Calindol, a positive allosteric modulator of the human Ca2+ receptor, activates an extracellular ligand-binding domain-deleted rhodopsin-like seven-transmembrane structure in the absence of Ca2+

Journal of Biological Chemistry

Volumn 280, Issue 44, 2005, Pages 37013-37020

  Ray, Kausik ^a,d   Tisdale, Justin ^a   Dodd, Robert H ^c   Dauban, Philippe ^c   Ruat, Martial ^b   Northup, John K ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

^b LABORATOIRE DE NEUROBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

^c CNRS   (France)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CALCIUM; CELL MEMBRANES; CELLS; MOLECULAR STRUCTURE; PROTEINS;

CALINDOL; LIGAND BINDING; POSITIVE ALLOSTERIC MODULATOR; SEVEN-TRANSMEMBRANE HELICAL DOMAIN (7TMD);

MODULATORS;

CALCIMIMETIC AGENT; CALCIUM ION; CALCIUM RECEPTOR; CALINDOL; G PROTEIN COUPLED RECEPTOR; N [3 (2 CHLOROPHENYL)PROPYL] 1 (3 METHOXYPHENYL)ETHYLAMINE; RHODOPSIN; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR BINDING; WILD TYPE;

ALLOSTERIC REGULATION; ANILINE COMPOUNDS; CALCIUM; CELLS, CULTURED; HUMANS; INDOLES; KIDNEY; LIGANDS; MEMBRANE PROTEINS; MUTAGENESIS, SITE-DIRECTED; NAPHTHALENES; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CALCIUM-SENSING; RHO GTP-BINDING PROTEINS; RHODOPSIN; SEQUENCE DELETION;

EID: 27744560413     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M506681200     Document Type: Article

References (35)

1. Brown, E. M., and MacLeod, R. J. (2001) Physiol. Rev. 81, 239-2971
2. Nemeth, E. F., and Fox, J. (1999) Trends Endocrinol. Metab. 10, 239-297
3. Nemeth, E. F., Steffey, M. E., Hammerland, L. G., Hung, B. C., Van Wagenen, B. C., DelMar, E. G., and Balandrin, M. F. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 4040-4045
4. Petrel, C., Kessler, A., Dauban, P., Dodd, R. H., Rognan, D., and Ruat, M. (2004) J. Biol. Chem. 279, 18990-18997
5. Kessler, A., Faure, H., Petrel, C., Ruat, M., Dauban, P., and Dodd, R. H. (2004) Bioorg. Med. Chem. Lett. 14, 3345-3349
6. Nemeth, E. F., Delmar, E. G., Heaton, W. L., Miller, M. A., Lambert, L. D., Conklin, R. L., Gowen, M., Gleason, J. G., Bhatnagar, P. K., and Fox, J. (2001) J. Pharmacol. Exp. Ther. 299, 323-331
7. Kessler, A., Faure, H., Roussanne, M. C., Ferry, S., Ruat, M., Dauban, P., and Dodd, R. H. (2004) ChemBioChem 5, 1131-1136
8. Petrel, C., Kessler, A., Maslah, F., Dauban, P., Dodd, R. H., Rognan, D., and Ruat, M. (2003) J. Biol. Chem. 278, 49487-49494
9. Bockaert, J., and Pin, J. P. (1999) EMBO J. 18, 1723-1729
10. Ray, K. (2001) Int. Arch. Biosci. 2001, 1027-1035
11. Okamoto, T., Sekiyama, N., Otsu, M., Shimada, Y., Sato, A., Nakanishi, S., and Jingami, H. (1998) J. Biol. Chem. 273, 13089-13096
12. Han, G., and Hampson, D. R. (1999) J. Biol. Chem. 274, 10008-10013
13. Galvez, T., Parmentier, M. L., Joly, C., Malitschek, B., Kaupmann, K., Kuhn, R., Bittiger, H., Froestl, W., Bettler, B., and Pin, J. P. (1999) J. Biol. Chem. 274, 13362-13369
14. Hammerland L. G., Krapcho, K. J., Garrett, J. E., Alasti, N., Hung, B. C., Simin, R. T., Levinthal, C., Nemeth, E. F., and Fuller, F. H. (1999) Mol. Pharmacol. 55, 642-648
15. Kunishima, N., Shimada, Y., Tsuji, Y., Sato, T., Yamamoto, M., Kumasaka, T., Nakanishi, S., Jingami, H., and Morikawa, K. (2000) Nature 407, 971-977
16. Ray, K., and Northup, J. (2002) J. Biol. Chem. 277, 18908-18913
17. Miedlich, S. U., Gama, L., Seuwen, K., Wolf, R. M., and Breitwieser, G. E. (2004) J. Biol. Chem. 279, 7254-7263
18. Ray, K., Fan, G. F., Goldsmith, P. K., and Spiegel, A. M. (1997) J. Biol. Chem. 272, 31355-31361
19. Krautwurst, D., Yau, K. W., and Reed, R. R. (1998) Cell 95, 917-926
20. Chandrashekar, J., Mueller, K. L., Hoon, M. A., Adler, E., Feng, L., Guo, W., Zuker, C. S., and Ryba, N. J. (2000) Cell 100, 703-711
21. Zhao, X., Hauache, O. M., Goldsmith, P. K., Collins, R., and Spiegel, A. M. (1999) FEBS Lett. 448, 180-184
22. Hartman, J. L., IV, and Northup, J. K. (1996) J. Biol. Chem. 271, 22591-22597
23. Fawzi, A. B., and Northup, J. K. (1990) Biochemistry 29, 3804-3812
24. Jian, X., Sainz, E., Clark, W. A., Jensen, R. T., Battey, J. F., and Northup, J. K. (1999) J. Biol. Chem. 274, 11573-11581
25. Ray, K., Clapp, P., Goldsmith, P. K., and Spiegel, A. M. (1998) J. Biol. Chem. 273, 34558-34567
26. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Science 289, 739-745
27. Schaffhauser, H., Rowe, B. A., Morales, S., Chavez-Noriega, L. E., Yin, R., Jachec, C., Rao, S. P., Bain, G., Pinkerton, A. B., Vernier, J. M., Bristow, L. J., Varney, M. A., and Daggett, L. P. (2003) Mol. Pharmacol. 64, 798-810
28. Kew, J. N. (2004) Pharmacol. Ther. 104, 233-244
29. Goudet, C., Gaven, F., Kniazeff, J., Vol, C., Liu, J., Cohen-Gonsaud, M., Acher, F., Prezeau, L., and Pin, J. P. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 378-383
30. Binet, V., Brajon, C., Le Corre, L., Acher, F., Pin, J. P., and Prezeau, L. (2004) J. Biol. Chem. 279, 29085-29091
31. Ray, K., Ghosh, S. P., and Northup, J. K. (2004) Endocrinology 145, 3892-3903
32. Hauache, O. M., Hu, J., Ray, K., Xie, R., Jacobson, K. A., and Spiegel, A. M. (2000) Endocrinology 141, 4156-4163
33. Kubo, Y., Miyashita, T., and Murata, Y. (1998) Science 279, 1722-1725
34. Wise, A., Green, A., Main, M. J., Wilson, R., Fraser, N., and Marshall, F. H. (1999) Neuropharmacology 38, 1647-1656
35. Gether, U., and Kobilka, B. K. (1998) J. Biol. Chem. 273, 17979-17982