364.
-
(1995)
Cancer Res.
, vol.55
, pp. 1358-1364
-
-
Wizigmann-Voos, S.1
Breier, G.2
Risau, W.3
Plate, K.H.4
-
72
-
-
0028670833
-
3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
-
3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79, 1157-1164.
-
(1994)
Cell
, vol.79
, pp. 1157-1164
-
-
Brooks, P.C.1
Montgomery, A.M.P.2
Rosenfeld, M.3
Reisfeld, R.A.4
Hu, T.5
Klier, G.6
Cheresh, D.A.7
-
74
-
-
0028851365
-
Approaches to studying cell adhesion molecules in angiogenesis
-
Bischoff, J. (1995) Approaches to studying cell adhesion molecules in angiogenesis. Trends Cell Biol, 5, 69-73.
-
(1995)
Trends Cell Biol
, vol.5
, pp. 69-73
-
-
Bischoff, J.1
-
75
-
-
0029611184
-
Up-regulation of endoglin on vascular endothelial cells in human solid tumors: Implications for diagnosis and therapy
-
Burrows, F.J., Derbyshire, E.J., Tazzari, P.L., Amlot, P. Gazdar, A.F., King, S.W., Letarte, M., Vitetta, E.S. and Thorpe, P.E. (1995) Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. Clin. Cancer Res., 1, 1623-1634.
-
(1995)
Clin. Cancer Res.
, vol.1
, pp. 1623-1634
-
-
Burrows, F.J.1
Derbyshire, E.J.2
Tazzari, P.L.3
Amlot, P.4
Gazdar, A.F.5
King, S.W.6
Letarte, M.7
Vitetta, E.S.8
Thorpe, P.E.9
-
76
-
-
0033168844
-
Five different Anti-Prostate-Specific Membrane Antigen (PSMA) antibodies confirm PSMA expression in tumor-associaled neovasculalure
-
Chang, S.S., Reuter, V.E., Heston, W.D., Bander, N.H., Grauer, L.S. and Gaudin, P.B. (1999) Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associaled neovasculalure. Cancer Res., 59, 3192-3198.
-
(1999)
Cancer Res.
, vol.59
, pp. 3192-3198
-
-
Chang, S.S.1
Reuter, V.E.2
Heston, W.D.3
Bander, N.H.4
Grauer, L.S.5
Gaudin, P.B.6
-
77
-
-
0028116528
-
The fibronectin isoform containing the ED-B oncofetal domain: A marker of angiogenesis
-
Castellani, P. Viale, G., Dorcaratto, A., Nicolo, G., Kaczmarek, J., Querze, G. and Zardi, L. (1994) The fibronectin isoform containing the ED-B oncofetal domain: a marker of angiogenesis. Int. J. Cancer, 59, 612-618. [Published erratum appears in Int. J. Cancer (1995), 62, 118.]
-
(1994)
Int. J. Cancer
, vol.59
, pp. 612-618
-
-
Castellani, P.1
Viale, G.2
Dorcaratto, A.3
Nicolo, G.4
Kaczmarek, J.5
Querze, G.6
Zardi, L.7
-
78
-
-
0030700632
-
Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform
-
Neri, D., Camemolla, B., Nissim, A., Leprini, A., Querze, G., Balza, E., Pini, A., Tarli, L., Halin, C., Neri, P., Zardi, L. and Winter, G. (1997) Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform. Nature Biotechnol., 15, 1271-1275.
-
(1997)
Nature Biotechnol.
, vol.15
, pp. 1271-1275
-
-
Neri, D.1
Camemolla, B.2
Nissim, A.3
Leprini, A.4
Querze, G.5
Balza, E.6
Pini, A.7
Tarli, L.8
Halin, C.9
Neri, P.10
Zardi, L.11
Winter, G.12
-
79
-
-
0033168617
-
A high-affinity human antibody that targets tumoral blood vessels
-
Tarli, L., Balza, E., Viti, F., Borsi, L., Castellani, P., Berndorff, D., Dinkelborg, L., Neri, D. and Zardi, L. (1999) A high-affinity human antibody that targets tumoral blood vessels. Blood, 94, 192-198.
-
(1999)
Blood
, vol.94
, pp. 192-198
-
-
Tarli, L.1
Balza, E.2
Viti, F.3
Borsi, L.4
Castellani, P.5
Berndorff, D.6
Dinkelborg, L.7
Neri, D.8
Zardi, L.9
-
80
-
-
0032582686
-
Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
-
Hiraoka, N., Allen, E., Apel, I.J., Gyetko, M.R. and Weiss, S.J. (1998) Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell, 95, 365-377.
-
(1998)
Cell
, vol.95
, pp. 365-377
-
-
Hiraoka, N.1
Allen, E.2
Apel, I.J.3
Gyetko, M.R.4
Weiss, S.J.5
-
81
-
-
0019133502
-
Angiogenesis in vitro
-
Folkman, J. and Haudenschild, C. (1980) Angiogenesis in vitro. Nature, 288, 551-555.
-
(1980)
Nature
, vol.288
, pp. 551-555
-
-
Folkman, J.1
Haudenschild, C.2
-
82
-
-
0030669894
-
Quantitative angiogenesis assays: Progress and problems
-
Jain, R.K., Schlenger, K., Hockel, M. and Yuan, F. (1997) Quantitative angiogenesis assays: progress and problems. Nature Med., 3, 1203-1208.
-
(1997)
Nature Med.
, vol.3
, pp. 1203-1208
-
-
Jain, R.K.1
Schlenger, K.2
Hockel, M.3
Yuan, F.4
-
83
-
-
0026495179
-
Methods in laboratory investigation: A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin and fibroblast growth factor
-
Passaniti, A., Taylor, R.M., Pili, R., Guo, Y., Long, P.V., Haney, J.A., Pauly, R.R., Grant, D.S. and Martin, G.R. (1992) Methods in laboratory investigation: a simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin and fibroblast growth factor. Lab. Invest., 67, 519.
-
(1992)
Lab. Invest.
, vol.67
, pp. 519
-
-
Passaniti, A.1
Taylor, R.M.2
Pili, R.3
Guo, Y.4
Long, P.V.5
Haney, J.A.6
Pauly, R.R.7
Grant, D.S.8
Martin, G.R.9
-
84
-
-
0033565247
-
Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity
-
Parish, C.R., Freeman, C., Brown, K.J., Francis, D.J. and Cowden, W.B. (1999) Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity. Cancer Res., 59, 3433-3441.
