메뉴 건너뛰기




Volumn 42, Issue 1, 2005, Pages 35-70

The calcium-sensing receptor in normal physiology and pathophysiology: A review

Author keywords

Acquired hypoparathyroidism; Autosomal dominant hypoparathyroidism; Calcilytic; Calcimimetic; Calcium homeostasis; Calcium sensing receptor; Familial hypocalciuric hypercalcemia; G protein; Hyperparathyroidism; Osteoporosis

Indexed keywords

1 (3 METHOXYPHENYL) N (3 PHENYLPROPYL)ETHYLAMINE; CALCIMIMETIC AGENT; CALCITONIN; CALCIUM SENSING RECEPTOR; CINACALCET; FUROSEMIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; PAMIDRONIC ACID; PARATHYROID HORMONE; PHOSPHOLIPASE C; PROTEIN KINASE B; VITAMIN D; CALCIUM;

EID: 18244363907     PISSN: 10408363     EISSN: None     Source Type: Journal    
DOI: 10.1080/10408360590886606     Document Type: Review
Times cited : (261)

References (212)
  • 1
    • 0027765508 scopus 로고
    • 2+-sensing receptor from bovine parathyroid
    • 2+-sensing receptor from bovine parathyroid. Nature 1993; 366: 575-80.
    • (1993) Nature , vol.366 , pp. 575-580
    • Brown, E.M.1    Gamba, G.2    Riccardi, D.3
  • 2
    • 0030788436 scopus 로고    scopus 로고
    • A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution
    • Herrada G, Dulac C. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Cell 1997; 90: 763-73.
    • (1997) Cell , vol.90 , pp. 763-773
    • Herrada, G.1    Dulac, C.2
  • 3
    • 0030848970 scopus 로고    scopus 로고
    • A multigene family encoding a diverse array of putative pheromone receptors in mammals
    • Matsunami H, Buck LB. A multigene family encoding a diverse array of putative pheromone receptors in mammals. Cell 1997; 90: 775-84.
    • (1997) Cell , vol.90 , pp. 775-784
    • Matsunami, H.1    Buck, L.B.2
  • 4
    • 0033582645 scopus 로고    scopus 로고
    • Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity
    • Hoon MA, Adler E, Lindemeier J, Battey JF, Ryba NJ, Zuker CS. Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity. Cell 1999; 96: 541-51.
    • (1999) Cell , vol.96 , pp. 541-551
    • Hoon, M.A.1    Adler, E.2    Lindemeier, J.3    Battey, J.F.4    Ryba, N.J.5    Zuker, C.S.6
  • 6
    • 0033800097 scopus 로고    scopus 로고
    • Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia
    • Hendy GN, D'Souza-Li L, Yang B, Canaff L, Cole DE. Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia. Hum Mutat 2000; 16: 281-96.
    • (2000) Hum Mutat , vol.16 , pp. 281-296
    • Hendy, G.N.1    D'Souza-Li, L.2    Yang, B.3    Canaff, L.4    Cole, D.E.5
  • 7
    • 0029055771 scopus 로고
    • Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs
    • Garrett JE, Capuano IV, Hammerland LG, et al. Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem 1995; 270: 12919-25.
    • (1995) J Biol Chem , vol.270 , pp. 12919-12925
    • Garrett, J.E.1    Capuano, I.V.2    Hammerland, L.G.3
  • 9
    • 0032483541 scopus 로고    scopus 로고
    • Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells
    • Bai M, Trivedi S, Brown EM. Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells. J Biol Chem 1998; 273: 23605-10.
    • (1998) J Biol Chem , vol.273 , pp. 23605-23610
    • Bai, M.1    Trivedi, S.2    Brown, E.M.3
  • 10
    • 0042233567 scopus 로고    scopus 로고
    • 2+- sensing receptor: Implications for its structure and function
    • 2+-sensing receptor: Implications for its structure and function. Trends Endocrinol Metab 2003; 14: 282-8.
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 282-288
    • Hu, J.1    Spiegel, A.M.2
  • 12
    • 0036415131 scopus 로고    scopus 로고
    • Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)
    • Jensen AA, Hansen JL, Sheikh SP, Brauner-Osborne H. Probing intermolecular protein-protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET). Eur J Biochem 2002; 269: 5076-87.
    • (2002) Eur J Biochem , vol.269 , pp. 5076-5087
    • Jensen, A.A.1    Hansen, J.L.2    Sheikh, S.P.3    Brauner-Osborne, H.4
  • 14
    • 0035860748 scopus 로고    scopus 로고
    • Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase
    • Hjalm G, MacLeod RJ, Kifor O, Chattopadhyay N, Brown EM. Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. J Biol Chem 2001; 276: 34880-7.
    • (2001) J Biol Chem , vol.276 , pp. 34880-34887
    • Hjalm, G.1    MacLeod, R.J.2    Kifor, O.3    Chattopadhyay, N.4    Brown, E.M.5
  • 15
    • 0032555476 scopus 로고    scopus 로고
    • The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells
    • Kifor O, Diaz R, Butters R, Kifor I, Brown EM. The calcium-sensing receptor is localized in caveolin-rich plasma membrane domains of bovine parathyroid cells. J Biol Chem 1998; 273: 21708-13.
    • (1998) J Biol Chem , vol.273 , pp. 21708-21713
    • Kifor, O.1    Diaz, R.2    Butters, R.3    Kifor, I.4    Brown, E.M.5
  • 16
    • 0030612562 scopus 로고    scopus 로고
    • 2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells
    • 2+-sensing receptor (CaR) activates phospholipases C, A2, and D in bovine parathyroid and CaR-transfected, human embryonic kidney (HEK293) cells. J Bone Miner Res 1997; 12: 715-25.
    • (1997) J Bone Miner Res , vol.12 , pp. 715-725
    • Kifor, O.1    Diaz, R.2    Butters, R.3    Brown, E.M.4
  • 17
    • 0035001612 scopus 로고    scopus 로고
    • Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells
    • Kifor O, MacLeod RJ, Diaz R, et al. Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells. Am J Physiol Renal Physiol 2001; 280: F291-302.
    • (2001) Am J Physiol Renal Physiol , vol.280
    • Kifor, O.1    MacLeod, R.J.2    Diaz, R.3
  • 18
    • 0035958057 scopus 로고    scopus 로고
    • 2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha-dependent ERK-independent pathway
    • 2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha-dependent ERK-independent pathway. J Biol Chem 2001; 276: 13941-8.
    • (2001) J Biol Chem , vol.276 , pp. 13941-13948
    • Handlogten, M.E.1    Huang, C.2    Shiraishi, N.3    Awata, H.4    Miller, R.T.5
  • 19
    • 0037036446 scopus 로고    scopus 로고
    • Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor
    • Huang C, Handlogten ME, Miller RT. Parallel activation of phosphatidylinositol 4-kinase and phospholipase C by the extracellular calcium-sensing receptor. J Biol Chem 2002; 277: 20293-300.
    • (2002) J Biol Chem , vol.277 , pp. 20293-20300
    • Huang, C.1    Handlogten, M.E.2    Miller, R.T.3
  • 21
    • 1442323677 scopus 로고    scopus 로고
    • Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellulary regulated kinase in a model of humoral hypercalcemia of malignancy
    • Tfelt-Hansen J, Chattopadhyay N, Yano S, et al. Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellulary regulated kinase in a model of humoral hypercalcemia of malignancy. Endocrinology 2004; 145: 1211-7. Epub 2003 Nov. 26.
    • (2004) Endocrinology , vol.145 , pp. 1211-1217
    • Tfelt-Hansen, J.1    Chattopadhyay, N.2    Yano, S.3
  • 22
    • 0025279014 scopus 로고
    • Regulation of cytosolic calcium by extracellular divalent cations in C-cells and parathyroid cells
    • Nemeth EF. Regulation of cytosolic calcium by extracellular divalent cations in C-cells and parathyroid cells. Cell Calcium 1990; 11: 323-7.
    • (1990) Cell Calcium , vol.11 , pp. 323-327
    • Nemeth, E.F.1
  • 23
    • 0031013392 scopus 로고    scopus 로고
    • Effect of magnesium on parathyroid cells: Evidence for two sensing receptors or two intracellular pathways?
    • Miki H, Maercklein PB, Fitzpatrick LA. Effect of magnesium on parathyroid cells: Evidence for two sensing receptors or two intracellular pathways? Am J Physiol 1997; 272: E1-6.
    • (1997) Am J Physiol , vol.272
    • Miki, H.1    Maercklein, P.B.2    Fitzpatrick, L.A.3
  • 24
    • 0030910045 scopus 로고    scopus 로고
    • 2+-sensing receptor in divalent mineral ion homeostasis
    • 2+-sensing receptor in divalent mineral ion homeostasis. J Exp Biol 1997; 200 (Pt 2): 295-302.
    • (1997) J Exp Biol , vol.200 , Issue.PART 2 , pp. 295-302
    • Hebert, S.C.1    Brown, E.M.2    Harris, H.W.3
  • 28
    • 0035138842 scopus 로고    scopus 로고
    • Extracellular calcium sensing and extracellular calcium signaling
    • Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 2001; 81: 239-97.
    • (2001) Physiol Rev , vol.81 , pp. 239-297
    • Brown, E.M.1    MacLeod, R.J.2
  • 29
    • 0041808856 scopus 로고    scopus 로고
    • L-Amino acid sensing by the calcium-sensing receptor: A general mechanism for coupling protein and calcium metabolism?
    • Conigrave AD, et al. L-Amino acid sensing by the calcium-sensing receptor: A general mechanism for coupling protein and calcium metabolism? Eur J Clin Nutr 2003; 57: 879.
    • (2003) Eur J Clin Nutr , vol.57 , pp. 879
    • Conigrave, A.D.1
  • 31
    • 0037072797 scopus 로고    scopus 로고
    • Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function
    • Zhang Z, Qiu W, Quinn SJ, Conigrave AD, Brown EM, Bai M. Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function. J Biol Chem 2002; 277: 33727-35.
