Sweet taste in man: A review

Journal of Food Science

Volumn 73, Issue 6, 2008, Pages

  Meyers, B ^a   Brewer, M S ^b  

^a NutraSweet Co   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Chemoreception; Protein sweeteners; Saccharides; Sweetness receptor; Sweetness transduction

Indexed keywords

G PROTEIN COUPLED RECEPTOR; LIGAND; PROTEIN SUBUNIT; SWEETENING AGENT; TASTE RECEPTORS, TYPE 1;

CHEMICAL STRUCTURE; DIMERIZATION; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SHORT SURVEY; SIGNAL TRANSDUCTION; TASTE; TASTE BUD;

DIMERIZATION; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SWEETENING AGENTS; TASTE; TASTE BUDS;

EID: 48749100421     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2008.00832.x     Document Type: Short Survey

References (79)

1. Arterburn DE, Maciejewski ML, Tsevat J. 2005. Impact of morbid obesity on medical expenditures in adults. Int J Obes 29 : 334 9.
2. Bachmanov AA. 2005. Genetic approach to characterize interaction of sweeteners with the sweet taste receptors in vivo. Chem Senses 30 (Suppl 1 i82 3.
3. 2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat. J Physiol 4902 : 325 36.
4. Bishay IE. 2006. The biology and chemistry of taste. Presented at the Illinois Inst. Technology, Chicago, Ill.
5. Bissantz C, Bernard P, Hibert M, Rognan D. 2003. Protein-based virtual screening of chemical databases. II. Are homology models of G-protein coupled receptors suitable targets? Proteins: Struct Function Genet 50 : 5 25.
6. Bopp BA, Price P. 2001. Cyclamate. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 63 85.
7. Borrego F, Montijano H. 2001. Neohesperidin dihydrochalcone. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 87 104.
8. Brand JG, Feign AM. 1996. Biochemistry of sweet taste transduction. Food Chem 563 : 199 207.
9. Butchko HH, Stargel WW, Comer CP, Mayhew DA, Andress SE. 2001. Aspartame. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 41 61.
10. 2-adrenergic G protein-coupled receptor. Science 318 : 1258 65.
11. Cui M, Jiang P, Maillet E, Max M, Margolskee RF, Osman R. 2006. The heterodimeric sweet taste receptor has multiple potential ligand binding sites. Curr Pharmaceut Des 12 : 4591 600.
12. Dubois GE. 2004. Unraveling the biochemistry of sweet and umami tastes. Proc Natl Acad Sci USA 10139 : 13972 3.
13. Eggers SC, Acree TE, Schallenberger RS. 2000. Sweetness chemoreception theory and sweetness transduction. Food Chem 68 : 45 9.
14. Esposito V, Gallucci R, Picone D, Saviano G, Tancredi T, Temussi TA. 2006. The importance of electrostatic potential in the interaction of sweet proteins with the sweet taste receptor. J Mol Biol 360 : 448 56.
15. Flegal KM, Troiano RP. 2000. Changes in the distribution of body mass index of adults and children in the US population. Int J Obes 24 : 807 18.
16. Freddolino PL, Yashar M, Kalani S, Vaidehi N, Floriano WB, Hall SE, Trabanino RJ, Kam VWT, Goddard WA III. 2004. Predicted 3D structure for the human β2 adrenergic receptor and its binding site for agonists and antagonists. Proc Natl Acad Sci USA 101 : 2736 41.
17. Fredholm BB, Hökfelt T, Miligan G. 2007. G-protein-coupled receptors: an update. Acta Physiol 190 : 3 7.
18. Furse KE, Lybrand TP. 2003. Three-dimensional models for β-adrenergic receptor complexes with agonists and antagonists. J Med Chem 46 : 4450 62.
19. Galindo-Cuspinera V, Breslin PAS. 2006. The liaison of sweet and savory. Chem Senses 31 : 221 5.
20. Galindo-Cuspinera V, Winning M, Bufe B, Meyerhof W, Breslin PAS. 2006. A TAS1R receptor-based explanation of sweet 'water-taste.' Nature 441 : 354 7.
21. Goldsmith LA, Merkel CM. 2001. Sucralose. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 185 207.
22. Goodman M, Del Valle JR, Amino Y, Benedetti E. 2002. Molecular basis of sweet taste in dipeptide ligands. Pure Appl Chem 747 : 1109 16.
23. 2-adrenergic receptor. Proteins 56 : 67 84.
24. Hoon M, Adler E, Lindemeier J, Battey JF, Ryba NJP, Zuker CS. 1999. Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 96 : 541 51.
25. 2 hybrids between C57BL/6ByJ and 129P3/J Mice. J Neurosci 249 : 2296 303.
26. Jiang P, Ji Q, Liu Z, Snyder LA, Benard LM, Margolskee RF, Max M. 2004. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J Biol Chem 27943 : 45068 75.