-
(1999)
Cancer Res.
, vol.59
, pp. 3433-3441
-
-
Parish, C.R.1
Freeman, C.2
Brown, K.J.3
Francis, D.J.4
Cowden, W.B.5
-
85
-
-
0026083903
-
Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma
-
Weidner, N., Semple, J.P., Welch, W.R. and Folkman, J. (1991) Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N. Engl. J. Med., 324, 1-8.
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 1-8
-
-
Weidner, N.1
Semple, J.P.2
Welch, W.R.3
Folkman, J.4
-
86
-
-
0029328266
-
Intramural microvessel density as a prognostic factor in cancer
-
Weidner, N. (1995) Intramural microvessel density as a prognostic factor in cancer. Am. J. Pathol, 147, 9-19.
-
(1995)
Am. J. Pathol
, vol.147
, pp. 9-19
-
-
Weidner, N.1
-
87
-
-
0028910567
-
Consequences of angiogenesis for tumor progression, metastasis and cancer therapy
-
Rak, J., St Croix, B. and Kerbel, R.S. (1995) Consequences of angiogenesis for tumor progression, metastasis and cancer therapy. Anticancer Drugs, 6, 3-18.
-
(1995)
Anticancer Drugs
, vol.6
, pp. 3-18
-
-
Rak, J.1
St Croix, B.2
Kerbel, R.S.3
-
88
-
-
0028214655
-
Progressive loss of sensitivity to endothelium-derived growth inhibitors expressed by human melanoma cells during disease progression
-
Rak, J.W., Hegmann, E.J., Lu, C. and Kerbel, R.S. (1994) Progressive loss of sensitivity to endothelium-derived growth inhibitors expressed by human melanoma cells during disease progression. J. Cell. Physiol., 159, 245-255.
-
(1994)
J. Cell. Physiol.
, vol.159
, pp. 245-255
-
-
Rak, J.W.1
Hegmann, E.J.2
Lu, C.3
Kerbel, R.S.4
-
89
-
-
0025717523
-
Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
-
Kerbel, R.S. (1991) Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. BioEssays, 13, 31-36.
-
(1991)
Bioessays
, vol.13
, pp. 31-36
-
-
Kerbel, R.S.1
-
90
-
-
0002354952
-
Acquired drug resistance driven by tumor cell genetic-instability: Circumvention by direct acting anti-angiogenic vascular targeting agents
-
Ehrlich, M. (ed.) Biotechniques Books, Natick, MA
-
Kerbel, R.S. (1999) Acquired drug resistance driven by tumor cell genetic-instability: circumvention by direct acting anti-angiogenic vascular targeting agents. In Ehrlich, M. (ed.) DNA Alterations in Cancer: Genetic and Epigenetic Changes. Biotechniques Books, Natick, MA, pp. 489-501.
-
(1999)
DNA Alterations in Cancer: Genetic and Epigenetic Changes
, pp. 489-501
-
-
Kerbel, R.S.1
-
91
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm, T., Folkman, J., Browder, T. and O'Reilly, M.S. (1997) Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature, 390, 404-407.
-
(1997)
Nature
, vol.390
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
O'Reilly, M.S.4
-
92
-
-
0001938378
-
A cautious awe greets drugs that eradicate tumors in mice
-
May 3, 1998.
-
Kolata, G. (1998) A cautious awe greets drugs that eradicate tumors in mice. The New York Times, May 3, 1998.
-
(1998)
The New York Times
-
-
Kolata, G.1
-
93
-
-
0032524068
-
The power of the front page of the new york times
-
Marshall, E. (1998) The power of the front page of The New York Times. Science, 280, 996-997.
-
(1998)
Science
, vol.280
, pp. 996-997
-
-
Marshall, E.1
-
94
-
-
0031728267
-
Multidrug resistance: Clinical relevance in solid tumours and strategies for circumvention
-
Kaye, S.B. (1998) Multidrug resistance: clinical relevance in solid tumours and strategies for circumvention. Curr. Opin. Oncol., 10 (Suppl. 1), S15-S19.
-
(1998)
Curr. Opin. Oncol.
, vol.10
, Issue.SUPPL. 1
-
-
Kaye, S.B.1
-
95
-
-
0003009070
-
Multidrug resistance is not an important factor in therapeutic outcome in human malignancies
-
Houghton, P.J. and Kaye, S.B. (1994) Multidrug resistance is not an important factor in therapeutic outcome in human malignancies. J. NIH Res., 6, 55.
-
(1994)
J. NIH Res.
, vol.6
, pp. 55
-
-
Houghton, P.J.1
Kaye, S.B.2
-
96
-
-
0010992283
-
Conventional cancer therapy: Promise broken or promise delayed?
-
Tannock, I.F. (1998) Conventional cancer therapy: promise broken or promise delayed? Lancet, 351 (Suppl. 2), S119-S116.
-
(1998)
Lancet
, vol.351
, Issue.SUPPL. 2
-
-
Tannock, I.F.1
-
97
-
-
0031785722
-
Chemotherapy targeted to tumor vasculature
-
Arap, W., Pasqualini, R. and Ruoslahti, E. (1998) Chemotherapy targeted to tumor vasculature. Curr. Opin. Oncol., 10, 560-565.
-
(1998)
Curr. Opin. Oncol.
, vol.10
, pp. 560-565
-
-
Arap, W.1
Pasqualini, R.2
Ruoslahti, E.3
-
98
-
-
84887186004
-
Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
-
in press
-
Browder, T., Butterfield, C.E., Kraling, B.M., Marshall, B., O'Reilly, M.S. and Folkman, J. (1999) Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res., in press.
-
(1999)
Cancer Res.
-
-
Browder, T.1
Butterfield, C.E.2
Kraling, B.M.3
Marshall, B.4
O'Reilly, M.S.5
Folkman, J.6
-
99
-
-
0034087691
-
Chronically sustained regressions of human tumor xenografts in the absence of overt toxicity by continuous low-dose vinblastine and anti-VEGF Receptor-2 antibody therapy
-
in press
-
Klement, G., Baruchel, S., Rak, J., Man, S., Clark, K., Hicklin, D.J., Bohlen, P. and Kerbel, R.S. (2000) Chronically sustained regressions of human tumor xenografts in the absence of overt toxicity by continuous low-dose vinblastine and anti-VEGF Receptor-2 antibody therapy. J. Clin. Invest., in press.
