Optical measurement of mGluR1 conformational changes reveals fast activation, slow deactivation, and sensitization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 27, 2009, Pages 11388-11393

  Marcaggi, Païkan ^a,b   Mutoh, Hiroki ^b   Dimitrov, Dimitar ^b   Beato, Marco ^a   Knöpfel, Thomas ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Dimer; G protein coupled receptor; Glutamate sensor; GPCR; Imaging

Indexed keywords

DIMER; GLUTAMIC ACID; METABOTROPIC RECEPTOR 1; POTASSIUM;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL STRAIN; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DESENSITIZATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; FREQUENCY ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; SENSITIZATION; SYNAPTIC TRANSMISSION; VOLTAGE CLAMP;

ANIMALS; FLUORESCENCE RESONANCE ENERGY TRANSFER; KINETICS; MODELS, BIOLOGICAL; PC12 CELLS; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; RATS; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 67650494991     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0901290106     Document Type: Article

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