Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: An integrated strategy for the development of new antiangiogenic compounds

Journal of Biological Chemistry

Volumn 285, Issue 12, 2010, Pages 8733-8742

  Colombo, Giorgio ^a   Margosio, Barbara ^b   Ragona, Laura ^c   Neves, Marco ^a   Bonifacio, Silvia ^b   Annis, Douglas S ^d   Stravalaci, Matteo ^b   Tomaselli, Simona ^c   Giavazzi, Raffaella ^b   Rusnati, Marco ^e   Presta, Marco ^e   Zetta, Lucia ^c   Mosher, Deane F ^d   Ribatti, Domenico ^f   Gobbi, Marco ^b   Taraboletti, Giulia ^a  

^a CNR   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e UNIVERSITY OF BRESCIA   (Italy)

^f UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANGIOGENIC FACTOR; ANTIANGIOGENIC AGENT; ANTIANGIOGENIC COMPOUND; BINDING ASSAYS; BINDING SEQUENCE; BIOLOGICAL INSIGHT; CALCIUM BINDING; CHICKEN CHORIOALLANTOIC MEMBRANES; DIFFERENT MECHANISMS; ENDOGENOUS INHIBITOR; FIBROBLAST GROWTH FACTOR-2; IN-VITRO; INTEGRATED STRATEGY; MOLECULAR DYNAMICS SIMULATIONS; MULTI-DISCIPLINARY APPROACH; PEPTIDE ARRAYS; PHARMACOPHORE MODELS; RECOMBINANT PROTEIN; SMALL MOLECULES; SYNTHETIC PEPTIDE; THERAPEUTIC AGENTS; THROMBOSPONDIN;

ASSAYS; BIOACTIVITY; CALCIUM; CELL CULTURE; CELL PROLIFERATION; ENDOTHELIAL CELLS; FIBROBLASTS; LEAD COMPOUNDS; MOLECULAR DYNAMICS; MOLECULES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RESONANCE; STRATEGIC PLANNING; TRAVELING SALESMAN PROBLEM;

PEPTIDES;

FIBROBLAST GROWTH FACTOR 2; RECOMBINANT PROTEIN; SYNTHETIC PEPTIDE; THROMBOSPONDIN 1; ANGIOGENESIS INHIBITOR; PEPTIDE;

AMINO ACID SEQUENCE; ANGIOGENESIS; ANIMAL CELL; ANTIANGIOGENIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG DETERMINATION; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN DATABASE; PROTEIN MICROARRAY; ANIMAL; CHEMISTRY; CHICKEN; CHORIOALLANTOIS; CHORION; DRUG ANTAGONISM; HUMAN; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION;

ANGIOGENESIS INHIBITORS; ANIMALS; CELL PROLIFERATION; CHICKENS; CHORIOALLANTOIC MEMBRANE; CHORION; FIBROBLAST GROWTH FACTOR 2; HUMANS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; THROMBOSPONDIN 1;

EID: 77950551541     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.085605     Document Type: Article

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