-
(2000)
J. Clin. Invest.
-
-
Klement, G.1
Baruchel, S.2
Rak, J.3
Man, S.4
Clark, K.5
Hicklin, D.J.6
Bohlen, P.7
Kerbel, R.S.8
-
100
-
-
0032544686
-
Tumor induction of VEGF promoter activity in stromal cells
-
Fukumura, D., Xavier, R., Sugiura, T., Chen, Y., Park, E.C., Lu, N., Selig, M., Nielsen, G., Taksir, T., Jain, R.K. and Seed, B. (1998) Tumor induction of VEGF promoter activity in stromal cells. Cell, 94, 715-725.
-
(1998)
Cell
, vol.94
, pp. 715-725
-
-
Fukumura, D.1
Xavier, R.2
Sugiura, T.3
Chen, Y.4
Park, E.C.5
Lu, N.6
Selig, M.7
Nielsen, G.8
Taksir, T.9
Jain, R.K.10
Seed, B.11
-
101
-
-
0024505574
-
Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies
-
Jain, R.K. (1989) Delivery of novel therapeutic agents in tumors: physiological barriers and strategies. J. Natl Cancer Inst., 81, 570-576.
-
(1989)
J. Natl Cancer Inst.
, vol.81
, pp. 570-576
-
-
Jain, R.K.1
-
102
-
-
0031059348
-
Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia
-
Perez-Atayde, A.R., Sallan, S.E., Tedrow, U., Connors, S., Allred, E. and Folkman, J. (1997) Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. Am. J. Pathol., 150, 815-820.
-
(1997)
Am. J. Pathol.
, vol.150
, pp. 815-820
-
-
Perez-Atayde, A.R.1
Sallan, S.E.2
Tedrow, U.3
Connors, S.4
Allred, E.5
Folkman, J.6
-
103
-
-
0033043613
-
Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma
-
Rajkumar, S.V., Fonseca, R., Witzig, T.E., Gertz, M.A. and Greipp, P.R. (1999) Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma. Leukemia, 13, 469-472.
-
(1999)
Leukemia
, vol.13
, pp. 469-472
-
-
Rajkumar, S.V.1
Fonseca, R.2
Witzig, T.E.3
Gertz, M.A.4
Greipp, P.R.5
-
104
-
-
0033002831
-
Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
-
Vacca, A., Ribatti, D., Ruco, L., Giacchetta, F., Nico, B., Quondamatteo, F., Ria, R., Iurlaro, M. and Dammacco, F. (1999) Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas. Br. J. Cancer, 79, 965-970.
-
(1999)
Br. J. Cancer
, vol.79
, pp. 965-970
-
-
Vacca, A.1
Ribatti, D.2
Ruco, L.3
Giacchetta, F.4
Nico, B.5
Quondamatteo, F.6
Ria, R.7
Iurlaro, M.8
Dammacco, F.9
-
105
-
-
0028216334
-
Thalidomide is an inhibitor of angiogenesis
-
D'Amato, R.J., Loughnan, M.S., Flynn, E. and Folkman, J. (1994) Thalidomide is an inhibitor of angiogenesis. Proc. Natl Acad. Sci. USA, 91, 4082-4085.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 4082-4085
-
-
D'Amato, R.J.1
Loughnan, M.S.2
Flynn, E.3
Folkman, J.4
-
106
-
-
0032748385
-
Antitumor activity of thalidomide in refractory multiple myeloma
-
Singhal, S., Mehta, J., Desikan, R., Ayers, D., Robertson, P., Eddelmon, P., Munshi, N., Anassie, E., Wilson, C., Dhodapkar, M., Zeldis, J. and Barlogie, B. (1999) Antitumor activity of thalidomide in refractory multiple myeloma. N. Engl. J. Meet., 341, 1565-1571.
-
(1999)
N. Engl. J. Meet.
, vol.341
, pp. 1565-1571
-
-
Singhal, S.1
Mehta, J.2
Desikan, R.3
Ayers, D.4
Robertson, P.5
Eddelmon, P.6
Munshi, N.7
Anassie, E.8
Wilson, C.9
Dhodapkar, M.10
Zeldis, J.11
Barlogie, B.12
-
107
-
-
0029802685
-
The microtubule-affecting drug paclitaxel has antiangiogenic activity
-
Belotti, D., Vergani, V., Drudis, T., Borsotti, P., Pitelli, M.R., Viale, G., Giavazzi, R. and Taraboletti, G. (1996) The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin. Cancer Res., 2, 1843-1849.
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 1843-1849
-
-
Belotti, D.1
Vergani, V.2
Drudis, T.3
Borsotti, P.4
Pitelli, M.R.5
Viale, G.6
Giavazzi, R.7
Taraboletti, G.8
-
108
-
-
0028896964
-
Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (D,L-lactic acid)
-
Burt, H.M., Jackson, J.K., Bains, S.K., Liggins, R.T., Oktaba, A.M.C., Arsenault, A.L. and Hunter, W.L. (1995) Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (D,L-lactic acid). Cancer Letts, 88, 73-79.
-
(1995)
Cancer Letts
, vol.88
, pp. 73-79
-
-
Burt, H.M.1
Jackson, J.K.2
Bains, S.K.3
Liggins, R.T.4
Oktaba, A.M.C.5
Arsenault, A.L.6
Hunter, W.L.7
-
109
-
-
0029902597
-
Antivascular approaches to solid tumour therapy: Evaluation of tubulin binding agents
-
Chaplin, D.J., Pettit, G.R., Parkins, C.S. and Hill, S.A. (1996) Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents. Br. J. Cancer, 74 (Suppl. 27). S86-S88.
-
(1996)
Br. J. Cancer
, vol.74
, Issue.SUPPL. 27
-
-
Chaplin, D.J.1
Pettit, G.R.2
Parkins, C.S.3
Hill, S.A.4
-
110
-
-
0032956544
-
Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan and CPT-11 studied in the mouse cornea model
-
O'Leary, J.J., Shapiro, R.L., Ren, C.J., Chuang, N., Cohen, H.W. and Potmesil, M. (1999) Antiangiogenic effects of camptothecin analogues 9-amino-20(S)-camptothecin, topotecan and CPT-11 studied in the mouse cornea model. Clin. Cancer Res., 5, 181-187.
