Positive and Negative Allosteric Modulators of the Ca2+-sensing Receptor Interact within Overlapping but Not Identical Binding Sites in the Transmembrane Domain

Journal of Biological Chemistry

Volumn 279, Issue 18, 2004, Pages 18990-18997

  Petrel, Christophe ^a   Kessler, Albane ^b   Dauban, Philippe ^b   Dodd, Robert H ^b   Rognan, Didier ^c   Ruat, Martial ^a  

^a LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

^b INSTITUT DE CHIMIE DES SUBSTANCES NATURELLES   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; PROTEINS; STRUCTURE (COMPOSITION);

ALLOSTERIC MODULATORS; BINDING POCKETS;

BIOCHEMISTRY;

ARGININE; CALCIUM SENSING RECEPTOR; INOSITOL PHOSPHATE; PHENYLALANINE;

ALLOSTERISM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; BENZAMIDES; BINDING SITES; CELL LINE; CYCLOHEXYLAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; NAPHTHALENES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCIUM-SENSING; TRANSFECTION;

EID: 2442548717     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M400724200     Document Type: Article

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