    • (2002) J Biol Chem , vol.277 , pp. 33727-33735
    • Zhang, Z.1    Qiu, W.2    Quinn, S.J.3    Conigrave, A.D.4    Brown, E.M.5    Bai, M.6
  • 32
    • 0037072771 scopus 로고    scopus 로고
    • L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites
    • Zhang Z, Jiang Y, Quinn SJ, Krapcho K, Nemeth EF, Bai M. L-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites. J Biol Chem 2002; 277: 33736-41.
    • (2002) J Biol Chem , vol.277 , pp. 33736-33741
    • Zhang, Z.1    Jiang, Y.2    Quinn, S.J.3    Krapcho, K.4    Nemeth, E.F.5    Bai, M.6
  • 34
    • 0034864299 scopus 로고    scopus 로고
    • Rapid suppression of S-PTH by oral calcitriol and calcium in healthy premenopausal women
    • Tfelt-Hansen J, Schwarz P, Torring O. Rapid suppression of S-PTH by oral calcitriol and calcium in healthy premenopausal women. Scand J Clin Lab Invest 2001; 61: 395-400.
    • (2001) Scand J Clin Lab Invest , vol.61 , pp. 395-400
    • Tfelt-Hansen, J.1    Schwarz, P.2    Torring, O.3
  • 35
    • 0027432591 scopus 로고
    • Dose response dependency in regulation of acute PTH (1-84) release and suppression in normal humans: A citrate and calcium infusion study
    • Schwarz P. Dose response dependency in regulation of acute PTH (1-84) release and suppression in normal humans: A citrate and calcium infusion study. Scand J Clin Lab Invest 1993; 53: 601-5.
    • (1993) Scand J Clin Lab Invest , vol.53 , pp. 601-605
    • Schwarz, P.1
  • 36
    • 0028792434 scopus 로고
    • Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene
    • Garrett JE, Tamir H, Kifor O, et al. Calcitonin-secreting cells of the thyroid express an extracellular calcium receptor gene. Endocrinology 1995; 136: 5202-11.
    • (1995) Endocrinology , vol.136 , pp. 5202-5211
    • Garrett, J.E.1    Tamir, H.2    Kifor, O.3
  • 37
    • 0029916843 scopus 로고    scopus 로고
    • Rat calcium-sensing receptor is regulated by vitamin D but not by calcium
    • Brown AJ, Zhong M, Finch J, et al. Rat calcium-sensing receptor is regulated by vitamin D but not by calcium. Am J Physiol 1996; 270: F454-60.
    • (1996) Am J Physiol , vol.270
    • Brown, A.J.1    Zhong, M.2    Finch, J.3
  • 38
    • 0034522826 scopus 로고    scopus 로고
    • Up-regulation of the parathyroid calcium-sensing receptor after burn injury in sheep: A potential contributory factor to postburn hypocalcemia
    • Murphey ED, Chattopadhyay N, Bai M, et al. Up-regulation of the parathyroid calcium-sensing receptor after burn injury in sheep: A potential contributory factor to postburn hypocalcemia. Crit Care Med 2000; 28: 3885-90.
    • (2000) Crit Care Med , vol.28 , pp. 3885-3890
    • Murphey, E.D.1    Chattopadhyay, N.2    Bai, M.3
  • 39
    • 0029060105 scopus 로고
    • 2+-sensing receptor messenger ribonucleic acid and protein
    • 2+-sensing receptor messenger ribonucleic acid and protein. Endocrinology 1995; 136: 3087-92.
    • (1995) Endocrinology , vol.136 , pp. 3087-3092
    • Mithal, A.1    Kifor, O.2    Kifor, I.3
  • 40
    • 0029090911 scopus 로고
    • Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with decreased calcium receptor expression
    • Brown AJ, Zhong M, Ritter C, Brown EM, Slatopolsky E. Loss of calcium responsiveness in cultured bovine parathyroid cells is associated with decreased calcium receptor expression. Biochem Biophys Res Commun 1995; 212: 861-7.
    • (1995) Biochem Biophys Res Commun , vol.212 , pp. 861-867
    • Brown, A.J.1    Zhong, M.2    Ritter, C.3    Brown, E.M.4    Slatopolsky, E.5
  • 42
    • 1842843939 scopus 로고    scopus 로고
    • Renal physiology of the extracellular calcium-sensing receptor
    • Ward DT, Riccardi D. Renal physiology of the extracellular calcium-sensing receptor. Pflugers Arch 2002; 445: 169-76.
    • (2002) Pflugers Arch , vol.445 , pp. 169-176
    • Ward, D.T.1    Riccardi, D.2
  • 44
    • 0028924833 scopus 로고
    • Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor
    • Riccardi D, Park J, Lee WS, Gamba G, Brown EM, Hebert SC. Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 1995; 92: 131-5.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 131-135
    • Riccardi, D.1    Park, J.2    Lee, W.S.3    Gamba, G.4    Brown, E.M.5    Hebert, S.C.6
  • 46
    • 0037119447 scopus 로고    scopus 로고
    • Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D
    • Canaff L, Hendy GN. Human calcium-sensing receptor gene. Vitamin D response elements in promoters P1 and P2 confer transcriptional responsiveness to 1,25-dihydroxyvitamin D. J Biol Chem 2002; 277: 30337-50.
    • (2002) J Biol Chem , vol.277 , pp. 30337-30350
    • Canaff, L.1    Hendy, G.N.2
  • 47
    • 0031771054 scopus 로고    scopus 로고
    • mRNAs coding for the calcium-sensing receptor along the rat nephron: Effect of a low-phosphate diet
    • Caride AJ, Chini EN, Homma S, Dousa TP, Penniston JT. mRNAs coding for the calcium-sensing receptor along the rat nephron: Effect of a low-phosphate diet. Kidney Blood Press Res 1998; 21: 305-9.
    • (1998) Kidney Blood Press Res , vol.21 , pp. 305-309
    • Caride, A.J.1    Chini, E.N.2    Homma, S.3    Dousa, T.P.4    Penniston, J.T.5
  • 48
    • 0034495967 scopus 로고    scopus 로고
    • +-dependent Pi transporter (NaPi-2) in the rat proximal tubule
    • +-dependent Pi transporter (NaPi-2) in the rat proximal tubule. Pflugers Arch 2000; 441: 379-87.
    • (2000) Pflugers Arch , vol.441 , pp. 379-387
    • Riccardi, D.1    Traebert, M.2    Ward, D.T.3
  • 49
    • 0031832532 scopus 로고    scopus 로고
    • Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats
    • Sands JM, Flores FX, Kato A, et al. Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats. Am J Physiol 1998; 274: F978-85.
    • (1998) Am J Physiol , vol.274
    • Sands, J.M.1    Flores, F.X.2    Kato, A.3
  • 50
    • 0242665678 scopus 로고    scopus 로고
    • Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport
    • Ba J, Brown D, Friedman PA. Calcium-sensing receptor regulation of PTH-inhibitable proximal tubule phosphate transport. Am J Physiol Renal Physiol 2003; 285: F1233-43.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • Ba, J.1    Brown, D.2    Friedman, P.A.3
  • 51
    • 0029793975 scopus 로고    scopus 로고
    • Ontogeny of the extracellular calcium-sensing receptor in rat kidney
    • Chattopadhyay N, Baum M, Bai M, et al. Ontogeny of the extracellular calcium-sensing receptor in rat kidney. Am J Physiol 1996; 271: F736-43.
    • (1996) Am J Physiol , vol.271
    • Chattopadhyay, N.1    Baum, M.2    Bai, M.3
  • 52
    • 0020516783 scopus 로고
    • Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism
    • Attie MF, Gill JR Jr, Stock JL, et al. Urinary calcium excretion in familial hypocalciuric hypercalcemia. Persistence of relative hypocalciuria after induction of hypoparathyroidism. Clin Invest 1983; 72: 667-76.
    • (1983) Clin Invest , vol.72 , pp. 667-676
    • Attie, M.F.1    Gill Jr., J.R.2    Stock, J.L.3
  • 53
    • 0036721367 scopus 로고    scopus 로고
    • Calcium-sensing receptor regulation of PTH-dependent calcium absorption by mouse cortical ascending limbs
    • Motoyama HI, Friedman PA. Calcium-sensing receptor regulation of PTH-dependent calcium absorption by mouse cortical ascending limbs. Am J Physiol Renal Physiol 2002; 283: F399-406.
    • (2002) Am J Physiol Renal Physiol , vol.283
    • Motoyama, H.I.1    Friedman, P.A.2
  • 54
    • 0032463167 scopus 로고    scopus 로고
    • Calcium-sensing receptor: Regulation of electrolyte transport in the thick ascending limb of Henle's loop
    • Desfleurs E, Wittner M, Simeone S, et al. Calcium-sensing receptor: Regulation of electrolyte transport in the thick ascending limb of Henle's loop. Kidney Blood Press Res 1998; 21: 401-12.
    • (1998) Kidney Blood Press Res , vol.21 , pp. 401-412
    • Desfleurs, E.1    Wittner, M.2    Simeone, S.3
  • 56
    • 0034519054 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase isoforms in the renal thick ascending limb: Effects of extracellular calcium
    • Wang D, McGiff JC, Ferreri NR. Regulation of cyclooxygenase isoforms in the renal thick ascending limb: Effects of extracellular calcium. J Physiol Pharmacol 2000; 51: 587-95.
    • (2000) J Physiol Pharmacol , vol.51 , pp. 587-595
    • Wang, D.1    McGiff, J.C.2    Ferreri, N.R.3
  • 61
    • 0029759098 scopus 로고    scopus 로고
    • 2+- induced inhibition of apical K+ channels in the TAL
    • 2+-induced inhibition of apical K+ channels in the TAL. Am J Physiol 1996; 271: C103-11.
    • (1996) Am J Physiol , vol.271
    • Wang, W.H.1    Lu, M.2    Hebert, S.C.3
  • 62
    • 0032132802 scopus 로고    scopus 로고
    • 2+ decreases chloride reabsorption in rat CTAL by inhibiting cAMP pathway
    • 2+ decreases chloride reabsorption in rat CTAL by inhibiting cAMP pathway. Am J Physiol 1998; 275: F198-203.