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 181-187
-
-
O'Leary, J.J.1
Shapiro, R.L.2
Ren, C.J.3
Chuang, N.4
Cohen, H.W.5
Potmesil, M.6
-
111
-
-
0033563116
-
Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process
-
Presta, M., Rusnati, M., Belleri, M., Morbidelli, L., Ziche, M. and Ribatti, D. (1999) Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process. Cancer Res., 59, 2417-2424.
-
(1999)
Cancer Res.
, vol.59
, pp. 2417-2424
-
-
Presta, M.1
Rusnati, M.2
Belleri, M.3
Morbidelli, L.4
Ziche, M.5
Ribatti, D.6
-
112
-
-
18244419396
-
Combined effects of angiostatin and ionizing radiation in antitumour therapy
-
Mauceri, H.J., Hanna, N.N., Beckett, M.A., Gorski, D.H., Staba, M.J., Stellato, K.A., Bigelow, K., Heimann, R., Gately, S., Dhanabal, M., Soff, G.A., Sukhatme, V.P., Kufe, D.W. and Weichselbaum, R.R. (1998) Combined effects of angiostatin and ionizing radiation in antitumour therapy. Nature, 394, 287-291.
-
(1998)
Nature
, vol.394
, pp. 287-291
-
-
Mauceri, H.J.1
Hanna, N.N.2
Beckett, M.A.3
Gorski, D.H.4
Staba, M.J.5
Stellato, K.A.6
Bigelow, K.7
Heimann, R.8
Gately, S.9
Dhanabal, M.10
Soff, G.A.11
Sukhatme, V.P.12
Kufe, D.W.13
Weichselbaum, R.R.14
-
113
-
-
0032169018
-
Endothelial cell death, angiogenesis and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
-
Jain, R.K., Safabakhsh, N., Sckell, A., Chen, Y., Jiang, P., Benjamin, L., Yuan, F. and Keshet, E. (1998) Endothelial cell death, angiogenesis and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proc. Natl Acad, Sci. USA, 95, 10820-10825.
-
(1998)
Proc. Natl Acad, Sci. USA
, vol.95
, pp. 10820-10825
-
-
Jain, R.K.1
Safabakhsh, N.2
Sckell, A.3
Chen, Y.4
Jiang, P.5
Benjamin, L.6
Yuan, F.7
Keshet, E.8
-
114
-
-
0031417489
-
Androgens regulate vascular endolhlelial growth factor content in normal and malignant prostatic tissue
-
Joseph, I.B.J.K., Nelson, J., Denmeade, S.R. and Isaacs, J.T. (1999) Androgens regulate vascular endolhlelial growth factor content in normal and malignant prostatic tissue. Clin. Cancer Res., 3, 2507-2511.
-
(1999)
Clin. Cancer Res.
, vol.3
, pp. 2507-2511
-
-
Joseph, I.B.J.K.1
Nelson, J.2
Denmeade, S.R.3
Isaacs, J.T.4
-
115
-
-
0027563591
-
Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy
-
Denekamp, J. (1993) Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy. Br. J. Radiol., 66, 181-196.
-
(1993)
Br. J. Radiol.
, vol.66
, pp. 181-196
-
-
Denekamp, J.1
-
116
-
-
0032963472
-
Vascular Endothelial Growth Factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression
-
Nor, J.E., Christensen, J., Mooney, D.J. and Polverini, P.J. (1999) Vascular endothelial growth factor (VEGF)-mediated angiogenesis is associated with enhanced endothelial cell survival and induction of Bcl-2 expression. Am. J. Pathol., 154, 375-381.
-
(1999)
Am. J. Pathol.
, vol.154
, pp. 375-381
-
-
Nor, J.E.1
Christensen, J.2
Mooney, D.J.3
Polverini, P.J.4
-
117
-
-
0032557564
-
Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
-
Gerber, H.P. Dixit, V. and Ferrara, N. (1998) Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J. Biol. Chem., 273, 13313-13316.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13313-13316
-
-
Gerber, H.P.1
Dixit, V.2
Ferrara, N.3
-
118
-
-
0032515047
-
Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/akt signal transduction pathway. Requirement for Flk-1/KDR activation
-
Gerber, H.P. McMurtrey, A., Kowalski, J., Yan, M., Keyt, B.A., Dixit, V. and Ferrara, N. (1998) Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem., 273, 30336-30343.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30336-30343
-
-
Gerber, H.P.1
McMurtrey, A.2
Kowalski, J.3
Yan, M.4
Keyt, B.A.5
Dixit, V.6
Ferrara, N.7
-
119
-
-
0033597718
-
Targeted deficiency orcytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
-
Carmeliet, P., Lampugnani, M.G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oostuyse, B., Dewerchin, M., Zanetti, A., Angellilo, A., Mattot, V., Nuyens, D., Lutgens, E., Clotman, F., duRuiter, M.C., Gittenberger-de, G.A., Poelmann, R., Lupu, F., Herbert, J.M., Collen, D. and Dejana, E. (1999) Targeted deficiency orcytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell, 98, 147-157.
-
(1999)
Cell
, vol.98
, pp. 147-157
-
-
Carmeliet, P.1
Lampugnani, M.G.2
Moons, L.3
Breviario, F.4
Compernolle, V.5
Bono, F.6
Balconi, G.7
Spagnuolo, R.8
Oostuyse, B.9
Dewerchin, M.10
Zanetti, A.11
Angellilo, A.12
Mattot, V.13
Nuyens, D.14
Lutgens, E.15
Clotman, F.16
Duruiter, M.C.17
Gittenberger-De, G.A.18
Poelmann, R.19
Lupu, F.20
Herbert, J.M.21
Collen, D.22
Dejana, E.23
more..
