Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors

Neuropharmacology

Volumn 50, Issue 2, 2006, Pages 245-253

  Frauli, Mélanie ^a   Neuville, Pascal ^a   Vol, Claire ^b,c   Pin, Jean Philippe ^b,c   Prézeau, Laurent ^b,c  

^a Faust Pharmaceuticals SA   (France)

^b INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^c UNIV MONTPELLIER   (France)

Author keywords

Class C GPCR; Classical l amino acid; Functional assay; Glutamate transporter exchanger; Ligand specificity; Metabotropic glutamate receptor

Indexed keywords

ALANINE; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTAMINE; ISOLEUCINE; LEUCINE; LYSINE; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 4; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR 6; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR 8; METHIONINE; PHENYLALANINE; PROLINE; SERINE; THREONINE; TRYPTOPHAN; TYROSINE; VALINE;

ALLOSTERISM; AMINO ACID ANALYSIS; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR BLOCKING;

AMINO ACID TRANSPORT SYSTEM X-AG; AMINO ACIDS; CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID TRANSPORTER 3; GLUTAMATES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; INOSITOL PHOSPHATES; LIGANDS; RECEPTORS, METABOTROPIC GLUTAMATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

EID: 30744475204     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.09.016     Document Type: Article

References (44)

1. F.C. Acher, and H.O. Bertrand Amino-acid recognition by Venus flytrap domains is encoded in an 8-residue motif Biopolymers 80 2005 357 366
2. M. Afshar, R.E. Hubbard, and J. Demaille Towards structural models of molecular recognition in olfactory receptors Biochimie 80 1998 129 135
3. I. Brabet, M.-L. Parmentier, J. Bockaert, F. Acher, and J.-P. Pin Effect of γ-carboxy-l-glutamate and DCG-IV on metabotropic glutamate receptor types 1, 2 and 4 Neuropharmacology 37 1998 1043 1051
4. V. Bruno, G. Battaglia, A. Copani, M. D'Onofrio, P. Di Iorio, A. De Blasi, D. Melchiorri, P.J. Flor, and F. Nicoletti Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs J. Cereb. Blood Flow Metab. 21 2001 1013 1033
5. A.D. Conigrave, S.J. Quinn, and E.M. Brown l-amino-acid sensing by the extracellular Ca2+-sensing receptor (see comments) Proc. Natl. Acad. Sci. U.S.A. 97 2000 4814 4819
6. N.C. Danbolt Glutamate uptake Prog. Neurobiol. 65 2001 1 105
7. J.A. Davies, S.J. Annels, B.G. Dickie, Y. Ellis, and N.J. Knott A comparison between the stimulated and paroxysmal release of endogenous amino-acids from rat cerebellar, striatal and hippocampal slices: a manifestation of spreading depression? J. Neurol. Sci. 131 1995 8 14
8. αq/i proteins: characterization of new anatgonists Mol. Pharmacol. 50 1996 923 930
9. C. Goudet, F. Gaven, J. Kniazeff, C. Vol, J. Liu, M. Cohen-Gonsaud, F. Acher, L. Prezeau, and J.P. Pin Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors Proc. Natl. Acad. Sci. U.S.A. 101 2004 378 383
10. C. Joly, J. Gomeza, I. Brabet, K. Curry, J. Bockaert, and J.-P. Pin Molecular, functional and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1 J. Neurosci. 15 1995 3970 3981
11. A. Kingston, J. Lowndes, N. Evans, B. Clark, R. Tomlinson, J. Burnett, N. Mayne, S. Cockerham, and D. Lodge Sulphur-containing amino-acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines Neuropharmacology 37 1998 277 287
12. N. Kunishima, Y. Shimada, Y. Tsuji, T. Sato, M. Yamamoto, T. Kumasaka, S. Nakanishi, H. Jingami, and K. Morikawa Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor Nature 407 2000 971 977
13. J.W. Lazarewicz, A. Ziembowicz, E. Matyja, A. Stafiej, and E. Zieminska Homocysteine-evoked 45Ca release in the rabbit hippocampus is mediated by both NMDA and group I metabotropic glutamate receptors: in vivo microdialysis study Neurochem. Res. 28 2003 259 269
14. X. Li, L. Staszewski, H. Xu, K. Durick, M. Zoller, and E. Adler Human receptors for sweet and umami taste Proc. Natl. Acad. Sci. U.S.A. 99 2002 4692 4696
15. U. Magnusson, B. Salopek-Sondi, L.A. Luck, and S.L. Mowbray X-ray structures of the leucine-binding protein illustrate conformational changes and the basis of ligand specificity J. Biol. Chem. 279 2004 8747 8752
16. G.J. McBean, and J. Flynn Molecular mechanisms of cystine transport Biochem. Soc. Trans. 29 2001 717 722
17. G.J. McBean Cerebral cystine uptake: a tale of two transporters Trends Pharmacol. Sci. 23 2002 299 302
18. R.I. Melendez, J. Vuthiganon, and P.W. Kalivas Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors J. Pharmacol. Exp. Ther. 314 2005 139 147
19. S. Molchanova, P. Koobi, S.S. Oja, and P. Saransaari Interstitial concentrations of amino-acids in the rat striatum during global forebrain ischemia and potassium-evoked spreading depression Neurochem. Res. 29 2004 1519 1527