    • (1998) Am J Physiol , vol.275
    • De Jesus Ferreira, M.C.1    Bailly, C.2
  • 65
    • 0030944936 scopus 로고    scopus 로고
    • Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct
    • Sands JM, Naruse M, Baum M, et al. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest 1997; 99: 1399-405.
    • (1997) J Clin Invest , vol.99 , pp. 1399-1405
    • Sands, J.M.1    Naruse, M.2    Baum, M.3
  • 66
  • 67
    • 3042598897 scopus 로고    scopus 로고
    • Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts
    • Chattopadhyay N, Yano S, Tfelt-Hansen J, et al. Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology 2004; 145: 3451-62.
    • (2004) Endocrinology , vol.145 , pp. 3451-3462
    • Chattopadhyay, N.1    Yano, S.2    Tfelt-Hansen, J.3
  • 68
    • 0033304645 scopus 로고    scopus 로고
    • Expression and signal transduction of calcium-sensing receptors in cartilage and bone
    • Chang W, Tu C, Chen TH, et al. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology 1999; 140: 5883-93.
    • (1999) Endocrinology , vol.140 , pp. 5883-5893
    • Chang, W.1    Tu, C.2    Chen, T.H.3
  • 71
    • 0034694833 scopus 로고    scopus 로고
    • Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line
    • Yamaguchi T, Chattopadhyay N, Kifor O, Sanders JL, Brown EM. Activation of p42/44 and p38 mitogen-activated protein kinases by extracellular calcium-sensing receptor agonists induces mitogenic responses in the mouse osteoblastic MC3T3-E1 cell line. Biochem Biophys Res Commun 2000; 279: 363-8.
    • (2000) Biochem Biophys Res Commun , vol.279 , pp. 363-368
    • Yamaguchi, T.1    Chattopadhyay, N.2    Kifor, O.3    Sanders, J.L.4    Brown, E.M.5
  • 72
    • 0035009373 scopus 로고    scopus 로고
    • Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line
    • Yamaguchi T, Chattopadhyay N, Kifor O, et al. Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line. Am J Physiol Cell Physiol 2001; 280: C382-93.
    • (2001) Am J Physiol Cell Physiol , vol.280
    • Yamaguchi, T.1    Chattopadhyay, N.2    Kifor, O.3
  • 73
    • 0034039641 scopus 로고    scopus 로고
    • Extracellular calcium-sensing-receptor (CaR)-mediated opening of an outward K(+) channel in murine MC3T3-E1 osteoblastic cells: Evidence for expression of a functional CaR
    • Ye CP, Yamaguchi T, Chattopadhyay N, Sanders JL, Vassilev PM, Brown EM. Extracellular calcium-sensing-receptor (CaR)-mediated opening of an outward K(+) channel in murine MC3T3-E1 osteoblastic cells: Evidence for expression of a functional CaR. Bone 2000; 27: 21-7.
    • (2000) Bone , vol.27 , pp. 21-27
    • Ye, C.P.1    Yamaguchi, T.2    Chattopadhyay, N.3    Sanders, J.L.4    Vassilev, P.M.5    Brown, E.M.6
  • 74
    • 0032772691 scopus 로고    scopus 로고
    • Failure to detect the extracellular calcium-sensing receptor (CasR) in human osteoblast cell lines
    • Pi M, Hinson TK, Quarles L. Failure to detect the extracellular calcium-sensing receptor (CasR) in human osteoblast cell lines. J Bone Miner Res 1999; 14: 1310-9.
    • (1999) J Bone Miner Res , vol.14 , pp. 1310-1319
    • Pi, M.1    Hinson, T.K.2    Quarles, L.3
  • 75
    • 0037449196 scopus 로고    scopus 로고
    • p44/42 MAPK activation is necessary for receptor activator of nuclear factor-kappaB ligand induction by high extracellular calcium
    • Kim YH, Kim JM, Kim SN, Kim GS, Baek JH. p44/42 MAPK activation is necessary for receptor activator of nuclear factor-kappaB ligand induction by high extracellular calcium. Biochem Biophys Res Commun 2003; 304: 729-35.
    • (2003) Biochem Biophys Res Commun , vol.304 , pp. 729-735
    • Kim, Y.H.1    Kim, J.M.2    Kim, S.N.3    Kim, G.S.4    Baek, J.H.5
  • 76
    • 0034602961 scopus 로고    scopus 로고
    • Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism
    • Pi M, Garner SC, Flannery P, Spurney RF, Quarles LD. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. J Biol Chem 2000; 275: 3256-63.
    • (2000) J Biol Chem , vol.275 , pp. 3256-3263
    • Pi, M.1    Garner, S.C.2    Flannery, P.3    Spurney, R.F.4    Quarles, L.D.5
  • 78
    • 0032540096 scopus 로고    scopus 로고
    • Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells
    • Kameda T, Mano H, Yamada Y, et al. Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells. Biochem Biophys Res Commun 1998; 245: 419-22.
    • (1998) Biochem Biophys Res Commun , vol.245 , pp. 419-422
    • Kameda, T.1    Mano, H.2    Yamada, Y.3
  • 79
    • 0033595148 scopus 로고    scopus 로고
    • High extracellular calcium inhibits osteoclast-like cell formation by directly acting on the calcium-sensing receptor existing in osteoclast precursor cells
    • Kanatani M, Sugimoto T, Kanzawa M, Yano S, Chihara K. High extracellular calcium inhibits osteoclast-like cell formation by directly acting on the calcium-sensing receptor existing in osteoclast precursor cells. Biochem Biophys Res Commun 1999; 261: 144-8.
    • (1999) Biochem Biophys Res Commun , vol.261 , pp. 144-148
    • Kanatani, M.1    Sugimoto, T.2    Kanzawa, M.3    Yano, S.4    Chihara, K.5
  • 81
    • 0034708166 scopus 로고    scopus 로고
    • High extracellular calcium concentrations directly stimulate osteoclast apoptosis
    • Lorget F, Kamel S, Mentaverri R, et al. High extracellular calcium concentrations directly stimulate osteoclast apoptosis. Biochem Biophys Res Commun 2000; 268: 899-903.
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 899-903
    • Lorget, F.1    Kamel, S.2    Mentaverri, R.3
  • 82
    • 0346363825 scopus 로고    scopus 로고
    • In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells
    • Shalhoub V, Grisanti M, Padagas J, et al. In vitro studies with the calcimimetic, cinacalcet HCl, on normal human adult osteoblastic and osteoclastic cells. Crit Rev Eukaryot Gene Expr 2003; 13: 89-106.
    • (2003) Crit Rev Eukaryot Gene Expr , vol.13 , pp. 89-106
    • Shalhoub, V.1    Grisanti, M.2    Padagas, J.3
  • 83
    • 0142210074 scopus 로고    scopus 로고
    • Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism
    • Tu Q, Pi M, Quarles LD. Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism. J Bone Miner Res 2003; 18: 1825-33.
    • (2003) J Bone Miner Res , vol.18 , pp. 1825-1833
    • Tu, Q.1    Pi, M.2    Quarles, L.D.3
  • 84
    • 0028845670 scopus 로고
    • A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    • Ho C, Conner DA, Pollak MR, et al. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 1995; 11: 389-94.
    • (1995) Nat Genet , vol.11 , pp. 389-394
    • Ho, C.1    Conner, D.A.2    Pollak, M.R.3
  • 85
    • 0034864513 scopus 로고    scopus 로고
    • Rickets in cation-sensing receptor-deficient mice: An unexpected skeletal phenotype
    • Garner SC, Pi M, Tu Q, Quarles LD. Rickets in cation-sensing receptor-deficient mice: An unexpected skeletal phenotype. Endocrinology 2001; 142: 3996-4005.
    • (2001) Endocrinology , vol.142 , pp. 3996-4005
    • Garner, S.C.1    Pi, M.2    Tu, Q.3    Quarles, L.D.4
  • 86
    • 0037382146 scopus 로고    scopus 로고
    • Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background
    • Tu Q, Pi M, Karsenty G, Simpson L, Liu S, Quarles LD. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest 2003; 111: 1029-37.
    • (2003) J Clin Invest , vol.111 , pp. 1029-1037
    • Tu, Q.1    Pi, M.2    Karsenty, G.3    Simpson, L.4    Liu, S.5    Quarles, L.D.6
  • 87
    • 0345505223 scopus 로고    scopus 로고
    • The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone
    • Kos CH, Karaplis AC, Peng JB, et al. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest 2003; 111: 1021-8.
    • (2003) J Clin Invest , vol.111 , pp. 1021-1028
    • Ch, K.1    Karaplis, A.C.2    Peng, J.B.3
  • 88
    • 0029813915 scopus 로고    scopus 로고
    • Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion
    • Freichel M, Zink-Lorenz A, Holloschi A, Hafner M, Flockerzi V, Raue F. Expression of a calcium-sensing receptor in a human medullary thyroid carcinoma cell line and its contribution to calcitonin secretion. Endocrinology 1996; 137: 3842-8.
    • (1996) Endocrinology , vol.137 , pp. 3842-3848
    • Freichel, M.1    Zink-Lorenz, A.2    Holloschi, A.3    Hafner, M.4    Flockerzi, V.5    Raue, F.6
  • 89
  • 90
    • 0042303745 scopus 로고    scopus 로고
    • Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells
    • Tfelt-Hansen J, MacLeod RJ, Chattopadhyay N, et al. Calcium-sensing receptor stimulates PTHrP release by pathways dependent on PKC, p38 MAPK, JNK, and ERK1/2 in H-500 cells. Am J Physiol Endocrinol Metab 2002; 285: E329-37.