-
120
-
-
0028834638
-
Both v-Ha-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells
-
Grugel, S., Finkenzeller, G., Weindel, K., Barleon, B. and Marme, D. (1995) Both v-Ha-ras and v-raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells. J. Biol. Chem., 270, 25915-25919.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 25915-25919
-
-
Grugel, S.1
Finkenzeller, G.2
Weindel, K.3
Barleon, B.4
Marme, D.5
-
121
-
-
0028901110
-
Interleukin 12: Newest member of the antiangiogenesis club
-
Kerbel, R.S. and Hawley, R.G. (1995) Interleukin 12: newest member of the antiangiogenesis club. J. Natl Cancer Inst., 87, 557-559.
-
(1995)
J. Natl Cancer Inst.
, vol.87
, pp. 557-559
-
-
Kerbel, R.S.1
Hawley, R.G.2
-
122
-
-
0001860784
-
Potentiation of cytotoxic cancer therapies by antiangiogenic agents
-
Teicher, B.A. (ed.) Humana Press Inc., Totowa, NJ.
-
Teicher, B.A. (1999) Potentiation of cytotoxic cancer therapies by antiangiogenic agents. In Teicher, B.A. (ed.) Antiangiogenic Agents in Cancer Therapy. Humana Press Inc., Totowa, NJ. pp. 277-316.
-
(1999)
Antiangiogenic Agents in Cancer Therapy
, pp. 277-316
-
-
Teicher, B.A.1
-
123
-
-
0029120875
-
Antiangiogenic trealment (TNP-4670/minocycline) increases tissue levels of anticancer drugs in mice hearing Lewis lung carcinoma
-
Teicher, B.A., Dupuis, N.P., Robinson, M.F., Emi, Y. and Goff, D.A. (1995) Antiangiogenic trealment (TNP-4670/minocycline) increases tissue levels of anticancer drugs in mice hearing Lewis lung carcinoma. Oncog. Res., 7, 237-243.
-
(1995)
Oncog. Res.
, vol.7
, pp. 237-243
-
-
Teicher, B.A.1
Dupuis, N.P.2
Robinson, M.F.3
Emi, Y.4
Goff, D.A.5
-
124
-
-
0029816983
-
Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravilal videomicroscopy
-
Borgstrom, P., Hillan, K.J., Sriramarao, P. and Ferrara, N. (1996) Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravilal videomicroscopy. Cancer Res., 56, 4032-4039.
-
(1996)
Cancer Res.
, vol.56
, pp. 4032-4039
-
-
Borgstrom, P.1
Hillan, K.J.2
Sriramarao, P.3
Ferrara, N.4
-
125
-
-
0032532391
-
Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4
-
Iyer, S., Chaplin, D.J., Rosenthal, D.S., Boulares, A.H., Li, L.Y. and Smulson, M.E. (1998) Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4. Cancer Res., 58, 4510-4514.
-
(1998)
Cancer Res.
, vol.58
, pp. 4510-4514
-
-
Iyer, S.1
Chaplin, D.J.2
Rosenthal, D.S.3
Boulares, A.H.4
Li, L.Y.5
Smulson, M.E.6
-
126
-
-
0033043239
-
Regression of metastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470
-
Offodile, R., Walton, T., Lee, M., Stiles, A. and Nguyen, M. (1999) Regression of metastatic breast cancer in a patient treated with the anti-angiogenic drug TNP-470. Tumori, 85, 51-53.
-
(1999)
Tumori
, vol.85
, pp. 51-53
-
-
Offodile, R.1
Walton, T.2
Lee, M.3
Stiles, A.4
Nguyen, M.5
-
127
-
-
0033523233
-
Anticancer agents targeting signaling molecules and cancer cell environment: Challenges for drug development
-
Gelmon, K., Eisenhauer, E., Harris, A.L., Ratain, M.J. and Workman, P. (1999) Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development. J. Natl Cancer Inst., 91, 1281-1287.
-
(1999)
J. Natl Cancer Inst.
, vol.91
, pp. 1281-1287
-
-
Gelmon, K.1
Eisenhauer, E.2
Harris, A.L.3
Ratain, M.J.4
Workman, P.5
-
128
-
-
0032473934
-
Complete remission of metastatic cervical cancer with the angiogenesis inhibitor TNP-470
-
Kudelka, A.P., Verschraegen, C.F. and Loyer, E. (1998) Complete remission of metastatic cervical cancer with the angiogenesis inhibitor TNP-470. N. Engl. J. Med., 338, 991-992.
-
(1998)
N. Engl. J. Med.
, vol.338
, pp. 991-992
-
-
Kudelka, A.P.1
Verschraegen, C.F.2
Loyer, E.3
-
129
-
-
0000182119
-
Endpoints for determination of efficacy of antiangiogenicagents in clinical trials
-
Teicher, B.A. (ed.)
-
Gradishar, W.J. (1999) Endpoints for determination of efficacy of antiangiogenicagents in clinical trials. In Teicher, B.A. (ed.) Antiangiogenic Agents in Cancer Therapy, Humana Press Inc., Totowa, NJ, pp. 341-353.
-
(1999)
Antiangiogenic Agents in Cancer Therapy, Humana Press Inc., Totowa, Nj
, pp. 341-353
-
-
Gradishar, W.J.1
-
130
-
-
0033041884
-
Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon α-2a
-
Kaban, L.B., Mulliken, J.B., Ezekowitz, R.A., Phil, D., Ebb, D., Smith, P.S. and Folkman, J. (1999) Antiangiogenic therapy of a recurrent giant cell tumor of the mandible with interferon α-2a. Pediatrics, 103, 1145-1149.
-
(1999)
Pediatrics
, vol.103
, pp. 1145-1149
-
-
Kaban, L.B.1
Mulliken, J.B.2
Ezekowitz, R.A.3
Phil, D.4
Ebb, D.5
Smith, P.S.6
Folkman, J.7
-
131
-
-
0031903646
-
Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment
-
Pegram, M.D., Lipton, A., Hayes, D.F., Weber, B.L., Baselga, J.M., Tripathy, D., Baly, D., Baughman, S.A., Twaddell, T., Glaspy, J.A. and Slamon, D.J. (1998) Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. J. Clin. Oncol., 16, 2659-2671.
