Phosphatidylinositol 3-kinase signaling in thymocytes: The need for stringent control

Science Signaling

Volumn 3, Issue 135, 2010, Pages

  Fayard, Elisabeth ^a   Moncayo, Gerald ^a   Hemmings, Brian A ^a   Holländer, Georg A ^b  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

AUTOIMMUNITY; CELL DEATH; CELL DIFFERENTIATION; GLYCOGEN SYNTHESIS; HUMAN; HYDROPHOBICITY; IMMUNE RESPONSE; IMMUNE SYSTEM; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; REVIEW; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

CELL PROLIFERATION; HEMATOPOIETIC STEM CELLS; MODELS, IMMUNOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 77956630628     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.3135re5     Document Type: Review

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175. Acknowledgments: We thank the referees for their constructive comments and suggestions. Funding: E.F. is supported by a European Molecular Biology Organization (EMBO) Long Term Fellowship ALTF 506-2005 and Marie-Curie Fellowship MEIF-CT-2006-025075; G.M. is supported by Oncossuise; G.A.H. is supported by the Swiss National Science Foundation (3100A0-122558/1). The Friedrich Miescher Institute for Biomedical research is part of the Novartis Research Foundation.