    • (2002) Am J Physiol Endocrinol Metab , vol.285
    • Tfelt-Hansen, J.1    MacLeod, R.J.2    Chattopadhyay, N.3
  • 91
    • 0029990437 scopus 로고    scopus 로고
    • Calcium-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line
    • Emanuel RL, Adler GK, Kifor O, et al. Calcium-sensing receptor expression and regulation by extracellular calcium in the AtT-20 pituitary cell line. Mol Endocrinol 1996; 10: 555-65.
    • (1996) Mol Endocrinol , vol.10 , pp. 555-565
    • Emanuel, R.L.1    Adler, G.K.2    Kifor, O.3
  • 92
    • 0035083228 scopus 로고    scopus 로고
    • Mechanism of action of the calcium-sensing receptor in human antral gastrin cells
    • Buchan AM, Squires PE, Ring M, Meloche RM. Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterologe 2001; 120: 1128-39.
    • (2001) Gastroenterologe , vol.120 , pp. 1128-1139
    • Buchan, A.M.1    Squires, P.E.2    Ring, M.3    Meloche, R.M.4
  • 93
    • 0034006586 scopus 로고    scopus 로고
    • The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion
    • Squires PE, Harris TE, Persaud SJ, Curtis SB, Buchan AM, Jones PM. The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion. Diabetes 2000; 49: 409-17.
    • (2000) Diabetes , vol.49 , pp. 409-417
    • Squires, P.E.1    Harris, T.E.2    Persaud, S.J.3    Curtis, S.B.4    Buchan, A.M.5    Jones, P.M.6
  • 94
    • 0033842780 scopus 로고    scopus 로고
    • The extracellular calcium-sensing receptor in PHHI beta cells: Does reduced auto-inhibitory input contribute to hypersecretion of insulin?
    • Squires PE, Persaud SJ, Jones PM, Buchan AM. The extracellular calcium-sensing receptor in PHHI beta cells: Does reduced auto-inhibitory input contribute to hypersecretion of insulin? Diabetologia 2000; 43: 1078-80.
    • (2000) Diabetologia , vol.43 , pp. 1078-1080
    • Squires, P.E.1    Persaud, S.J.2    Jones, P.M.3    Buchan, A.M.4
  • 95
    • 0033326948 scopus 로고    scopus 로고
    • Expression of calcium-sensing receptor and characterization of intracellular signaling in human pituitary adenomas
    • Romoli R, Lania A, Mantovani G, Corbetta S, Persani L, Spada A. Expression of calcium-sensing receptor and characterization of intracellular signaling in human pituitary adenomas. J Clin Endocrinol Metab 1999; 84: 2848-53.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2848-2853
    • Romoli, R.1    Lania, A.2    Mantovani, G.3    Corbetta, S.4    Persani, L.5    Spada, A.6
  • 97
    • 0033378509 scopus 로고    scopus 로고
    • Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells
    • Chattopadhyay N, Ye CP, Yamaguchi T, Kerner R, Vassilev PM, Brown EM. Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells. Brain Res 1999; 851: 116-24.
    • (1999) Brain Res , vol.851 , pp. 116-124
    • Chattopadhyay, N.1    Ye, C.P.2    Yamaguchi, T.3    Kerner, R.4    Vassilev, P.M.5    Brown, E.M.6
  • 99
    • 0344825840 scopus 로고    scopus 로고
    • Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer
    • Tfelt-Hansen J, Schwarz P, Terwilliger EF, Brown EM, Chattopadhyay N. Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer. Endocrinology 2003; 144: 5188-93.
    • (2003) Endocrinology , vol.144 , pp. 5188-5193
    • Tfelt-Hansen, J.1    Schwarz, P.2    Terwilliger, E.F.3    Brown, E.M.4    Chattopadhyay, N.5
  • 100
    • 0034632058 scopus 로고    scopus 로고
    • Signal transduction mechanisms linking increased extracellular calcium to proliferation in ovarian surface epithelial cells
    • Hobson SA, McNeil SE, Lee F, Rodland KD. Signal transduction mechanisms linking increased extracellular calcium to proliferation in ovarian surface epithelial cells. Exp Cell Res 2000; 258: 1-11.
    • (2000) Exp Cell Res , vol.258 , pp. 1-11
    • Hobson, S.A.1    McNeil, S.E.2    Lee, F.3    Rodland, K.D.4
  • 101
    • 0031936174 scopus 로고    scopus 로고
    • Functional calcium-sensing receptor expression in ovarian surface epithelial cells
    • McNeil L, Hobson S, Nipper V, Rodland KD. Functional calcium-sensing receptor expression in ovarian surface epithelial cells. Am J Obstet Gynecol 1998; 178: 305-13.
    • (1998) Am J Obstet Gynecol , vol.178 , pp. 305-313
    • McNeil, L.1    Hobson, S.2    Nipper, V.3    Rodland, K.D.4
  • 102
    • 0031985158 scopus 로고    scopus 로고
    • Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium
    • McNeil SE, Hobson SA, Nipper V, Rodland KD. Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium. J Biol Chem 1998; 273: 1114-20.
    • (1998) J Biol Chem , vol.273 , pp. 1114-1120
    • McNeil, S.E.1    Hobson, S.A.2    Nipper, V.3    Rodland, K.D.4
  • 103
    • 0035947035 scopus 로고    scopus 로고
    • Calcium- and vitamin D-regulated keratinocyte differentiation
    • Bikle DD, Ng D, Tu CL, Oda Y, Xie Z. Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 2001; 177: 161-71.
    • (2001) Mol Cell Endocrinol , vol.177 , pp. 161-171
    • Bikle, D.D.1    Ng, D.2    Tu, C.L.3    Oda, Y.4    Xie, Z.5
  • 104
    • 0035798614 scopus 로고    scopus 로고
    • The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes
    • Tu CL, Chang W, Bikle DD. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J Biol Chem 2001; 276: 41079-85.
    • (2001) J Biol Chem , vol.276 , pp. 41079-41085
    • Tu, C.L.1    Chang, W.2    Bikle, D.D.3
  • 105
    • 0031764207 scopus 로고    scopus 로고
    • Identification and localization of the extracellular calcium-sensing receptor in human breast
    • Cheng I, Klingensmith ME, Chattopadhyay N, et al. Identification and localization of the extracellular calcium-sensing receptor in human breast. J Clin Endocrinol Metab 1998; 83: 703-7.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 703-707
    • Cheng, I.1    Klingensmith, M.E.2    Chattopadhyay, N.3
  • 106
    • 0032547239 scopus 로고    scopus 로고
    • Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor
    • Lin KI, Chattopadhyay N, Bai M, et al. Elevated extracellular calcium can prevent apoptosis via the calcium-sensing receptor. Biochem Biophys Res Commun 1998; 249: 325-31.
    • (1998) Biochem Biophys Res Commun , vol.249 , pp. 325-331
    • Lin, K.I.1    Chattopadhyay, N.2    Bai, M.3
  • 108
    • 0033776185 scopus 로고    scopus 로고
    • Intercellular communication mediated by the extracellular calcium-sensing receptor
    • Hofer AM, Curci S, Doble MA, Brown EM, Soybel DI. Intercellular communication mediated by the extracellular calcium-sensing receptor. Nat Cell Biol 2000; 2: 392-8.
    • (2000) Nat Cell Biol , vol.2 , pp. 392-398
    • Hofer, A.M.1    Curci, S.2    Doble, M.A.3    Brown, E.M.4    Soybel, D.I.5
  • 110
    • 17744369268 scopus 로고    scopus 로고
    • Familial hypercalcemia and hypercalciuria caused by a novel mutation in the cytoplasmic tail of the calcium receptor
    • Carling T, Szabo E, Bai M, et al. Familial hypercalcemia and hypercalciuria caused by a novel mutation in the cytoplasmic tail of the calcium receptor. J Clin Endocrinol Metab 2000; 85: 2042-7.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 2042-2047
    • Carling, T.1    Szabo, E.2    Bai, M.3
  • 111
    • 0035163266 scopus 로고    scopus 로고
    • An acceptor splice site mutation in the calcium-sensing receptor (CASR) gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    • [Ill] D'Souza-Li L, Canaff L, Janicic N, Cole DE, Hendy GN. An acceptor splice site mutation in the calcium-sensing receptor (CASR) gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Hum Mutat 2001; 18: 411-21.
    • (2001) Hum Mutat , vol.18 , pp. 411-421
    • D'Souza-Li, L.1    Canaff, L.2    Janicic, N.3    Cole, D.E.4    Hendy, G.N.5
  • 112
    • 0028940268 scopus 로고
    • 2+-sensing receptor gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    • 2+-sensing receptor gene in familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Am J Hum Genet 1995; 56: 880-6.
    • (1995) Am J Hum Genet , vol.56 , pp. 880-886
    • Janicic, N.1    Pausova, Z.2    Cole, D.E.3    Hendy, G.N.4
  • 113
    • 0028848215 scopus 로고
    • Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
    • Pearce SH, Trump D, Wooding C, et al. Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism. J Clin Invest 1995; 96: 2683-92.
    • (1995) J Clin Invest , vol.96 , pp. 2683-2692
    • Pearce, S.H.1    Trump, D.2    Wooding, C.3
  • 114
    • 0003436550 scopus 로고    scopus 로고
    • Center for Medical Genetics. John Hopkins University (Baltimore) and National Center for Biotechnology Information (Bethesda, MD)
    • 2004 On-line Mendelian Inheritance in Man (OMIM). Center for Medical Genetics. John Hopkins University (Baltimore) and National Center for Biotechnology Information. National Library of Medicine (Bethesda, MD). http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM
    • 2004 On-line Mendelian Inheritance in Man (OMIM)
  • 116
    • 0036141731 scopus 로고    scopus 로고
    • Familial isolated hyperparathyroidism: Clinical and genetic characteristics of 36 kindreds
    • Simonds WF, James-Newton LA, Agarwal SK, et al. Familial isolated hyperparathyroidism: Clinical and genetic characteristics of 36 kindreds. Medicine (Baltimore) 2002; 81: 1-26.
