N,N′-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: Novel allosteric enhancers of γ-aminobutyric acidB receptor function

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 1, 2003, Pages 322-330

  Urwyler, Stephan ^a   Pozza, Mario F ^a   Lingenhoehl, Kurt ^a   Mosbacher, Johannes ^a   Lampert, Christina ^a   Froestl, Wolfgang ^a   Koller, Manuel ^a   Kaupmann, Klemens ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 [1 [[2 HYDROXY 3 [HYDROXY(4 METHOXYBENZYL)PHOSPHINYL]PROPYL]AMINO]ETHYL]BENZOIC ACID; 3 AMINOPROPANEPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; CGA 14566; CGA 19414; CGA 19418; CGA 28942; CGA 37456; CGA 38493; CGA 38906; CGA 44010; CGA 50739; CGP 10773; GS 39783; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); N,N' DICYCLOPENTYL 2 METHYLSULFANYL 5 NITROPYRIMIDINE 4,6 DIAMINE; POTASSIUM CHANNEL; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; BACLOFEN; CYCLOPENTANE DERIVATIVE; N,N' DICYCLOPENTYL 2 METHYLSULFANYL 5 NITRO PYRIMIDINE 4,6 DIAMINE; N,N'-DICYCLOPENTYL-2-METHYLSULFANYL-5-NITRO-PYRIMIDINE-4,6-DIAMINE; PYRIMIDINE DERIVATIVE; SULFUR;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BRAIN MEMBRANE; CALCIUM SIGNALING; CHO CELL; CONTROLLED STUDY; DISSOCIATION; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; HIPPOCAMPUS; HUMAN; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STRUCTURE ANALYSIS; XENOPUS; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; HAMSTER; KINETICS; METABOLISM; OOCYTE; PHYSIOLOGY; RADIOASSAY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; BACLOFEN; CHO CELLS; CRICETINAE; CYCLOPENTANES; GABA AGONISTS; GAMMA-AMINOBUTYRIC ACID; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HIPPOCAMPUS; HUMANS; KINETICS; OOCYTES; POTASSIUM CHANNELS; PYRIMIDINES; RADIOLIGAND ASSAY; RECEPTORS, GABA-B; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR RADIOISOTOPES; XENOPUS;

EID: 0141742370     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.053074     Document Type: Article

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