Homology Modeling of the Transmembrane Domain of the Human Calcium Sensing Receptor and Localization of an Allosteric Binding Site

Journal of Biological Chemistry

Volumn 279, Issue 8, 2004, Pages 7254-7263

  Miedlich, Susanne U ^a,c   Gama, Lucio ^a,d   Seuwen, Klaus ^b   Wolf, Romain M ^b   Breitwieser, Gerda E ^a  

^a SYRACUSE UNIVERSITY   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CALCIUM; CHEMICAL BONDS; MUTAGENESIS; PROTEINS;

ALLOSTERIC MODULATORS; FUNCTIONAL ASSAYS;

BIOCHEMISTRY;

CALCIUM SENSING RECEPTOR; G PROTEIN COUPLED RECEPTOR; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PHENYLALANINE;

ALLOSTERISM; ALPHA HELIX; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CELL MEMBRANE; CHIMERA; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STIMULUS RESPONSE;

ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCIUM; CATTLE; CELL LINE; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCIUM-SENSING; RHODOPSIN; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS; TRANSFECTION;

BOVINAE;

EID: 1342346546     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M307191200     Document Type: Article

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