-
(1998)
J. Clin. Oncol.
, vol.16
, pp. 2659-2671
-
-
Pegram, M.D.1
Lipton, A.2
Hayes, D.F.3
Weber, B.L.4
Baselga, J.M.5
Tripathy, D.6
Baly, D.7
Baughman, S.A.8
Twaddell, T.9
Glaspy, J.A.10
Slamon, D.J.11
-
132
-
-
0025793698
-
Inhibition of growth of colon 38 adenocarcinnma by vinblastine and colchicine: Evidence for a vascular mechanism
-
Baguley, B.C., Holdaway, K.M., Thomsen, L.L., Zhuang, L. and Zwi, L.J. (1991) Inhibition of growth of colon 38 adenocarcinnma by vinblastine and colchicine: evidence for a vascular mechanism. Eur.J. Cancer, 27, 482-487.
-
(1991)
Eur.j. Cancer
, vol.27
, pp. 482-487
-
-
Baguley, B.C.1
Holdaway, K.M.2
Thomsen, L.L.3
Zhuang, L.4
Zwi, L.J.5
-
133
-
-
0030951899
-
Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
-
Dark, G.G., Hill, S.A., Prise, V.E., Tozer, G.M., Pettit, G.R. and Chaplin, D.J. (1997) Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res., 57, 1829-1834.
-
(1997)
Cancer Res.
, vol.57
, pp. 1829-1834
-
-
Dark, G.G.1
Hill, S.A.2
Prise, V.E.3
Tozer, G.M.4
Pettit, G.R.5
Chaplin, D.J.6
-
134
-
-
0031026481
-
Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
-
Huang, X., Molema, G., King, S., Watkins, L., Edgington, T.S. and Thorpe, P.E. (1997) Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science, 275, 547-550.
-
(1997)
Science
, vol.275
, pp. 547-550
-
-
Huang, X.1
Molema, G.2
King, S.3
Watkins, L.4
Edgington, T.S.5
Thorpe, P.E.6
-
135
-
-
0031946469
-
Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor
-
Pham, C.D., Roberts, T.P., van Bruggen, N., Melnyk, O., Mann, J., Ferrara, N., Cohen, R.L. and Brasch, R.C. (1998) Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. Cancer Invest., 16, 225-230.
-
(1998)
Cancer Invest.
, vol.16
, pp. 225-230
-
-
Pham, C.D.1
Roberts, T.P.2
Van Bruggen, N.3
Melnyk, O.4
Mann, J.5
Ferrara, N.6
Cohen, R.L.7
Brasch, R.C.8
-
136
-
-
0027952724
-
Incremental angiogenesis assessed by color doppler ultrasound in the tumorigenesis of ovarian neoplasms
-
Wu, C.C., Lee, C.N., Chen, T.M., Shyu, M.K., Hsieh, C.Y., Chen, H.Y. and Hsieh, F.J. (1994) Incremental angiogenesis assessed by color Doppler ultrasound in the tumorigenesis of ovarian neoplasms. Cancer, 73, 1251-1256.
-
(1994)
Cancer
, vol.73
, pp. 1251-1256
-
-
Wu, C.C.1
Lee, C.N.2
Chen, T.M.3
Shyu, M.K.4
Hsieh, C.Y.5
Chen, H.Y.6
Hsieh, F.J.7
-
137
-
-
0028584431
-
Contrast-enhanced magnetic-resonance imaging estimation of altered capillary permeability in experimental mammary carcinomas after X-irradiation
-
Cohen, F.M., Kuwatsuru, R., Shames, D.M., Neuder, M., Mann, J.S., Vexler, V., Rosenau, W. and Brasch, R.C. (1994) Contrast-enhanced magnetic-resonance imaging estimation of altered capillary permeability in experimental mammary carcinomas after X-irradiation. Invest. Radiol., 29, 970-977.
-
(1994)
Invest. Radiol.
, vol.29
, pp. 970-977
-
-
Cohen, F.M.1
Kuwatsuru, R.2
Shames, D.M.3
Neuder, M.4
Mann, J.S.5
Vexler, V.6
Rosenau, W.7
Brasch, R.C.8
-
138
-
-
0031946469
-
Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor
-
Pham, C.D., Roberts, T.P., van Bruggen, N., Melnyk, O., Mann, J., Ferrara, N., Cohen, R.L. and Brasch, R.C. (1998) Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor. Cancer Invest., 16, 225-230.
-
(1998)
Cancer Invest.
, vol.16
, pp. 225-230
-
-
Pham, C.D.1
Roberts, T.P.2
Van Bruggen, N.3
Melnyk, O.4
Mann, J.5
Ferrara, N.6
Cohen, R.L.7
Brasch, R.C.8
-
139
-
-
0028593961
-
Correlation between contrast enhancement in dynamic magnetic resonance imaging of the breast and tumor angiogenesis
-
Frouge, C., Guinebretiere, J.M., Contesso, G., Di Paola, R. and Blery, M. (1994) Correlation between contrast enhancement in dynamic magnetic resonance imaging of the breast and tumor angiogenesis. Invest. Radiol., 29, 1043-1049.
-
(1994)
Invest. Radiol.
, vol.29
, pp. 1043-1049
-
-
Frouge, C.1
Guinebretiere, J.M.2
Contesso, G.3
Di Paola, R.4
Blery, M.5
-
140
-
-
0031917719
-
Spastic diplegia as a complication of interferon α-2a treatment of hemangiomas of infancy
-
Barlow, C.F., Priebe, C.J., Mulliken, J.B., Barnes, P.D., Mac, D.D., Folkman, J. and Ezekowitz, R.A. (1998) Spastic diplegia as a complication of interferon α-2a treatment of hemangiomas of infancy. J. Pediatr, 132, 527-530.
-
(1998)
J. Pediatr
, vol.132
, pp. 527-530
-
-
Barlow, C.F.1
Priebe, C.J.2
Mulliken, J.B.3
Barnes, P.D.4
Mac, D.D.5
Folkman, J.6
Ezekowitz, R.A.7
-
141
-
-
0032931234
-
VEGF is required for growth and survival in neonatal mice
-
Gerber, H.P. Hillan, K.J., Ryan, A.M., Kowalski, J., Keller, G.A., Rangell, L., Wright, B.D., Radtke, F., Aguet, M. and Ferrara, N. (1999) VEGF is required for growth and survival in neonatal mice. Development, 126, 1149-1159.
