Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor.

The Journal of biological chemistry

Volumn 278, Issue 49, 2003, Pages 49487-49494

  Petrel, Christophe ^a   Kessler, Albane ^a   Maslah, Fouzia ^a   Dauban, Philippe ^a   Dodd, Robert H ^a   Rognan, Didier ^a   Ruat, Martial ^a  

^a Institut Fédératif de Recherche 2118 CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BENZAMIDE DERIVATIVE; CALCIUM SENSING RECEPTOR; CYCLOHEXYLAMINE DERIVATIVE; N(1) (4 CHLOROBENZOYL) N(2) (1 (1 NAPHTHYL)ETHYL) 1,2 DIAMINOCYCLOHEXANE; N(1)-(4-CHLOROBENZOYL)-N(2)-(1-(1-NAPHTHYL)ETHYL)-1,2-DIAMINOCYCLOHEXANE;

ALLOSTERISM; AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; BENZAMIDES; BINDING SITES; CELL LINE; CYCLOHEXYLAMINES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECEPTORS, CALCIUM-SENSING; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 1442358771     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308010200     Document Type: Article

References (0)