Mutational analysis and molecular modeling of the allosteric binding site of a novel, selective, noncompetitive antagonist of the metabotropic glutamate 1 receptor

Journal of Biological Chemistry

Volumn 278, Issue 10, 2003, Pages 8340-8347

  Malherbe, Pari ^a   Kratochwil, Nicole ^b   Knoflach, Frédéric ^a   Zenner, Marie Thérèse ^a   Kew, James N C ^a,c   Kratzeisen, Claudia ^a   Maerki, Hans P ^b   Adam, Geo ^b   Mutel, Vincent ^a,d  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c GLAXOSMITHKLINE   (United Kingdom)

^d ADDEX PHARMACEUTICALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CALCIUM; CRYSTAL STRUCTURE; ENZYMES;

MUTATIONAL ANALYSIS;

BIOCHEMISTRY;

1 ETHYL 2 METHYL 6 OXO 4 (1,2,4,5 TETRAHYDROBENZO[D]AZEPIN 3 YL) 1,6 DIHYDROPYRIMIDINE 5 CARBONITRILE; CYANIDE; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR ANTAGONIST; RHODOPSIN; UNCLASSIFIED DRUG; METABOTROPIC RECEPTOR;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPETITIVE INHIBITION; COMPLEX FORMATION; CRYSTAL STRUCTURE; EVOKED RESPONSE; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; SYNAPTIC TRANSMISSION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; GENETICS; HAMSTER; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, METABOTROPIC GLUTAMATE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037424518     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211759200     Document Type: Article

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