-
(1999)
Development
, vol.126
, pp. 1149-1159
-
-
Gerber, H.P.1
Hillan, K.J.2
Ryan, A.M.3
Kowalski, J.4
Keller, G.A.5
Rangell, L.6
Wright, B.D.7
Radtke, F.8
Aguet, M.9
Ferrara, N.10
-
142
-
-
0022336939
-
Expression of organ-specific antigens on capillary endothelial cells
-
Auerbach, R., Alby, L., Morrissey, L.W., Tu, M. and Joseph, J. (1985) Expression of organ-specific antigens on capillary endothelial cells. Microvas. Res., 29, 401-411.
-
(1985)
Microvas. Res.
, vol.29
, pp. 401-411
-
-
Auerbach, R.1
Alby, L.2
Morrissey, L.W.3
Tu, M.4
Joseph, J.5
-
143
-
-
0032818846
-
Angiogenic zip code
-
Folkman, J. (1999) Angiogenic zip code. Nature Biotechnol., 17, 749.
-
(1999)
Nature Biotechnol.
, vol.17
, pp. 749
-
-
Folkman, J.1
-
144
-
-
0025870807
-
Generation of monoclonal antibodies directed against organ-specific endothelial cell surface determinants
-
Zhu, D.Z. and Pauli, B.U. (1991) Generation of monoclonal antibodies directed against organ-specific endothelial cell surface determinants. J. Histochem. Cytochem., 39, 1137-1142.
-
(1991)
J. Histochem. Cytochem.
, vol.39
, pp. 1137-1142
-
-
Zhu, D.Z.1
Pauli, B.U.2
-
145
-
-
0025819277
-
Differences in vascular response between primary and transplanted tumours
-
Field, S.B., Needham, S., Burney, I.A., Maxwell, R.J., Coggle, J.E. and Griffiths, J.R. (1991) Differences in vascular response between primary and transplanted tumours. Br. J. Cancer, 63, 723-726.
-
(1991)
Br. J. Cancer
, vol.63
, pp. 723-726
-
-
Field, S.B.1
Needham, S.2
Burney, I.A.3
Maxwell, R.J.4
Coggle, J.E.5
Griffiths, J.R.6
-
146
-
-
0031005838
-
Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression
-
Chishima, T., Miyagi, Y., Wang, X., Yamaoka, H., Shimada, H., Moossa, A.R. and Hoffman, R.M. (1997) Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res., 37, 2042-2047.
-
(1997)
Cancer Res.
, vol.37
, pp. 2042-2047
-
-
Chishima, T.1
Miyagi, Y.2
Wang, X.3
Yamaoka, H.4
Shimada, H.5
Moossa, A.R.6
Hoffman, R.M.7
-
147
-
-
0033206335
-
Noninvasive assessment of tumor cell proliferation in animal models
-
Edinger, M., Sweeney, T.J., Tucker, A.A., Olomu, A.B., Negrin, R.S. and Contag, C.H. (1999) Noninvasive assessment of tumor cell proliferation in animal models. Neoplasia, 1, 303-310.
-
(1999)
Neoplasia
, vol.1
, pp. 303-310
-
-
Edinger, M.1
Sweeney, T.J.2
Tucker, A.A.3
Olomu, A.B.4
Negrin, R.S.5
Contag, C.H.6
-
148
-
-
0032410157
-
Orthotopic models are necessary to predict therapy of transplantable tumors in mice
-
Killion, J.J., Radinsky, R. and Fidler, I.J. (1998) Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev., 17, 279-284.
-
(1998)
Cancer Metastasis Rev.
, vol.17
, pp. 279-284
-
-
Killion, J.J.1
Radinsky, R.2
Fidler, I.J.3
-
149
-
-
0000357044
-
Modulation of doxorubicin sensitivity and level of P-glycoprotein expression in human colon carcinomacells by ectopic and ortholopic environments in nude mice
-
Willmanns, C., Fan, D., O'Brian, C.A., Radinsky, R., Bucana, C.D., Tsan, R. and Fidler, I.J. (1993) Modulation of doxorubicin sensitivity and level of P-glycoprotein expression in human colon carcinomacells by ectopic and ortholopic environments in nude mice. Int. J. Cancer, 3, 412-122.
-
(1993)
Int. J. Cancer
, vol.3
, pp. 412-1122
-
-
Willmanns, C.1
Fan, D.2
O'Brian, C.A.3
Radinsky, R.4
Bucana, C.D.5
Tsan, R.6
Fidler, I.J.7
-
150
-
-
0026706954
-
Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil
-
Wilmanns, C., Fan, D., O'Brian, C.A., Bucana, C.D. and Fidler, I.J. (1992) Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int. J. Cancer, 52, 98-104.
-
(1992)
Int. J. Cancer
, vol.52
, pp. 98-104
-
-
Wilmanns, C.1
Fan, D.2
O'Brian, C.A.3
Bucana, C.D.4
Fidler, I.J.5
-
151
-
-
0030005902
-
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth
-
Parangi, S., O'Reilly, M.S., Christofori, G., Holmgren, L., Grosfeld, J., Folkman, J. and Hanahan, D. (1996) Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. Proc. Natl Acad. Sci. USA, 93, 2002-2007.
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 2002-2007
-
-
Parangi, S.1
O'Reilly, M.S.2
Christofori, G.3
Holmgren, L.4
Grosfeld, J.5
Folkman, J.6
Hanahan, D.7
-
152
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
Bergers, G., Javaherian, K., Lo, K.M., Folkman, J. and Hanahan, D. (1999) Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science, 284, 808-812.
-
(1999)
Science
, vol.284
, pp. 808-812
-
-
Bergers, G.1
Javaherian, K.2
Lo, K.M.3
Folkman, J.4
Hanahan, D.5
-
153
-
-
0027203149
-
Chemotherapy of mammary carcinomas arising in rax transgenic mice
-
Dexter, D.L., Diamond, M., Creveling, J. and Chen, S.F. (1993) Chemotherapy of mammary carcinomas arising in rax transgenic mice. Invest. New Draw, 11, 161-168.
-
(1993)
Invest. New Draw
, vol.11
, pp. 161-168
-
-
Dexter, D.L.1
Diamond, M.2
Creveling, J.3
Chen, S.F.4
-
154
-
-
0032582664
-
Dying like flies
-
Meier, P. and Evan, G. (1998) Dying like flies. Cell, 95, 295-298.