    • (2002) Medicine (Baltimore) , vol.81 , pp. 1-26
    • Simonds, W.F.1    James-Newton, L.A.2    Agarwal, S.K.3
  • 117
    • 12144288720 scopus 로고    scopus 로고
    • Genetic testing in familial isolated hyperparathyroidism: Unexpected results and their implications
    • Warner J, Epstein M, Sweet A, et al. Genetic testing in familial isolated hyperparathyroidism: Unexpected results and their implications. J Med Genet 2004: 41: 155-60.
    • (2004) J Med Genet , vol.41 , pp. 155-160
    • Warner, J.1    Epstein, M.2    Sweet, A.3
  • 118
    • 18744429143 scopus 로고
    • The gene responsible for familial hypocalciuric hypercalcemia maps to chromosome 3q in four unrelated families
    • Chou YH, Brown EM, Levi T, et al. The gene responsible for familial hypocalciuric hypercalcemia maps to chromosome 3q in four unrelated families. Nat Genet 1992; 1: 295-300.
    • (1992) Nat Genet , vol.1 , pp. 295-300
    • Chou, Y.H.1    Brown, E.M.2    Levi, T.3
  • 119
    • 9244231284 scopus 로고    scopus 로고
    • Clustered inactivating mutations and benign polymorphisms of the calcium receptor gene in familial benign hypocalciuric hypercalcemia suggest receptor functional domains
    • Heath H 3rd, Odelberg S, Jackson CE, et al. Clustered inactivating mutations and benign polymorphisms of the calcium receptor gene in familial benign hypocalciuric hypercalcemia suggest receptor functional domains. J Clin Endocrinol Metab 1996; 81: 1312-7.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1312-1317
    • Heath III, H.1    Odelberg, S.2    Jackson, C.E.3
  • 120
    • 0033366514 scopus 로고    scopus 로고
    • Localization of familial benign hypercalcemia, Oklahoma variant (FBHOk), to chromosome 19ql3
    • Lloyd SE, Pannett AA, Dixon PH, Whyte MP, Thakker RV. Localization of familial benign hypercalcemia, Oklahoma variant (FBHOk), to chromosome 19ql3. Am J Hum Genet 1999; 64: 189-95.
    • (1999) Am J Hum Genet , vol.64 , pp. 189-195
    • Lloyd, S.E.1    Pannett, A.A.2    Dixon, P.H.3    Whyte, M.P.4    Thakker, R.V.5
  • 121
    • 0027787680 scopus 로고
    • 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
    • 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 1993; 75: 1297-303.
    • (1993) Cell , vol.75 , pp. 1297-1303
    • Pollak, M.R.1    Brown, E.M.2    Chou, Y.H.3
  • 122
    • 0033020243 scopus 로고    scopus 로고
    • Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function
    • Bai M, Trivedi S, Kifor O, Quinn SJ, Brown EM. Intermolecular interactions between dimeric calcium-sensing receptor monomers are important for its normal function. Proc Natl Acad Sci USA 1999; 96: 2834-9.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 2834-2839
    • Bai, M.1    Trivedi, S.2    Kifor, O.3    Quinn, S.J.4    Brown, E.M.5
  • 124
    • 0028220464 scopus 로고
    • Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype
    • Pollak MR, Chou YH, Marx SJ, et al. Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype. J Clin Invest 1994; 93: 1108-12.
    • (1994) J Clin Invest , vol.93 , pp. 1108-1112
    • Pollak, M.R.1    Chou, Y.H.2    Marx, S.J.3
  • 125
    • 0030743057 scopus 로고    scopus 로고
    • Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism
    • Kobayashi M, Tanaka H, Tsuzuki K, et al. Two novel missense mutations in calcium-sensing receptor gene associated with neonatal severe hyperparathyroidism. J Clin Endocrinol Metab 1997; 82: 2716-9.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2716-2719
    • Kobayashi, M.1    Tanaka, H.2    Tsuzuki, K.3
  • 126
    • 0035176619 scopus 로고    scopus 로고
    • Activating mutations of the calcium-sensing receptor: Management of hypocalcemia
    • Lienhardt A, Bai M, Lagarde JP, et al. Activating mutations of the calcium-sensing receptor: Management of hypocalcemia. J Clin Endocrinol Metab 2001; 86: 5313-23.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5313-5323
    • Lienhardt, A.1    Bai, M.2    Lagarde, J.P.3
  • 127
    • 0028074712 scopus 로고
    • Preliminary localization of a gene for autosomal dominant hypoparathyroidism to chromosome 3ql3
    • Finegold DN, Armitage MM, Galiani M, et al. Preliminary localization of a gene for autosomal dominant hypoparathyroidism to chromosome 3ql3. Pediatr Res 1994; 36: 414-7.
    • (1994) Pediatr Res , vol.36 , pp. 414-417
    • Finegold, D.N.1    Armitage, M.M.2    Galiani, M.3
  • 129
    • 10144256536 scopus 로고    scopus 로고
    • A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor
    • Pearce SH, Williamson C, Kifor O, et al. A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor. N Engl J Med 1996; 335: 1115-22.
    • (1996) N Engl J Med , vol.335 , pp. 1115-1122
    • Pearce, S.H.1    Williamson, C.2    Kifor, O.3
  • 130
    • 0029967961 scopus 로고    scopus 로고
    • Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells
    • Pearce SH, Bai M, Quimi SJ, Kifor O, Brown EM, Thakker RV. Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells. J Clin Invest 1996; 98: 1860-6.
    • (1996) J Clin Invest , vol.98 , pp. 1860-1866
    • Pearce, S.H.1    Bai, M.2    Quimi, S.J.3    Kifor, O.4    Brown, E.M.5    Thakker, R.V.6
  • 131
    • 0036959850 scopus 로고    scopus 로고
    • Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia
    • D'Souza-Li L, Yang B, Canaff L, et al. Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. J Clin Endocrinol Metab 2002; 87: 1309-18.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1309-1318
    • D'Souza-Li, L.1    Yang, B.2    Canaff, L.3
  • 132
    • 0035110928 scopus 로고    scopus 로고
    • A novel activating mutation (C129S) in the calcium-sensing receptor gene in a japanese family with autosomal dominant hypocalcemia
    • Hirai H, Nakajima S, Miyauchi A, et al. A novel activating mutation (C129S) in the calcium-sensing receptor gene in a Japanese family with autosomal dominant hypocalcemia. J Hum Genet 2001; 46: 41-4.
    • (2001) J Hum Genet , vol.46 , pp. 41-44
    • Hirai, H.1    Nakajima, S.2    Miyauchi, A.3
  • 133
    • 0031027244 scopus 로고    scopus 로고
    • 2+-sensing receptor gene: Normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial benign hypocalciuric hypercalcemia
    • 2+-sensing receptor gene: Normal maternal calcium homeostasis as a cause of secondary hyperparathyroidism in familial benign hypocalciuric hypercalcemia. J Clin Invest 1997; 99: 88-96.
    • (1997) J Clin Invest , vol.99 , pp. 88-96
    • Bai, M.1    Pearce, S.H.2    Kifor, O.3
  • 134
    • 0020075824 scopus 로고
    • An association between neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia in three kindreds
    • Marx SJ, Attie MF, Spiegel AM, Levine MA, Lasker RD, Fox M. An association between neonatal severe primary hyperparathyroidism and familial hypocalciuric hypercalcemia in three kindreds. N Engl J Med 1982; 306: 257-64.
    • (1982) N Engl J Med , vol.306 , pp. 257-264
    • Marx, S.J.1    Attie, M.F.2    Spiegel, A.M.3    Levine, M.A.4    Lasker, R.D.5    Fox, M.6
  • 135
    • 0024422565 scopus 로고
    • Familial benign (hypocalciuric) hypercalcemia. A troublesome mimic of mild primary hyperparathyroidism
    • Heath H 3rd. Familial benign (hypocalciuric) hypercalcemia. A troublesome mimic of mild primary hyperparathyroidism. Endocrinol Metab Clin North Am 1989; 18: 723-40.
    • (1989) Endocrinol Metab Clin North Am , vol.18 , pp. 723-740
    • Heath III, H.1
  • 136
    • 0021247453 scopus 로고
    • Altered parathyroid set point to calcium in familial hypocalciuric hypercalcaemia
    • Auwerx J, Demedts M, Bouillon R. Altered parathyroid set point to calcium in familial hypocalciuric hypercalcaemia. Acta Endocrinol (Copenh) 1984; 106: 215-8.
    • (1984) Acta Endocrinol (Copenh) , vol.106 , pp. 215-218
    • Auwerx, J.1    Demedts, M.2    Bouillon, R.3
  • 137
    • 0027522832 scopus 로고
    • Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism
    • Khosla S, Ebeling PR, Firek AF, Burritt MM, Kao PC, Heath H 3rd. Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism. J Clin Endocrinol Metab 1993; 76: 715-20.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 715-720
    • Khosla, S.1    Ebeling, P.R.2    Firek, A.F.3    Burritt, M.M.4    Kao, P.C.5    Heath III, H.6
  • 138
    • 0033082906 scopus 로고    scopus 로고
    • Physiology and pathophysiology of the extracellular calcium-sensing receptor
    • Brown EM. Physiology and pathophysiology of the extracellular calcium-sensing receptor. Am J Med 1999; 106: 238-53.
    • (1999) Am J Med , vol.106 , pp. 238-253
    • Brown, E.M.1
  • 139
    • 0019765009 scopus 로고
    • Maximal urine-concentrating ability: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism
    • Marx SJ, Attie MF, Stock JL, Spiegel AM, Levine MA. Maximal urine-concentrating ability: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism. J Clin Endocrinol Metab 1981; 52: 736-40.
    • (1981) J Clin Endocrinol Metab , vol.52 , pp. 736-740
    • Marx, S.J.1    Attie, M.F.2    Stock, J.L.3    Spiegel, A.M.4    Levine, M.A.5
  • 140
    • 0036962244 scopus 로고    scopus 로고
    • Parathyroid adenoma in a subject with familial hypocalciuric hypercalcemia: Coincidence or causality?
