The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors

Neuropharmacology

Volumn 60, Issue 1, 2011, Pages 82-92

  Rondard, Philippe ^a   Goudet, Cyril ^a   Kniazeff, Julie ^a   Pin, Jean Philippe ^a   Prézeau, Laurent ^a  

^a INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

Author keywords

Allosteric communication; Allosteric modulator; Calcium sensing receptor; Dimerization; Taste receptor

Indexed keywords

2,6 DI TERT BUTYL 4 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOL; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID C RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 5,7 DI TERT BUTYL 3 HYDROXY 3 TRIFLUOROMETHYL 3H BENZOFURAN 2 ONE; AMINO ACID DERIVATIVE; AUTOANTIBODY; BACLOFEN; CALCIUM; CARBOHYDRATE DERIVATIVE; CINACALCET; CPG 7930; G PROTEIN COUPLED RECEPTOR; GLUTAMIC ACID; HETERODIMER; HOMODIMER; ION; METABOTROPIC RECEPTOR; N,N' DICYCLOPENTYL 2 METHYLTHIO 5 NITRO 4,6 PYRIMIDINEDIAMINE; NEUROTRANSMITTER; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; DIMERIZATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG TARGETING; HUMAN; MOLECULAR RECOGNITION; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; SPASTICITY; STRUCTURE ANALYSIS;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; DIMERIZATION; HUMANS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, GABA-B; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78149497839     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.08.009     Document Type: Review

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