27. Jiang P, Cui M, Ji Q, Snyder L, Liu Z, Bernard L, Margolskee RF, Osman R, Max M. 2005a. Molecular mechanisms of sweet receptor function. Chem Senses 30 (Suppl 1 i17 8.
28. Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, Benard LMJ, Osman R, Margolskee RF, Max M. 2005b. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem 28015 : 15238 46.
29. Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF. 2005c. Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem 28040 : 34296 305.
30. Kier LB. 1972. Molecular theory of sweet taste. J Pharmacy Sci 61 : 1394 7.
31. Kinghorn D, Compadre C. 2001. Less common high-potency sweeteners. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 209 33.
32. Kinnamon SC, Margolskee RF. 1996. Mechanisms of taste transduction. Curr Opin Neurobiol 6 : 506 13.
33. Kitagawa M, Kusakabe Y, Miura H, Ninomiya Y, Hino A. 2001. Molecular genetic identification of a candidate receptor gene for sweet taste. BioChem Biophys Res Comm 2831 : 236 42.
34. Koizumi A, Nakajima K, Asakura T, Morita Y, Ito K, Shimizu-Ibuka A, Misaka T, Abe K. 2007. Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain. Biochem Biophys Res Comm 358 : 585 9.
35. Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W. 2004. Bitter taste receptors for saccharin and acesulfame-K. J Neurosci 244 : 10260 5.
36. Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. 2000. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407 : 971 7.
37. Li X, Inoue M, Reed DR, Huque T, Puchalski RB, Tordoff MG, Ninomiya Y, Beauchamp GK, Bachmanov AA. 2001. High-resolution genetic mapping of the saccharin preference locus Sac and the putative sweet taste receptor T1R1 gene Gpr70 to mouse distal chromosome 4. Mammal Genome 12 : 13 6.
38. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler. 2002. Human receptors for sweet and umami taste. Proc Natl Acad Sci USA 997 : 4692 6.
39. Margolskee RF. 2002. Molecular mechanisms of taste transduction. Pure Appl Chem 747 : 1125 33.
40. Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF. 2001. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet 281 : 58 63.
41. Montmayeur JP, Liberles SD, Matsunami H, Buck LB. 2001. A candidate taste receptor gene near a sweet taste locus. Nat Neurosci 4 : 492 8.
42. Morini G, Bassoli A, Temussi PA. 2005. From small sweeteners to sweet proteins: anatomy of the binding sites of the human T1R2_T1R3 receptor. J Med Chem 48 : 5520 9.
43. Muto T, Tsuchiya D, Morikawa K, Jingami H. 2007. Structures of the extracellular regions of the group II/III metabotropic glutamate receptors. Proc Natl Acad Sci USA 104 : 3759 64.
44. Naim H, Huang L, Spielman AI, Shaul ME, Aliluiko A. 2006. Stimulation of taste cells by sweet taste compounds. In : Spillane WJ, editor. Optimizing sweet taste in foods. Boca Raton, Fla. : CRC Press. p 3 29.
45. Nagarajan S, Kellogg MS, DuBois GE. 1996. Understanding the mechanism of sweet taste: synthesis of ultrapotent guanidinoacetic acid photoaffinity labeling reagents. J Med Chem 3921 : 4167 72.
46. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS. 2001. Mammalian sweet taste receptors. Cell 106 : 381 90.
47. Nie Y, Hobbs J Vigues S, Olson WJ, Conn CL, Munger SD. 2006. Expression and purification of functional ligand-binding domains of T1R3 taste receptors. Chem Sense 31 : 505 13.
48. Nie Y, Vigues S, Hobbs JR, Conn GL, Munger SD. 2005. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr Biol 15 : 1948 52.
49. Nofre C, Tinti J. 1996. Sweetness reception in man: the multipoint attachment theory. Food Chem 563 : 263 74.
50. Ozeck M, Brust P, Xu H, Servant G. 2004. Receptors for bitter, sweet and umami taste couple to inhibitory G protein signaling pathways. Eur J Pharm 489 : 139 49.
51. Pearson RL. 2001. Saccharin. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 147 65.
52. Perez CA, Huang L, Rong M, Kozak A, Preuss AK, Zhang H, Max M, Margolskee RF. 2002. A transient receptor potential channel expressed in taste receptor cells. Nat Neurosci 511 : 1169 76.
53. Perez CA, Margolskee RF, Kinnamon SC, Ogura T. 2003. Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells. Cell Calcium 33 : 541 9.