    • Burski K, Torjussen B, Paulsen AQ, Boman H, Bollerslev J. Parathyroid adenoma in a subject with familial hypocalciuric hypercalcemia: Coincidence or causality? J Clin Endocrinol Metab 2002; 87: 1015-6.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1015-1016
    • Burski, K.1    Torjussen, B.2    Paulsen, A.Q.3    Boman, H.4    Bollerslev, J.5
  • 141
    • 0035199744 scopus 로고    scopus 로고
    • Inactivating mutations of calcium-sensing receptor results in parathyroid lipohyperplasia
    • Fukumoto S, Chikatsu N, Okazaki R, et al. Inactivating mutations of calcium-sensing receptor results in parathyroid lipohyperplasia. Diagn Mol Pathol 2001; 10: 242-7.
    • (2001) Diagn Mol Pathol , vol.10 , pp. 242-247
    • Fukumoto, S.1    Chikatsu, N.2    Okazaki, R.3
  • 142
    • 0036894681 scopus 로고    scopus 로고
    • Familial hypocalciuric hypercalcemia caused by an R648stop mutation in the calcium-sensing receptor gene
    • Yamauchi M, Sugimoto T, Yamaguchi T, et al. Familial hypocalciuric hypercalcemia caused by an R648stop mutation in the calcium-sensing receptor gene. J Bone Miner Res 2002; 17: 2174-82.
    • (2002) J Bone Miner Res , vol.17 , pp. 2174-2182
    • Yamauchi, M.1    Sugimoto, T.2    Yamaguchi, T.3
  • 143
    • 0030744407 scopus 로고    scopus 로고
    • Neonatal severe hyperparathyroidism, secondary hyperparathyroidism, and familial hypocalciuric hypercalcemia: Multiple different phenotypes associated with an inactivating Alu insertion mutation of the calcium-sensing receptor gene
    • Cole DE, Janicic N, Salisbury SR, Hendy GN. Neonatal severe hyperparathyroidism, secondary hyperparathyroidism, and familial hypocalciuric hypercalcemia: Multiple different phenotypes associated with an inactivating Alu insertion mutation of the calcium-sensing receptor gene. Am J Med Genet 1997; 71: 202-10.
    • (1997) Am J Med Genet , vol.71 , pp. 202-210
    • Cole, D.E.1    Janicic, N.2    Salisbury, S.R.3    Hendy, G.N.4
  • 144
    • 0015904472 scopus 로고
    • Roentgenographic features of "primary" hyperparathyroidism in infancy
    • Grantmyre EB. Roentgenographic features of "primary" hyperparathyroidism in infancy. J Can Assoc Radiol 1973; 24: 257-60.
    • (1973) J Can Assoc Radiol , vol.24 , pp. 257-260
    • Grantmyre, E.B.1
  • 145
    • 0019950870 scopus 로고
    • Primary infantile hyperparathyroidism: Clinical, laboratory, and radiographic features in 21 cases
    • Eftekhari F, Yousefzadeh DK. Primary infantile hyperparathyroidism: Clinical, laboratory, and radiographic features in 21 cases. Skeletal Radiol 1982; 8: 201-8.
    • (1982) Skeletal Radiol , vol.8 , pp. 201-208
    • Eftekhari, F.1    Yousefzadeh, D.K.2
  • 147
    • 0034485333 scopus 로고    scopus 로고
    • Comparison of hypocalcemic hypercalciuria between patients with idiopathic hypoparathyroidism and those with gain-of-function mutations in the calcium-sensing receptor: Is it possible to differentiate the two disorders?
    • Yamamoto M, Akatsu T, Nagase T, Ogata E. Comparison of hypocalcemic hypercalciuria between patients with idiopathic hypoparathyroidism and those with gain-of-function mutations in the calcium-sensing receptor: Is it possible to differentiate the two disorders? J Clin Endocrinol Metab 2000; 85: 4583-91.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4583-4591
    • Yamamoto, M.1    Akatsu, T.2    Nagase, T.3    Ogata, E.4
  • 148
    • 0032906973 scopus 로고    scopus 로고
    • A novel activating mutation in calcium-sensing receptor gene associated with a family of autosomal dominant hypocalcemia
    • Okazaki R, Chikatsu N, Nakatsu M, et al. A novel activating mutation in calcium-sensing receptor gene associated with a family of autosomal dominant hypocalcemia. J Clin Endocrinol Metab 1999; 84: 363-6.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 363-366
    • Okazaki, R.1    Chikatsu, N.2    Nakatsu, M.3
  • 149
    • 0036707879 scopus 로고    scopus 로고
    • Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome
    • Vargas-Poussou R, Huang C, Hulin P, et al. Functional characterization of a calcium-sensing receptor mutation in severe autosomal dominant hypocalcemia with a Bartter-like syndrome. J Am Soc Nephrol 2002; 13: 2259-66.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2259-2266
    • Vargas-Poussou, R.1    Huang, C.2    Hulin, P.3
  • 150
    • 0037206034 scopus 로고    scopus 로고
    • Association between activating mutations of calcium-sensing receptor and Bartter's syndrome
    • Watanabe S, Fukumoto S, Chang H, et al. Association between activating mutations of calcium-sensing receptor and Bartter's syndrome. Lancet 2002; 360: 692-4.
    • (2002) Lancet , vol.360 , pp. 692-694
    • Watanabe, S.1    Fukumoto, S.2    Chang, H.3
  • 151
    • 0014047474 scopus 로고
    • The incidence of adrenal and other antibodies in the sera of patients with idiopathic adrenal insufficiency (Addison's disease)
    • Blizzard RM, Chee D, Davis W. The incidence of adrenal and other antibodies in the sera of patients with idiopathic adrenal insufficiency (Addison's disease). Clin Exp Immunol 1967; 2: 19-30.
    • (1967) Clin Exp Immunol , vol.2 , pp. 19-30
    • Blizzard, R.M.1    Chee, D.2    Davis, W.3
  • 152
    • 0022788111 scopus 로고
    • Parathyroid cell surface autoantibodies that inhibit parathyroid hormone secretion from dispersed human parathyroid cells
    • Posillico JT, Wortsman J, Srikanta S, Eisenbarth GS, Mallette LE, Brown EM. Parathyroid cell surface autoantibodies that inhibit parathyroid hormone secretion from dispersed human parathyroid cells. J Bone Miner Res 1986; 1: 475-83.
    • (1986) J Bone Miner Res , vol.1 , pp. 475-483
    • Posillico, J.T.1    Wortsman, J.2    Srikanta, S.3    Eisenbarth, G.S.4    Mallette, L.E.5    Brown, E.M.6
  • 153
    • 0030051024 scopus 로고    scopus 로고
    • Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism
    • Li Y, Song YH, Rais N, et al. Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism. J Clin Invest 1996; 97: 910-4.
    • (1996) J Clin Invest , vol.97 , pp. 910-914
    • Li, Y.1    Song, Y.H.2    Rais, N.3
  • 154
    • 1442327820 scopus 로고    scopus 로고
    • Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism
    • Kifor O, McElduff A, LeBoff MS, et al. Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab 2004; 89: 548-56.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 548-556
    • Kifor, O.1    McElduff, A.2    Leboff, M.S.3
  • 155
    • 0742289430 scopus 로고    scopus 로고
    • Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism
    • Goswami R, Brown EM, Kochupillai N, et al. Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism. Eur J Endocrinol 2004; 150: 9-18.
    • (2004) Eur J Endocrinol , vol.150 , pp. 9-18
    • Goswami, R.1    Brown, E.M.2    Kochupillai, N.3
  • 156
    • 10744233772 scopus 로고    scopus 로고
    • Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I
    • Soderbergh A, Myhre AG, Ekwall O, et al. Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I. J Clin Endocrinol Metab 2004; 89: 557-62.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 557-562
    • Soderbergh, A.1    Myhre, A.G.2    Ekwall, O.3
  • 157
    • 0037244847 scopus 로고    scopus 로고
    • A syndrome of hypocalciuric hypercalcemia caused by autoantibodies
    • Kifor O, Moore FD Jr, Delaney M, et al. A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. J Clin Endocrinol Metab 2003; 88: 60-72.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 60-72
    • Kifor, O.1    Moore Jr., F.D.2    Delaney, M.3
  • 159
    • 0037853212 scopus 로고    scopus 로고
    • Decreased expression of calcium receptor in parathyroid tissue in patients with hyperparathyroidism secondary to chronic renal failure
    • Martin-Salvago M, Villar-Rodriguez JL, Palma-Alvarez A, Beato-Moreno A, Galera-Davidson H. Decreased expression of calcium receptor in parathyroid tissue in patients with hyperparathyroidism secondary to chronic renal failure. Endocr Pathol 2003; 14: 61-70.
    • (2003) Endocr Pathol , vol.14 , pp. 61-70
    • Martin-Salvago, M.1    Villar-Rodriguez, J.L.2    Palma-Alvarez, A.3    Beato-Moreno, A.4    Galera-Davidson, H.5
  • 160
    • 0038069520 scopus 로고    scopus 로고
    • Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas
    • Yano S, Sugimoto T, Tsukamoto T, et al. Decrease in vitamin D receptor and calcium-sensing receptor in highly proliferative parathyroid adenomas. Eur J Endocrinol 2003; 148: 403-11.
    • (2003) Eur J Endocrinol , vol.148 , pp. 403-411
    • Yano, S.1    Sugimoto, T.2    Tsukamoto, T.3
  • 161
    • 0034783848 scopus 로고    scopus 로고
    • Heterogeneous expression of receptor mRNAs in parathyroid glands of secondary hyperparathyroidism
    • Valimaki S, Farnebo F, Forsberg L, Larsson C, Farnebo LO. Heterogeneous expression of receptor mRNAs in parathyroid glands of secondary hyperparathyroidism. Kidney Int 2001; 60: 1666-75.