20. H.C. Mun, A.H. Franks, E.L. Culverston, K. Krapcho, E.F. Nemeth, and A.D. Conigrave The Venus Fly Trap domain of the extracellular Ca2+-sensing receptor is required for l-amino-acid sensing J. Biol. Chem. 279 2004 51739 51744
21. H.C. Mun, E.L. Culverston, A.H. Franks, C.A. Collyer, R.J. Clifton-Bligh, and A.D. Conigrave A double mutation in the extracellular Ca2+-sensing receptor's Venus flytrap domain that selectively disables l-amino-acid sensing J. Biol. Chem. 280 2005 29067 29072
22. G. Nelson, M.A. Hoon, J. Chandrashekar, Y. Zhang, N.J.P. Ryba, and C.S. Zuker Mammalian sweet taste receptors Cell 106 2001 381 390
23. G. Nelson, J. Chandrashekar, M.A. Hoon, L. Feng, G. Zhao, N.J. Ryba, and C.S. Zuker An amino-acid taste receptor Nature 416 2002 199 202
24. P.J. O'Hara, P.O. Sheppard, H. Thogersen, D. Venezia, B.A. Haldeman, V. McGrane, K.M. Houamed, C. Thomsen, T.L. Gilbert, and E.R. Mulvihill The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins Neuron 11 1993 41 52
25. E. Palmer, D.T. Monaghan, and C.W. Cotman trans-ACPD, a selective agonist of the phosphoinositide coupled excitatory amino-acid receptor Eur. J. Pharmacol. 166 1989 585 587
26. M.L. Parmentier, C. Joly, S. Restituito, J. Bockaert, Y. Grau, and J.-P. Pin The G-protein coupling profile of metabotropic glutamate receptors, as determined with exogenous G-proteins, is independent of their ligand recognition domain Mol. Pharmacol. 53 1998 778 786
27. M.L. Parmentier, T. Galvez, F. Acher, B. Peyre, R. Pellicciari, Y. Grau, J. Bockaert, and J.P. Pin Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution Neuropharmacology 39 2000 1119 1131
28. J.-P. Pin, and F. Acher The metabotropic glutamate receptors: structure, activation mechanism and pharmacology Curr. Drug Targets 1 2002 297 317
29. J.-P. Pin, T. Galvez, and L. Prezeau Evolution, structure and activation mechanism of family 3/C G-protein coupled receptors Pharmacol. Ther. 98 2003 325 354
30. D.V. Pow Visualising the activity of the cystine-glutamate antiporter in glial cells using antibodies to aminoadipic acid, a selectively transported substrate Glia 34 2001 27 38
31. A.I. Qureshi, Z. Ali, M.F. Suri, A. Shuaib, G. Baker, K. Todd, L.R. Guterman, and L.N. Hopkins Extracellular glutamate and other amino-acids in experimental intracerebral hemorrhage: an in vivo microdialysis study Crit. Care Med. 31 2003 1482 1489
32. Y. Sagara, and D. Schubert The activation of metabotropic glutamate receptors protects nerve cells from oxidative stress J. Neurosci. 18 1998 6662 6671
33. H. Sato, M. Tamba, S. Okuno, K. Sato, K. Keino-Masu, M. Masu, and S. Bannai Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain J. Neurosci. 22 2002 8028 8033
34. D.D. Schoepp, D.E. Jane, and J.A. Monn Pharmacological agents acting at subtypes of metabotropic glutamate receptors Neuropharmacology 38 1999 1431 1476
35. Q. Shi, J.E. Savage, S.J. Hufeisen, L. Rauser, E. Grajkowska, P. Ernsberger, J.T. Wroblewski, J.H. Nadeau, and B.L. Roth l-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists J. Pharmacol. Exp. Ther. 305 2003 131 142
36. N. Shimada, R. Graf, G. Rosner, and W.D. Heiss Ischemia-induced accumulation of extracellular amino-acids in cerebral cortex, white matter, and cerebrospinal fluid J. Neurochem. 60 1993 66 71
37. D.J. Speca, D.M. Lin, P.W. Sorensen, E.Y. Isacoff, J. Ngai, and A.H. Dittman Functional identification of a goldfish odorant receptor Neuron 23 1999 487 498
38. P. Wellendorph, K.B. Hansen, A. Balsgaard, J.R. Greenwood, J. Egebjerg, and H. Brauner-Osborne Deorphanization of GPRC6A: a promiscuous l-{alpha}-amino-acid receptor with preference for basic amino-acids Mol. Pharmacol. 67 2005 589 597
39. J. Wichmann, K. Bleicher, E. Vieira, T. Woltering, F. Knoflach, and V. Mutel Alkyl diphenylacetyl, 9H-xanthene- and 9H-thioxanthene-carbonyl carbamates as positive allosteric modulators of mGlu1 receptors Farmaco 57 2002 989 992
40. Z.X. Xi, H. Shen, D.A. Baker, and P.W. Kalivas Inhibition of non-vesicular glutamate release by group III metabotropic glutamate receptors in the nucleus accumbens J. Neurochem. 87 2003 1204 1212
41. H. Xu, L. Staszewski, H. Tang, E. Adler, M. Zoller, and X. Li Different functional roles of T1R subunits in the heteromeric taste receptors Proc. Natl. Acad. Sci. U.S.A. 101 2004 14258 14263
42. N. Zerangue, and M.P. Kavanaugh Interaction of l-cysteine with a human excitatory amino-acid transporter J. Physiol. 493 Pt 2 1996 419 423
43. Z. Zhang, Y. Jiang, S.J. Quinn, K. Krapcho, E.F. Nemeth, and M. Bai l-phenylalanine and NPS R-467 synergistically potentiate the function of the extracellular calcium-sensing receptor through distinct sites J. Biol. Chem. 277 2002 33736 33741
44. Z. Zhang, W. Qiu, S.J. Quinn, A.D. Conigrave, E.M. Brown, and M. Bai Three adjacent serines in the extracellular domains of the CaR are required for l-amino-acid-mediated potentiation of receptor function J. Biol. Chem. 277 2002 33727 33735