Closed state of both binding domains of homodimeric mGlu receptors is required for full activity

Nature Structural and Molecular Biology

Volumn 11, Issue 8, 2004, Pages 706-713

  Kniazeff, Julie ^a   Bessis, Anne Sophie ^a,c   Maurel, Damien ^a,b   Ansanay, Hervé ^b   Prézeau, Laurent ^a   Pin, Jean Philippe ^a  

^a CNRS   (France)

^b CIS Bio International   (France)

^c ADDEX PHARMACEUTICALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; G PROTEIN COUPLED RECEPTOR; MEMBRANE RECEPTOR; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST;

ARTICLE; CONFORMATION; DELETION MUTANT; DRUG BINDING SITE; DRUG RECEPTOR BINDING; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; WILD TYPE;

BINDING SITES; CALCIUM; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; INOSITOL PHOSPHATES; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GABA-B; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 3543036363     PISSN: 15459993     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsmb794     Document Type: Article

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