-
(1998)
Cell
, vol.95
, pp. 295-298
-
-
Meier, P.1
Evan, G.2
-
155
-
-
0028329172
-
Apoptosis. Its significance in cancer and cancer therapy
-
Kerr, J.F., Winterford, C.M. and Harmon, B.V. (1994) Apoptosis. Its significance in cancer and cancer therapy. Cancer, 73, 2013-2026.
-
(1994)
Cancer
, vol.73
, pp. 2013-2026
-
-
Kerr, J.F.1
Winterford, C.M.2
Harmon, B.V.3
-
156
-
-
0032542528
-
Gene therapy strategies for tumor antiangiogenesis
-
Kong, H.L. and Crystal, R.G. (1998) Gene therapy strategies for tumor antiangiogenesis. J. Natl Cancer Inst., 90, 273-286.
-
(1998)
J. Natl Cancer Inst.
, vol.90
, pp. 273-286
-
-
Kong, H.L.1
Crystal, R.G.2
-
157
-
-
0032892179
-
Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene
-
Blezinger, P., Wang, J., Gondo, M., Quezada, A., Mehrens, D., French, M., Singhal, A., Sullivan, S., Rolland, A., Ralston, R. and Min, W. (1999) Systemic inhibition of tumor growth and tumor metastases by intramuscular administration of the endostatin gene. Nature Bioiechnol., 17, 343-348.
-
(1999)
Nature Bioiechnol.
, vol.17
, pp. 343-348
-
-
Blezinger, P.1
Wang, J.2
Gondo, M.3
Quezada, A.4
Mehrens, D.5
French, M.6
Singhal, A.7
Sullivan, S.8
Rolland, A.9
Ralston, R.10
Min, W.11
-
158
-
-
0032562232
-
Induction of neoangiogenesis in ischemic myocardium by human growth factors: First clinical results of a new treatment of coronary heart disease
-
Schumacher, B., Pecher, P. von Specht, B.U. and Stegmann, T. (1998) Induction of neoangiogenesis in ischemic myocardium by human growth factors: first clinical results of a new treatment of coronary heart disease. Circulation, 97, 645-650.
-
(1998)
Circulation
, vol.97
, pp. 645-650
-
-
Schumacher, B.1
Pecher, P.2
Von Specht, B.U.A.3
Stegmann, T.4
-
159
-
-
15844420661
-
Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb
-
Isner, J.M., Pieczek, A., Schainfeld, R., Blair, R., Haley, L., Asahara, T., Rosenfield, K., Razvi, S., Walsh, K. and Symes, J.F. (1996) Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet, 348, 370-374.
-
(1996)
Lancet
, vol.348
, pp. 370-374
-
-
Isner, J.M.1
Pieczek, A.2
Schainfeld, R.3
Blair, R.4
Haley, L.5
Asahara, T.6
Rosenfield, K.7
Razvi, S.8
Walsh, K.9
Symes, J.F.10
-
160
-
-
0031664069
-
Angiogenesis in endometriosis
-
Matsuzaki, S., Canis, M., Darcha, C., Dechelotte, P., Pouly, J.L. and Bruhat, M.A. (1998) Angiogenesis in endometriosis, Gynecol. Obstet. Invest., 46, 111-115.
-
(1998)
Gynecol. Obstet. Invest.
, vol.46
, pp. 111-115
-
-
Matsuzaki, S.1
Canis, M.2
Darcha, C.3
Dechelotte, P.4
Pouly, J.L.5
Bruhat, M.A.6
-
161
-
-
0033528705
-
Cancer and atherosclerosis: The broad mandate of angiogenesis
-
Isner, J.M. (1999) Cancer and atherosclerosis: the broad mandate of angiogenesis. Circulation, 99, 1653-1655.
-
(1999)
Circulation
, vol.99
, pp. 1653-1655
-
-
Isner, J.M.1
-
162
-
-
0033528660
-
Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice
-
Moulton, K.S., Heller, E., Konerding, M.A., Flynn, E., Palinski, W. and Folkman, J. (1999) Angiogenesis inhibitors endostatin or TNP-470 reduce intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Circulation, 99, 1726-1732.
-
(1999)
Circulation
, vol.99
, pp. 1726-1732
-
-
Moulton, K.S.1
Heller, E.2
Konerding, M.A.3
Flynn, E.4
Palinski, W.F.J.5
-
163
-
-
0032543390
-
Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis
-
Ji, W.R., Barrientos, L.G., Llinas, M., Gray, H., Villarreal, X., DeFord, M.E., Castellino, F.J., Kramer, R.A. and Trail, P.A. (1998) Selective inhibition by kringle 5 of human plasminogen on endothelial cell migration, an important process in angiogenesis. Biochem. Biophys. Res. Commun., 247, 414-419.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.247
, pp. 414-419
-
-
Ji, W.R.1
Barrientos, L.G.2
Llinas, M.3
Gray, H.4
Villarreal, X.5
Deford, M.E.6
Castellino, F.J.7
Kramer, R.A.8
Trail, P.A.9
-
164
-
-
0030930671
-
Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth
-
Cao, Y., Chen, A., An, S.S.A., Ji, R.W., Davidson, D. and Llinas, M. (1997) Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth. J. Biol. Chem., 272, 22924-22928.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 22924-22928
-
-
Cao, Y.1
Chen, A.2
An, S.S.A.3
Ji, R.W.4
Davidson, D.5
Llinas, M.6
-
165
-
-
0033599308
-
Antiangiogenic activity of restin, NC10 domain of human collagen XV: Comparison with endostatin
-
Ramchandran, R., Dhanabal, M., Volk, R., Waterman, M.J., Segal, M., Lu, H., Knebelmann, B. and Sukhatme, V.P. (1999) Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison with endostatin. Biochem. Biophys. Res. Commun., 255, 735-739.
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.255
, pp. 735-739
-
-
Ramchandran, R.1
Dhanabal, M.2
Volk, R.3
Waterman, M.J.4
Segal, M.5
Lu, H.6
Knebelmann, B.7
Sukhatme, V.P.8
-
166
-
-
0028618340
-
Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein
-
Jackson, D., Volpert, O.V., Bouck, N. and Linzer, D.I. (1994) Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein. Science, 266, 1581-1584.
-
(1994)
Science
, vol.266
, pp. 1581-1584
-
-
Jackson, D.1
Volpert, O.V.2
Bouck, N.3
Linzer, D.I.4
|