    • (2001) Kidney Int , vol.60 , pp. 1666-1675
    • Valimaki, S.1    Farnebo, F.2    Forsberg, L.3    Larsson, C.4    Farnebo, L.O.5
  • 162
    • 0031042732 scopus 로고    scopus 로고
    • Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism
    • Gogusev J, Duchambon P, Hory B, et al. Depressed expression of calcium receptor in parathyroid gland tissue of patients with hyperparathyroidism. Kidney Int 1997; 51: 328-36.
    • (1997) Kidney Int , vol.51 , pp. 328-336
    • Gogusev, J.1    Duchambon, P.2    Hory, B.3
  • 163
    • 0030986465 scopus 로고    scopus 로고
    • Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism
    • Farnebo F, Enberg U, Grimelius L, et al. Tumor-specific decreased expression of calcium sensing receptor messenger ribonucleic acid in sporadic primary hyperparathyroidism. J Clin Endocrinol Metab 1997; 82: 3481-6.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3481-3486
    • Farnebo, F.1    Enberg, U.2    Grimelius, L.3
  • 164
    • 0029873489 scopus 로고    scopus 로고
    • 2+-sensing receptor in primary and uremic secondary hyperparathyroidism
    • 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab 1996; 81: 1598-606.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1598-1606
    • Kifor, O.1    Moore Jr., F.D.2    Wang, P.3
  • 166
  • 167
    • 0032918925 scopus 로고    scopus 로고
    • Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: Role of dietary phosphate
    • Brown AJ, Ritter CS, Finch JL, Slatopolsky EA. Decreased calcium-sensing receptor expression in hyperplastic parathyroid glands of uremic rats: Role of dietary phosphate. Kidney Int 1999; 55: 1284-92.
    • (1999) Kidney Int , vol.55 , pp. 1284-1292
    • Brown, A.J.1    Ritter, C.S.2    Finch, J.L.3    Slatopolsky, E.A.4
  • 168
    • 0033753656 scopus 로고    scopus 로고
    • Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism
    • Yano S, Sugimoto T, Tsukamoto T, et al. Association of decreased calcium-sensing receptor expression with proliferation of parathyroid cells in secondary hyperparathyroidism. Kidney Int 2000; 58: 1980-6.
    • (2000) Kidney Int , vol.58 , pp. 1980-1986
    • Yano, S.1    Sugimoto, T.2    Tsukamoto, T.3
  • 169
    • 0034778610 scopus 로고    scopus 로고
    • Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor
    • Ritter CS, Finch JL, Slatopolsky KA, Brown AJ. Parathyroid hyperplasia in uremic rats precedes down-regulation of the calcium receptor. Kidney Int 2001; 60: 1737-44.
    • (2001) Kidney Int , vol.60 , pp. 1737-1744
    • Ritter, C.S.1    Finch, J.L.2    Slatopolsky, K.A.3    Brown, A.J.4
  • 170
    • 0036895625 scopus 로고    scopus 로고
    • Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function
    • Ritter CS, Martin DR, Lu Y, Slatopolsky E, Brown AJ. Reversal of secondary hyperparathyroidism by phosphate restriction restores parathyroid calcium-sensing receptor expression and function. J Bone Miner Res 2002; 17: 2206-13.
    • (2002) J Bone Miner Res , vol.17 , pp. 2206-2213
    • Ritter, C.S.1    Martin, D.R.2    Lu, Y.3    Slatopolsky, E.4    Brown, A.J.5
  • 171
    • 0036066178 scopus 로고    scopus 로고
    • Persistent downregulation of calcium-sensing receptor mRNA in rat parathyroids when severe secondary hyperparathyroidism is reversed by an isogenic kidney transplantation
    • Lewin E, Garfia B, Recio FL, Rodriguez M, Olgaard K. Persistent downregulation of calcium-sensing receptor mRNA in rat parathyroids when severe secondary hyperparathyroidism is reversed by an isogenic kidney transplantation. J Am Soc Nephrol 2002; 13: 2110-6.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2110-2116
    • Lewin, E.1    Garfia, B.2    Recio, F.L.3    Rodriguez, M.4    Olgaard, K.5
  • 172
    • 0033537347 scopus 로고    scopus 로고
    • A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations
    • Cole DE, Peltekova VD, Rubin LA, et al. A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations. Lancet 1999; 353: 112-5.
    • (1999) Lancet , vol.353 , pp. 112-115
    • Cole, D.E.1    Peltekova, V.D.2    Rubin, L.A.3
  • 173
    • 0035718923 scopus 로고    scopus 로고
    • Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene
    • Cole DE, Vieth R, Trang HM, Wong BY, Hnidy GN, Rubin KA. Association between total serum calcium and the A986S polymorphism of the calcium-sensing receptor gene. Mol Genet Metab 2001; 72: 168-74.
    • (2001) Mol Genet Metab , vol.72 , pp. 168-174
    • Cole, D.E.1    Vieth, R.2    Trang, H.M.3    Wong, B.Y.4    Hnidy, G.N.5    Rubin, K.A.6
  • 174
    • 0033848709 scopus 로고    scopus 로고
    • Association of polymorphic alleles of the calcium-sensing receptor gene with parathyroid hormone secretion in hemodialysis patients
    • Yano S, Sugimoto T, Kanzawa M, et al. Association of polymorphic alleles of the calcium-sensing receptor gene with parathyroid hormone secretion in hemodialysis patients. Nephron 2000; 85: 317-23.
    • (2000) Nephron , vol.85 , pp. 317-323
    • Yano, S.1    Sugimoto, T.2    Kanzawa, M.3
  • 175
    • 0035063797 scopus 로고    scopus 로고
    • Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls
    • Lorentzon M, Lorentzon R, Lerner UH, Nordstrom P. Calcium sensing receptor gene polymorphism, circulating calcium concentrations and bone mineral density in healthy adolescent girls. Eur J Endocrinol 2001; 144: 257-61.
    • (2001) Eur J Endocrinol , vol.144 , pp. 257-261
    • Lorentzon, M.1    Lorentzon, R.2    Lerner, U.H.3    Nordstrom, P.4
  • 176
    • 0036063742 scopus 로고    scopus 로고
    • Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism
    • Cetani F, Borsari S, Vignali E, et al. Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism. J Endocrinol Invest 2002; 25: 614-9.
    • (2002) J Endocrinol Invest , vol.25 , pp. 614-619
    • Cetani, F.1    Borsari, S.2    Vignali, E.3
  • 177
    • 0037531251 scopus 로고    scopus 로고
    • Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women
    • Cetani F, Pardi E, Borsari S, et al. Calcium-sensing receptor gene polymorphism is not associated with bone mineral density in Italian postmenopausal women. Eur J Endocrinol 2003; 148: 603-7.
    • (2003) Eur J Endocrinol , vol.148 , pp. 603-607
    • Cetani, F.1    Pardi, E.2    Borsari, S.3
  • 178
    • 0033962445 scopus 로고    scopus 로고
    • Association of bone mineral density with polymorphism of the human calcium-sensing receptor locus
    • Tsukamoto K, Orimo H, Hosoi T, et al. Association of bone mineral density with polymorphism of the human calcium-sensing receptor locus. Calcif Tissue Int 2000; 66: 181-3.
    • (2000) Calcif Tissue Int , vol.66 , pp. 181-183
    • Tsukamoto, K.1    Orimo, H.2    Hosoi, T.3
  • 179
    • 0034845674 scopus 로고    scopus 로고
    • Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism
    • Yamauchi M, Sugimoto T, Yamaguchi T, et al. Association of polymorphic alleles of the calcium-sensing receptor gene with the clinical severity of primary hyperparathyroidism. Clin Endocrinol (Oxf) 2001; 55: 373-9.
    • (2001) Clin Endocrinol (Oxf) , vol.55 , pp. 373-379
    • Yamauchi, M.1    Sugimoto, T.2    Yamaguchi, T.3
  • 180
    • 0036166832 scopus 로고    scopus 로고
    • Calcium-sensing receptor gene polymorphism affects the parathyroid response to moderate hypercalcemic suppression in patients with end-stage renal disease
    • Yokoyama K, Shigematsu T, Tsukada T, et al. Calcium-sensing receptor gene polymorphism affects the parathyroid response to moderate hypercalcemic suppression in patients with end-stage renal disease. Clin Nephrol 2002; 57: 131-5.
    • (2002) Clin Nephrol , vol.57 , pp. 131-135
    • Yokoyama, K.1    Shigematsu, T.2    Tsukada, T.3
  • 181
    • 0033287568 scopus 로고    scopus 로고
    • Calcium-induced activation of a mutant G-protein-coupled receptor causes in vitro transformation of NIH/3T3 cells
    • Hoff AO, Cote GJ, Fritsche HA Jr, Qiu H, Schultz PN, Gagel RF. Calcium-induced activation of a mutant G-protein-coupled receptor causes in vitro transformation of NIH/3T3 cells. Neoplasia 1999; 1: 485-91.
    • (1999) Neoplasia , vol.1 , pp. 485-491
    • Hoff, A.O.1    Cote, G.J.2    Fritsche Jr., H.A.3    Qiu, H.4    Schultz, P.N.5    Gagel, R.F.6
  • 182
    • 0033934254 scopus 로고    scopus 로고
    • Dietary calcium and growth modulation of human colon cancer cells: Role of the extracellular calcium-sensing receptor
    • Kallay E, Bajna E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Dietary calcium and growth modulation of human colon cancer cells: Role of the extracellular calcium-sensing receptor. Cancer Detect Prev 2000; 24: 127-36.
    • (2000) Cancer Detect Prev , vol.24 , pp. 127-136
    • Kallay, E.1    Bajna, E.2    Wrba, F.3    Kriwanek, S.4    Peterlik, M.5    Cross, H.S.6
  • 183
    • 0031555878 scopus 로고    scopus 로고
    • Calcium-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: A role for a luminal extracellular calcium-sensing receptor
    • Kallay E, Kifor O, Chattopadhyay N, et al. Calcium-dependent c-myc proto-oncogene expression and proliferation of Caco-2 cells: A role for a luminal extracellular calcium-sensing receptor. Biochem Biophys Res Commun 1997; 232: 80-3.
