The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

Nature Immunology

Volumn 5, Issue 5, 2004, Pages 539-545

  Hinton, Heather J ^a,b   Alessi, Dario R ^b   Cantrell, Doreen A ^b  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; PHOSPHOINOSITIDE DEPENDENT KINASE 1; PROTEIN KINASE C; PROTEIN SERINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE DELETION; GENETIC MANIPULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; T LYMPHOCYTE; THYMUS;

ANIMALS; CELL DIFFERENTIATION; GENE DELETION; INTEGRASES; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); MICE; PROTEIN-SERINE-THREONINE KINASES; T-LYMPHOCYTES; THYMUS GLAND; VIRAL PROTEINS;

EID: 2442681621     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni1062     Document Type: Article

References (45)

1. Borowski, C. et al. On the brink of becoming a T cell. Curr. Opin. Immunol. 14, 200-206 (2002).
2. Michie, A.M., Soh, J.W., Hawley, R.G., Weinstein, I.B. & Zuniga-Pflucker, J.C. Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes. Proc. Natl. Acad. Sci. USA 98, 609-614 (2001).
3. Michie, A.M. & Zuniga-Pflucker, J.C. Regulation of thymocyte differentiation: pre-TCR signals and β-selection. Semin. Immunol. 14, 311-323 (2002).
4. Spits, H. Development of αβ T cells in the human thymus. Nat. Rev. Immunol. 2, 760-772 (2002).
5. Cantrell, D.A. Regulation and function of serine kinase networks in lymphocytes. Curr. Opin. Immunol. 15, 294-298 (2003).
6. Acuto, O. & Cantrell, D. T cell activation and the cytoskeleton. Annu. Rev. Immunol. 18, 165-184 (2000).
7. Cantrell, D.A. Transgenic analysis of thymocyte signal transduction. Nat. Rev. Immunol. 2, 20-27 (2002).
8. Samelson, L.E. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20, 371-394 (2002).
9. Koretzky, G.A. et al. Regulation of hematopoietic cell development and activation by adapter proteins. Immunol. Res. 27, 357-366 (2003).
10. Marklund, U., Lightfoot, K. & Cantrell, D. Intracellular location and cell context-dependent function of protein kinase D. Immunity 19, 491-501 (2003).
11. Rodriguez-Borlado, L. et al. Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio. J. Immunol. 170, 4475-4482 (2003).
12. Suzuki, A. et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 14, 523-534 (2001).
13. s6k gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 17, 6649-6659 (1998).
14. Peng, X.D, et al. Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2. Genes. Dev. 17, 1352-1365 (2003).
15. Leitges, M. et al. Targeted disruption of the ζPKC gene results in the impairment of the NF-κB pathway. Mol. Cell. 8, 771-780 (2001).
16. Leitges, M. et al. Protein kinase C-δ is a negative regulator of antigen-induced mast cell degranulation. Mol. Cell. Biol. 22, 3970-3980 (2002).
17. Leitges, M. et al. Immunodeficiency in protein kinase cβ-deficient mice. Science 273, 788-791 (1996).
18. Castrillo, A. et al. Protein kinase CE is required for macrophage activation and defense against bacterial infection. J. Exp. Med. 194, 1231-1242 (2001).
19. Mecklenbrauker, I., Saijo, K., Zheng, N.Y., Leitges, M. & Tarakhovsky, A. Protein kinase Cδ controls self-antigen-induced B-cell tolerance. Nature 416, 860-865 (2002).
20. Su, T.T. et al. PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling. Nat. Immunol. 3, 780-786 (2002).
21. Sun, Z. et al. PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes. Nature 404, 402-407 (2000).
22. Parker, P.J. & Parkinson, S.J. AGC protein kinase phosphorylation and protein kinase C. Biochem. Soc. Trans. 29, 860-863 (2001).
23. Alessi, D.R. et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7, 261-269 (1997).
24. Lawlor, M.A. et al. Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 21, 3728-3738 (2002).
25. Mora, A. et al. Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia. EMBO J. 22, 4666-4676 (2003).
26. Takahama, Y. et al. Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene. Eur. J. Immunol. 28, 2159-2166 (1998).
27. lck with the pre-T cell receptor during thymocyte development. Eur. J. Immunol. 30, 8-18 (2000).
28. Aifantis, I., Buer, J., von Boehmer, H. & Azogui, O. Essential role of the pre-T cell receptor in allelic exclusion of the T cell receptor β locus. Immunity 7, 601-607 (1997).
29. Azzam, H.S. et al. CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity. J. Exp. Med. 188, 2301-2311 (1998).
30. Rodewald, H.R. et al. FcγRII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8-murine thymocytes: in vivo developmental kinetics and T cell receptor β chain rearrangement status. J. Exp. Med. 177, 1079-1092 (1993).
31. Gomez, M., Kioussis, D. & Cantrell, D.A. The GTPase Rac-1 controls cell fate in the thymus by diverting thymocytes from positive to negative selection. Immunity 15, 703-713 (2001).
32. Trigueros, C. et al. Pre-TCR signaling regulates IL-7 receptor α expression promoting thymocyte survival at the transition from the double-negative to double-positive stage. Eur. J. Immunol. 33, 1968-1977 (2003).
33. Gallandrini, R., Henning, S. & Cantrell, D.A. Different functions for the GTPase Rho in prothymocytes and late pre-T cells. Immunity 7, 163-174 (1997).
34. Costello, P.S., Cleverley, S.C., Galandrini, R., Henning, S.W. & Cantrell, D.A. The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. J. Exp. Med. 192, 77-85 (2000).
35. Vanhaesebroeck, B, & Alessi, D.R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J. 346 Pt 3, 561-576 (2000).
36. Lizcano, J.M. et al. Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B. Biochem. J. 374, 297-306 (2003).
37. Lafont, V., Astoul, E., Laurence, A., Liautard, J. & Cantrell, D. The T cell antigen receptor activates phosphatidylinositol 3-kinase-regulated serine kinases protein kinase B and ribosomal S6 kinase 1. FEBS Lett. 486, 38-42 (2000).
38. H2 cytokines. Nat. Immunol. 2, 37-44 (2001).
39. Wolfer, A., Wilson, A., Nemir, M., MacDonald, H.R. & Radtke, F. Inactivation of Notch1 impairs VDJβ rearrangement and allows pre-TCR-independent survival of early αβ lineage thymocytes. Immunity 16, 869-879 (2002).
40. Thomas, G. The S6 kinase signaling pathway in the control of development and growth. Biol. Res. 35, 305-313 (2002).
41. Ward, S.G. & Cantrell, D.A. Phosphoinositide 3-kinases in T lymphocyte activation. Curr. Opin. Immunol. 13, 332-338 (2001).
42. Okkenhaug, K. et al. Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice. Science 297, 1031-1034 (2002).
43. Cantrell, D.A. Phosphoinositide 3-kinase signalling pathways. J. Cell. Sci. 114, 1439-1445 (2001).
44. Harris, T.K. PDK1 and PKB/Akt: ideal targets for development of new strategies to structure-based drug design. IUBMB Life 55, 117-126 (2003).
45. Williams, M.R. et al. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr. Biol. 10, 439-448 (2000).