GABAB2 is essential for G-protein coupling of the GABAB receptor heterodimer

Journal of Neuroscience

Volumn 21, Issue 20, 2001, Pages 8043-8052

  Robbins, Melanie J ^a   Calver, Andrew R ^a   Filippov, Alexander K ^b   Hirst, Warren D ^a   Russell, Robert B ^a   Wood, Martyn D ^a   Nasir, Shabina ^a   Couve, Andrés ^b   Brown, David A ^b   Moss, Stephen J ^b   Pangalos, Menelas N ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Dimerization; G protein coupling; GABAB; GPCR; Receptor subunits; Signaling

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B1 RECEPTOR; 4 AMINOBUTYRIC ACID B2 RECEPTOR; DIMER; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; EFFECTOR CELL; HUMAN; HUMAN CELL; LIGAND BINDING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0035887699     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-20-08043.2001     Document Type: Article

References (39)

1. AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
2. ALSCRIPT: A tool to format multiple sequence alignments
3. Nonlinear regression using spreadsheets
4. B receptor pharmacology
5. B receptor subunits mediate intracellular trafficking, but are not required for receptor signaling
6. 2+ current via Gαo in rat sympathetic neurones
7. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
8. B receptors
9. B receptors: A new paradigm in G protein signaling
10. Ab initio modelling and molecular dynamics simulation of the albadrenergic receptor activation
11. 2+ current in sympathetic neurons
12. Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation
13. B receptor recognises G-protein alpha subunit C-termini
14. B1 subunit
15. B receptors
16. B receptor function
17. Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes
18. Heterodimerization of micro and delta opioid receptors: A role in opiate synergy
19. The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins
20. Modelling G protein-coupled receptors. Theoretical biochemistry: Processes and properties of biological systems
21. B2 receptors
22. GPCRDB: An information system for G protein-coupled receptors
23. B2
24. B receptor heterodimers
25. G-protein-coupled receptor heterodimerization modulates receptor function
26. B receptors uncovers similarity to metabotropic glutamate receptors
27. B receptor subtypes assemble into functional heteromeric complexes
28. B receptors
29. B receptor function
30. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
31. The role of members of the pertussis toxinsensitive family of G proteins in coupling receptors to the activation of the G protein-gated inwardly rectifying potassium channel
32. The N-terminal domain of gamma-aminobutyric acid(B) receptors is sufficient to specify agonist and antagonist binding
33. B receptor heterodimerization
34. Oligomerisation of G protein-coupled receptors
35. B receptor activity
36. Receptors for dopamine and somatostatin: Formation of heterooligomers with enhanced functicnal activity
37. B receptor
38. B2 heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen
39. Distinct roles of the second and third cytoplasmic loops of bovine rhodopsin in G protein activation