    • (1997) Biochem Biophys Res Commun , vol.232 , pp. 80-83
    • Kallay, E.1    Kifor, O.2    Chattopadhyay, N.3
  • 184
    • 0342314479 scopus 로고    scopus 로고
    • Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa
    • Sheinin Y, Kallay E, Wrba F, Kriwanek S, Peterlik M, Cross HS. Immunocytochemical localization of the extracellular calcium-sensing receptor in normal and malignant human large intestinal mucosa. J Histochem Cytochem 2000; 48: 595-602.
    • (2000) J Histochem Cytochem , vol.48 , pp. 595-602
    • Sheinin, Y.1    Kallay, E.2    Wrba, F.3    Kriwanek, S.4    Peterlik, M.5    Cross, H.S.6
  • 185
    • 0842305872 scopus 로고    scopus 로고
    • Molecular and functional characterization of the extracellular calcium-sensing receptor in human colon cancer cells
    • Kallay E, Bonner E, Wrba F, Thakker RV, Peterlik M, Cross HS. Molecular and functional characterization of the extracellular calcium-sensing receptor in human colon cancer cells. Oncol Res 2003; 13: 551-9.
    • (2003) Oncol Res , vol.13 , pp. 551-559
    • Kallay, E.1    Bonner, E.2    Wrba, F.3    Thakker, R.V.4    Peterlik, M.5    Cross, H.S.6
  • 186
    • 0037224244 scopus 로고    scopus 로고
    • Extracellular calcium and calcium sensing receptor function in human colon carcinomas: Promotion of E-cadherin expression and suppression of beta-catenin/TCF activation
    • Chakrabarty S, Radjendirane V, Appelman H, Varani J. Extracellular calcium and calcium sensing receptor function in human colon carcinomas: Promotion of E-cadherin expression and suppression of beta-catenin/TCF activation. Cancer Res 2003; 63: 67-71.
    • (2003) Cancer Res , vol.63 , pp. 67-71
    • Chakrabarty, S.1    Radjendirane, V.2    Appelman, H.3    Varani, J.4
  • 188
    • 0035976856 scopus 로고    scopus 로고
    • Human gastrinoma cells express calcium-sensing receptor
    • Itami A, Kato M, Komoto I, et al. Human gastrinoma cells express calcium-sensing receptor. Life Sci 2001; 70: 119-29.
    • (2001) Life Sci , vol.70 , pp. 119-129
    • Itami, A.1    Kato, M.2    Komoto, I.3
  • 189
    • 0034129676 scopus 로고    scopus 로고
    • Calcium stimulates parathyroid hormone-related protein production in Leydig tumor cells through a putative cation-sensing mechanism
    • Buchs N, Manen D, Bonjour JP, Rizzoli R. Calcium stimulates parathyroid hormone-related protein production in Leydig tumor cells through a putative cation-sensing mechanism. Eur J Endocrinol 2000; 142: 500-5.
    • (2000) Eur J Endocrinol , vol.142 , pp. 500-505
    • Buchs, N.1    Manen, D.2    Bonjour, J.P.3    Rizzoli, R.4
  • 190
    • 0034673543 scopus 로고    scopus 로고
    • Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy
    • Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Brown EM. Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy. Biochem Biophys Res Commun 2000; 269: 427-32.
    • (2000) Biochem Biophys Res Commun , vol.269 , pp. 427-432
    • Sanders, J.L.1    Chattopadhyay, N.2    Kifor, O.3    Yamaguchi, T.4    Brown, E.M.5
  • 193
    • 0034526037 scopus 로고    scopus 로고
    • Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines
    • Sanders JL, Chattopadhyay N, Kifor O, Yamaguchi T, Butters RR, Brown EM. Extracellular calcium-sensing receptor expression and its potential role in regulating parathyroid hormone-related peptide secretion in human breast cancer cell lines. Endocrinology 2000; 141: 4357-64.
    • (2000) Endocrinology , vol.141 , pp. 4357-4364
    • Sanders, J.L.1    Chattopadhyay, N.2    Kifor, O.3    Yamaguchi, T.4    Butters, R.R.5    Brown, E.M.6
  • 194
    • 0032584086 scopus 로고    scopus 로고
    • Calcimimetics with potent and selective activity on the parathyroid calcium receptor
    • Nemeth EF, Steffey ME, Hammerland LG, et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proc Natl acad Sci USA 1998; 95: 4040-5.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4040-4045
    • Nemeth, E.F.1    Steffey, M.E.2    Hammerland, L.G.3
  • 195
    • 0030877460 scopus 로고    scopus 로고
    • Stimulation of cell proliferation by calcium and a calcimimetic compound
    • Mailland M, Waelchli R, Ruat M, Boddeke HG, Seuwen K. Stimulation of cell proliferation by calcium and a calcimimetic compound. Endocrinology 1997; 138: 3601-5.
    • (1997) Endocrinology , vol.138 , pp. 3601-3605
    • Mailland, M.1    Waelchli, R.2    Ruat, M.3    Boddeke, H.G.4    Seuwen, K.5
  • 196
    • 0030667380 scopus 로고    scopus 로고
    • Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism
    • Silverberg SJ, Bone HG 3rd, Marriott TB, et al. Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism. N Engl J Med 1997; 337: 1506-10.
    • (1997) N Engl J Med , vol.337 , pp. 1506-1510
    • Silverberg, S.J.1    Bone III, H.G.2    Marriott, T.B.3
  • 199
    • 0037378029 scopus 로고    scopus 로고
    • Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors
    • Ogata H, Ritz E, Odoni G, Amann K, Orth SR. Beneficial effects of calcimimetics on progression of renal failure and cardiovascular risk factors. J Am Soc Nephrol 2003; 14: 959-67.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 959-967
    • Ogata, H.1    Ritz, E.2    Odoni, G.3    Amann, K.4    Orth, S.R.5
  • 202
    • 0033998869 scopus 로고    scopus 로고
    • Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism
    • Wada M, Nagano N, Furuya Y, Chin J, Nemeth EF, Fox J. Calcimimetic NPS R-568 prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism. Kidney Int 2000; 57: 50-8.
    • (2000) Kidney Int , vol.57 , pp. 50-58
    • Wada, M.1    Nagano, N.2    Furuya, Y.3    Chin, J.4    Nemeth, E.F.5    Fox, J.6
  • 203
    • 0031466527 scopus 로고    scopus 로고
    • The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor
    • Wada M, Furuya Y, Sakiyama J, et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. J Clin Invest l997; 100: 2977-83.
    • (1997) J Clin Invest , vol.100 , pp. 2977-2983
    • Wada, M.1    Furuya, Y.2    Sakiyama, J.3
  • 204
    • 0032985183 scopus 로고    scopus 로고
    • The calcimimetic NPS R-568 decreases plasma PTH in rats with mild and severe renal or dietary secondary hyperparathyroidism
    • Fox J, Lowe SH, Conklhi RL, Nemeth EF. The calcimimetic NPS R-568 decreases plasma PTH in rats with mild and severe renal or dietary secondary hyperparathyroidism. Endocrine 1999; 10: 97-103.
    • (1999) Endocrine , vol.10 , pp. 97-103
    • Fox, J.1    Lowe, S.H.2    Conklhi, R.L.3    Nemeth, E.F.4
  • 205
    • 0034012178 scopus 로고    scopus 로고
    • Activation of the calcium receptor by a calcimimetic compound halts the progression of secondary hyperparathyroidism in uremic rats
    • Chin J, Miller SC, Wada M, Nagano N, Nemeth EF, Fox J. Activation of the calcium receptor by a calcimimetic compound halts the progression of secondary hyperparathyroidism in uremic rats. J Am Soc Nephrol 2000; 11: 903-11.
    • (2000) J Am Soc Nephrol , vol.11 , pp. 903-911
    • Chin, J.1    Miller, S.C.2    Wada, M.3    Nagano, N.4    Nemeth, E.F.5    Fox, J.6
  • 206
    • 0031888842 scopus 로고    scopus 로고
    • A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Rapid communication
    • Antonsen JE, Sherrard DJ, Andress DL. A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Rapid communication. Kidney Int 1998; 53: 223-7.
    • (1998) Kidney Int , vol.53 , pp. 223-227
    • Antonsen, J.E.1    Sherrard, D.J.2    Andress, D.L.3
  • 207
    • 0033935152 scopus 로고    scopus 로고
    • A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism
    • Goodman WG, Frazao JM, Goodkin DA, Turner SA, Liu W, Coburn JW. A calcimimetic agent lowers plasma parathyroid hormone levels in patients with secondary hyperparathyroidism. Kidney Int 2000; 58: 436-45.
    • (2000) Kidney Int , vol.58 , pp. 436-445
    • Goodman, W.G.1    Frazao, J.M.2    Goodkin, D.A.3    Turner, S.A.4    Liu, W.5    Coburn, J.W.6
  • 208
    • 0036208986 scopus 로고    scopus 로고
    • The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism
    • Goodman WG, Hladik GA, Turner SA, et al. The calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J Am Soc Nephrol 2002; 13: 1017-24.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1017-1024
    • Goodman, W.G.1    Hladik, G.A.2    Turner, S.A.3
  • 209
    • 6444245707 scopus 로고    scopus 로고
    • The calcimimetic AMG 073 reduces parathyroid hormone and calcium × phosphorus in secondary hyperparathyroidism
    • Lindberg JS, Moe SM, Goodman WG, et al. The calcimimetic AMG 073 reduces parathyroid hormone and calcium × phosphorus in secondary hyperparathyroidism. Kidney Int 2003; 63: 248-54.
    • (2003) Kidney Int , vol.63 , pp. 248-254
    • Lindberg, J.S.1    Moe, S.M.2    Goodman, W.G.3
  • 212
    • 0034123554 scopus 로고    scopus 로고
    • Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats
    • Gowen M, Stroup GB, Dodds RA, et al. Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. J Clin Invest 2000; 105: 1595-604.
    • (2000) J Clin Invest , vol.105 , pp. 1595-1604
    • Gowen, M.1    Stroup, G.B.2    Dodds, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.