Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

EMBO Journal

Volumn 24, Issue 3, 2005, Pages 499-509

  Hlavackova, Veronika ^a,b   Goudet, Cyril ^b   Kniazeff, Julie ^b   Zikova, Alice ^a   Maurel, Damien ^b,c   Vol, Claire ^b   Trojanova, Johana ^a   Prézeau, Laurent ^b   Pin, Jean Philippe ^b,d   Blahos, Jaroslav ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Czech Republic)

^b CNRS   (France)

^c CIS Bio International   (France)

^d CCIPE   (France)

Author keywords

Allostery; G protein coupling; Metabotropic glutamate receptors; Receptor activation

Indexed keywords

2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 4 AMINOBUTYRIC ACID B RECEPTOR; CALCIUM ION; CELL SURFACE RECEPTOR; DIMER; G PROTEIN COUPLED RECEPTOR; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR AGONIST; PHOSPHOLIPASE C; QUISQUALIC ACID; RECEPTOR SUBUNIT;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL COMMUNICATION; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN;

CELL LINE; DIMERIZATION; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; KINETICS; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; PYRIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 20044364938     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600557     Document Type: Article

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