54. Pin JP, Kniazeff J, Liu J, Binet V, Goudet C, Rondard P, Prezéau L. 2005. Allosteric functioning of dimeric class C G-protein-coupled receptors. Fed Exp Biol Soc Lett 272 : 2947 55.
55. Sainz E, Korley JN, Battey JF, Sullivan SL. 2001. Identification of a novel member of the T1R family of putative taste receptors. J Neurochem 77 : 896 903.
56. Salbe AD, DelParigi A, Pratley RE, Drewnowski A, Tataranni PA. 2004. Taste preferences and body weight changes in an obesity-prone population. Am J Clin Nut 79 : 372 8.
57. Shallenberger RS. 1996. The AH-B glycophore and general taste chemistry. Food Chem 563 : 209 14.
58. Schallenberger RS, Acree TE. 1967. Molecular theory of sweet taste. Nature 216 : 480 2.
59. Schiffman SS, Sattely-Miller EA, Bishay IE. 2007. Time to maximum sweetness intensity of binary and ternary blends of sweeteners. Food Qual Pref 18 : 405 15.
60. Schiffman SS, Sattely-Miller E, Bishay IE. 2008. Sensory properties of neotame: comparison with other sweeteners. In : Weerasinghe DK, Dubois GE, editors. Sweetness and sweeteners: biology, chemistry, and psychophysics. Washington, D.C. : American Chemical Society. p 511 29.
61. Shimizu-Ibuka A, Morita Y, Terada T, Asakura T, Nakajima K, Iwata S, Misaka T, Sorimachi H, Arai S, Abe K. 2006. Crystal structure of neoculin: insights into its sweetness and taste-modifying activity. J Mol Biol 359 : 148 58.
62. Spadacini R, Trabucco F, Saviano G, Picone D, Crescenzi O, Tancredi T, Temussi PA. 2003. The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI. J Mol Biol 328 : 683 92.
63. Stargel WW, Mayhew DA, Comer CP, Andress SE, Butchko HH. 2001. Neotame. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 129 45.
64. Sugimoto K, Shigemura N, Yasumatsu K, Ohta R, Nakashima K, Kawai K, Ninomiya Y. 2002. Ion channels and second messengers involved in transduction and modulation of sweet taste in mouse taste cells. Pure Appl Chem 747 : 1141 51.
65. Tancredi T, Pastore A, Salvadori S, Esposito V, Temussi PA. 2004. Interaction of sweet proteins with their receptor: a conformational study of peptides corresponding to loops of brazzein, monellin and thaumatin. Eur J Biochem 271 : 2231 40.
66. Temussi PA. 2002. Why are sweet proteins sweet? Interaction of brazzein, monellin and thaumatin with the T1R2-T1R3 receptor. Fed Exp Biol Soc Lett 526 : 1 4.
67. Temussi P. 2005. From oligopeptides to sweet proteins. J Pept Sci 111 : 262 4.
68. Temussi P. 2006a. The history of sweet taste: not exactly a piece of cake. J Mol Recognit 19 : 188 99.
69. Temussi PA. 2006b. Natural sweet macromolecules: how sweet proteins work. Cell Mol Life Sci 63 : 1876 88.
70. von Rymon Lipinski GW, Hanger LY. 2001. Acesulfame-K. In : O'Brien Nabors L, editor. Alternative sweeteners. 3rd ed., revised and expanded. New York : Marcel Dekker. p 13 30.
71. Walters DE. 2002. Homology-based model of the extracellular domain of the taste receptor T1R3. Pure Appl Chem 74 : 1117 23.
72. Walters DE, Hellekant G. 2006. Interactions of the sweet protein brazzein with the sweet taste receptor. J Agric Food Chem 54 : 10129 33.
73. Walters DE, Hinds M. 1994. Genetically evolved receptor models: a computational approach to construction of receptor models. J Med Chem 37 : 2527 36.
74. Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X. 2004. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Nat Acad Sci USA 10139 : 14258 63.
75. Yu L, Liang S, Liu X, He Q, Studholme DJ, Wu Q. 2004. NCD3G: a novel nine-cysteine domain in family 3 GPCRs. Trends Biochem Sci 29 : 458 61.
76. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, Zuker CS. 2003. The receptors for mammalian sweet and umami taste. Cell 115 : 255 66.
77. Zhang Y, Hoon M, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJP. 2003. Coding of sweet bitter and umami tastes: different receptor cells sharing similar signaling pathways. Cell 112 : 293 301.
78. Zhang Y, Devries ME, Skolnick J. 2006. Structure modeling of all identified G protein-coupled receptors in the human genome. PLoS Comput Biol 2 : 88 99.
79. Zubare-Samuelov M, Shaul ME, Peri I, Aliluiko A, Tirosh O, Naim M. 2005. Inhibition of signal termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste signal termination. Am J Physiol Cell Physiol 289 : 483 92.