No ligand binding in the GB2 subunit of the GABAB receptor is required for activation and allosteric interaction between the subunits

Journal of Neuroscience

Volumn 22, Issue 17, 2002, Pages 7352-7361

  Kniazeff, Julie ^a   Galvez, Thierry ^a,c   Labesse, Gilles ^b   Pin, Jean Philippe ^a  

^a CNRS   (France)

^b UNIV MONTPELLIER   (France)

^c STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Allostery; Baclofen; Dimerization; Evolution; GPCR; Ligand recognition; Three dimensional modeling

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B1 RECEPTOR; 4 AMINOBUTYRIC ACID B2 RECEPTOR; METABOTROPIC RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CAENORHABDITIS ELEGANS; DIMERIZATION; EVOLUTION; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

EID: 0036759170     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-17-07352.2002     Document Type: Article

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